Selected Publications
Paraoan L, Sharif U, Carlsson E, Supharattanasitthi W, Mahmud NM, Kamalden TA, Hiscott P, Jackson M, Grierson I.
Prog Retin Eye Res. 2020 Apr 9:100859. doi: 10.1016/j.preteyeres.2020.100859.
View abstract on Pubmed link: https://pubmed.ncbi.nlm.nih.gov/32278708/
Dhirachaikulpanich D, Li X, Porter LF, Paraoan L.
Integrated Microarray and RNAseq Transcriptomic Analysis of Retinal Pigment Epithelium/Choroid in Age-Related Macular Degeneration.
Front Cell Dev Biol. 2020 Aug 21;8:808. doi: 10.3389/fcell.2020.00808
View abstract on Pubmed link: https://pubmed.ncbi.nlm.nih.gov/32984320/
Roberts O, Paraoan L.
PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP.
Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188393. doi: 10.1016/j.bbcan.2020.188393.
View abstract on Pubmed link: https://pubmed.ncbi.nlm.nih.gov/32679166/
Carlsson E, Supharattanasitthi W, Jackson M & Paraoan L.
Increased Rate of Retinal Pigment Epithelial Cell Migration and Pro-Angiogenic Potential Ensuing From Reduced Cystatin C Expression
Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):9. doi: 10.1167/iovs.61.2.9.
View abstract on Pubmed link:https://www.ncbi.nlm.nih.gov/pubmed/32049341
McDonnell S.J., Spiller D.G., White M.R.H., Prior I. & Paraoan L.
Cell Death Discovery (2019) 5:132; doi:10.1038/s41420-019-0212-4
View abstract on Pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/31508245
ER stress-modulated increased interaction of PERP and SERCA2b at ER-plasma membrane points of contact
Muangnoi C, Ratnatilaka Na Bhuket P, Jithavech P, Supasena W, Paraoan L, Patumraj S, Rojsitthisak P.
Curcumin diethyl disuccinate, a prodrug of curcumin, enhances anti-proliferative effect of curcumin against HepG2 cells via apoptosis induction.
Sci Rep. 2019 Aug 12;9(1):11718. doi: 10.1038/s41598-019-48124-1.
Supharattanasitthi W, Carlsson E, Sharif U, Paraoan L.
CRISPR/Cas9-mediated one step bi-allelic change of genomic DNA in iPSCs and human RPE cells in vitro with dual antibiotic selection.
Sci Rep 2019 9:174. doi: 10.1038/s41598-018-36740-2.
View abstract on Pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/30655567
Pluripotent stem cells following first gene editing of AMD risk factor (Sci Rep 2019 9:174)
Muangnoi C, Sharif U, Ratnatilaka Na Bhuket P, Rojsitthisak P, Paraoan L.
Int J Mol Sci. 2019 Jul 9;20(13). pii: E3367. doi: 10.3390/ijms20133367.
View abstract on Pubmed link:https://www.ncbi.nlm.nih.gov/pubmed/31323999
Porter LF, Saptarshi N, Fang Y, Rathi S, den Hollander AI, de Jong EK, Clark SJ, Bishop PN, Olsen TW, Liloglou T, Chavali VRM, Paraoan L.
Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes.
Clin Epigenetics. 2019 11(1):6. doi: 10.1186/s13148-019-0608-2.
View abstract on Pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/30642396
Sharif U, Mahmud NM, Kay P, Yang YC, Harding SP, Grierson I, Kamalden TA, Jackson MJ, Paraoan L.
Advanced glycation end products-related modulation of cathepsin L and NF-κB signalling effectors in retinal pigment epithelium lead to augmented response to TNFα.
Epub 2018 Oct 19. J Cell Mol Med. 2019 23(1):405-416. doi: 10.1111/jcmm.13944. Epub 2018 Oct 19.
View abstract on Pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/30338926
Butler JM, Hall N, Narendran N, Yang YC, Paraoan L.
Identification of candidate protective variants for common diseases and evaluation of their protective potential.
BMC Genomics. 2017 18(1):575. doi: 10.1186/s12864-017-3964-3.
Awais, Spiller, White, Paraoan. p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma. Br J Cancer. 2016 Sep 1. PMID: 27584665. View Abstract on PubMed
Sant'Anna R, Navarro S, Ventura S, Paraoan L, Foguel D.
Amyloid properties of the leader peptide of variant B cystatin C: implications for Alzheimer and Macular Degeneration. FEBS Lett. 2016 Feb 10. PMID: 26865059 View abstract on PubMed
Butler JM, Sharif U, Ali M, McKibbin M, Thompson JP, Gale R, Yang YC, Inglehearn C, Paraoan L.
A missense variant in CST3 exerts a recessive effect on susceptibility to age-related macular degeneration resembling its association with Alzheimer's disease. Hum Genet. 2015 Apr 19. PMID: 25893795 View abstract on Pubmed
Hallstrom KN, Srikanth CV, Agbor TA, Dumont CM, Peters K, Paraoan L, Casanova JE, Boll EJ, McCormick BA.
PERP, a Host Tetraspanning Membrane Protein, is Required for Salmonella-Induced Inflammation. Cell Microbiol. 2014 Dec 9. PMID: 25486861 View abstract on Pubmed
Soriano-Romaní L, García-Posadas L, López-García A, Paraoan L, Diebold Y.
Thrombospondin-1 induces differential response in human corneal and conjunctival epithelial cells lines under in vitro inflammatory and apoptotic conditions. Exp Eye Res. 2015 May;134:1-14. doi: 10.1016/j.exer.2015.03.004 View Abstract on Pubmed
Kay P, Yang YC, Hiscott P, Gray D, Maminishkis A, Paraoan L.
