Liverpool Bio-Innovation Hub (LBIH) Biobank


Manuscripts published from LBIH Biobank (Formerly LTB and CTBRC) material.


Hannah A. Davies, Eva Caamaño-Gutiérrez, Ya Hua Chim, Mark Field, Omar Nawaytou, Lorenzo Ressel, Riaz Akhtar & Jillian Madine. Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid. Amyloid, DOI:10.1080/13506129.2019.1625323


Areege Kamal, Anthony Valentijn, Roger Barraclough, Philip Rudland, Nihad Rahmatalla, Pierre Martin-Hirsch, Helen Stringfellow, Shandya B. Decruze and Dharani K. Hapangama. High AGR2 protein is a feature of low grade endometrial cancer cells. Oncotarget, 2018, Vol. 9, (No. 59), pp: 31459-31472


Raymond Q. Migrino, Hannah A. Davies, Seth Truran, Nina Karamanova, Daniel A. Franco, Thomas G. Beach, Geidy E. Serrano, Danh Truong, Mehdi Nikkhah, and Jillian Madine Amyloidogenic medin induces endothelial dysfunction and vascular inflammation through the receptor for advanced glycation endproducts. Cardiovascular Research, Volume 113, Issue 11, 1 September 2017, Pages 1389–1402.

Ahmed A, Pritchard DM, Burkitt MD. PTH-060 Expression of MAdCAM-1 in the upper gastrointestinal tract: Is there a role for disrupting interactions between MAdCAM -1 and alpha-4/beta-7 integrin in upper GI Crohn’s disease? Gut 2017. 66 (S2) A236. doi: 10.1136/gutjnl-2017-314472.459 Presented as a poster at the British Society of Gastroenterology’s Annual Meeting 2017.

Thamir M. Ismail, Daimark Bennett, Angela M. Platt-Higgins, Morteta Al-Medhity, Roger Barraclough, and Philip S. Rudland. S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer. Cancer Res; 77(3) February 1, 2017


Rasheed Zakaria, Angela Platt-Higgins, Nitika Rathi, Daniel Crooks, Andrew Brodbelt, Emmanuel Chavredakis, David Lawson, Michael D Jenkinson and Philip S Rudland. Metastasis-inducing proteins are widely expressed in human brain metastases and associated with intracranial progression and radiation response. British Journal of Cancer (2016) 114, 1101–1108 | doi: 10.1038/bjc.2016.103

Hiu-Fung Yuen1, Ka-Kui Chan1, Angela Platt-Higgins2, El-Habib Dakir1,4, Kyle B. Matchett1, Yusuf Ahmed Haggag1,7, Puthen V. Jithesh6, Tanwir Habib6, Ahmed Faheem5, Fennell A. Dean3, Richard Morgan4, Philip S. Rudland2, Mohamed El-Tanani4. Ran GTPase promotes cancer progression via Met receptor mediated downstream signalling. Oncotarget, Vol. 7, No. 46


Presentations given by Andrew Schache
• International Conference on Oral & Maxillofacial Surgery (ICOMS), Melbourne, Australia. 2015
• British Association of Oral & Maxillofacial Surgeons, Liverpool (BAOMS), 2015


Presentations given by Andrew Schache
• European Society of Surgical Oncology (ESSO). 2014
• British Association of Oral & Maxillofacial Surgeons, Edinburgh (BAOMS). 2014
• International Agency for Research on Cancer (IARC) - Emerging Issues in Head and Neck Cancer, Italy. 2014


Thornton M, Aslam MA, Tweedle EM, Ang C, Campbell F, Jackson R, Costello E, Rooney PS, Vlatković N, Boyd MT. The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer. Int J Cancer. 2013 Sep 15;133(6):1408-18.

P V Jithesh*, J M Risk, A G Schache, J Dhanda, B Lane, T Liloglou and R J Shaw. The epigenetic landscape of oral squamous cell carcinoma. British Journal of Cancer (2013) 108, 370–379

A G Schache*, T Liloglou, J M Risk, T M Jones, X-J Ma, H Wang, S Bui, Y Luo, P Sloan, R J Shaw and M Robinson. Validation of a novel diagnostic standard in HPV-positive oropharyngeal squamous cell carcinoma. British Journal of Cancer (2013) 108, 1332–1339

Hannah Barrow & Jonathan M. Rhodes & Lu-Gang Yu. Simultaneous determination of serum galectin-3 and -4 levels detects metastases in colorectal cancer patients. Cell Oncol. (2013) 36:9–13

