Dr Bettina Wilm Dr rer nat

Senior Lecturer Women's & Children's Health

+44 (0)151 795 4988
Work email B.Wilm@liverpool.ac.uk
Personal Websitehttp://www.liv.ac.uk/physiology/research/wilm/

Publications

Filter the publication list

Filter list by type

Show all
Journal article
Conference paper
Chapter
Other

2023

Intravenous Administration of Human Umbilical Cord Mesenchymal Stromal Cells Leads to an Inflammatory Response in the Lung. (Journal article)

Hernandez Pichardo, A., Wilm, B., Liptrott, N. J., & Murray, P. (2023). Intravenous Administration of Human Umbilical Cord Mesenchymal Stromal Cells Leads to an Inflammatory Response in the Lung.. Stem cells international, 2023, 7397819. doi:10.1155/2023/7397819

DOI: 10.1155/2023/7397819

Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using Deep Learning-based semantic segmentation in histology. (Journal article)

Luchian, A., Cepeda, K. T., Harwood, R., Murray, P., Wilm, B., Kenny, S., . . . Ressel, L. (2023). Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using Deep Learning-based semantic segmentation in histology.. Biology open, bio.059988. doi:10.1242/bio.059988

DOI: 10.1242/bio.059988

Mesothelial cells exhibit characteristics of perivascular cells in anin vitroangiogenesis assay (Preprint)

DOI: 10.1101/2023.08.11.552910

Multispectral optoacoustic tomography is more sensitive than micro-computed tomography for tracking gold nanorod labelled mesenchymal stromal cells (Journal article)

Pichardo, A. H., Littlewood, J., Taylor, A., Wilm, B., Levy, R., & Murray, P. (2023). Multispectral optoacoustic tomography is more sensitive than micro-computed tomography for tracking gold nanorod labelled mesenchymal stromal cells. JOURNAL OF BIOPHOTONICS. doi:10.1002/jbio.202300109

DOI: 10.1002/jbio.202300109

Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach (Journal article)

Calcat-i-Cervera, S., Rendra, E., Scaccia, E., Amadeo, F., Hanson, V., Wilm, B., . . . Bieback, K. (2023). Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach. STEM CELL RESEARCH & THERAPY, 14(1). doi:10.1186/s13287-023-03352-1

DOI: 10.1186/s13287-023-03352-1

VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells (Journal article)

Mondru, A. K., Aljasir, M. A., Alrumayh, A., Nithianandarajah, G. N., Ahmed, K., Muller, J., . . . Cross, M. J. (2023). VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells. CELLS, 12(6). doi:10.3390/cells12060967

DOI: 10.3390/cells12060967

Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system (Journal article)

Amadeo, F., Hanson, V., Liptrott, N. J., Wilm, B., Murray, P., & Taylor, A. (2023). Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system. BIOMEDICINE & PHARMACOTHERAPY, 159. doi:10.1016/j.biopha.2022.114191

DOI: 10.1016/j.biopha.2022.114191

The transition zone in Hirschsprung's bowel contains abnormal hybrid ganglia with characteristics of extrinsic nerves (Journal article)

Smith, M., Chhabra, S., Shukla, R., Kenny, S., Almond, S., Edgar, D., & Wilm, B. (2023). The transition zone in Hirschsprung's bowel contains abnormal hybrid ganglia with characteristics of extrinsic nerves. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 27(2), 287-298. doi:10.1111/jcmm.17659

DOI: 10.1111/jcmm.17659

2022

Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated cell Survival (Journal article)

Muñiz-García, A., Wilm, B., Murray, P., & Cross, M. J. (n.d.). Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated cell Survival. Cells, 11(23), 3750. doi:10.3390/cells11233750

DOI: 10.3390/cells11233750

Optical Tissue Clearing to Study the Intra-Pulmonary Biodistribution of Intravenously Delivered Mesenchymal Stromal Cells and Their Interactions with Host Lung Cells (Journal article)

Pichardo, A. H., Amadeo, F., Wilm, B., Lévy, R., Ressel, L., Murray, P., & Sée, V. (n.d.). Optical Tissue Clearing to Study the Intra-Pulmonary Biodistribution of Intravenously Delivered Mesenchymal Stromal Cells and Their Interactions with Host Lung Cells. International Journal of Molecular Sciences, 23(22), 14171. doi:10.3390/ijms232214171

DOI: 10.3390/ijms232214171

Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung (Preprint)

DOI: 10.1101/2022.09.26.509547

Multicentre comparison of biological and functional properties of mesenchymal stromal cells from different sources cultivated using a harmonised manufacturing workflow (Preprint)

DOI: 10.1101/2022.09.14.507944

Comparison between optical tissue clearing methods for detecting administered mesenchymal stromal cells in mouse lungs (Preprint)

DOI: 10.1101/2022.07.23.501233

The transition zone in Hirschsprung’s bowel contains abnormal hybrid ganglia with characteristics of extrinsic nerves (Preprint)

DOI: 10.1101/2022.06.15.22276240

Computed tomography lacks sensitivity to image gold labelled mesenchymal stromal cells in vivo as evidenced by multispectral optoacoustic tomography (Preprint)

DOI: 10.1101/2022.06.15.495483

Murine models of renal ischemia reperfusion injury: An opportunity for refinement using noninvasive monitoring methods (Journal article)

Harwood, R., Bridge, J., Ressel, L., Scarfe, L., Sharkey, J., Czanner, G., . . . Murray, P. (2022). Murine models of renal ischemia reperfusion injury: An opportunity for refinement using noninvasive monitoring methods. Physiological Reports, 10(5). doi:10.14814/phy2.15211

DOI: 10.14814/phy2.15211

Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies (Journal article)

Amadeo, F., Plagge, A., Chacko, A., Wilm, B., Hanson, V., Liptrott, N., . . . Taylor, A. (2022). Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 49(3), 796-808. doi:10.1007/s00259-021-05439-4

DOI: 10.1007/s00259-021-05439-4

2021

Mesenchymal stromal cells: what have we learned so far about their therapeutic potential and mechanisms of action? (Journal article)

Amadeo, F., Cepeda, K. T., Littlewood, J., Wilm, B., Taylor, A., & Murray, P. (2021). Mesenchymal stromal cells: what have we learned so far about their therapeutic potential and mechanisms of action?. EMERGING TOPICS IN LIFE SCIENCES, 5(4), 549-562. doi:10.1042/ETLS20210013

DOI: 10.1042/ETLS20210013

Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice (Journal article)

Wilm, T. P., Tanton, H., Mutter, F., Foisor, V., Middlehurst, B., Ward, K., . . . Wilm, B. (2021). Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-95380-1

DOI: 10.1038/s41598-021-95380-1

Post-Surgical Peritoneal Scarring and Key Molecular Mechanisms (Journal article)

Herrick, S. E., & Wilm, B. (2021). Post-Surgical Peritoneal Scarring and Key Molecular Mechanisms. BIOMOLECULES, 11(5). doi:10.3390/biom11050692

DOI: 10.3390/biom11050692

2020

Multimodal Imaging Techniques Show Differences in Homing Capacity Between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models (Journal article)

Taylor, A., Sharkey, J., Harwood, R., Scarfe, L., Barrow, M., Rosseinsky, M. J., . . . Murray, P. (2020). Multimodal Imaging Techniques Show Differences in Homing Capacity Between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models. MOLECULAR IMAGING AND BIOLOGY, 22(4), 904-913. doi:10.1007/s11307-019-01458-8

DOI: 10.1007/s11307-019-01458-8

Perylene Diimide Nanoprobes for In Vivo Tracking of Mesenchymal Stromal Cells Using Photoacoustic Imaging. (Journal article)

Yang, Y., Fryer, C., Sharkey, J., Thomas, A., Wais, U., Jackson, A. W., . . . Zhang, H. (2020). Perylene Diimide Nanoprobes for In Vivo Tracking of Mesenchymal Stromal Cells Using Photoacoustic Imaging.. ACS applied materials & interfaces, 12(25), 27930-27939. doi:10.1021/acsami.0c03857

DOI: 10.1021/acsami.0c03857

Measuring Kidney Perfusion, pH, and Renal Clearance Consecutively Using MRI and Multispectral Optoacoustic Tomography (Journal article)

Minhas, A. S., Sharkey, J., Randtke, E. A., Murray, P., Wilm, B., Pagel, M. D., & Poptani, H. (2020). Measuring Kidney Perfusion, pH, and Renal Clearance Consecutively Using MRI and Multispectral Optoacoustic Tomography. MOLECULAR IMAGING AND BIOLOGY, 22(3), 494-503. doi:10.1007/s11307-019-01429-z

DOI: 10.1007/s11307-019-01429-z

Regenerative medicine therapies: lessons from the kidney (Journal article)

Davies, J. A., Murray, P., & Wilm, B. (2020). Regenerative medicine therapies: lessons from the kidney. CURRENT OPINION IN PHYSIOLOGY, 14, 41-47. doi:10.1016/j.cophys.2019.12.008

DOI: 10.1016/j.cophys.2019.12.008

Expression of neurones and neuronal precursors in the transition zone of short-segment Hirschsprung's disease. (Journal article)

Doherty, J., Chhabra, S., Smith, M., Edgar, D., Almond, S., Kenny, S., & Wilm, B. (2020). Expression of neurones and neuronal precursors in the transition zone of short-segment Hirschsprung's disease.. Clinical medicine (London, England), 20(Suppl 2), s105-s106. doi:10.7861/clinmed.20-2-s105

DOI: 10.7861/clinmed.20-2-s105

2019

A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction (Journal article)

Sharkey, J., Ressel, L., Brillant, N., Scarfe, L., Wilm, B., Park, B. K., & Murray, P. (2019). A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction. Stem Cells International, 2019. doi:10.1155/2019/7386954

DOI: 10.1155/2019/7386954

In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells. (Journal article)

Ashraf, S., Taylor, A., Sharkey, J., Barrow, M., Murray, P., Wilm, B., . . . Lévy, R. (2019). In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells.. Nanoscale advances, 1(1), 367-377. doi:10.1039/c8na00098k

DOI: 10.1039/c8na00098k

2018

Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc‐Based BRET Reporter in Combination with Firefly Luciferase (Journal article)

TAYLOR, A., Sharkey, J., Plagge, A. J., Wilm, B., & Murray, P. (2018). Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc‐Based BRET Reporter in Combination with Firefly Luciferase. Contrast Media and Molecular Imaging, 2018. doi:10.1155/2018/2514796

DOI: 10.1155/2018/2514796

Transdermal Measurement of Glomerular Filtration Rate in Mice. (Journal article)

Scarfe, L., Schock-Kusch, D., Ressel, L., Friedemann, J., Shulhevich, Y., Murray, P., . . . de Caestecker, M. (2018). Transdermal Measurement of Glomerular Filtration Rate in Mice.. Journal of visualized experiments : JoVE, 140. doi:10.3791/58520

DOI: 10.3791/58520

In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells (Journal article)

Ashraf, S., Taylor, A., Sharkey, J., Barrow, M., Murray, P., Wilm, B., . . . Levy, R. (2018). In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells. Nanoscale Advances. doi:10.1039/C8NA00098K

DOI: 10.1039/C8NA00098K

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo (vol 10, pg 7106, 2016) (Journal article)

Comenge, J., Fragueiro, O., Sharkey, J., Taylor, A., Held, M., Burton, N. C., . . . Levy, R. (2018). Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo (vol 10, pg 7106, 2016). ACS NANO, 12(8), 8831. doi:10.1021/acsnano.8b05577

DOI: 10.1021/acsnano.8b05577

Functional molecules in mesothelial-to-mesenchymal transition revealed by transcriptome analyses (Journal article)

Namvar, S., Woolf, A. S., Zeef, L. A. H., Wilm, T., Wilm, B., & Herrick, S. E. (2018). Functional molecules in mesothelial-to-mesenchymal transition revealed by transcriptome analyses. JOURNAL OF PATHOLOGY, 245(4), 491-501. doi:10.1002/path.5101

DOI: 10.1002/path.5101

Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy (Journal article)

Held, M., Santeramo, I., Wilm, B., Murray, P., & Levy, R. (2018). Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy. PLoS One, 13(7). doi:10.1371/journal.pone.0199918

DOI: 10.1371/journal.pone.0199918

Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy (Journal article)

Held, M., Santeramo, I., Wilm, B., Murray, P., & Lévy, R. (2018). Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy. PLoS One. doi:10.1371/journal.pone.0199918

DOI: 10.1371/journal.pone.0199918

Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes. (Journal article)

Comenge, J., Sharkey, J., Fragueiro, O., Wilm, B., Brust, M., Murray, P., . . . Plagge, A. (2018). Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes.. eLife, 7. doi:10.7554/elife.33140

