2020
Ferguson, F., McLennan, A. G., Urbaniak, M. D., Jones, N. J., & Copeland, N. A. (2020). Re-evaluation of Diadenosine Tetraphosphate (Ap<sub>4</sub>A) From a Stress Metabolite to <i>Bona Fide</i> Secondary Messenger. FRONTIERS IN MOLECULAR BIOSCIENCES, 7. doi:10.3389/fmolb.2020.606807DOI: 10.3389/fmolb.2020.606807
2019
Kramer, S., & McLennan, A. G. (2019). The complex enzymology of mRNA decapping: Enzymes of four classes cleave pyrophosphate bonds. WILEY INTERDISCIPLINARY REVIEWS-RNA, 10(1). doi:10.1002/wrna.1511DOI: 10.1002/wrna.1511
2018
DNA damage, repair, and mutagenesis (Chapter)
McLennan, A. G. (2018). DNA damage, repair, and mutagenesis. In DNA Replication in Plants (pp. 135-186). doi:10.1201/9781351071512DOI: 10.1201/9781351071512
2017
Abdelraheim, S. R., Spiller, D. G., & McLennan, A. G. (2017). Mouse Nudt13 is a Mitochondrial Nudix Hydrolase with NAD(P)H Pyrophosphohydrolase Activity. PROTEIN JOURNAL, 36(5), 425-432. doi:10.1007/s10930-017-9734-xDOI: 10.1007/s10930-017-9734-x
2016
NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes (Journal article)
Marriott, A. S., Vasieva, O., Fang, Y., Copeland, N. A., McLennan, A. G., & Jones, N. J. (2016). NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes. PLOS ONE, 11(5). doi:10.1371/journal.pone.0154674DOI: 10.1371/journal.pone.0154674
2015
Diadenosine 5′, 5′′′-P1,P4-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication (Journal article)
Marriott, A. S., Copeland, N. A., Cunningham, R., Wilkinson, M. C., McLennan, A. G., & Jones, N. J. (2015). Diadenosine 5′, 5′′′-P1,P4-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication. DNA REPAIR, 33, 90-100. doi:10.1016/j.dnarep.2015.06.008DOI: 10.1016/j.dnarep.2015.06.008
2013
Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both? (Journal article)
McLennan, A. G. (2013). Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?. Cellular and molecular life sciences : CMLS, 70(3), 373-385. doi:10.1007/s00018-012-1210-3DOI: 10.1007/s00018-012-1210-3
2012
Instant Notes in Molecular Biology (Book)
McLennan, A. G., Bates, A. D., Turner, P. C., & White, M. R. H. (2012). Instant Notes in Molecular Biology. New York: Taylor and Francis.
2010
Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch? (Journal article)
Winward, L., Whitfield, W. G. F., McLennan, A. G., & Safrany, S. T. (2010). Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch?. The international journal of biochemistry & cell biology, 42(7), 1174-1181. doi:10.1016/j.biocel.2010.04.003DOI: 10.1016/j.biocel.2010.04.003
XRCC1-deficient CHO cells have a high level of diadenosine tetraphosphate (Journal article)
Cunningham, R., Jones, N. J., & McLennan, A. G. (2010). XRCC1-deficient CHO cells have a high level of diadenosine tetraphosphate. Abstracts 6th Framework Programme International Symposium on the DNA Damage Response, -, 9.
2009
Ametabolic embryos of Artemia franciscana accumulate DNA damage during prolonged anoxia. (Journal article)
McLennan, A. G. (2009). Ametabolic embryos of Artemia franciscana accumulate DNA damage during prolonged anoxia.. The Journal of experimental biology, 212(Pt 6), 785-789. doi:10.1242/jeb.023663DOI: 10.1242/jeb.023663
2008
Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells. (Journal article)
Fisher, D. I., & McLennan, A. G. (2008). Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells.. Cancer letters, 259(2), 186-191. doi:10.1016/j.canlet.2007.10.007DOI: 10.1016/j.canlet.2007.10.007
2007
Folate synthesis: an old enzyme identified. (Journal article)
McLennan, A. G. (2007). Folate synthesis: an old enzyme identified.. Structure (London, England : 1993), 15(8), 891-892. doi:10.1016/j.str.2007.07.002DOI: 10.1016/j.str.2007.07.002
Decapitation: poxvirus makes RNA lose its head. (Journal article)
McLennan, A. G. (2007). Decapitation: poxvirus makes RNA lose its head.. Trends in biochemical sciences, 32(7), 297-299. doi:10.1016/j.tibs.2007.05.001DOI: 10.1016/j.tibs.2007.05.001
Characterisation of a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster. (Journal article)
Winward, L., Whitfield, W. G. F., Woodman, T. J., McLennan, A. G., & Safrany, S. T. (2007). Characterisation of a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster.. The international journal of biochemistry & cell biology, 39(5), 943-954. doi:10.1016/j.biocel.2007.01.017DOI: 10.1016/j.biocel.2007.01.017
2006
Characterization of the Mn2+-stimulated (di)adenosine polyphosphate hydrolase encoded by the Deinococcus radiodurans DR2356 nudix gene. (Journal article)
Fisher, D. I., Cartwright, J. L., & McLennan, A. G. (2006). Characterization of the Mn2+-stimulated (di)adenosine polyphosphate hydrolase encoded by the Deinococcus radiodurans DR2356 nudix gene.. Archives of microbiology, 186(5), 415-424. doi:10.1007/s00203-006-0155-zDOI: 10.1007/s00203-006-0155-z
The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. (Journal article)
Carloto, A., Costas, M. J., Cameselle, J. C., McLennan, A. G., & Ribeiro, J. M. (2006). The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.. Biochimica et biophysica acta, 1760(10), 1545-1551. doi:10.1016/j.bbagen.2006.06.003DOI: 10.1016/j.bbagen.2006.06.003
The Nudix hydrolase superfamily. (Journal article)
McLennan, A. G. (2006). The Nudix hydrolase superfamily.. Cellular and molecular life sciences : CMLS, 63(2), 123-143. doi:10.1007/s00018-005-5386-7DOI: 10.1007/s00018-005-5386-7
2005
Structure and substrate-binding mechanism of human Ap4A hydrolase. (Journal article)
Swarbrick, J. D., Buyya, S., Gunawardana, D., Gayler, K. R., McLennan, A. G., & Gooley, P. R. (2005). Structure and substrate-binding mechanism of human Ap4A hydrolase.. The Journal of biological chemistry, 280(9), 8471-8481. doi:10.1074/jbc.m412318200DOI: 10.1074/jbc.m412318200
1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP. (Journal article)
Swarbrick, J. D., Buyya, S., Gunawardana, D., Fletcher, J. I., Branson, K., Smith, B., . . . Gooley, P. R. (2005). 1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP.. Journal of biomolecular NMR, 31(2), 181-182. doi:10.1007/s10858-004-7440-4DOI: 10.1007/s10858-004-7440-4
Instant Notes in Molecular Biology (Book)
Turner, P., McLennan, A., Bates, A., & White, M. (2005). Instant Notes in Molecular Biology. Abingdon: Taylor and Francis.