Chen Chen, Carrie A. Duckworth, Qicheng Zhao, David Mark Pritchard, Jonathan M. Rhodes, and Lu-Gang Yu. Increased Circulation of Galectin-3 in Cancer Induces Secretion of Metastasis-Promoting Cytokines from Blood Vascular Endothelium. Clin Cancer Res 2013;19:1693-1704

Yuen, H-F., Gunasekharan, V-K., Chan, K-K., Zhang, S-D., Platt-Higgins, A., Gately, K., O’byrne, K., Fennel, D.A., Johnston, P.G., Rudland, P.S., El-Tanani, M. RanGTPase: A candidate for c-myc-mediated cancer progression. J. Natl Cancer Inst., 105, 475-488 (2013).


Noon AP, Polański R, El-Fert AY, Kalirai H, Shawki H, Campbell F, Dodson A, Eccles RM, Lloyd BH, Sibson DR, Coupland SE, Lake SL, Parsons K, Vlatković N, Boyd MT. Combined p53 and MDM2 biomarker analysis shows a unique pattern of expression associated with poor prognosis in patients with renal cell carcinoma undergoing radical nephrectomy. BJU Int. 2012 Apr;109(8):1250-7.


Vlatkovic N, El-Fert A, Devling T, Ray-Sinha A, Gore D M, Rubbi C P, Dodson A, Jones A S, Helliwell T R, Jones T M and Boyd M T (2011) Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck. Cancer vol 117 issue 13 pp 2939-50.


Al Omar S, Middleton D, Marshall E, Porter D, Xinarianos G, Raji O, Field JK, Christmas SE. Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors. Hum Immunol. 2010 Oct;71(10):976-81.


Susan Sewart, Roger Barraclough, Philip S. Rudland, Christopher R. West, Dong Liu Barraclough. Molecular analysis of a collection of clinical specimens stored at 4°C as an alternative to snap-freezing. Int J. Oncology Vol 35 Issue 2 381-386 (Aug 2009).

Mark R Pickard, Andrew R Green, Ian O Ellis, Carlos Caldas, Vanessa L Hedge, Mirna Mourtada-Maarabouni and Gwyn T Williams. Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer Breast Cancer Research 2009 11/4/R60.

M Mourtada-Maarabouni1, MR Pickard1, VL Hedge1, F Farzaneh2 and GT Williams1. GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene 28 195-208 2009.


Michael P.A. Davies, Dong Liu Barraclough, Ceri Stewart, Kathryn A. Joyce, Richard M. Eccles, Roger Barraclough, Philip S. Rudland and David Ross Sibson. Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. Int. J. Cancer: 123, 85–88 (2008).

Gukas IGD, Jennings BA, Mandong BM, Prime W, Girling AC, Leinster SJ. A comparison of clinicopathological features and molecular markers in British and Nigerian women with breast cancer. Clinical Medicine: Oncology 2008;2:347-351.


Diss JK, Faulkes DJ, Walker MM, Patel A, Foster CS, Budhram-Mahadeo V, Djamgoz MB, Latchman DS. Brn-3a neuronal transcription factor functional expression in human prostate cancer. Prostate Cancer Prostatic Dis. 2006;9(1):83-91. IF:1.14

de Silva Rudland S, Martin L, Roshanlall C, Winstanley J, Leinster S, Platt-Higgins A, Carroll J, West C, Barraclough R, Rudland P. Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer. Clin Cancer Res. 2006 Feb 15;12(4):1192-200. IF:5.62

Innes HE, Lui D, Barraclough R, Davies MPA, O’Neill PA, Platt-Higgins A, de Silva Rudland S, Sibson DR, Rudland PS. Significance of the metastasis inducing protein AGR2 for outcome in hormonally treated breast cancer patients. Br J Cancer. 2006 94:1057-1065. IF:3.74

Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A, Jenkins RE, Lemoine NR, Crnogorac-Jurcevic T, Yin HL, Costello E. Pancreatic cancer cells overexpress gelsolin family capping proteins which contribute to their cell motility. Gut 2006. IF:7.69


Sutton CD, O'Byrne K, Goddard JC, Marshall LJ, Jones L, Garcea G, Dennison AR, Poston G, Lloyd DM, Berry DP. Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis. Clin Cancer Res. 2005 Sep 15;11(18):6567-73. IF:5.62

Allsup DJ, Kamiguti AS, Lin K, Sherrington PD, Matrai Z, Slupsky JR, Cawley JC, Zuzel M. B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia. Cancer Res. 2005 Aug 15;65(16):7328-37. IF:7.69

Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W, Campbell F, Brentnall TA, Costello E, Neoptolemos J, Lemoine NR. Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology. 2005 Nov;129(5):1454-63. IF:13.09

Vimalachandran D, Greenhalf W, Thompson C, Luttges J, Prime W, Campbell F, Dodson A, Watson R, Crnogorac-Jurcevic T, Lemoine N, Neoptolemos J, Costello E. High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients. Cancer Res. 2005 Apr 15;65(8):3218-25. IF:7.69

Davies MP, O'Neill PA, Innes H, Sibson DR. Hypersensitive K303R oestrogen receptor-alpha variant not found in invasive carcinomas. Breast Cancer Res. 2005;7(1):R113-8. Epub 2004 Nov 23. IF:2.98

Liu D, Rudland PS, Sibson DR, Platt-Higgins A, Barraclough R. Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomas. Cancer Res. 2005 May 1;65(9):3796-805. IF:7.69


El-Ghobashy AA, Shaaban AM, Herod J, Innes J, Prime W, Herrington CS. Overexpression of cyclins A and B as markers of neoplastic glandular lesions of the cervix. Gynecol Oncol. 2004 Feb;92(2):628-34. IF:2.08

Parker CJ, Shawcross SG, Li H, Wang QY, Herrington CS, Kumar S, MacKie RM, Prime W, Rennie IG, Sisley K, Kumar P. Expression of PAX 3 alternatively spliced transcripts and identification of two new isoforms in human tumors of neural crest origin. Int J Cancer. 2004 Jan 10;108(2):314-20. IF:3.28

Jones LE, Humphreys MJ, Campbell F, Neoptolemos JP, Boyd MT. Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival. Clin Cancer Res. 2004 Apr 15;10(8):2832-45. IF:5.62

Davies MP, O'Neill PA, Innes H, Sibson DR, Prime W, Holcombe C, Foster CS. Correlation of mRNA for oestrogen receptor beta splice variants ERbeta1, ERbeta2/ERbetacx and ERbeta5 with outcome in endocrine-treated breast cancer. J Mol Endocrinol. 2004 Dec;33(3):773-82. IF:3.86

O'Neill PA, Davies MP, Shaaban AM, Innes H, Torevell A, Sibson DR, Foster CS. Wild-type oestrogen receptor beta (ERbeta1) mRNA and protein expression in Tamoxifen-treated post-menopausal breast cancers. Br J Cancer. 2004 Nov 1;91(9):1694-702. IF:3.74

O'Neill PA, Shaaban AM, West CR, Dodson A, Jarvis C, Moore P, Davies MP, Sibson DR, Foster CS. Increased risk of malignant progression in benign proliferating breast lesions defined by expression of heat shock protein 27. Br J Cancer. 2004 Jan 12;90(1):182-8. IF:3.74


Dunn JR, Risk JM, Langan JE, Marlee D, Ellis A, Campbell F, Watson AJ, Field JK. Physical and transcript map of the minimally deleted region III on 17p implicated in the early development of Barrett's oesophageal adenocarcinoma. Oncogene. 2003 Jun 26;22(26):4134-42. IF:6.2

Shaaban AM, O'Neill PA, Davies MP, Sibson R, West CR, Smith PH, Foster CS. Declining estrogen receptor-beta expression defines malignant progression of human breast neoplasia. Am J Surg Pathol. 2003 Dec;27(12):1502-12. IF:3.6

Crnogorac-Jurcevic T, Missiaglia E, Blaveri E, Gangeswaran R, Jones M, Terris B, Costello E, Neoptolemos JP, Lemoine NR. Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent. J Pathol. 2003 Sep;201(1):63-74. IF:4.62

Shekouh AR, Thompson CC, Prime W, Campbell F, Hamlett J, Herrington CS, Lemoine NR, Crnogorac-Jurcevic T, Buechler MW, Friess H, Neoptolemos JP, Pennington SR, Costello E. Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics. 2003 Oct;3(10):1988-2001. IF:5.77


Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP. Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. Br J Cancer. 2002 Apr 22;86(8):1262-9. IF:3.74

Liu D, Rudland PS, Sibson DR, Barraclough R. Identification of mRNAs differentially-expressed between benign and malignant breast tumour cells. Br J Cancer. 2002 Aug 12;87(4):423-31. IF:3.74

Rudland PS, Platt-Higgins A, El-Tanani M, De Silva Rudland S, Barraclough R, Winstanley JH, Howitt R, West CR. Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer. Cancer Res. 2002 Jun 15;62(12):3417-27. IF:7.69

