2021
Luis, A. S., Jin, C., Pereira, G. V., Glowacki, R. W. P., Gugel, S. R., Singh, S., . . . Martens, E. C. (2021). A single sulfatase is required to access colonic mucin by a gut bacterium. NATURE, 598(7880), 332-+. doi:10.1038/s41586-021-03967-5DOI: 10.1038/s41586-021-03967-5
Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (Journal article)
Luis, A., Baslé, A., Byrne, D., Wright, G. S. A., London, J., Chunsheng, J., . . . Cartmell, A. (2021). Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota. doi:10.1101/2021.07.23.453482DOI: 10.1101/2021.07.23.453482
Byrne, D. P., London, J. A., Eyers, P. A., Yates, E. A., & Cartmell, A. (2021). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (vol 478, pg 735, 2021). BIOCHEMICAL JOURNAL, 478(1), 2537-2538. doi:10.1042/BCJ20200952_CORDOI: 10.1042/BCJ20200952_COR
Byrne, D. P., London, J. A., Eyers, P. A., Yates, E. A., & Cartmell, A. (2021). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity. BIOCHEMICAL JOURNAL, 478(4), 735-748. doi:10.1042/BCJ20200952DOI: 10.1042/BCJ20200952
Gray, D. A., White, J. B. R., Oluwole, A. O., Rath, P., Glenwright, A. J., Mazur, A., . . . van den Berg, B. (2021). Insights into SusCD-mediated glycan import by a prominent gut symbiont. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-020-20285-yDOI: 10.1038/s41467-020-20285-y
2020
Byrne, D., London, J., Eyers, P., Yates, E., & Cartmell, A. (2020). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity. doi:10.1101/2020.12.01.406876DOI: 10.1101/2020.12.01.406876
Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (vol 11, 646, 2020) (Journal article)
Ndeh, D., Basle, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (vol 11, 646, 2020). NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18097-1DOI: 10.1038/s41467-020-18097-1
Ndeh, D., Baslé, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nature Communications, 11. doi:10.1038/s41467-020-14509-4DOI: 10.1038/s41467-020-14509-4
2019
Labourel, A., Basle, A., Munoz-Munoz, J., Ndeh, D., Booth, S., Nepogodiev, S. A., . . . Cartmell, A. (2019). Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(19), 7711-7721. doi:10.1074/jbc.RA118.006626DOI: 10.1074/jbc.RA118.006626
2018
Ndeh, D., Munoz, J. M., Cartmell, A., Bulmer, D., Wills, C., Henrissat, B., & Gray, J. (2018). The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan-degrading polysaccharide lyase family PL29. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(46), 17906-17916. doi:10.1074/jbc.RA118.004510DOI: 10.1074/jbc.RA118.004510
Cartmell, A., Munoz-Munoz, J., Briggs, J. A., Ndeh, D. A., Lowe, E. C., Basle, A., . . . Gilbert, H. (2018). A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Nature Microbiology, 3(11), 1314-1326. doi:10.1038/s41564-018-0258-8DOI: 10.1038/s41564-018-0258-8
Urresti, S., Cartmell, A., Liu, F., Walton, P. H., & Davies, G. J. (2018). Structural studies of the unusual metal-ion site of the GH124 endoglucanase from Ruminiclostridium thermocellum. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 74, 496-505. doi:10.1107/S2053230X18006842DOI: 10.1107/S2053230X18006842
Luis, A. S., Briggs, J., Zhang, X., Farnell, B., Ndeh, D., Labourel, A., . . . Gilbert, H. J. (2018). Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. Nature Microbiology, 3(2), 210-219. doi:10.1038/s41564-017-0079-1DOI: 10.1038/s41564-017-0079-1
2017
Munoz-Munoz, J., Cartmell, A., Terrapon, N., Basle, A., Henrissat, B., & Gilbert, H. J. (2017). An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins. Journal of Biological Chemistry, 292(32), 13271-13283. doi:10.1074/jbc.M117.794578DOI: 10.1074/jbc.M117.794578
Cartmell, A., Lowe, E. C., Basle, A., Firbank, S. J., Ndeh, D. A., Murray, H., . . . Bolam, D. N. (2017). How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proceedings of the National Academy of Sciences of the United States of America, 114(27), 7037-7042. doi:10.1073/pnas.1704367114DOI: 10.1073/pnas.1704367114
