Dr Ben Francis M.Math. Ph.D.
Research Associate Pharmacology & Therapeutics
- Work email B.R.Francis@liverpool.ac.uk
- Personal WebsiteResearchGate
Publications
Selected Publications
- Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response (Journal article - 2017)
- Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies (Journal article - 2018)
- A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction (Journal article - 2014)
Filter the publication list
2020
Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation (Conference Paper)
King, C., McKenna, A., Farzan, N., Vijverberg, S. J., van der Schee, M. P., Maitland-van der Zee, A. H., . . . Hawcutt, D. B. (2020). Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation. In PHARMACOGENOMICS JOURNAL Vol. 20 (pp. 621-628). doi:10.1038/s41397-019-0140-y
Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization (Journal article)
King, C., McKenna, A., Farzan, N., Vijverberg, S. J., van der Schee, M. P., Maitland-van der Zee, A. H., . . . Hawcutt, D. B. (2020). Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization. Pharmacogenomics J. doi:10.1038/s41397-020-0178-x
2019
Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink (Journal article)
Carr, D. (2019). Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink. Clinical Pharmacology and Therapeutics, 106(6), 1353-1361. doi:10.1002/cpt.1557
Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy (Journal article)
Silvennoinen, K., de Lange, N., Zagaglia, S., Balestrini, S., Androsova, G., Wassenaar, M., . . . Consortium, E. (2019). Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy. EPILEPSIA OPEN, 4(3), 420-430. doi:10.1002/epi4.12349
Genome-wide association study of inhaled corticosteroid response in admixed children with asthma (Journal article)
Hawcutt, D. B., & Pirmohamed, M. (2019). Genome-wide association study of inhaled corticosteroid response in admixed children with asthma. Clinical and Experimental Allergy, 49(6), 789-798. doi:10.1111/cea.13354
Safety and Efficacy of the SNAP 12-hour Acetylcysteine Regimen for the Treatment of Paracetamol Overdose (Journal article)
Pettie, J. M., Caparrotta, T. M., Hunter, R. W., Morrison, E. E., Wood, D. M., Dargan, P. I., . . . Dear, J. W. (n.d.). Safety and Efficacy of the SNAP 12-hour Acetylcysteine Regimen for the Treatment of Paracetamol Overdose. EClinicalMedicine. doi:10.1016/j.eclinm.2019.04.005
A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine. (Journal article)
Berghuis, B., Stapleton, C., Sonsma, A. C. M., Hulst, J., de Haan, G. -J., Lindhout, D., . . . McCormack, M. (2019). A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine.. Epilepsia Open, 4(1), 102-109. doi:10.1002/epi4.12297
Role of a pre-operative radiological scoring system in determining resectability for potentially resectable hilar cholangiocarcinoma (Journal article)
Bird, N., McKenna, A., Dunne, D., Francis, B., Fenwick, S., Poston, G., . . . Malik, H. (2019). Role of a pre-operative radiological scoring system in determining resectability for potentially resectable hilar cholangiocarcinoma. EJSO, 45(2), 192-197. doi:10.1016/j.ejso.2018.08.018
2018
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies (Journal article)
The International League Against Epilepsy Consortium on Complex Epilepsies. (2018). Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nature Communications, 9. doi:10.1038/s41467-018-07524-z
17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use (Journal article)
Farzan, N., Vijverberg, S. J., Hernandez-Pacheco, N., Bel, E. H. D., Berce, V., Bonnelykke, K., . . . Maitland-van der Zee, A. -H. (2018). 17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use. ALLERGY, 73(10), 2083-2088. doi:10.1111/all.13499
Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies (Journal article)
Martin, A. P., Downing, J., Cochrane, M., Collins, B., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 130, 92-107. doi:10.1016/j.critrevonc.2018.07.012
Sensitivity and specificity of microRNA-122 for liver disease in dogs (Journal article)
Oosthuyzen, W., Ten Berg, P. W. L., Francis, B., Campbell, S., Macklin, V., Milne, E., . . . Dear, J. W. (2018). Sensitivity and specificity of microRNA-122 for liver disease in dogs. JOURNAL OF VETERINARY INTERNAL MEDICINE, 32(5), 1637-1644. doi:10.1111/jvim.15250
Rare coding variants in genes encoding GABA(A) receptors in genetic generalised epilepsies: an exome-based case-control study (Journal article)
May, P., Girard, S., Harrer, M., Bobbili, D. R., Schubert, J., Wolking, S., . . . Consortium, E. (2018). Rare coding variants in genes encoding GABA(A) receptors in genetic generalised epilepsies: an exome-based case-control study. LANCET NEUROLOGY, 17(8), 699-708. doi:10.1016/S1474-4422(18)30215-1
Adrenal suppression with inhaled corticosteroids: the seed and the soil reply (Journal article)
Hawcutt, D. B., Francis, B., & Pirmohamed, M. (2018). Adrenal suppression with inhaled corticosteroids: the seed and the soil reply. LANCET RESPIRATORY MEDICINE, 6(6), E20. doi:10.1016/S2213-2600(18)30149-8
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study (Journal article)
Hawcutt, D. B., Francis, B., Carr, D., Jorgensen, A. L., Yin, P., Wallin, N., . . . Pirmohamed, M. (2018). Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. The Lancet Respiratory Medicine, 6(6), 442-450. doi:10.1016/S2213-2600(18)30058-4
Variants in genes coding for glutathione S-transferases and asthma outcomes in children (Journal article)
Turner, S., Francis, B., Wani, N., Vijverberg, S., Pino-Yanes, M., Mukhopadhyay, S., . . . Asthma, P. C. (2018). Variants in genes coding for glutathione S-transferases and asthma outcomes in children. PHARMACOGENOMICS, 19(8), 707-713. doi:10.2217/pgs-2018-0027
TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers. (Journal article)
Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A. L., Park, B. K., . . . Antoine, D. J. (2018). TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers.. Journal of hepatology. doi:10.1016/j.jhep.2018.04.024
Childhood asthma exacerbations and ADRB2 polymorphism: Caution is needed Reply (Journal article)
Turner, S., & Francis, B. (2018). Childhood asthma exacerbations and ADRB2 polymorphism: Caution is needed Reply. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 141(5), 1955-1956. doi:10.1016/j.jaci.2018.01.024
TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES (Conference Paper)
Martin, A. P., Downing, J., Collins, B., Cochrane, M., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES. In VALUE IN HEALTH Vol. 21 (pp. S43). doi:10.1016/j.jval.2018.04.248
Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies (Journal article)
Dear, J. W., Clarke, J. I., Francis, B., Allen, L., Wraight, J., Shen, J., . . . Antoine, D. J. (2018). Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies. The Lancet Gastroenterology and Hepatology, 3(2), 104-113. doi:10.1016/S2468-1253(17)30266-2
2017
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients (Journal article)
McCormack, M., Gui, H., Ingason, A., Speed, D., Wright, G. E. B., Zhang, E. J., . . . Rau, S. (2017). Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients. Neurology, 90(4). doi:10.1212/WNL.0000000000004853
Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity (Journal article)
Forootan, S. S., Mutter, F. E., Kipar, A., Iwawaki, T., Francis, B., Goldring, C. E., . . . Copple, I. M. (2017). Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity. SCIENTIFIC REPORTS, 7, 11 pages. doi:10.1038/s41598-017-16491-2
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (Journal article)
Androsova, G., Krause, R., Borghei, M., Wassenaar, M., Auce, P., Avbersek, A., . . . Consortium, E. (2017). Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. EPILEPSIA, 58(10), 1734-1741. doi:10.1111/epi.13871
Genome-wide association study of asthma exacerbations in European children treated with inhaled corticosteroids (Conference Paper)
Vijverberg, S. J. H., Hernandez-Pacheco, N., Farzan, N., Francis, B., Flores, C., Schieck, M., . . . Maitland-Van der Zee, A. -H. (2017). Genome-wide association study of asthma exacerbations in European children treated with inhaled corticosteroids. In EUROPEAN RESPIRATORY JOURNAL Vol. 50. doi:10.1183/1393003.congress-2017.PA1817
Genome-wide association study of inhaled corticosteroid response in African-admixed children with asthma (Conference Paper)
Hernandez-Pacheco, N., Farzan, N., Vijverberg, S. J., Francis, B., Schieck, M., Pirmohamed, M., . . . Pino-Yanes, M. (2017). Genome-wide association study of inhaled corticosteroid response in African-admixed children with asthma. In EUROPEAN RESPIRATORY JOURNAL Vol. 50. doi:10.1183/1393003.congress-2017.PA4688
17q21 gene variation increases the risk of exacerbations in asthmatic children treated with inhaled corticosteroids: A meta-analysis in the multi-ethnic pica consortium (Conference Paper)
Farzan, N., Vijverberg, S. J., Hernandez-Pacheco, N., Berce, V., Burchard, E. G., Canino, G., . . . Maitland-Van der Zee, A. H. (2017). 17q21 gene variation increases the risk of exacerbations in asthmatic children treated with inhaled corticosteroids: A meta-analysis in the multi-ethnic pica consortium. In ALLERGY Vol. 72 (pp. 269-270). Retrieved from http://gateway.webofknowledge.com/
Genome-Wide Association Study of Asthma Exacerbations in European Children Treated with Inhaled Corticosteroids (Conference Paper)
Vijverberg, S. J. H., Hernandez-Pacheco, N., Farzan, N., Francis, B., Flores, C., Schieck, M., . . . Maitland-van der Zee, A. -H. (2017). Genome-Wide Association Study of Asthma Exacerbations in European Children Treated with Inhaled Corticosteroids. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 26 (pp. 25-26). Retrieved from http://gateway.webofknowledge.com/
Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy (Journal article)
Berghuis, B., van der Palen, J., de Haan, G. -J., Lindhout, D., Koeleman, B. P. C., Sander, J. W., & Consortium, E. (2017). Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy. EPILEPSIA, 58(7), 1227-1233. doi:10.1111/epi.13777
Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity (Conference Paper)
Dear, J. W., Clarke, J. I., Francis, B., Philips, L., Wraight, J., Dargan, P. I., . . . Antoine, D. J. (2017). Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity. In CLINICAL TOXICOLOGY Vol. 55 (pp. 468). Retrieved from http://gateway.webofknowledge.com/
Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response (Journal article)
Zhang, J. E., Klein, K., Jorgensen, A. L., Francis, B., Alfirevic, A., Bourgeois, S., . . . Pirmohamed, M. (2017). Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00323
17q21 Gene Variance Increases The Risk Of Exacerbations In Asthmatic Children Treated With Inhaled Corticosteroids: A Meta-Analysis In The Pica Consortium (Conference Paper)
Farzan, N., Vijverberg, S., Hernandez-Pacheco, N., Berce, V., Burchard, E. G., Canino, G., . . . Maitland-van Der Zee, A. -H. (2017). 17q21 Gene Variance Increases The Risk Of Exacerbations In Asthmatic Children Treated With Inhaled Corticosteroids: A Meta-Analysis In The Pica Consortium. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 195. Washington DC. Retrieved from http://gateway.webofknowledge.com/
Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity (Conference Paper)
Yip, V., Zhang, E., Clarke, K., Francis, B., Rainbow, L., Falciani, F., . . . Pirmohamed, M. (2017). Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity. In LANCET Vol. 389 (pp. 104). Retrieved from http://gateway.webofknowledge.com/