Taylor S, Herrington S, Prime W, Rudland PS, Barraclough R. S100A4 (p9Ka) protein in colon carcinoma and liver metastases: association with carcinoma cells and T-lymphocytes. Br J Cancer. 2002 Feb 1;86(3):409-16. IF:3.74

Davies BR, O'Donnell M, Durkan GC, Rudland PS, Barraclough R, Neal DE, Mellon JK. Expression of S100A4 protein is associated with metastasis and reduced survival in human bladder cancer. J Pathol. 2002 Mar;196(3):292-9. IF:4.62


Evans JD, Cornford PA, Dodson A, Greenhalf W, Foster CS, Neoptolemos JP. Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas. Pancreatology. 2001;1(3):254-62. IF:1.1

Bing C, Taylor S, Tisdale MJ, Williams G. Cachexia in MAC16 adenocarcinoma:suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y. J. Neurochemistry 2001 79:1-10. IF:4.82


Harris RJ, Pettitt AR, Schmutz C, Sherrington PD, Zuzel M, Cawley JC, Griffiths SD. Granulocyte macrophage colony stimulating factor as an autocrine survival factor for mature normal and malignant B lymphocytes. J. Immunol. 2000 164:3887-3893. IF:7.41

Prime W, Sobel ME, Herrington CS. Utilisation of human tissue in breast cancer research. Breast Cancer Res. 2000 2:237-240. IF:2.98

Platt-Higgins AM, Renshaw CA, West CR, Winstanley JH, De Silva Rudland S, Barraclough R, Rudland PS. Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer. Int J Cancer. 2000 Mar 20;89(2):198-208. IF:3.28

Rudland PS, Platt-Higgins A, Renshaw C, West CR, Winstanley JH, Robertson L, Barraclough R. Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer. Cancer Res. 2000 Mar 15;60(6):1595-603. IF:7.69

Nikitenko LL, Lloyd BH, Rudland PS, Fear S, Barraclough R. Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens. Int J Cancer. 2000 Apr 15;86(2):219-28. IF:3.28

Liu D, Rudland PS, Sibson DR, Platt-Higgins A, Barraclough R. Expression of calcium-binding protein S100A2 in breast lesions. Br J Cancer. 2000 Dec;83(11):1473-9. IF:3.74


Whitham KM, Hadley JL, Morris HG, Andrew SM, Nieduszynski IA, Brown GM. An improved method for the structural profiling of keratan sulfates: analysis of keratan sulfates from brain and ovarian tumors. Glycobiology. 1999 9(3):285-291. IF:4.10

Taylor SL, Rudland PS, Barraclough R. c-erbB2 mRNA in breast cancer specimens that exhibit membrane or cytoplasmic immunoreactivity for c-erbB2. Oncol Res. 1999 11:311-317. IF:1.36

Hugh TJ, Dillon SA, O'Dowd G, Getty B, Pignatelli M, Poston GJ, Kinsella AR. beta-catenin expression in primary and metastatic colorectal carcinoma. Int J Cancer. 1999 Aug 12;82(4):504-11. IF:3.28

Budhram-Mahadeo V, Ndisang D, Ward T, Weber BL, Latchman DS. The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells. Oncogene. 1999 Nov 18;18(48):6684-91. IF:6.32


Thorsteinsson L, O'Dowd GM, Harrington PM, Johnson PM The complement regulatory proteins CD46 and CD59, but not CD55, are highly expressed by glandular epithelium of human breast and colorectal tumour tissues. APMIS. 1998 Sep;106(9):869-78. IF:

Taylor SL, Platt-Higgins A, Rudland PS, Winstanley JH, Barraclough R. Cytoplasmic staining of c-erbB-2 is not associated with the presence of detectable c-erbB-2 mRNA in breast cancer specimens. Int J Cancer. 1998 May 18;76(4):459-63. IF:3.28


Carron JA, Fraser WD, Gallagher JA. PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours. Br J Cancer. 1997;76(8):1095-8. IF:3.74


Brew R, Southern SA, Flanagan BF, McDicken IW, Christmas SE. Detection of interleukin-8 mRNA and protein in human colorectal carcinoma cells. Eur J Cancer. 1996 Nov;32A(12):2142-7. IF:3.71


McCulloch PG, Ochiai A, O'Dowd GM, Nash JR, Sasako M, Hirohashi S Comparison of the molecular genetics of c-erb-B2 and p53 expression in stomach cancer in Britain and Japan. Cancer. 1995 Feb 15;75(4):920-5. IF: