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Welcome to the Centre for Proteome Research at The University of Liverpool. We are a well equipped lab, led by two academics, addressing a range of challenges in protein mass spectrometry and proteomics as applied to biology and biomedical sciences. The CPR also acts in part as a Shared Research Facility. If you are interested in working with CPR, or accessing any of the CPR facilities, please contact Dr Philip Brownridge or Prof Claire Eyers.


Happy New Year

It seems odd to be saying that, but there is a chance that by the end of 2021, CPR will have resumed some sort of normality. In the interim, we'll do our best to support our external users, as well as the research team here, but our normal level of support will inevitably be compromised.


Personalia and other news (to see all news items, jump [here])



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A million litres!
At about 8pm on January 27th, Rob's on-line buffer calculator broached the one million hits mark. A million litres of buffer is the same as in the AquaDom in Berlin.
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New CPR member: Welcome to Elena Sou
Elena joins CPR in a joint project working with Claire and Dr Ursula McClurg with Dr Wee-Wei Tee in Singapore. Welcome Elena! Find out more here.
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Rethinking posters in science
We know this is going to be contentious, but have posters become too overwhelming? We tried a different interpretation at BMSS last year.
[
LINK]

Recent publications (to see all our papers jump [
here])


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New paper on NFkB and DNA damage A new paper by Amy Campbell, Philip, Cat and Claire, using label-free quantitative phosphoproteomics. [here]

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New papers by Ed. Using single cell proteomics to explore macrophage heterogeneity and SCOPE2
3,000+ proteins in nearly 1500 individual cells. That's quite an achievement! [paper here]. Also, see this comprehensive, hand-on guide to SCOPE2 [here]

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Sperm competition
Two new papers on our work with MBE - one on seminal vesicle fluid plasticity and the other using stable isotopes to track relative ejaculate investment in voles.
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Non canonical phosphorylation published! Lovely work from Claire et al., on the ever-increasing complexity of protein modification. This paper, now published, was previously posted on bioarxiv, drawing over 1800 downloads - the value of preprint sharing! [here]
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Gels and MS still have their place. A new paper with our colleague and friend Nobuaki Takemori, showing just how much information can be recovered by MS of gel-recovered proteins. [here]
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Catnip!
No, not yet another dodgy titled paper with an acronym of QconCATnip! This is a collaboration with colleagues in Iwate University, showing that cats anoint themselves with catnip to repel mosquitoes. [here]

Other news


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CPR Datasets in PRIDE.
We are working hard to support open access and open data initiatives, and deposit raw data in [
PRIDE]. You can find our submitted datasets elsewhere on the ProteomeExchange site [HERE]. If you want to see why making data available is important, look [here] and [here], in that order.
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New funding and research opportunities
There may be postdoc and PhD student opportunities with Claire and Ed. Please make direct contact with them for general enquiries.
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Annual CPR ‘Year in review” posters
At the end of each year we produce a poster that captures our research outputs for the year, and also collates all of our main events, outreach, STEM activities etc. If you’d like to see these posters, then look for [EVENTS 2018] and [PUBS 2018] (PDF files). You can find our papers here (main menu, Papers) and pick up news information here.

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Posters of our work
We’ve prepared a full sized poster that covers the work we published: [
2014] [2015] [2016] [2017][2018][2019]. We also publish an annual summary of great events. [EVENTS 2015] [EVENTS 2016] [EVENTS 2017][EVENTS 2018][EVENTS 2019]. The 2020 posters will appear here at the end of the year.
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Web resources for proteomics
Pastel Biosciences have compiled an impressive set of web resources for proteomics. [HERE]

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QconCAT on YouTube
View a short YouTube video that explains how to use QconCATs for isoform quantification [
Video]

PLus, if you want to know what it is like working in CPR, see [
this interview with Rosie].



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