2016
A Genome-Wide two-Component Mixture Model Expectation-Maximization Algorithm for Time to Event Data (Conference Paper)
Francis, B., Yin, P., Cook, J., Jorgensen, A., Hutton, J., & Morris, A. (2016). A Genome-Wide two-Component Mixture Model Expectation-Maximization Algorithm for Time to Event Data. In GENETIC EPIDEMIOLOGY Vol. 40 (pp. 637). Retrieved from http://gateway.webofknowledge.com/
Childhood asthma exacerbations and the Arg16 beta(2)-receptor polymorphism: A meta-analysis stratified by treatment (Journal article)
Turner, S., Francis, B., Vijverberg, S., Pino-Yanes, M., Maitland-van der Zee, A. H., Basu, K., . . . Asthma, P. C. (2016). Childhood asthma exacerbations and the Arg16 beta(2)-receptor polymorphism: A meta-analysis stratified by treatment. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(1), 107-113.E5. doi:10.1016/j.jaci.2015.10.045
A Genome-Wide Two-Component Mixture Model Expectation-Maximisation Algorithm for Time to Event Data (Conference Paper)
Francis, B., Yin, P., Cook, J. P., Jorgensen, A. L., Hutton, J., & Morris, A. P. (2016). A Genome-Wide Two-Component Mixture Model Expectation-Maximisation Algorithm for Time to Event Data. In HUMAN HEREDITY Vol. 81 (pp. 212-213). Retrieved from http://gateway.webofknowledge.com/
2015
CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure (Journal article)
Stutchfield, B. M., Antoine, D. J., Mackinnon, A. C., Gow, D. J., Bain, C. C., Hawley, C. A., . . . Forbes, S. J. (2015). CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure. GASTROENTEROLOGY, 149(7), 1896-+. doi:10.1053/j.gastro.2015.08.053
Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury (Journal article)
Antoine, D., Sabbisetti, V., Francis, B., Jorgensen, A., Craig, D., Simpson, K., . . . Dear, J. (2015). Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury. Hepatology, 62(2), 591-599. doi:10.1002/hep.27857
ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults (Journal article)
Vijverberg, S. J. H., Koster, E. S., Tavendale, R., Leusink, M., Koenderman, L., Raaijmakers, J. A. M., . . . Maitland-van der Zee, A. H. (2015). ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults. Clinical and Experimental Allergy, 45(6), 1051-1059. doi:10.1111/cea.12492
Genome-Wide Two-Way Competing Risks Approach to Analyse Time to Antiepileptic Drug Withdrawal (Conference Paper)
Francis, B., Jorgensen, A., Morris, A., Ingason, A., Marson, A., Johnson, M., . . . Consortium, E. (2015). Genome-Wide Two-Way Competing Risks Approach to Analyse Time to Antiepileptic Drug Withdrawal. In HUMAN HEREDITY Vol. 80 (pp. 109-110). Retrieved from http://gateway.webofknowledge.com/
Two-Component Mixture Modelling Approach Integrating Genetic and Clinical Variables in Analysis of Time to First Seizure in Epilepsy (Conference Paper)
Francis, B., Jorgensen, A., Morris, A., Marson, A., Johnson, M., Sills, G., & Consortium, E. (2015). Two-Component Mixture Modelling Approach Integrating Genetic and Clinical Variables in Analysis of Time to First Seizure in Epilepsy. In HUMAN HEREDITY Vol. 79 (pp. 34). Retrieved from http://gateway.webofknowledge.com/
2014
A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction (Journal article)
Francis, B., Lane, S., Pirmohamed, M., & Jorgensen, A. (2014). A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction. PLoS One, 9(12). doi:10.1371/journal.pone.0114896
Undated
Stochastic control methods to individualise drug therapy by incorporating pharmacokinetic, pharmacodynamic and adverse event data (Thesis / Dissertation)
Francis, B. (n.d.). Stochastic control methods to individualise drug therapy by incorporating pharmacokinetic, pharmacodynamic and adverse event data. (PhD Thesis, University of Liverpool).