2004
Fisher, D. I., Cartwright, J. L., Harashima, H., Kamiya, H., & McLennan, A. G. (2004). Characterization of a nudix hydrolase from Deinococcus radiodurans with a marked specificity for (deoxy)ribonucleoside 5'-diphosphates.. BMC biochemistry, 5, 7. doi:10.1186/1471-2091-5-7DOI: 10.1186/1471-2091-5-7
Synthesis of dinucleoside tetraphosphates in transfected cells by a firefly luciferase reporter gene. (Journal article)
Murphy, G. A., & McLennan, A. G. (2004). Synthesis of dinucleoside tetraphosphates in transfected cells by a firefly luciferase reporter gene.. Cellular and molecular life sciences : CMLS, 61(4), 497-501. doi:10.1007/s00018-003-3420-1DOI: 10.1007/s00018-003-3420-1
2003
Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. (Journal article)
Abdelraheim, S. R., Spiller, D. G., & McLennan, A. G. (2003). Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein.. The Biochemical journal, 374(Pt 2), 329-335. doi:10.1042/bj20030441DOI: 10.1042/bj20030441
Regulation of dinucleoside polyphosphate pools by the YgdP and ApaH hydrolases is essential for the ability of Salmonella enterica serovar typhimurium to invade cultured mammalian cells. (Journal article)
Ismail, T. M., Hart, C. A., & McLennan, A. G. (2003). Regulation of dinucleoside polyphosphate pools by the YgdP and ApaH hydrolases is essential for the ability of Salmonella enterica serovar typhimurium to invade cultured mammalian cells.. The Journal of biological chemistry, 278(35), 32602-32607. doi:10.1074/jbc.m305994200DOI: 10.1074/jbc.m305994200
Regulation of Dinucleoside Polyphosphate Pools by the YgdP and ApaH Hydrolases Is Essential for the Ability of Salmonella enterica serovar Typhimurium to Invade Cultured Mammalian Cells (Journal article)
Ismail, T. M., Hart, C. A., & McLennan, A. G. (2003). Regulation of Dinucleoside Polyphosphate Pools by the YgdP and ApaH Hydrolases Is Essential for the Ability of Salmonella enterica serovar Typhimurium to Invade Cultured Mammalian Cells. Journal of Biological Chemistry, 278(35), 32602-32607. doi:10.1074/jbc.m305994200DOI: 10.1074/jbc.m305994200
Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases. (Journal article)
Guranowski, A., Starzyńska, E., McLennan, A. G., Baraniak, J., & Stec, W. J. (2003). Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases.. The Biochemical journal, 373(Pt 2), 635-640. doi:10.1042/bj20030320DOI: 10.1042/bj20030320
Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis. (Journal article)
Abdelghany, H. M., Bailey, S., Blackburn, G. M., Rafferty, J. B., & McLennan, A. G. (2003). Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis.. The Journal of biological chemistry, 278(7), 4435-4439. doi:10.1074/jbc.m211983200DOI: 10.1074/jbc.m211983200
2002
Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (Journal article)
Fisher, D. I., Safrany, S. T., Strike, P., McLennan, A. G., & Cartwright, J. L. (2002). Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate.. The Journal of biological chemistry, 277(49), 47313-47317. doi:10.1074/jbc.m209795200DOI: 10.1074/jbc.m209795200
Leslie, N. R., McLennan, A. G., & Safrany, S. T. (2002). Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.. BMC biochemistry, 3, 20. doi:10.1186/1471-2091-3-20DOI: 10.1186/1471-2091-3-20
(Journal article)
Leslie, N. R., McLennan, A. G., & Safrany, S. T. (2002). Unknown Title. BMC Biochemistry, 3(1), 20. doi:10.1186/1471-2091-3-20DOI: 10.1186/1471-2091-3-20
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms. (Journal article)
Bailey, S., Sedelnikova, S. E., Blackburn, G. M., Abdelghany, H. M., Baker, P. J., McLennan, A. G., & Rafferty, J. B. (2002). The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms.. Structure (London, England : 1993), 10(4), 589-600. doi:10.1016/s0969-2126(02)00746-3DOI: 10.1016/s0969-2126(02)00746-3
AbdelRaheim, S. R., & McLennan, A. G. (2002). The Caenorhabditis elegans Y87G2A.14 Nudix hydrolase is a peroxisomal coenzyme A diphosphatase.. BMC biochemistry, 3, 5. doi:10.1186/1471-2091-3-5DOI: 10.1186/1471-2091-3-5
(Journal article)
AbdelRaheim, S. R., & McLennan, A. G. (2002). Unknown Title. BMC Biochemistry, 3(1), 5. doi:10.1186/1471-2091-3-5DOI: 10.1186/1471-2091-3-5
Crystallization of a complex of Caenorhabditis elegans diadenosine tetraphosphate hydrolase and a non-hydrolysable substrate analogue, AppCH2ppA. (Journal article)
Bailey, S., Sedelnikova, S. E., Blackburn, G. M., Abdelghany, H. M., McLennan, A. G., & Rafferty, J. B. (2002). Crystallization of a complex of Caenorhabditis elegans diadenosine tetraphosphate hydrolase and a non-hydrolysable substrate analogue, AppCH2ppA.. Acta crystallographica. Section D, Biological crystallography, 58(Pt 3), 526-528. doi:10.1107/s0907444902000768DOI: 10.1107/s0907444902000768
Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose). (Journal article)
Lin, S., Gasmi, L., Xie, Y., Ying, K., Gu, S., Wang, Z., . . . McLennan, A. G. (2002). Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose).. Biochimica et biophysica acta, 1594(1), 127-135. doi:10.1016/s0167-4838(01)00296-5DOI: 10.1016/s0167-4838(01)00296-5
'Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases (Journal article)
Leslie, N. R., McLennan, A. G., & Safrany, S. T. (2002). 'Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochemistry, 3(20).
'The Caenorhabditis elegans Y87G2A.14 Nudix hydrolase is a peroxisomal coenzyme A diphosphatase' (Journal article)
AbdelRaheim, S. R., & McLennan, A. G. (2002). 'The Caenorhabditis elegans Y87G2A.14 Nudix hydrolase is a peroxisomal coenzyme A diphosphatase'. BMC Biochemistry, 3(5).
GTP:GTP guanylyltransferase: trapping procedures for detecting and characterizing chemical nature of enzyme-nucleotide phosphoramidate reaction intermediate. (Chapter)
Cartwright, J. L., & McLennan, A. G. (2002). GTP:GTP guanylyltransferase: trapping procedures for detecting and characterizing chemical nature of enzyme-nucleotide phosphoramidate reaction intermediate.. In Unknown Book (Vol. 354, pp. 251-260). doi:10.1016/s0076-6879(02)54021-0DOI: 10.1016/s0076-6879(02)54021-0
The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates. (Journal article)
Cartwright, J. L., Safrany, S. T., Dixon, L. K., Darzynkiewicz, E., Stepinski, J., Burke, R., & McLennan, A. G. (2002). The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates.. Journal of virology, 76(3), 1415-1421. doi:10.1128/jvi.76.3.1415-1421.2002DOI: 10.1128/jvi.76.3.1415-1421.2002
2001
Cloning, characterisation and crystallisation of a diadenosine 5',5"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans. (Journal article)
Abdelghany, H. M., Gasmi, L., Cartwright, J. L., Bailey, S., Rafferty, J. B., & McLennan, A. G. (2001). Cloning, characterisation and crystallisation of a diadenosine 5',5"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans.. Biochimica et biophysica acta, 1550(1), 27-36. doi:10.1016/s0167-4838(01)00263-1DOI: 10.1016/s0167-4838(01)00263-1
The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives (Journal article)
GASMI, L., & McLENNAN, A. G. (2001). The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Biochemical Journal, 357(1), 33-38. doi:10.1042/bj3570033DOI: 10.1042/bj3570033
The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. (Journal article)
Gasmi, L., & McLennan, A. G. (2001). The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives.. The Biochemical journal, 357(Pt 1), 33-38. doi:10.1042/0264-6021:3570033DOI: 10.1042/0264-6021:3570033
Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. (Journal article)
Lin, S., McLennan, A. G., Ying, K., Wang, Z., Gu, S., Jin, H., . . . Mao, Y. (2001). Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene.. The Journal of biological chemistry, 276(22), 18695-18701. doi:10.1074/jbc.m011084200DOI: 10.1074/jbc.m011084200
Recent progress in the study of the intracellular functions of diadenosine polyphosphates (Journal article)
McLennan, A. G., Barnes, L. D., Blackburn, G. M., Brenner, C., Guranowski, A., Miller, A. D., . . . Sillero, A. (2001). Recent progress in the study of the intracellular functions of diadenosine polyphosphates. Drug Development Research, 52(1-2), 249-259. doi:10.1002/ddr.1122DOI: 10.1002/ddr.1122
The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes. (Journal article)
AbdelRaheim, S. R., Cartwright, J. L., Gasmi, L., & McLennan, A. G. (2001). The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes.. Archives of biochemistry and biophysics, 388(1), 18-24. doi:10.1006/abbi.2000.2268DOI: 10.1006/abbi.2000.2268
2000
Diadenosine polyphosphates are largely ineffective as agonists at natively expressed P2Y(1) and P2Y(2) receptors on cultured human saphenous vein endothelial cells. (Journal article)
Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. (2000). Diadenosine polyphosphates are largely ineffective as agonists at natively expressed P2Y(1) and P2Y(2) receptors on cultured human saphenous vein endothelial cells.. Journal of vascular research, 37(6), 548-555. doi:10.1159/000054088DOI: 10.1159/000054088
The human NUDT family of nucleotide hydrolases. Enzymes of diverse substrate specificity. (Chapter)
McLennan, A. G., Cartwright, J. L., & Gasmi, L. (2000). The human NUDT family of nucleotide hydrolases. Enzymes of diverse substrate specificity.. In Unknown Book (Vol. 486, pp. 115-118). doi:10.1007/0-306-46843-3_23DOI: 10.1007/0-306-46843-3_23
The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active toward coenzyme A and its derivatives. (Journal article)
Cartwright, J. L., Gasmi, L., Spiller, D. G., & McLennan, A. G. (2000). The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active toward coenzyme A and its derivatives.. The Journal of biological chemistry, 275(42), 32925-32930. doi:10.1074/jbc.m005015200DOI: 10.1074/jbc.m005015200
Dinucleoside polyphosphates-friend or foe? (Journal article)
McLennan, A. G. (2000). Dinucleoside polyphosphates-friend or foe?. Pharmacology & therapeutics, 87(2-3), 73-89. doi:10.1016/s0163-7258(00)00041-3DOI: 10.1016/s0163-7258(00)00041-3
Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors. (Conference Paper)
Conant, A., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (2000). Cultured human saphenous vein endothelial cells are largely unresponsive to the diadenosine polyphosphates via the natively expressed P2Y receptors.. In Journal of Physiology-Paris Vol. 525 (pp. 84p). Elsevier.
The Fhit tumor suppressor protein regulates the intracellular concentration of diadenosine triphosphate but not diadenosine tetraphosphate. (Journal article)
Murphy, G. A., Halliday, D., & McLennan, A. G. (2000). The Fhit tumor suppressor protein regulates the intracellular concentration of diadenosine triphosphate but not diadenosine tetraphosphate.. Cancer research, 60(9), 2342-2344.
1999
Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif. (Journal article)
Gasmi, L., Cartwright, J. L., & McLennan, A. G. (1999). Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif.. The Biochemical journal, 344 Pt 2, 331-337. doi:10.1042/bj3440331DOI: 10.1042/bj3440331
Cloning, expression and characterization of YSA1H, a human adenosine 5′-diphosphosugar pyrophosphatase possessing a MutT motif (Journal article)
GASMI, L., CARTWRIGHT, J. L., & MCLENNAN, A. G. (1999). Cloning, expression and characterization of YSA1H, a human adenosine 5′-diphosphosugar pyrophosphatase possessing a MutT motif. Biochemical Journal, 344(2), 331-337. doi:10.1042/bj3440331DOI: 10.1042/bj3440331
Diadenosine polyphosphates and the control of cyclic AMP concentrations in isolated rat liver cells. (Journal article)
Edgecombe, M., McLennan, A. G., & Fisher, M. J. (1999). Diadenosine polyphosphates and the control of cyclic AMP concentrations in isolated rat liver cells.. FEBS letters, 457(3), 455-458. doi:10.1016/s0014-5793(99)01099-6DOI: 10.1016/s0014-5793(99)01099-6
The intracellular level of diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) depends on the expression of the fragile histidine triad gene. (Conference Paper)
McLennan, A. G., & Murphy, G. (1999). The intracellular level of diadenosine 5',5'''-P1,P3-triphosphate (Ap3A) depends on the expression of the fragile histidine triad gene.. In Proceedings of the American Association for Cancer Research Vol. 40 (pp. 4609).
Ap4A induces apoptosis in human cultured cells. (Journal article)
Vartanian, A., Alexandrov, I., Prudowski, I., McLennan, A., & Kisselev, L. (1999). Ap4A induces apoptosis in human cultured cells.. FEBS letters, 456(1), 175-180. doi:10.1016/s0014-5793(99)00956-4DOI: 10.1016/s0014-5793(99)00956-4
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. (Journal article)
Safrany, S. T., Ingram, S. W., Cartwright, J. L., Falck, J. R., McLennan, A. G., Barnes, L. D., & Shears, S. B. (1999). The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.. The Journal of biological chemistry, 274(31), 21735-21740. doi:10.1074/jbc.274.31.21735DOI: 10.1074/jbc.274.31.21735
Dinucleoside polyphosphates — friend or foe? (Conference Paper)
McLennan, A. G. (1999). Dinucleoside polyphosphates — friend or foe?. In Cellular and Molecular Biology Letters Vol. 4 (pp. 421). Springer Nature.
Methanetrisphosphonate and its adenine nucleotide derivatives as inhibitors of animal and plant Ap4A hydrolases (Conference Paper)
Maksel, D., Gayler, K., Liu, X., Blackburn GM., McLennan, A., & Guranowski, A. (1999). Methanetrisphosphonate and its adenine nucleotide derivatives as inhibitors of animal and plant Ap4A hydrolases. In Cellular and Molecular Biology Letters Vol. 4 (pp. 418). Springer Nature.
