Photo of Prof Rachel Bearon

Prof Rachel Bearon PhD

Professor of Mathematical Biology Mathematical Sciences

    Publications

    2019

    In silico-guided optimisation of oxygen gradients in hepatic spheroids (Journal article)

    Leedale, J., Colley, H. E., Gaskell, H., Williams, D. P., Bearon, R. N., Chadwick, A. E., . . . Webb, S. D. (2019). In silico-guided optimisation of oxygen gradients in hepatic spheroids. Computational Toxicology, 12, 100093. doi:10.1016/j.comtox.2019.100093

    DOI: 10.1016/j.comtox.2019.100093

    A model of strongly-biased chemotaxis reveals the tradeoffs of different bacterial migration strategies. (Journal article)

    Bearon, R., & Durham, W. (n.d.). A model of strongly-biased chemotaxis reveals the tradeoffs of different bacterial migration strategies.. Mathematical Medicine and Biology: A Journal of the IMA. doi:10.1093/imammb/dqz007

    DOI: 10.1093/imammb/dqz007

    2018

    Enhanced sedimentation of elongated plankton in simple flows (Journal article)

    Bearon, R., CLIFTON, W., & Bees, M. (2018). Enhanced sedimentation of elongated plankton in simple flows. IMA Journal of Applied Mathematics.

    Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms (Journal article)

    Pridgeon, C. S., Schlott, C., Wong, M. W., Heringa, M. B., Heckel, T., Leedale, J., . . . Goldring, C. E. P. (2018). Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms. ARCHIVES OF TOXICOLOGY, 92(2), 557-569. doi:10.1007/s00204-018-2152-9

    DOI: 10.1007/s00204-018-2152-9

    2017

    Sedimentation of inertia-less prolate spheroids in homogenous isotropic turbulence with application to non-motile phytoplankton (Journal article)

    Ardekani, M. N., Sardina, G., Brandt, L., Karp-Boss, L., Bearon, R. N., & Variano, E. A. (2017). Sedimentation of inertia-less prolate spheroids in homogenous isotropic turbulence with application to non-motile phytoplankton. JOURNAL OF FLUID MECHANICS, 831, 655-674. doi:10.1017/jfm.2017.670

    DOI: 10.1017/jfm.2017.670

    Gyrotactic swimmer dispersion in pipe flow: testing the theory (Journal article)

    Bearon, R., Croze, O. A., & Bees, M. A. (2017). Gyrotactic swimmer dispersion in pipe flow: testing the theory. Journal of Fluid Mechanics, 816, 481-506. doi:10.1017/jfm.2017.90

    DOI: 10.1017/jfm.2017.90

    2016

    Transport of helical gyrotactic swimmers in channels (Journal article)

    Alqarni, M. S., & Bearon, R. N. (2016). Transport of helical gyrotactic swimmers in channels. PHYSICS OF FLUIDS, 28(7). doi:10.1063/1.4958733

    DOI: 10.1063/1.4958733

    2015

    The trapping in high-shear regions of slender bacteria undergoing chemotaxis in a channel (Journal article)

    Bearon, R. N., & Hazel, A. L. (2015). The trapping in high-shear regions of slender bacteria undergoing chemotaxis in a channel. JOURNAL OF FLUID MECHANICS, 771. doi:10.1017/jfm.2015.198

    DOI: 10.1017/jfm.2015.198

    2014

    Modeling the dynamics of hypoxia inducible factor-1 alpha (HIF-1 alpha) within single cells and 3D cell culture systems (Journal article)

    Leedale, J., Herrmann, A., Bagnall, J., Fercher, A., Papkovsky, D., See, V., & Bearon, R. N. (2014). Modeling the dynamics of hypoxia inducible factor-1 alpha (HIF-1 alpha) within single cells and 3D cell culture systems. MATHEMATICAL BIOSCIENCES, 258, 33-43. doi:10.1016/j.mbs.2014.09.007

    DOI: 10.1016/j.mbs.2014.09.007

    Tight Control of Hypoxia-inducible Factor-alpha Transient Dynamics Is Essential for Cell Survival in Hypoxia (Journal article)

    Bagnall, J., Leedale, J., Taylor, S. E., Spiller, D. G., White, M. R. H., Sharkey, K. J., . . . See, V. (2014). Tight Control of Hypoxia-inducible Factor-alpha Transient Dynamics Is Essential for Cell Survival in Hypoxia. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(9), 5549-5564. doi:10.1074/jbc.M113.500405

    DOI: 10.1074/jbc.M113.500405

    2013

    Helical swimming can provide robust upwards transport for gravitactic single-cell algae; a mechanistic model (Journal article)

    Bearon, R. N. (2013). Helical swimming can provide robust upwards transport for gravitactic single-cell algae; a mechanistic model. Journal of Mathematical Biology, 66(7), 1341-1359. doi:10.1007/s00285-012-0531-z

    DOI: 10.1007/s00285-012-0531-z

    2012

    Biased swimming cells do not disperse in pipes as tracers: a population model based on microscale behaviour (Journal article)

    Bearon, R. N., Bees, M. A., & Croze, O. A. (n.d.). Biased swimming cells do not disperse in pipes as tracers: a population model based on microscale behaviour. Phys. Fluids, 24, 121902. doi:10.1063/1.4772189

    DOI: 10.1063/1.4772189

    Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate (Journal article)