DOI: 10.7554/elife.33140

2017

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. (Journal article)

Scarfe, L., Brillant, N., Kumar, J. D., Ali, N., Alrumayh, A., Amali, M., . . . Park, B. K. (2017). Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. NPJ REGENERATIVE MEDICINE, 2. doi:10.1038/s41536-017-0029-9

DOI: 10.1038/s41536-017-0029-9

Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration. (Journal article)

Scarfe, L., Taylor, A., Sharkey, J., Harwood, R., Barrow, M., Comenge, J., . . . Wilm, B. (2018). Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration. STEM CELL RESEARCH & THERAPY, 9. doi:10.1186/s13287-018-1076-x

DOI: 10.1186/s13287-018-1076-x

Utilising multispectral optoacoustic tomography (MSOT) to assess organ function and track labelled therapeutic cells for regenerative medicine therapies in vivo (Journal article)

Sharkey, J., Scarfe, L., Comenge, J., Brillant, N., Burton, N., Antoine, D., . . . Murray, P. (2017). Utilising multispectral optoacoustic tomography (MSOT) to assess organ function and track labelled therapeutic cells for regenerative medicine therapies in vivo. HUMAN GENE THERAPY, 28(8), A19. Retrieved from https://www.webofscience.com/

Nephron Progenitors (Chapter)

Santeramo, I., Wilm, B., & Murray, P. (2017). Nephron Progenitors. In KIDNEY TRANSPLANTATION, BIOENGINEERING, AND REGENERATION: KIDNEY TRANSPLANTATION IN THE REGENERATIVE MEDICINE ERA (pp. 1053-1065). doi:10.1016/B978-0-12-801734-0.00076-X

DOI: 10.1016/B978-0-12-801734-0.00076-X

Optimising the use of medicines to reduce acute kidney injury in children and babies (Journal article)

Oni, L., Hawcutt, D. B., Turner, M. A., Beresford, M. W., McWilliam, S., Barton, C., . . . Antoine, D. J. (2017). Optimising the use of medicines to reduce acute kidney injury in children and babies. Pharmacology and Therapeutics, 174, 55-62. doi:10.1016/j.pharmthera.2017.02.018

DOI: 10.1016/j.pharmthera.2017.02.018

Human Kidney-Derived Cells Ameliorate Acute Kidney Injury Without Engrafting into Renal Tissue. (Journal article)

Santeramo, I., Herrera Perez, Z., Illera, A., Taylor, A., Kenny, S., Murray, P., . . . Gretz, N. (2017). Human Kidney‐Derived Cells Ameliorate Acute Kidney Injury Without Engrafting into Renal Tissue. Stem Cells Translational Medicine, 6(5), 1373-1384. doi:10.1002/sctm.16-0352

DOI: 10.1002/sctm.16-0352

Multimodal stem cell imaging and tracking (Conference Paper)

Ashraf, S., Barrow, M., Comenge, J., Taylor, A., Sharkey, J., Murray, P., . . . Levy, R. (2017). Multimodal stem cell imaging and tracking. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254. Retrieved from https://www.webofscience.com/

2016

Extracellular matrix scaffolds as a platform for kidney regeneration. (Journal article)

Peloso, A., Tamburrini, R., Edgar, L., Wilm, B., Katari, R., Perin, L., . . . Orlando, G. (2016). Extracellular matrix scaffolds as a platform for kidney regeneration. EUROPEAN JOURNAL OF PHARMACOLOGY, 790, 21-27. doi:10.1016/j.ejphar.2016.07.038

DOI: 10.1016/j.ejphar.2016.07.038

Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease (Journal article)

Sharkey, J., Scarfe, L., Santeramo, I., Garcia-Finana, M., Park, B. K., Poptani, H., . . . Murray, P. (2016). Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease. EUROPEAN JOURNAL OF PHARMACOLOGY, 790, 74-82. doi:10.1016/j.ejphar.2016.06.056

DOI: 10.1016/j.ejphar.2016.06.056

Autologous Cells for Kidney Bioengineering. (Journal article)

Wilm, B., Tamburrini, R., Orlando, G., & Murray, P. (2016). Autologous Cells for Kidney Bioengineering.. Current transplantation reports, 3, 207-220. doi:10.1007/s40472-016-0107-8

DOI: 10.1007/s40472-016-0107-8

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo (Journal article)

Comenge, J., Fragueiro, O., Sharkey, J., Taylor, A., Held, M., Burton, N. C., . . . Lévy, R. (2016). Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. ACS Nano, 10(7), 7106-7116. doi:10.1021/acsnano.6b03246

DOI: 10.1021/acsnano.6b03246

Characterisation of cultured mesothelial cells derived from the murine adult omentum (Journal article)

Dauleh, S., Santeramo, I., Fielding, C., Ward, K., Herrmann, A., Murray, P. M., & Wilm, B. (2016). Characterisation of cultured mesothelial cells derived from the murine adult omentum. PLoS ONE, 11(7). doi:10.1371/journal.pone.0158997

DOI: 10.1371/journal.pone.0158997

Amniotic Fluid Stem Cells within Chimeric Kidney Rudiments Differentiate to Functional Podocytes after Transplantation into Mature Rat Kidneys (Journal article)

Wilm, B., & Murray, P. (2016). Amniotic Fluid Stem Cells within Chimeric Kidney Rudiments Differentiate to Functional Podocytes after Transplantation into Mature Rat Kidneys. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 27(5), 1266-1268. doi:10.1681/ASN.2015101115

DOI: 10.1681/ASN.2015101115

INTEGRATING NOVEL IMAGING TECHNOLOGIES TO INVESTIGATE DRUG-INDUCED KIDNEY TOXICITY (Chapter)

Wilm, B., & Burton, N. C. (2016). INTEGRATING NOVEL IMAGING TECHNOLOGIES TO INVESTIGATE DRUG-INDUCED KIDNEY TOXICITY. In DRUG DISCOVERY TOXICOLOGY: FROM TARGET ASSESSMENT TO TRANSLATIONAL BIOMARKERS (pp. 454-457). Retrieved from https://www.webofscience.com/

The Role of WT1 in Embryonic Development and Normal Organ Homeostasis (Journal article)

Wilm, B., & Munoz-Chapuli, R. (2016). The Role of WT1 in Embryonic Development and Normal Organ Homeostasis. WILMS' TUMOR (WT1) GENE, 1467, 23-39. doi:10.1007/978-1-4939-4023-3_3

DOI: 10.1007/978-1-4939-4023-3_3

Tools and Techniques for Wt1-Based Lineage Tracing (Journal article)

Wilm, B., & Munoz-Chapuli, R. (2016). Tools and Techniques for Wt1-Based Lineage Tracing. WILMS' TUMOR (WT1) GENE, 1467, 41-59. doi:10.1007/978-1-4939-4023-3_4

DOI: 10.1007/978-1-4939-4023-3_4

2015

Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy (Journal article)

Scarfe, L., Rak-Raszewska, A., Geraci, S., Darssan, D., Sharkey, J., Huang, J., . . . Wilm, B. (2015). Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. Scientific Reports, 5. doi:10.1038/srep13601

DOI: 10.1038/srep13601

2014

The role of ERK5 in endothelial cell function (Journal article)

Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2014). The role of ERK5 in endothelial cell function. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 1584-1589. doi:10.1042/BST20140276

DOI: 10.1042/BST20140276

2013

Correction: Stem Cells Derived from Neonatal Mouse Kidney Generate Functional Proximal Tubule-Like Cells and Integrate into Developing Nephrons In Vitro (Journal article)

Ranghini, E., Mora, C. F., Edgar, D., Kenny, S. E., Murray, P., & Wilm, B. (n.d.). Correction: Stem Cells Derived from Neonatal Mouse Kidney Generate Functional Proximal Tubule-Like Cells and Integrate into Developing Nephrons In Vitro. PLoS ONE, 8(6). doi:10.1371/annotation/57bd3cdf-4d63-41a6-972a-904e00c369ad

DOI: 10.1371/annotation/57bd3cdf-4d63-41a6-972a-904e00c369ad

Stem Cells Derived from Neonatal Mouse Kidney Generate Functional Proximal Tubule-Like Cells and Integrate into Developing Nephrons In Vitro (Journal article)

Ranghini, E., Mora, C. F., Edgar, D., Kenny, S. E., Murray, P., & Wilm, B. (n.d.). Stem Cells Derived from Neonatal Mouse Kidney Generate Functional Proximal Tubule-Like Cells and Integrate into Developing Nephrons In Vitro. PLoS ONE, 8(5), e62953. doi:10.1371/journal.pone.0062953

