Photo of Dr Joseph Leedale

Dr Joseph Leedale PhD

Research Fellow Mathematical Sciences

Publications

2021

Mathematical modelling of oxygen gradients in stem cell-derived liver tissue (Journal article)

Leedale, J. A., Lucendo-Villarin, B., Meseguer-Ripolles, J., Kasarinaite, A., Webb, S. D., & Hay, D. C. (2021). Mathematical modelling of oxygen gradients in stem cell-derived liver tissue. PLOS ONE, 16(2). doi:10.1371/journal.pone.0244070

DOI: 10.1371/journal.pone.0244070

2020

Mathematical modelling and statistical analysis of indocyanine green and other biomarkers of hepatic function and drug-induced liver injury (Journal article)

Leedale, J., Mason, C., Brillant, N., Webb, S., & Dear, J. (2020). Mathematical modelling and statistical analysis of indocyanine green and other biomarkers of hepatic function and drug-induced liver injury. Computational Toxicology, 16. doi:10.1016/j.comtox.2020.100134

DOI: 10.1016/j.comtox.2020.100134

Multiscale modelling of drug transport and metabolism in liver spheroids (Journal article)

Leedale, J. A., Kyffin, J., Harding, A., Colley, H., Murdoch, C., Sharma, P., . . . Bearon, R. (2020). Multiscale modelling of drug transport and metabolism in liver spheroids. Interface Focus, 10(2). doi:10.1098/rsfs.2019.0041

DOI: 10.1098/rsfs.2019.0041

2019

A systems toxicology paracetamol overdose framework: accounting for high-risk individuals (Journal article)

Mason, C. L., Leedale, J., Tasoulis, S., Jarman, I., & Webb, S. D. (2019). A systems toxicology paracetamol overdose framework: accounting for high-risk individuals. Computational Toxicology, 12, 100103. doi:10.1016/j.comtox.2019.100103

DOI: 10.1016/j.comtox.2019.100103

In silico-guided optimisation of oxygen gradients in hepatic spheroids (Journal article)

Leedale, J., Colley, H. E., Gaskell, H., Williams, D. P., Bearon, R. N., Chadwick, A. E., . . . Webb, S. D. (2019). In silico-guided optimisation of oxygen gradients in hepatic spheroids. Computational Toxicology, 12, 100093. doi:10.1016/j.comtox.2019.100093

DOI: 10.1016/j.comtox.2019.100093

Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid-Overlay Technique. (Journal article)

Kyffin, J. A., Cox, C. R., Leedale, J., Colley, H. E., Murdoch, C., Mistry, P., . . . Sharma, P. (2019). Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid-Overlay Technique.. Current protocols in toxicology, 81(1), e87. doi:10.1002/cptx.87

DOI: 10.1002/cptx.87

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism. (Journal article)

Kelly, R., Leedale, J. A., Calleja, D., Enoch, S., Harrell, A., Chadwick, A., & Webb, S. (2019). Modelling changes in glutathione homeostasis as a function of quinone redox metabolism. Scientific Reports, 9. doi:10.1038/s41598-019-42799-2

DOI: 10.1038/s41598-019-42799-2

Characterisation of a functional rat hepatocyte spheroid model. (Journal article)

Kyffin, J. A., Sharma, P., Leedale, J., Colley, H. E., Murdoch, C., Harding, A. L., . . . Webb, S. D. (2019). Characterisation of a functional rat hepatocyte spheroid model. TOXICOLOGY IN VITRO, 55, 160-172. doi:10.1016/j.tiv.2018.12.014

DOI: 10.1016/j.tiv.2018.12.014

2018

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture (Journal article)

Kelly, R. A., Leedale, J. A., Harrell, A., Beard, D. A., Randle, L. E., Chadwick, A. E., & Webb, S. D. (2018). Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS One, 13(11). doi:10.1371/journal.pone.0207803