    Duchesne, L., Octeau, V., Bearon, R. N., Beckett, A., Prior, I. A., Lounis, B., & Fernig, D. G. (2012). Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate. PLOS BIOLOGY, 10(7). doi:10.1371/journal.pbio.1001361

    DOI: 10.1371/journal.pbio.1001361

    2011

    The spatial distribution of gyrotactic swimming micro-organisms in laminar flow fields (Journal article)

    BEARON, R. N., HAZEL, A. L., & THORN, G. J. (2011). The spatial distribution of gyrotactic swimming micro-organisms in laminar flow fields. Journal of Fluid Mechanics, 680, 602-635. doi:10.1017/jfm.2011.198

    DOI: 10.1017/jfm.2011.198

    2010

    Diffusion about the mean drift location in a biased random walk (Journal article)

    Codling, E. A., Bearon, R. N., & Thorn, G. J. (2010). Diffusion about the mean drift location in a biased random walk. Ecology, 91(10), 3106-3113. doi:10.1890/09-1729.1

    DOI: 10.1890/09-1729.1

    Transport of spherical gyrotactic organisms in general three-dimensional flow fields (Journal article)

    Thorn, G. J., & Bearon, R. N. (2010). Transport of spherical gyrotactic organisms in general three-dimensional flow fields. Physics of Fluids, 22(4), 041902. doi:10.1063/1.3381168

    DOI: 10.1063/1.3381168

    Simple models of the chemical field around swimming plankton (Journal article)

    Bearon, R. N., & Magar, V. (2010). Simple models of the chemical field around swimming plankton. Journal of Plankton Research, 32(11), 1599-1608. doi:10.1093/plankt/fbq075

    DOI: 10.1093/plankt/fbq075

    2008

    From individual behaviour to population models: A case study using swimming algae (Journal article)

    Bearon, R. N., & Grünbaum, D. (2008). From individual behaviour to population models: A case study using swimming algae. Journal of Theoretical Biology, 251(4), 679-697. doi:10.1016/j.jtbi.2008.01.007

    DOI: 10.1016/j.jtbi.2008.01.007

    2007

    A Model for Bacterial Colonization of Sinking Aggregates (Journal article)

    Bearon, R. N. (2007). A Model for Bacterial Colonization of Sinking Aggregates. Bulletin of Mathematical Biology, 69(1), 417-431. doi:10.1007/s11538-005-9038-8

    DOI: 10.1007/s11538-005-9038-8

    2006

    Bioconvection in a stratified environment: Experiments and theory (Journal article)

    Bearon, R. N., & Grünbaum, D. (2006). Bioconvection in a stratified environment: Experiments and theory. Physics of Fluids, 18(12), 127102. doi:10.1063/1.2402490

    DOI: 10.1063/1.2402490

    Effects of salinity structure on swimming behavior and harmful algal bloom formation in Heterosigma akashiwo, a toxic raphidophyte (Journal article)

    Bearon, R. N., Grünbaum, D., & Cattolico, R. A. (2006). Effects of salinity structure on swimming behavior and harmful algal bloom formation in Heterosigma akashiwo, a toxic raphidophyte. Marine Ecology Progress Series, 306, 153-163. doi:10.3354/meps306153

    DOI: 10.3354/meps306153

    2005

    Bioluminescent response of the dinoflagellateLingulodinium polyedrumto developing flow: Tuning of sensitivity and the role of desensitization in controlling a defensive behavior of a planktonic cell (Journal article)

    von Dassow, P., Bearon, R. N., & Latz, M. I. (2005). Bioluminescent response of the dinoflagellateLingulodinium polyedrumto developing flow: Tuning of sensitivity and the role of desensitization in controlling a defensive behavior of a planktonic cell. Limnology and Oceanography, 50(2), 607-619. doi:10.4319/lo.2005.50.2.0607

    DOI: 10.4319/lo.2005.50.2.0607

    2004

    Relating cell-level swimming behaviors to vertical population distributions inHeterosigma akashiwo(Raphidophyceae), a harmful alga (Journal article)

    Bearon, R. N., Grünbaum, D., & Cattolico, R. A. (2004). Relating cell-level swimming behaviors to vertical population distributions inHeterosigma akashiwo(Raphidophyceae), a harmful alga. Limnology and Oceanography, 49(2), 607-613. doi:10.4319/lo.2004.49.2.0607

    DOI: 10.4319/lo.2004.49.2.0607

    2003

    An extension of generalized Taylor dispersion in unbounded homogeneous shear flows to run-and-tumble chemotactic bacteria (Journal article)

    Bearon, R. N. (2003). An extension of generalized Taylor dispersion in unbounded homogeneous shear flows to run-and-tumble chemotactic bacteria. Physics of Fluids, 15(6), 1552. doi:10.1063/1.1569482

    DOI: 10.1063/1.1569482

    2001

    Run-and-tumble chemotaxis in an ambient shear flow (Thesis / Dissertation)

    Bearon, R. N. (2001). Run-and-tumble chemotaxis in an ambient shear flow. (PhD Thesis, The University of Cambridge).

    2000

    Modelling Run-and-Tumble Chemotaxis in a Shear Flow (Journal article)

    Bearon, R. (2000). Modelling Run-and-Tumble Chemotaxis in a Shear Flow. Bulletin of Mathematical Biology, 62(4), 775-791. doi:10.1006/bulm.2000.0178

    DOI: 10.1006/bulm.2000.0178