The Saccharomyces cerevisiae YOR163w gene encodes a diadenosine 5', 5"'-P1,P6-hexaphosphate (Ap6A) hydrolase member of the MutT motif (Nudix hydrolase) family. (Journal article)
Cartwright, J. L., & McLennan, A. G. (1999). The Saccharomyces cerevisiae YOR163w gene encodes a diadenosine 5', 5"'-P1,P6-hexaphosphate (Ap6A) hydrolase member of the MutT motif (Nudix hydrolase) family.. The Journal of biological chemistry, 274(13), 8604-8610. doi:10.1074/jbc.274.13.8604DOI: 10.1074/jbc.274.13.8604
The IalA invasion gene of Bartonella bacilliformis encodes a (de)nucleoside polyphosphate hydrolase of the MutT motif family and has homologs in other invasive bacteria. (Journal article)
Cartwright, J. L., Britton, P., Minnick, M. F., & McLennan, A. G. (1999). The IalA invasion gene of Bartonella bacilliformis encodes a (de)nucleoside polyphosphate hydrolase of the MutT motif family and has homologs in other invasive bacteria.. Biochemical and biophysical research communications, 256(3), 474-479. doi:10.1006/bbrc.1999.0354DOI: 10.1006/bbrc.1999.0354
Formation of a covalent Nepsilon2-guanylylhistidyl reaction intermediate by the GTP:GTP guanylyltransferase from the brine shrimp Artemia. (Journal article)
Cartwright, J. L., & McLennan, A. G. (1999). Formation of a covalent Nepsilon2-guanylylhistidyl reaction intermediate by the GTP:GTP guanylyltransferase from the brine shrimp Artemia.. Archives of biochemistry and biophysics, 361(1), 101-105. doi:10.1006/abbi.1998.0970DOI: 10.1006/abbi.1998.0970
The IaIA invasion gene of Bartonella bacilliformis encodes a (di)nucleoside polyphosphate hydrolase of the MutT motif family and has homologs in other invasive bacteria (Journal article)
Cartwright, J. L., Britton, P., Minnick, M. F., & McLennan, A. G. (1999). The IaIA invasion gene of Bartonella bacilliformis encodes a (di)nucleoside polyphosphate hydrolase of the MutT motif family and has homologs in other invasive bacteria. Biochem. Biophys. Res. Commun., 256(3), 474-479.
The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review). (Journal article)
McLennan, A. G. (1999). The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review).. International journal of molecular medicine, 4(1), 79-89. doi:10.3892/ijmm.4.1.79DOI: 10.3892/ijmm.4.1.79
1998
The hydrolytic activity of bovine adrenal medullary plasma membranes towards diadenosine polyphosphates is due to alkaline phosphodiesterase-I. (Journal article)
Gasmi, L., Cartwright, J. L., & McLennan, A. G. (1998). The hydrolytic activity of bovine adrenal medullary plasma membranes towards diadenosine polyphosphates is due to alkaline phosphodiesterase-I.. Biochimica et biophysica acta, 1405(1-3), 121-127. doi:10.1016/s0167-4889(98)00097-4DOI: 10.1016/s0167-4889(98)00097-4
Characterization of the P2 receptors on the human umbilical vein endothelial cell line ECV304. (Journal article)
Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. (1998). Characterization of the P2 receptors on the human umbilical vein endothelial cell line ECV304.. British journal of pharmacology, 125(2), 357-364. doi:10.1038/sj.bjp.0702082DOI: 10.1038/sj.bjp.0702082
A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304 (Conference Paper)
Conant, A. R., Fisher, M. J., McLennan, A. G., & Simpson, A. W. M. (1998). A comparison of the purinoceptor populations of primary human umbilical vein endothelial cells and the derived cell line ECV304. In Journal of Physiology-Paris Vol. 506 (pp. 33p-34p). Elsevier.
Diadenosine polyphosphate-mediated activation of phospholipase D in isolated rat liver cells. (Journal article)
Edgecombe, M., Eckersley, S. P., McLennan, A. G., & Fisher, M. J. (1998). Diadenosine polyphosphate-mediated activation of phospholipase D in isolated rat liver cells.. Cellular signalling, 10(7), 505-509. doi:10.1016/s0898-6568(97)00177-0DOI: 10.1016/s0898-6568(97)00177-0
Chromosomal localization of the human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1) to 9p13. (Journal article)
McLennan, A. G., Flannery, A. V., Morten, J. E., & Ridanpää, M. (1998). Chromosomal localization of the human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1) to 9p13.. Genomics, 47(2), 307-309. doi:10.1006/geno.1997.5092DOI: 10.1006/geno.1997.5092
1997
The MutT motif-containing ORF163w protein from the yeast Saccharomyces cerevisiae encodes a (di)nucleoside polyphosphate hydrolase. (Conference Paper)
Cartwright, J. L., & McLennan, A. G. (1997). The MutT motif-containing ORF163w protein from the yeast Saccharomyces cerevisiae encodes a (di)nucleoside polyphosphate hydrolase.. In Biochemical Society transactions Vol. 25 (pp. S580). doi:10.1042/bst025s580DOI: 10.1042/bst025s580
Diadenosine polyphosphate-stimulated gluconeogenesis in isolated rat proximal tubules. (Journal article)
Edgecombe, M., Craddock, H. S., Smith, D. C., McLennan, A. G., & Fisher, M. J. (1997). Diadenosine polyphosphate-stimulated gluconeogenesis in isolated rat proximal tubules.. The Biochemical journal, 323 ( Pt 2), 451-456. doi:10.1042/bj3230451DOI: 10.1042/bj3230451
Molecular cloning of diadenosine tetraphosphatase from pig small intestinal mucosa and identification of sequence blocks common to diadenosine polyphosphate hydrolases and phosphorylases. (Journal article)
Hankin, S., Winterø, A. K., & McLennan, A. G. (1997). Molecular cloning of diadenosine tetraphosphatase from pig small intestinal mucosa and identification of sequence blocks common to diadenosine polyphosphate hydrolases and phosphorylases.. The international journal of biochemistry & cell biology, 29(2), 317-323. doi:10.1016/s1357-2725(96)00153-7DOI: 10.1016/s1357-2725(96)00153-7
Diadenosine polyphosphates induce intracellular Ca2+ mobilization in human neutrophils via a pertussis toxin sensitive G-protein (Journal article)
Gasmi, L., McLennan, A. G., & Edwards, S. W. (1997). Diadenosine polyphosphates induce intracellular Ca2+ mobilization in human neutrophils via a pertussis toxin sensitive G-protein. IMMUNOLOGY, 90(1), 154-159. doi:10.1046/j.1365-2567.1997.00123.xDOI: 10.1046/j.1365-2567.1997.00123.x
1996
Anabaena flos-aquae and other cyanobacteria possess diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) phosphorylase activity. (Journal article)
McLennan, A. G., Mayers, E., & Adams, D. G. (1996). Anabaena flos-aquae and other cyanobacteria possess diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) phosphorylase activity.. The Biochemical journal, 320 ( Pt 3), 795-800. doi:10.1042/bj3200795DOI: 10.1042/bj3200795