DOI: 10.1371/journal.pone.0207803

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity (Journal article)

Leedale, J., Sharkey, K., Colley, H., Norton, A., Peeney, D., Mason, C., . . . Webb, S. (2018). A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity. iScience, 4, 84-96. doi:10.1016/j.isci.2018.05.012

DOI: 10.1016/j.isci.2018.05.012

Systems Toxicology Approach to Identifying Paracetamol Overdose (Journal article)

Mason, C. L., Leedale, J., Tasoulis, S., Jarman, I., Antoine, D. J., & Webb, S. D. (2018). Systems Toxicology Approach to Identifying Paracetamol Overdose. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 7(6), 394-403. doi:10.1002/psp4.12298

DOI: 10.1002/psp4.12298

Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment (Journal article)

Kyffin, J. A., Sharma, P., Leedale, J., Colley, H. E., Murdoch, C., Mistry, P., & Webb, S. D. (2018). Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment. TOXICOLOGY IN VITRO, 48, 262-275. doi:10.1016/j.tiv.2018.01.023

DOI: 10.1016/j.tiv.2018.01.023

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms (Journal article)

Park, B. K., & Goldring, C. (2018). Innovative Organotypic In Vitro Models for Safety Assessment: Aligning with regulatory requirements and understanding models of the heart, skin and liver as paradigms. Archives of Toxicology, 92(2), 557-569. doi:10.1007/s00204-018-2152-9

DOI: 10.1007/s00204-018-2152-9

2016

A dynamic, climate-driven model of Rift Valley fever (Journal article)

Leedale, J., Jones, A. E., Caminade, C., & Morse, A. P. (2016). A dynamic, climate-driven model of Rift Valley fever. Geospatial Health, 11(1s), 78-93. doi:10.4081/gh.2016.394

DOI: 10.4081/gh.2016.394

Environmental change and Rift Valley fever in eastern Africa: projecting beyond HEALTHY FUTURES (Journal article)

Taylor, D., Hagenlocher, M., Jones, A. E., Kienberger, S., Leedale, J., & Morse, A. P. (2016). Environmental change and Rift Valley fever in eastern Africa: projecting beyond HEALTHY FUTURES. GEOSPATIAL HEALTH, 11, 115-128. doi:10.4081/gh.2016.387

DOI: 10.4081/gh.2016.387

Projecting malaria hazard from climate change in eastern Africa using large ensembles to estimate uncertainty (Journal article)

Leedale, J., Tompkins, A. M., Caminade, C., Jones, A. E., Nikulin, G., & Morse, A. P. (2016). Projecting malaria hazard from climate change in eastern Africa using large ensembles to estimate uncertainty. GEOSPATIAL HEALTH, 11, 102-114. doi:10.4081/gh.2016.393

DOI: 10.4081/gh.2016.393

2014

Tight Control of Hypoxia-inducible Factor-alpha Transient Dynamics Is Essential for Cell Survival in Hypoxia (Journal article)

Bagnall, J., Leedale, J., Taylor, S. E., Spiller, D. G., White, M. R. H., Sharkey, K. J., . . . See, V. (2014). Tight Control of Hypoxia-inducible Factor-alpha Transient Dynamics Is Essential for Cell Survival in Hypoxia. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(9), 5549-5564. doi:10.1074/jbc.M113.500405

DOI: 10.1074/jbc.M113.500405

Modeling the dynamics of hypoxia inducible factor-1a (HIF-1a) within single cells and 3D cell culture systems (Journal article)

Leedale, J., Herrmann, A., Bagnall, J., Fercher, A., Papkovsky, D., See, V., & Bearon, R. (2014). Modeling the dynamics of hypoxia inducible factor-1a (HIF-1a) within single cells and 3D cell culture systems. Mathematical Biosciences, 258, 33-43. doi:10.1016/j.mbs.2014.09.007

DOI: 10.1016/j.mbs.2014.09.007