Mr Aaron Dane MSc.

Honorary Senior Lecturer and Statistical Consultant Pharmacology & Therapeutics

Work email Aaron.Dane@liverpool.ac.uk
Personal WebsiteStatistical Consultancy Website

Publications

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2017

Progress in the Fight Against Multidrug-Resistant Bacteria 2005–2016: Modern Noninferiority Trial Designs Enable Antibiotic Development in Advance of Epidemic Bacterial Resistance (Journal article)

Rex, J. H., Talbot, G. H., Goldberger, M. J., Eisenstein, B. I., Echols, R. M., Tomayko, J. F., . . . Dane, A. (2017). Progress in the Fight Against Multidrug-Resistant Bacteria 2005–2016: Modern Noninferiority Trial Designs Enable Antibiotic Development in Advance of Epidemic Bacterial Resistance. Clinical Infectious Diseases, 65(1), 141-146. doi:10.1093/cid/cix246

DOI: 10.1093/cid/cix246

Factors for defining the robustness of the PK/PD package…..and how this affects the size of the clinical development program (Presentation material)

Dane, A. (2017). Factors for defining the robustness of the PK/PD package…..and how this affects the size of the clinical development program. Washington DC.

Statistical and design approaches to allow more feasible antibiotic drug development (Presentation material)

Dane, A. (2017). Statistical and design approaches to allow more feasible antibiotic drug development. London.

2016

Efficient Delivery of Investigational Antibacterial Agents via Sustainable Clinical Trial Networks (Journal article)

McDonnell, A., Rex, J. H., Goossens, H., Bonten, M., Fowler, V. G., & Dane, A. (2016). Efficient Delivery of Investigational Antibacterial Agents via Sustainable Clinical Trial Networks. Clinical Infectious Diseases, 63(suppl 2), S57-S59. doi:10.1093/cid/ciw244

DOI: 10.1093/cid/ciw244

Subgroup Analysis Approaches to Inform Regulatory Labelling. Outputs from the PSI Working Group on Subgroup Analysis. (Presentation material)

Dane, A. (2016). Subgroup Analysis Approaches to Inform Regulatory Labelling. Outputs from the PSI Working Group on Subgroup Analysis.. Berlin.

The application of platform trials to antibiotic development (Presentation material)

Dane, A. (2016). The application of platform trials to antibiotic development. Berlin.

2015

The use of limited data to achieve regulatory drug approval: Options for Antibiotic Drug Development. (Presentation material)

Dane, A. (2015). The use of limited data to achieve regulatory drug approval: Options for Antibiotic Drug Development.. London.

2014

Statistical Considerations for a Tiered Approach to antibiotic drug development (Presentation material)

Dane, A. (2014). Statistical Considerations for a Tiered Approach to antibiotic drug development. Washington DC.

Tackling emerging antibiotic resistance: Statistical challenges and options (Poster)

Dane, A., & Wilson, D. (2014). Tackling emerging antibiotic resistance: Statistical challenges and options. Poster session presented at the meeting of BioInfect 2014. Alderley Park, Macclesfield.

Confidence intervals for the difference between independent binomial proportions: comparison using a graphical approach and moving averages (Journal article)

Laud, P. J., & Dane, A. (2014). Confidence intervals for the difference between independent binomial proportions: comparison using a graphical approach and moving averages. Pharmaceutical Statistics, 13(5), 294-308. doi:10.1002/pst.1631

DOI: 10.1002/pst.1631

Statistical considerations associated with a comprehensive regulatory framework to address the unmet need for new antibacterial therapies (Journal article)

Dane, A., & Wetherington, J. D. (2014). Statistical considerations associated with a comprehensive regulatory framework to address the unmet need for new antibacterial therapies. Pharmaceutical Statistics, 13(4), 222-228. doi:10.1002/pst.1625

DOI: 10.1002/pst.1625

2013

Statistical Input for Due Diligence - The do’s and don’ts (Presentation material)

Dane, A. (2013). Statistical Input for Due Diligence - The do’s and don’ts. Glasgow.

A comprehensive regulatory framework to address the unmet need for new antibacterial treatments (Journal article)

Rex, J. H., Eisenstein, B. I., Alder, J., Goldberger, M., Meyer, R., Dane, A., . . . Jackson, J. (2013). A comprehensive regulatory framework to address the unmet need for new antibacterial treatments. The Lancet Infectious Diseases, 13(3), 269-275. doi:10.1016/s1473-3099(12)70293-1

DOI: 10.1016/s1473-3099(12)70293-1

2011

Active controlled studies in antibiotic drug development (Journal article)

Dane, A. (2011). Active controlled studies in antibiotic drug development. Pharmaceutical Statistics, 10(5), 454-460. doi:10.1002/pst.518

DOI: 10.1002/pst.518

Use of Pre-clinical Data for Clinical Decision Making in Antibiotic Drug Development (Presentation material)

Dane, A. (2011). Use of Pre-clinical Data for Clinical Decision Making in Antibiotic Drug Development. Gloucestershire.

2009

Models for the analysis of C-reactive protein in statin trials (Journal article)

Southworth, H., & Dane, A. (2009). Models for the analysis of C-reactive protein in statin trials. Pharmaceutical Statistics, 8(2), 87-97. doi:10.1002/pst.335

DOI: 10.1002/pst.335

2006

Clinical Development & Registration issues for Anti-Infective products (Presentation material)

Dane, A. (2006). Clinical Development & Registration issues for Anti-Infective products. London.

Design Considerations for Factorial Designs in Clinical Trials (Presentation material)

Dane, A. (2006). Design Considerations for Factorial Designs in Clinical Trials. Bristol.