GTP:GTP guanylyltransferase activity from encysted embryos of the brine shrimp Artemia is associated with a single 110 kDa polypeptide. (Conference Paper)
Cartwright, J. L., & McLennan, A. G. (1996). GTP:GTP guanylyltransferase activity from encysted embryos of the brine shrimp Artemia is associated with a single 110 kDa polypeptide.. In Biochemical Society transactions Vol. 24 (pp. 419S). doi:10.1042/bst024419sDOI: 10.1042/bst024419s
Molecular cloning of diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) from porcine small intestine: relationship to other enzymes of Ap4A catabolism. (Journal article)
Hankin, S., Winterø, A. K., & McLennan, A. G. (1996). Molecular cloning of diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) from porcine small intestine: relationship to other enzymes of Ap4A catabolism.. Biochemical Society transactions, 24(3), 418S. doi:10.1042/bst024418sDOI: 10.1042/bst024418s
Regulation of neutrophil apoptosis by diadenosine pentaphosphate and GM-CSF (Journal article)
Gasmi, L., McLennan, A. G., & Edwards, S. W. (1996). Regulation of neutrophil apoptosis by diadenosine pentaphosphate and GM-CSF. BIOCHEMICAL SOCIETY TRANSACTIONS, 24(3), S491. doi:10.1042/bst024491sDOI: 10.1042/bst024491s
The cyanobacterium Anabaena flos-aquae possesses diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) phosphorylase activity. (Journal article)
McLennan, A. G., Meyers, E., & Adams, D. G. (1996). The cyanobacterium Anabaena flos-aquae possesses diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) phosphorylase activity.. Biochemical Society transactions, 24(3), 417S. doi:10.1042/bst024417sDOI: 10.1042/bst024417s
Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) possesses a MutT motif. (Journal article)
Thorne, N. M., Hankin, S., Wilkinson, M. C., Nuñez, C., Barraclough, R., & McLennan, A. G. (1996). Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) possesses a MutT motif.. Biochemical Society transactions, 24(2), 209S. doi:10.1042/bst024209sDOI: 10.1042/bst024209s
The diadenosine polyphosphates Ap(3)A and Ap(4)A and adenosine triphosphate interact with granulocyte-macrophage colony-stimulating factor to delay neutrophil apoptosis: Implications for neutrophil platelet interactions during inflammation (Journal article)
Gasmi, L., McLennan, A. G., & Edwards, S. W. (1996). The diadenosine polyphosphates Ap(3)A and Ap(4)A and adenosine triphosphate interact with granulocyte-macrophage colony-stimulating factor to delay neutrophil apoptosis: Implications for neutrophil platelet interactions during inflammation. BLOOD, 87(8), 3442-3449. doi:10.1182/blood.V87.8.3442.bloodjournal8783442DOI: 10.1182/blood.V87.8.3442.bloodjournal8783442
Characterization of the binding of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to rat liver cell membranes. (Journal article)
Edgecombe, M., McLennan, A. G., & Fisher, M. J. (1996). Characterization of the binding of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to rat liver cell membranes.. The Biochemical journal, 314 ( Pt 2), 687-693. doi:10.1042/bj3140687DOI: 10.1042/bj3140687
Neutrophil apoptosis is delayed by the diadenosine polyphosphates, Ap(5)A and Ap(6)A: Synergism with granulocyte-macrophage colony-stimulating factor (Journal article)
Gasmi, L., McLennan, A. G., & Edwards, S. W. (1996). Neutrophil apoptosis is delayed by the diadenosine polyphosphates, Ap(5)A and Ap(6)A: Synergism with granulocyte-macrophage colony-stimulating factor. BRITISH JOURNAL OF HAEMATOLOGY, 95(4), 637-639. doi:10.1046/j.1365-2141.1996.d01-1960.xDOI: 10.1046/j.1365-2141.1996.d01-1960.x
1995
HUMAN DIADENOSINE 5',5'''-P-1,P-4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE IS A MEMBER OF THE MUTT FAMILY OF NUCLEOTIDE PYROPHOSPHATASES (Journal article)
MATHEW, N., THORNE, H., HANKIN, S., WILKINSON, M. C., NUNEZ, C., BARRACLOUGH, R., & MCLENNAN, A. G. (1995). HUMAN DIADENOSINE 5',5'''-P-1,P-4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE IS A MEMBER OF THE MUTT FAMILY OF NUCLEOTIDE PYROPHOSPHATASES. BIOCHEMICAL JOURNAL, 311, 717-721. doi:10.1042/bj3110717DOI: 10.1042/bj3110717
Lanterns of the firefly Photinus pyralis contain abundant diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase activity. (Journal article)
McLennan, A. G., Mayers, E., Walker-Smith, I., & Chen, H. (1995). Lanterns of the firefly Photinus pyralis contain abundant diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase activity.. The Journal of biological chemistry, 270(8), 3706-3709. doi:10.1074/jbc.270.8.3706DOI: 10.1074/jbc.270.8.3706
Diadenosine 5',5"'-P1,P4-tetraphosphate hydrolase is present in human erythrocytes, leukocytes and platelets. (Journal article)
Hankin, S., Matthew, N., Thorne, H., & McLennan, A. G. (1995). Diadenosine 5',5"'-P1,P4-tetraphosphate hydrolase is present in human erythrocytes, leukocytes and platelets.. The international journal of biochemistry & cell biology, 27(2), 201-206. doi:10.1016/1357-2725(94)00076-nDOI: 10.1016/1357-2725(94)00076-n
1994
Characterization of the HeLa cell DNA polymerase alpha-associated Ap4A binding protein by photoaffinity labeling. (Journal article)
Baxi, M. D., McLennan, A. G., & Vishwanatha, J. K. (1994). Characterization of the HeLa cell DNA polymerase alpha-associated Ap4A binding protein by photoaffinity labeling.. Biochemistry, 33(48), 14601-14607. doi:10.1021/bi00252a028DOI: 10.1021/bi00252a028
PRIMING OF THE RESPIRATORY BURST OF HUMAN NEUTROPHILS BY THE DIADENOSINE POLYPHOSPHATES, AP(4)A AND AP(3)A - ROLE OF INTRACELLULAR CALCIUM (Journal article)
GASMI, L., MCLENNAN, A. G., & EDWARDS, S. W. (1994). PRIMING OF THE RESPIRATORY BURST OF HUMAN NEUTROPHILS BY THE DIADENOSINE POLYPHOSPHATES, AP(4)A AND AP(3)A - ROLE OF INTRACELLULAR CALCIUM. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 202(1), 218-224. doi:10.1006/bbrc.1994.1915DOI: 10.1006/bbrc.1994.1915
The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohydrolase and phosphorylase activities. (Journal article)
McLennan, A. G., Mayers, E., Hankin, S., Thorne, N. M., Prescott, M., & Powls, R. (1994). The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohydrolase and phosphorylase activities.. The Biochemical journal, 300 ( Pt 1), 183-189. doi:10.1042/bj3000183DOI: 10.1042/bj3000183
