Dr Mirela Domijan PhD

Research Overview

My work is in Applied Mathematics with a focus on Mathematical Biology. In my research I have developed and applied an array of mathematical methods coming from a broad range of mathematical areas, such as dynamical systems theory, algebraic geometry and graph theory. I have worked on a wide spectrum of biological applications, from molecular biology, chemical reaction networks to calcium dynamics, and on questions across different biological scales, from population to single cell level. I am also very interested in computational aspects of Applied Mathematics and have contributed to a scientific software.

Currently, I am particularly interest in circadian clocks in mammals and plants. After several long leaves, I am now looking to grow my group again, so if you are interested, please get in touch!

Current PhDs:
1. Daniel Warren, (co-supervisor), working on "Computational Modelling of the Human Microbiome".

Past group members:
1. Dr Sara Frecentese, PDRA, working on "Coupling circadian rhythms with drug metabolism: a new tool for studying chronopharmacokinetics", funding: EPSRC RA in Mathematical Sciences call (departmental) and also working on another shorter project funded by my LMS Emmy Noether Fellowship 2021-2022.
2. Dr Matt Leak, PDRA, working on "Circadian Rhythms in the light of COVID-19:Formulating optimal time-of-day regimens for antiviral drugs using human 3D models and in-silico modelling", funding: UKRI BBSRC COVID-19 agile call.
3. Jess Moore, PhD student, working on "Mathematical modelling of plant circadian clocks -addressing the question of how the clock oscillators are coordinated in plants", funding: departmental GTA position. Jess is now in Cambridge completing an MPhil in data science.
4. Dr Louis Gall, (2019-2020 ) worked on projects "The role of non-canonical NRF2 signalling in
circadian clock regulation" and "The role of nuclear protein lamin A in circadian clock regulation:
implications for laminopathies", funding: Liverpool Mathematics in Healthcare Centre Pump
Prime Award. Present position: AstraZeneca
5. Daniel Warren, (2018), worked on project: "Modelling insulin effects on cell cycle and bio-energetics",
funding: Liverpool Mathematics in Healthcare Centre Pump Prime Award. Present position: Daniel is currently pursuing a PhD in "Modelling the Human Microbiome", co-supervised by Profs. F. Falciani and A. Darby and myself.


Funding for recent research has come from:
1) UKRI BBSRC COVID-19 agile call.
2) LMS Emmy Noether Fellowship
3) EPSRC RA departmental call
with four smaller collaborative awards; three Pump Priming awards from the Liverpool Mathematics in Healthcare and UK Multiscale Biology Network Award. BBSRC DTP project (co-I with Dr Vanja Pekovich Vaughan as a PI).