DOI: 10.1371/journal.pone.0062953

Regulation of Progenitor Cell Proliferation and Neuronal Differentiation in Enteric Nervous System Neurospheres (Journal article)

Theocharatos, S., Wilkinson, D. J., Darling, S., Wilm, B., Kenny, S. E., & Edgar, D. (2013). Regulation of Progenitor Cell Proliferation and Neuronal Differentiation in Enteric Nervous System Neurospheres. PLOS ONE, 8(1). doi:10.1371/journal.pone.0054809

DOI: 10.1371/journal.pone.0054809

2012

ERK5: Structure, regulation and function (Journal article)

Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Mueller, J., & Cross, M. J. (2012). ERK5: Structure, regulation and function. CELLULAR SIGNALLING, 24(11), 2187-2196. doi:10.1016/j.cellsig.2012.07.007

DOI: 10.1016/j.cellsig.2012.07.007

Development of embryonic stem cells in recombinant kidneys (Journal article)

Rak-Raszewska, A., Wilm, B., Edgar, D., Kenny, S., Woolf, A. S., & Murray, P. (2012). Development of embryonic stem cells in recombinant kidneys. ORGANOGENESIS, 8(4), 125-136. doi:10.4161/org.22597

DOI: 10.4161/org.22597

Integration potential of mouse and human bone marrow-derived mesenchymal stem cells (Journal article)

Kuzma-Kuzniarska, M., Rak-Raszewska, A., Kenny, S., Edgar, D., Wilm, B., Mora, C. F., . . . Murray, P. (2012). Integration potential of mouse and human bone marrow-derived mesenchymal stem cells. DIFFERENTIATION, 83(3), 128-137. doi:10.1016/j.diff.2011.11.004

DOI: 10.1016/j.diff.2011.11.004

Differentiation of Podocyte and Proximal Tubule-Like Cells from a Mouse Kidney-Derived Stem Cell Line (Journal article)

Mora, C. F., Ranghini, E., Bruno, S., Bussolati, B., Camussi, G., Wilm, B., . . . Murray, P. (2012). Differentiation of Podocyte and Proximal Tubule-Like Cells from a Mouse Kidney-Derived Stem Cell Line. STEM CELLS AND DEVELOPMENT, 21(2), 296-307. doi:10.1089/scd.2010.0470

DOI: 10.1089/scd.2010.0470

2011

Integration potential of mouse and human bone marrow-derived mesenchymal stem cells (Journal article)

Kuzma-Kuzniarska, M., Rak-Raszewska, A., Kenny, S., Edgar, D., Wilm, B., Fuente, M. C., . . . Murray, P. (2011). Integration potential of mouse and human bone marrow-derived mesenchymal stem cells. Differentiation, 83, 128-137.

2010

The potential of small chemical functional groups for directing the differentiation of kidney stem cells (Journal article)

Murray, P., Vasilev, K., Mora, C. F., Ranghini, E., Tensaout, H., Rak-Raszewska, A., . . . Kenny, S. E. (2010). The potential of small chemical functional groups for directing the differentiation of kidney stem cells. BIOCHEMICAL SOCIETY TRANSACTIONS, 38, 1062-1066. doi:10.1042/BST0381062

DOI: 10.1042/BST0381062

A report of the first international WT1 meeting, University of Manchester UK, 2008. (Journal article)

Wilm, B., & Ladomery, M. R. (2010). A report of the first international WT1 meeting, University of Manchester UK, 2008.. International journal of molecular epidemiology and genetics, 1(1), 76-82.

The potential of small chemical functional groups for directing the differentiation of kidney stem cells (Journal article)

Murray, P., Vasilev, K., Mora Fuente, C., Ranghini, E., Tensaout, H., Rak-Raszewska, A., . . . Kenny, S. E. (2010). The potential of small chemical functional groups for directing the differentiation of kidney stem cells. Biochem Soc Trans., 38(4), 1062-1066.