Enzymes of diadenosine tetraphosphate (Ap4A) catabolism in the green alga Scenedesmus obliquus. (Conference Paper)
McLennan, A. G., Mayers, E., Gunaratne, R. S., Prescott, M., & Powls, R. (1994). Enzymes of diadenosine tetraphosphate (Ap4A) catabolism in the green alga Scenedesmus obliquus.. In Biochemical Society transactions Vol. 22 (pp. 231S). doi:10.1042/bst022231sDOI: 10.1042/bst022231s
Purification and properties of GTP:GTP guanylyltransferase from embryos of the brine shrimp Artemia. (Conference Paper)
Liu, J. J., & McLennan, A. G. (1994). Purification and properties of GTP:GTP guanylyltransferase from embryos of the brine shrimp Artemia.. In Biochemical Society transactions Vol. 22 (pp. 219S). doi:10.1042/bst022219sDOI: 10.1042/bst022219s
Purification and properties of GTP:GTP guanylyltransferase from encysted embryos of the brine shrimp Artemia. (Journal article)
Liu, J. J., & McLennan, A. G. (1994). Purification and properties of GTP:GTP guanylyltransferase from encysted embryos of the brine shrimp Artemia.. The Journal of biological chemistry, 269(16), 11787-11794. doi:10.1016/s0021-9258(17)32641-8DOI: 10.1016/s0021-9258(17)32641-8
1993
The bis(adenosin-N6-yl) alkanes, a family of potential dinucleoside polyphosphate analogue precursors. Mechanism of growth inhibition and suppression of adenosine toxicity in lymphoid cells. (Journal article)
Chen, H., & McLennan, A. G. (1993). The bis(adenosin-N6-yl) alkanes, a family of potential dinucleoside polyphosphate analogue precursors. Mechanism of growth inhibition and suppression of adenosine toxicity in lymphoid cells.. European journal of biochemistry, 215(2), 465-471. doi:10.1111/j.1432-1033.1993.tb18055.xDOI: 10.1111/j.1432-1033.1993.tb18055.x
The bis(adenosin-N6-yl)alkanes, a family of potential dinucleoside-polyphosphate analogue precursors. Cytotoxicity, adenosine-receptor binding and metabolism. (Journal article)
Chen, H., & McLennan, A. G. (1993). The bis(adenosin-N6-yl)alkanes, a family of potential dinucleoside-polyphosphate analogue precursors. Cytotoxicity, adenosine-receptor binding and metabolism.. European journal of biochemistry, 214(3), 935-944. doi:10.1111/j.1432-1033.1993.tb17997.xDOI: 10.1111/j.1432-1033.1993.tb17997.x
Adenine dinucleotide-mediated cytosolic free Ca2+ oscillations in single hepatocytes. (Journal article)
Green, A. K., Dixon, C. J., McLennan, A. G., Cobbold, P. H., & Fisher, M. J. (1993). Adenine dinucleotide-mediated cytosolic free Ca2+ oscillations in single hepatocytes.. FEBS letters, 322(2), 197-200. doi:10.1016/0014-5793(93)81567-jDOI: 10.1016/0014-5793(93)81567-j
Adenine dinucleotide-mediated activation of glycogen phosphorylase in isolated liver cells. (Journal article)
Craik, K. M., McLennan, A. G., & Fisher, M. J. (1993). Adenine dinucleotide-mediated activation of glycogen phosphorylase in isolated liver cells.. Cellular signalling, 5(1), 89-96. doi:10.1016/0898-6568(93)90011-aDOI: 10.1016/0898-6568(93)90011-a
Plasmid encoded beta-lactamases resistant to inhibition by clavulanic acid produced by calf faecal coliforms. (Journal article)
Hunter, J. E., Corkill, J. E., McLennan, A. G., Fletcher, J. N., & Hart, C. A. (1993). Plasmid encoded beta-lactamases resistant to inhibition by clavulanic acid produced by calf faecal coliforms.. Research in veterinary science, 55(3), 367-370. doi:10.1016/0034-5288(93)90109-sDOI: 10.1016/0034-5288(93)90109-s
1992
Ap4A and Other Dinucleoside Polyphosphates (Book)
McLennan, A. G. (Ed.) (1992). Ap4A and Other Dinucleoside Polyphosphates. Boca Raton: CRC Press.
Characterisation of a bis(5'-nucleosidyl) triphosphate pyrophosphohydrolase from encysted embryos of the brine shrimp Artemia. (Journal article)
Prescott, M., Thorne, N. M., Milne, A. D., & McLennan, A. G. (1992). Characterisation of a bis(5'-nucleosidyl) triphosphate pyrophosphohydrolase from encysted embryos of the brine shrimp Artemia.. The International journal of biochemistry, 24(4), 565-571. doi:10.1016/0020-711x(92)90328-xDOI: 10.1016/0020-711x(92)90328-x
Dinucleoside polyphosphates: an introduction (Chapter)
McLennan, A. G., & Zamecnik, P. C. (1992). Dinucleoside polyphosphates: an introduction. In A. G. McLennan (Ed.), Ap4A and Other Dinucleoside Polyphosphates (pp. 1-7). Boca Raton: CRC Press.
Synthetic structural analogues of dinucleoside polyphosphates (Chapter)
Blackburn, G. M., Guo, M. J., & McLennan, A. G. (1992). Synthetic structural analogues of dinucleoside polyphosphates. In A. G. McLennan (Ed.), Ap4A and Other Dinucleoside Polyphosphate (pp. 305-342). Boca Raton: CRC Press.
1991
Comment: di(1,N6-ethenoadenosine)-5',5'''-P1,P4-tetraphosphate, a fluorescent enzymatically active derivative of Ap4A. (Journal article)
McLennan, A. G. (1991). Comment: di(1,N6-ethenoadenosine)-5',5'''-P1,P4-tetraphosphate, a fluorescent enzymatically active derivative of Ap4A.. FEBS letters, 291(1), 153-154. doi:10.1016/0014-5793(91)81125-rDOI: 10.1016/0014-5793(91)81125-r
Characterization of a beta-lactamase produced by Pseudomonas paucimobilis. (Journal article)
Corkill, J. E., Hart, C. A., McLennan, A. G., & Aspinall, S. (1991). Characterization of a beta-lactamase produced by Pseudomonas paucimobilis.. Journal of general microbiology, 137(6), 1425-1429. doi:10.1099/00221287-137-6-1425DOI: 10.1099/00221287-137-6-1425
Properties of the diadenosine tetraphosphate nucleoside analogue, bis (N6-adenosyl)dodecane, and its possible use in the treatment of disorders of purine metabolism. (Journal article)
Chen, H., Cosstick, R., & McLennan, A. G. (1991). Properties of the diadenosine tetraphosphate nucleoside analogue, bis (N6-adenosyl)dodecane, and its possible use in the treatment of disorders of purine metabolism.. Biochemical Society transactions, 19(2), 123S. doi:10.1042/bst019123sDOI: 10.1042/bst019123s
1990
Studies on Bis(5′-Adenosyl)-P<sup>1</sup>, P<sup>4</sup>-Tetraphosphate, Appppa, and Some Synthetic Isosteric and Isopolar Phosphonate Analogues Using the Specific Appppaases from<i>Artemia</i>and Lupin (Journal article)
Blackburn, G. M., Guranowski, A., Guo, M. -J., McLennan, A. G., & Taylor, G. E. (1990). Studies on Bis(5′-Adenosyl)-P<sup>1</sup>, P<sup>4</sup>-Tetraphosphate, Appppa, and Some Synthetic Isosteric and Isopolar Phosphonate Analogues Using the Specific Appppaases from<i>Artemia</i>and Lupin. Phosphorus, Sulfur, and Silicon and the Related Elements, 51(1-4), 31-34. doi:10.1080/10426509008040675DOI: 10.1080/10426509008040675
