Photo of Professor Joao Pedro De Magalhaes

Professor Joao Pedro De Magalhaes Ph.D.

Professor Musculoskeletal & Ageing Science

    Research

    Integrative Genomics of Ageing

    Although our work integrates different strategies, its focal point is developing and applying experimental and computational methods that help bridge the gap between genotype and phenotype, a major challenge of the post-genome era, and help decipher the human genome and how it regulates complex processes like ageing. Ongoing projects involve cellular models and stem cells, systems biology of ageing, genetics of caloric restriction, cancer genomics, comparative and evolutionary genomics, and biology of long-lived organisms. Please see our lab website for further details and publications/reprints. The databases and computational resources we develop are also available online.

    Research Grants

    Human Ageing Genomic Resources

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2018 - May 2022

    GeneFriends: A gene co-expression resource

    WELLCOME TRUST (UK)

    August 2018 - February 2022

    Data-Driven Discovery of Novel Correlations Between Genes and Ageing-Related Changes in Humans

    LEVERHULME TRUST (UK)

    September 2016 - February 2020

    Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

    WELLCOME TRUST (UK)

    May 2015 - November 2018

    Sequencing the genome of the longest-lived mammal to identify longevity assurance mechanisms

    METHUSELAH FOUNDATION (USA)

    July 2013 - June 2014

    Identifying novel caloric restriction mimetic drugs in worms

    ROYAL SOCIETY (CHARITABLE)

    March 2013 - May 2014

    Using massive-scale mRNA sequencing to unravel the mechanisms of ageing and its modulation by diet

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    May 2010 - May 2013

    Modelling Human Ageing: Development and Interrogating an Integrated Model of Ageing to Identify Casual Relationships Between Hormonal Changes and Gene Expression Changes.

    EUROPEAN COMMISSION

    November 2012 - November 2014

    Establishment and functional characterization of a large DNA fragment resource from the long-lived naked mole-rat for comparison with mice

    THE ELLISON MEDICAL FOUNDATION (USA)

    October 2010 - September 2012

    Development of web tools for the integration and visualization of age-related changes at various biological levels

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    September 2009 - March 2011

    Uncovering the Mechanisms of Cryoprotectant Toxicity

    LONGECITY (USA), THE GERMAN SOCIETY FOR APPLIED BIOSTASIS (GERMANY)

    May 2012 - March 2013

    Developing online databases and bioinformatics tools for the biology of ageing

    WELLCOME TRUST (UK)

    November 2011 - May 2015

    Identification and functional characterization of genes associated with cellular biomarkers of longevity - LONGENES

    EUROPEAN COMMISSION

    October 2009 - September 2013

    GeneFriends: An online tool to unravel transcriptional regulation in mammals

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2013 - September 2015