2008

Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development (Journal article)

Que, J., Wilm, B., Hasegawa, H., Wang, F., Bader, D., & Hogan, B. L. M. (2008). Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(43), 16626-16630. doi:10.1073/pnas.0808649105

DOI: 10.1073/pnas.0808649105

Serosal mesothelium retains vasculogenic potential (vol 236, pg 2973, 2007) (Journal article)

Kawaguchi, M., Bader, D. M., & Wilm, B. (2008). Serosal mesothelium retains vasculogenic potential (vol 236, pg 2973, 2007). DEVELOPMENTAL DYNAMICS, 237(2), 525. doi:10.1002/dvdy.21443

DOI: 10.1002/dvdy.21443

2007

Serosal mesothelium retains vasculogenic potential (Journal article)

Kawaguchi, M., Bader, D. M., & Wilm, B. (2007). Serosal mesothelium retains vasculogenic potential. DEVELOPMENTAL DYNAMICS, 236(11), 2973-2979. doi:10.1002/dvdy.21334

DOI: 10.1002/dvdy.21334

2006

CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis (Journal article)

Shim, J. H., Xiao, C. C., Hayden, M. S., Lee, K. Y., Trombetta, E. S., Pypaert, M., . . . Ghosh, S. (2006). CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. JOURNAL OF CELL BIOLOGY, 172(7), 1045-1056. doi:10.1083/jcb.200509041

DOI: 10.1083/jcb.200509041

2005

The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature (Journal article)

Wilm, B., Ipenberg, A., Hastie, N. D., Burch, J. B. E., & Bader, D. M. (2005). The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature. DEVELOPMENT, 132(23), 5317-5328. doi:10.1242/dev.02141

DOI: 10.1242/dev.02141

2004

The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate (Journal article)

Wilm, B., James, R. G., Schultheiss, T. A., & Hogan, B. L. M. (2004). The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. DEVELOPMENTAL BIOLOGY, 271(1), 176-189. doi:10.1016/j.ydbio.2004.03.034

DOI: 10.1016/j.ydbio.2004.03.034

2003

Undulated shod-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1 (Journal article)

Kokubu, C., Wilm, B., Kokubu, T., Wahl, M., Rodrigo, I., Sakai, N., . . . Imai, K. (2003). Undulated shod-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1. GENETICS, 165(1), 299-307. Retrieved from https://www.webofscience.com/

1999

Pax1 and Pax9 synergistically regulate vertebral column development (Journal article)

Peters, H., Wilm, B., Sakai, N., Imai, K., Maas, R., & Balling, R. (1999). Pax1 and Pax9 synergistically regulate vertebral column development. DEVELOPMENT, 126(23), 5399-5408. Retrieved from https://www.webofscience.com/

Identification of caspases and apoptosis in the simple metazoan Hydra (Journal article)

Cikala, M., Wilm, B., Hobmayer, E., Bottger, A., & David, C. N. (1999). Identification of caspases and apoptosis in the simple metazoan Hydra. CURRENT BIOLOGY, 9(17), 959-962. doi:10.1016/S0960-9822(99)80423-0

DOI: 10.1016/S0960-9822(99)80423-0

1998

Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency (Journal article)

Wilm, B., Dahl, E., Peters, H., Balling, R., & Imai, K. (1998). Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(15), 8692-8697. doi:10.1073/pnas.95.15.8692

DOI: 10.1073/pnas.95.15.8692

Publications

2023

Intravenous Administration of Human Umbilical Cord Mesenchymal Stromal Cells Leads to an Inflammatory Response in the Lung. (Journal article)

Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using Deep Learning-based semantic segmentation in histology. (Journal article)

Mesothelial cells exhibit characteristics of perivascular cells in an<i>in vitro</i>angiogenesis assay (Preprint)

Multispectral optoacoustic tomography is more sensitive than micro-computed tomography for tracking gold nanorod labelled mesenchymal stromal cells (Journal article)

Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach (Journal article)

VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells (Journal article)

Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system (Journal article)

The transition zone in Hirschsprung's bowel contains abnormal hybrid ganglia with characteristics of extrinsic nerves (Journal article)

2022

Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated cell Survival (Journal article)

Optical Tissue Clearing to Study the Intra-Pulmonary Biodistribution of Intravenously Delivered Mesenchymal Stromal Cells and Their Interactions with Host Lung Cells (Journal article)

Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung (Preprint)

Multicentre comparison of biological and functional properties of mesenchymal stromal cells from different sources cultivated using a harmonised manufacturing workflow (Preprint)

Comparison between optical tissue clearing methods for detecting administered mesenchymal stromal cells in mouse lungs (Preprint)

The transition zone in Hirschsprung’s bowel contains abnormal hybrid ganglia with characteristics of extrinsic nerves (Preprint)