Variation in intracellular P1P4-bis(5'-adenosyl) tetraphosphate (Ap4A) in virus-infected cells. (Journal article)
Johnston, D. J., Hart, C. A., & McLennan, A. G. (1990). Variation in intracellular P1P4-bis(5'-adenosyl) tetraphosphate (Ap4A) in virus-infected cells.. The Biochemical journal, 268(3), 791-793. doi:10.1042/bj2680791DOI: 10.1042/bj2680791
Synthesis and applications of 8-azido photoaffinity analogs of P1,P3-bis(5'-adenosyl)triphosphate and P1,P4-bis(5'-adenosyl)tetraphosphate. (Journal article)
Prescott, M., & McLennan, A. G. (1990). Synthesis and applications of 8-azido photoaffinity analogs of P1,P3-bis(5'-adenosyl)triphosphate and P1,P4-bis(5'-adenosyl)tetraphosphate.. Analytical biochemistry, 184(2), 330-337. doi:10.1016/0003-2697(90)90690-bDOI: 10.1016/0003-2697(90)90690-b
A biological role for the heat shock response in crustaceans (Journal article)
McLennan, A. G., & Miller, D. (1990). A biological role for the heat shock response in crustaceans. Journal of Thermal Biology, 15(1), 61-66. doi:10.1016/0306-4565(90)90049-nDOI: 10.1016/0306-4565(90)90049-n
Synthesis of bridged dinucleosides (Journal article)
Agathocleous, D. C., Bulman Page, P. C., Cosstick, R., Galpin, I. J., McLennan, A. G., & Prescott, M. (1990). Synthesis of bridged dinucleosides. Tetrahedron, 46(6), 2047-2058. doi:10.1016/s0040-4020(01)89771-4DOI: 10.1016/s0040-4020(01)89771-4
1989
Recognition of beta beta'-substituted and alpha beta,alpha'beta'-disubstituted phosphonate analogues of bis(5'-adenosyl) tetraphosphate by the bis(5'-nucleosidyl)-tetraphosphate pyrophosphohydrolases from Artemia embryos and Escherichia coli. (Journal article)
McLennan, A. G., Taylor, G. E., Prescott, M., & Blackburn, G. M. (1989). Recognition of beta beta'-substituted and alpha beta,alpha'beta'-disubstituted phosphonate analogues of bis(5'-adenosyl) tetraphosphate by the bis(5'-nucleosidyl)-tetraphosphate pyrophosphohydrolases from Artemia embryos and Escherichia coli.. Biochemistry, 28(9), 3868-3875. doi:10.1021/bi00435a036DOI: 10.1021/bi00435a036
Characterization of the bis(5'-nucleosidyl) tetraphosphate pyrophosphohydrolase from encysted embryos of the brine shrimp Artemia. (Journal article)
Prescott, M., Milne, A. D., & McLennan, A. G. (1989). Characterization of the bis(5'-nucleosidyl) tetraphosphate pyrophosphohydrolase from encysted embryos of the brine shrimp Artemia.. The Biochemical journal, 259(3), 831-838. doi:10.1042/bj2590831DOI: 10.1042/bj2590831
Identification of point of specific enzymic cleavage of P1,P4-bis(5'-adenosyl) tetraphosphate by negative ion FAB mass spectrometry. (Journal article)
McLennan, A. G., Prescott, M., & Evershed, R. P. (1989). Identification of point of specific enzymic cleavage of P1,P4-bis(5'-adenosyl) tetraphosphate by negative ion FAB mass spectrometry.. Biomedical & environmental mass spectrometry, 18(6), 450-452. doi:10.1002/bms.1200180615DOI: 10.1002/bms.1200180615
The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin -<u>N</u><sup>6</sup>- YL) Alkanes<sup>1</sup> (Journal article)
Prescott, M., McLennan, A. G., Agathocleous, D. C., Bulman Page, P. C., Cosstick, R., & Galpin, I. J. (1989). The Inhibition of Adenosine Kinase by α,ω-Di (Adenosin -<u>N</u><sup>6</sup>- YL) Alkanes<sup>1</sup>. Nucleosides and Nucleotides, 8(2), 297-303. doi:10.1080/07328318908054174DOI: 10.1080/07328318908054174
1988
Biological activity of (<i>N</i>6-N6)-bridged diadenosines (Journal article)
AGATHOCLEOUS, D. C., COSSTICK, R., GALPIN, I. J., McLENNAN, A. G., PAGE, P. C. B., & PRESCOTT, M. (1988). Biological activity of (<i>N</i>6-N6)-bridged diadenosines. Biochemical Society Transactions, 16(5), 756-757. doi:10.1042/bst0160756DOI: 10.1042/bst0160756
Phosphonate analogues of bis(5′-adenosyl)tetraphosphate (Journal article)
TAYLOR, G. E., BLACKBURN, G. M., PRESCOTT, M., & McLENNAN, A. G. (1988). Phosphonate analogues of bis(5′-adenosyl)tetraphosphate. Biochemical Society Transactions, 16(5), 713-714. doi:10.1042/bst0160713DOI: 10.1042/bst0160713
The heat shock response of the cryptobiotic brine Shrimp artemia—I. A comparison of the thermotolerance of cysts and larvae (Journal article)
Miller, D., & McLennan, A. G. (1988). The heat shock response of the cryptobiotic brine Shrimp artemia—I. A comparison of the thermotolerance of cysts and larvae. Journal of Thermal Biology, 13(3), 119-123. doi:10.1016/0306-4565(88)90022-8DOI: 10.1016/0306-4565(88)90022-8
The heat shock response of the cryptobiotic brine shrimp Artemia — II. Heat shock proteins (Journal article)
Miller, D., & McLennan, A. G. (1988). The heat shock response of the cryptobiotic brine shrimp Artemia — II. Heat shock proteins. Journal of Thermal Biology, 13(3), 125-134. doi:10.1016/0306-4565(88)90023-xDOI: 10.1016/0306-4565(88)90023-x
1987
Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1,P4-bis(5'-adenosyl) tetraphosphate. (Journal article)
Blackburn, G. M., Taylor, G. E., Thatcher, G. R., Prescott, M., & McLennan, A. G. (1987). Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1,P4-bis(5'-adenosyl) tetraphosphate.. Nucleic acids research, 15(17), 6991-7004. doi:10.1093/nar/15.17.6991DOI: 10.1093/nar/15.17.6991
Immunological detection of a DNA polymerase-β polypeptide in embryonic cysts and larvae of the brine shrimp Artemia (Journal article)
McLennan, A. G. (1987). Immunological detection of a DNA polymerase-β polypeptide in embryonic cysts and larvae of the brine shrimp Artemia. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 86(2), 315-320. doi:10.1016/0305-0491(87)90299-9DOI: 10.1016/0305-0491(87)90299-9
The repair of ultraviolet light-induced DNA damage in plant cells (Journal article)
McLennan, A. G. (1987). The repair of ultraviolet light-induced DNA damage in plant cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 181(1), 1-7. doi:10.1016/0027-5107(87)90281-8DOI: 10.1016/0027-5107(87)90281-8
1986
Changes in intracellular levels of Ap3A and Ap4A in cysts and larvae of Artemia do not correlate with changes in protein synthesis after heat-shock. (Journal article)
Miller, D., & McLennan, A. G. (1986). Changes in intracellular levels of Ap3A and Ap4A in cysts and larvae of Artemia do not correlate with changes in protein synthesis after heat-shock.. Nucleic acids research, 14(15), 6031-6040. doi:10.1093/nar/14.15.6031DOI: 10.1093/nar/14.15.6031
An endonuclease activity from suspension cultures of Daucus carota which acts upon pyrimidine dimers (Journal article)
McLennan, A. G., & Eastwood, A. C. (1986). An endonuclease activity from suspension cultures of Daucus carota which acts upon pyrimidine dimers. Plant Science, 46(3), 151-157. doi:10.1016/0168-9452(86)90186-xDOI: 10.1016/0168-9452(86)90186-x
1985
Repair replication in ultraviolet light-irradiated protoplasts of Daucus carota (Journal article)
Eastwood, A. C., & McLennan, A. G. (1985). Repair replication in ultraviolet light-irradiated protoplasts of Daucus carota. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 826(1), 13-19. doi:10.1016/s0167-4781(85)80003-8DOI: 10.1016/s0167-4781(85)80003-8
Enhanced reactivation of UV-irradiated adenovirus 2 in HeLa cells treated with non-mutagenic chemical agents. (Journal article)
Piperakis, S. M., & McLennan, A. G. (1985). Enhanced reactivation of UV-irradiated adenovirus 2 in HeLa cells treated with non-mutagenic chemical agents.. Mutation research, 142(3), 83-85. doi:10.1016/0165-7992(85)90044-2DOI: 10.1016/0165-7992(85)90044-2
1984
Diadenosine 5',5'"-P1,P4-tetraphosphate in developing embryos of Artemia. (Journal article)
McLennan, A. G., & Prescott, M. (1984). Diadenosine 5',5'"-P1,P4-tetraphosphate in developing embryos of Artemia.. Nucleic acids research, 12(3), 1609-1619. doi:10.1093/nar/12.3.1609DOI: 10.1093/nar/12.3.1609
Diadenosine tetraphosphate and diadenosine tetraphosphate-binding proteins in developing embryos of Artemia. (Journal article)
McLennan, A. G., & Prescott, M. (1984). Diadenosine tetraphosphate and diadenosine tetraphosphate-binding proteins in developing embryos of Artemia.. Advances in experimental medicine and biology, 179, 507-511. doi:10.1007/978-1-4684-8730-5_52DOI: 10.1007/978-1-4684-8730-5_52
Heat-enhanced reactivation of UV-irradiated adenovirus 2 is not associated with enhanced mutagenesis in HeLa cells. (Journal article)
Piperakis, S. M., & McLennan, A. G. (1984). Heat-enhanced reactivation of UV-irradiated adenovirus 2 is not associated with enhanced mutagenesis in HeLa cells.. Mutation research, 139(4), 173-176. doi:10.1016/0165-7992(84)90123-4DOI: 10.1016/0165-7992(84)90123-4
Piperakis, S. M., & McLennan, A. G. (1984). Hyperthermia enhances the reactivation of irradiated adenovirus in HeLa cells.. British journal of cancer, 49(2), 199-205. doi:10.1038/bjc.1984.32DOI: 10.1038/bjc.1984.32
1982
DNA polymerases alpha and gamma during pre-emergence and early larval development of Artemia. (Journal article)
Slater, J. M., & McLennan, A. G. (1982). DNA polymerases alpha and gamma during pre-emergence and early larval development of Artemia.. European journal of biochemistry, 129(2), 415-421. doi:10.1111/j.1432-1033.1982.tb07066.xDOI: 10.1111/j.1432-1033.1982.tb07066.x
The heterogeneity of DNA polymerase-α from mouse embryos and embryonal carcinoma cells (Journal article)
CLARK, D. R., & McLENNAN, A. G. (1982). The heterogeneity of DNA polymerase-α from mouse embryos and embryonal carcinoma cells. Biochemical Society Transactions, 10(5), 348. doi:10.1042/bst0100348DOI: 10.1042/bst0100348
1980
Uracil-DNA glycosylase in developing embryos of the brine shrimp (Artemia salina). (Journal article)
Birch, D. J., & McLennan, A. G. (1980). Uracil-DNA glycosylase in developing embryos of the brine shrimp (Artemia salina).. Biochemical Society transactions, 8(6), 730-731. doi:10.1042/bst0080730aDOI: 10.1042/bst0080730a
Effect of aphidicolin and 2',3'-dideoxythymidine on mitochondrial DNA replication. (Journal article)
McLennan, A. G. (1980). Effect of aphidicolin and 2',3'-dideoxythymidine on mitochondrial DNA replication.. Biochemical and biophysical research communications, 94(1), 116-122. doi:10.1016/s0006-291x(80)80195-1DOI: 10.1016/s0006-291x(80)80195-1
1977
The deoxyribonucleic acid polymerases of non-vertebrate eukaryotes. (Journal article)
McLennan, A. G., & Keir, H. M. (1977). The deoxyribonucleic acid polymerases of non-vertebrate eukaryotes.. Biochemical Society symposium, (42), 55-73.
Variation of deoxyribonucleic acid polymerases in the cell cycle. (Journal article)
Keir, H. M., Craig, R. K., & McLennan, A. G. (1977). Variation of deoxyribonucleic acid polymerases in the cell cycle.. Biochemical Society symposium, (42), 37-54.
1975
Deoxyribonucleic acid polymerases of Euglena gracilis. Primer-template utilization of and enzyme activities associated with the two deoxyribonucleic acid polymerases of high molecular weight. (Journal article)
McLennan, A. G., & Keir, H. M. (1975). Deoxyribonucleic acid polymerases of Euglena gracilis. Primer-template utilization of and enzyme activities associated with the two deoxyribonucleic acid polymerases of high molecular weight.. The Biochemical journal, 151(2), 239-247. doi:10.1042/bj1510239DOI: 10.1042/bj1510239
Deoxyribonucleic acid polymerases of Euglena gracilis. Purification and properties of two distinct deoxyribonucleic acid polymerases of high molecular weight. (Journal article)
McLennan, A. G., & Keir, H. M. (1975). Deoxyribonucleic acid polymerases of Euglena gracilis. Purification and properties of two distinct deoxyribonucleic acid polymerases of high molecular weight.. The Biochemical journal, 151(2), 227-238. doi:10.1042/bj1510227DOI: 10.1042/bj1510227
Subcellular location and growth stage dependence of the DNA polymerases of Euglena gracilis. (Journal article)
McLennan, A. G., & Keir, H. M. (1975). Subcellular location and growth stage dependence of the DNA polymerases of Euglena gracilis.. Biochimica et biophysica acta, 407(3), 253-262. doi:10.1016/0005-2787(75)90092-1DOI: 10.1016/0005-2787(75)90092-1
DNA polymerases of Euglena gracilis: heterogeneity of molecular weight and subunit structure. (Journal article)
McLennan, A. G., & Keir, H. M. (1975). DNA polymerases of Euglena gracilis: heterogeneity of molecular weight and subunit structure.. Nucleic acids research, 2(2), 223-237. doi:10.1093/nar/2.2.223DOI: 10.1093/nar/2.2.223
Euglena gracilis deoxyribonucleic acid polymerases: subcellular locations and variations during the cell cycle. (Journal article)
McLennan, A. G., & Keir, H. M. (1975). Euglena gracilis deoxyribonucleic acid polymerases: subcellular locations and variations during the cell cycle.. Biochemical Society transactions, 3(5), 652. doi:10.1042/bst0030652DOI: 10.1042/bst0030652