Munoz-Munoz, J., Cartmell, A., Terrapon, N., Henrissat, B., & Gilbert, H. J. (2017). Unusual active site location and catalytic apparatus in a glycoside hydrolase family. Proceedings of the National Academy of Sciences of the United States of America, 114(19), 4936-4941. doi:10.1073/pnas.1701130114DOI: 10.1073/pnas.1701130114
Ndeh, D., Rogowski, A., Cartmell, A., Luis, A. S., Basle, A., Gray, J., . . . Gilbert, H. J. (2017). Complex pectin metabolism by gut bacteria reveals novel catalytic functions. NATURE, 544(7648), 65-70. doi:10.1038/nature21725DOI: 10.1038/nature21725
2015
Hernandez-Gomez, M. C., Rydahl, M. G., Rogowski, A., Morland, C., Cartmell, A., Crouch, L., . . . Knox, J. P. (2015). Recognition of xyloglucan by the crystalline cellulose-binding site of a family 3a carbohydrate-binding module. FEBS LETTERS, 589(18), 2297-2303. doi:10.1016/j.febslet.2015.07.009DOI: 10.1016/j.febslet.2015.07.009
Evidence for a Boat Conformation at the Transition State of GH76 alpha-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism (Journal article)
Thompson, A. J., Speciale, G., Iglesias-Fernandez, J., Hakki, Z., Belz, T., Cartmell, A., . . . Davies, G. J. (2015). Evidence for a Boat Conformation at the Transition State of GH76 alpha-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(18), 5378-5382. doi:10.1002/anie.201410502DOI: 10.1002/anie.201410502
Cuskin, F., Lowe, E. C., Temple, M. J., Zhu, Y., Cameron, E. A., Pudlo, N. A., . . . Gilbert, H. J. (2015). Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism. NATURE, 517(7533), 165-U86. doi:10.1038/nature13995DOI: 10.1038/nature13995
2011
Cartmell, A., McKee, L. S., Pena, M. J., Larsbrink, J., Brumer, H., Kaneko, S., . . . Marles-Wright, J. (2011). The Structure and Function of an Arabinan-specific alpha-1,2-Arabinofuranosidase Identified from Screening the Activities of Bacterial GH43 Glycoside Hydrolases. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(17), 15483-15495. doi:10.1074/jbc.M110.215962DOI: 10.1074/jbc.M110.215962
Bras, J. L. A., Cartmell, A., Carvalho, A. L. M., Verze, G., Bayer, E. A., Vazana, Y., . . . Gilbert, H. J. (2011). Structural insights into a unique cellulase fold and mechanism of cellulose hydrolysis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(13), 5237-5242. doi:10.1073/pnas.1015006108DOI: 10.1073/pnas.1015006108
2009
Analysis of the Structural and Functional Diversity of Plant Cell Wall Specific Family 6 Carbohydrate Binding Modules (Journal article)
Abbott, D. W., Ficko-Blean, E., van Bueren, A. L., Rogowski, A., Cartmell, A., Coutinho, P. M., . . . Boraston, A. B. (2009). Analysis of the Structural and Functional Diversity of Plant Cell Wall Specific Family 6 Carbohydrate Binding Modules. BIOCHEMISTRY, 48(43), 10395-10404. doi:10.1021/bi9013424DOI: 10.1021/bi9013424
Montanier, C., Money, V. A., Pires, V. M. R., Flint, J. E., Pinheiro, B. A., Goyal, A., . . . Gilbert, H. J. (2009). The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions. PLOS BIOLOGY, 7(3), 687-697. doi:10.1371/journal.pbio.1000071DOI: 10.1371/journal.pbio.1000071
2008
Cartmell, A., Topakas, E., Ducros, V. M. -A., Suits, M. D. L., Davies, G. J., & Gilbert, H. J. (2008). The Cellvibrio japonicus Mannanase CjMan26C Displays a Unique exo-Mode of Action That Is Conferred by Subtle Changes to the Distal Region of the Active Site. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(49), 34403-34413. doi:10.1074/jbc.M804053200DOI: 10.1074/jbc.M804053200
Probing the beta-1,3 : 1,4 glucanase, CtLic26A, with a thio-oligosaccharide and enzyme variants (Journal article)
Money, V. A., Cartmell, A., Guerreiro, C. I. P. D., Ducros, V. M. -A., Fontes, C. M. G. A., Gilbertb, H. J., & Davies, G. J. (2008). Probing the beta-1,3 : 1,4 glucanase, CtLic26A, with a thio-oligosaccharide and enzyme variants. ORGANIC & BIOMOLECULAR CHEMISTRY, 6(5), 851-853. doi:10.1039/b719288fDOI: 10.1039/b719288f