Computed tomography lacks sensitivity to image gold labelled mesenchymal stromal cells in vivo as evidenced by multispectral optoacoustic tomography (Preprint)

Murine models of renal ischemia reperfusion injury: An opportunity for refinement using noninvasive monitoring methods (Journal article)

Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies (Journal article)

2021

Mesenchymal stromal cells: what have we learned so far about their therapeutic potential and mechanisms of action? (Journal article)

Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice (Journal article)

Post-Surgical Peritoneal Scarring and Key Molecular Mechanisms (Journal article)

2020

Multimodal Imaging Techniques Show Differences in Homing Capacity Between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models (Journal article)

Perylene Diimide Nanoprobes for In Vivo Tracking of Mesenchymal Stromal Cells Using Photoacoustic Imaging. (Journal article)

Measuring Kidney Perfusion, pH, and Renal Clearance Consecutively Using MRI and Multispectral Optoacoustic Tomography (Journal article)

Regenerative medicine therapies: lessons from the kidney (Journal article)

Expression of neurones and neuronal precursors in the transition zone of short-segment Hirschsprung's disease. (Journal article)

2019

A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction (Journal article)

<i>In vivo</i> fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells. (Journal article)

2018

Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc‐Based BRET Reporter in Combination with Firefly Luciferase (Journal article)

Transdermal Measurement of Glomerular Filtration Rate in Mice. (Journal article)

In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells (Journal article)

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo (vol 10, pg 7106, 2016) (Journal article)

Functional molecules in mesothelial-to-mesenchymal transition revealed by transcriptome analyses (Journal article)

Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy (Journal article)

Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy (Journal article)

Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes. (Journal article)

2017

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. (Journal article)

Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration. (Journal article)

Utilising multispectral optoacoustic tomography (MSOT) to assess organ function and track labelled therapeutic cells for regenerative medicine therapies in vivo (Journal article)

Nephron Progenitors (Chapter)

Optimising the use of medicines to reduce acute kidney injury in children and babies (Journal article)

Human Kidney-Derived Cells Ameliorate Acute Kidney Injury Without Engrafting into Renal Tissue. (Journal article)

Multimodal stem cell imaging and tracking (Conference Paper)

2016

Extracellular matrix scaffolds as a platform for kidney regeneration. (Journal article)

Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease (Journal article)

Autologous Cells for Kidney Bioengineering. (Journal article)

Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo (Journal article)

Characterisation of cultured mesothelial cells derived from the murine adult omentum (Journal article)

Amniotic Fluid Stem Cells within Chimeric Kidney Rudiments Differentiate to Functional Podocytes after Transplantation into Mature Rat Kidneys (Journal article)

INTEGRATING NOVEL IMAGING TECHNOLOGIES TO INVESTIGATE DRUG-INDUCED KIDNEY TOXICITY (Chapter)

The Role of WT1 in Embryonic Development and Normal Organ Homeostasis (Journal article)

Tools and Techniques for Wt1-Based Lineage Tracing (Journal article)

2015

Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy (Journal article)

2014

The role of ERK5 in endothelial cell function (Journal article)

2013

Correction: Stem Cells Derived from Neonatal Mouse Kidney Generate Functional Proximal Tubule-Like Cells and Integrate into Developing Nephrons In Vitro (Journal article)

Stem Cells Derived from Neonatal Mouse Kidney Generate Functional Proximal Tubule-Like Cells and Integrate into Developing Nephrons In Vitro (Journal article)

Regulation of Progenitor Cell Proliferation and Neuronal Differentiation in Enteric Nervous System Neurospheres (Journal article)

2012

ERK5: Structure, regulation and function (Journal article)

Development of embryonic stem cells in recombinant kidneys (Journal article)

Integration potential of mouse and human bone marrow-derived mesenchymal stem cells (Journal article)

Differentiation of Podocyte and Proximal Tubule-Like Cells from a Mouse Kidney-Derived Stem Cell Line (Journal article)

2011

Integration potential of mouse and human bone marrow-derived mesenchymal stem cells (Journal article)

2010

The potential of small chemical functional groups for directing the differentiation of kidney stem cells (Journal article)

A report of the first international WT1 meeting, University of Manchester UK, 2008. (Journal article)

The potential of small chemical functional groups for directing the differentiation of kidney stem cells (Journal article)

2008