Age-related changes of cystatin C expression and polarized secretion by retinal pigment epithelium: potential age-related macular degeneration links. Invest Ophthalmol Vis Sci. 2014 Feb 14. PMID: 24458156 View abstract on Pubmed
Kay P, Yang YC, Paraoan L.
Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration. J Cell Mol Med. 2013 May 11. PMID: 23663427 View abstract on Pubmed
Davies L, Spiller D, White M R H, Grierson I, Paraoan L.
PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. Cell Death and Disease 2011 Mar 31; 2:e136. PMID: 21451571 View abstract on Pubmed
O'Reilly S, Pollock N, Currie L, Paraoan L, Clark AF, Grierson I.
Inducers of cross-linked actin networks in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7316-24. doi: 10.1167/iovs.10-6692 View abstract on Pubmed
Paraoan L, Hiscott P, Gosden C, Grierson I.
Cystatin C in macular and neuronal degenerations: Implications for mechanism(s) of Age-related Macular Degeneration. Vision Res. 2010 mar 31;50(7):737-742. PMID: 19917302 View abstract on Pubmed
Davies L, Gray D, Spiller D, White MRH, Damato B, Grierson I, Paraoan L.
P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma. J Cell Mol Med. 2009 13;8B:1995-2007. PMID: 19040420 View abstract on Pubmed
Paraoan L, Gray D, Hiscott P, Garcia-Fianana M, Lane B, Damato B, Grierson I.
Cathepsin S and its inhibitor Cystatin C: imbalance in uveal melanoma. Frontiers in Bioscience. 2009 Jan 1;14:2504-2513. PMID: 19273215 View abstract on Pubmed
Paraoan L, Gray D, Hiscott P, Ebrahimi B, Damato B, Grierson I.
Expression of p53-induced apoptosis effector PERP in primary uveal melanomas: downregulation is associated with aggressive type. Exp Eye Res. 2006 Oct;83(4):911-9. PMID: 16784742 View Abstract on PubMed
Paraoan L, Grierson I.
Focus on molecules: Cystatin C. Exp Eye Res. 2007 Jun;84(6):1019-20. PMID: 16626703 View Abstract on PubMed
Ratnayaka A, Paraoan L, Spiller DG, Hiscott P, Nelson G, White MR, Grierson I.
A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: An additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility. Exp Eye Res. 2007 Jun;84(6):1135-9. PMID: 16635487 View Abstract on PubMed
Paraoan L, Grierson I, Maden BE.
Fate of cystatin C lacking the leader sequence in RPE cells. Exp Eye Res. 2003 Jun;76(6):753-6. PMID: 12742358 View Abstract on PubMed
Paraoan L, Grierson I, Maden BE.
Analysis of expressed sequence tags of retinal pigment epithelium: cystatin C is an abundant transcript. Int J Biochem Cell Biol. 2000 Apr;32(4):417-26. PMID: 10762067 View Abstract on PubMed
O'Reilly S, Pollock N, Currie L, Paraoan L, Clark AF, Grierson I.
Inducers of cross-linked actin networks in trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7316-24. PMID: 21849423 View Abstract on PubMed
Wade NC, Grierson I, O'Reilly S, Hoare MJ, Cracknell KP, Paraoan L, Brotchie D, Clark AF.
Cross-linked actin networks (CLANs) in bovine trabecular meshwork cells. Exp Eye Res. 2009;89(5):648-659. PMID: 19540832 View abstract on Pubmed
Cryan LM, Paraoan L, Hiscott P, Damato B, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, O'Brien C.
Expression of COX-2 and prognostic outcome in uveal melanoma. Curr Eye Res. 2008 Mar 3;33:117-184. PMID: 18293189 View Abstract on Pubmed
Ratnayaka A, Paraoan L, Nelson G, Spiller DG, White MR, Hiscott P.
Trafficking of osteonectin by retinal pigment epithelial cells: evidence for basolateral secretion. Int J Biochem Cell Biol. 2007;39(1):85-92. PMID: 17035068 View Abstract on PubMed
Hiscott P, Paraoan L, Choudhary A, Ordonez JL, Al-Khaier A, Armstrong DJ.
Thrombospondin 1, thrombospondin 2 and the eye. Prog Retin Eye Res. 2006 Jan;25(1):1-18. PMID: 15996506 View Abstract on PubMed
Ordonez JL, Paraoan L, Hiscott P, Gray D, Garcia-Finana M, Grierson I, Damato B.
Differential expression of angioregulatory matricellular proteins in posterior uveal melanoma. Melanoma Res. 2005 Dec;15(6):495-502. PMID: 16314734 View Abstract on PubMed
Paraoan L, Ratnayaka A, Spiller DG, Hiscott P, White MR, Grierson I.
Unexpected intracellular localization of the AMD-associated cystatin C variant. Traffic. 2004 Nov;5(11):152-65. PMID: 15479453 View Abstract on PubMed
Hiscott P, Hagan S, Heathcote L, Sheridan CM, Groenewald CP, Grierson I, Wong D, Paraoan L.
Pathobiology of epiretinal and subretinal membranes: Possible roles for the matricellular proteins thrombospondin 1 and osteonectin (SPARC). Eye. 2002 Jul;16(4):393-403. PMID: 12101446 View Abstract on PubMed
Paraoan L, White MR, Spiller DG, Grierson I, Maden BE.
Precursor cystatin C in cultured retinal pigment epithelial cells: evidence for processing through the secretory pathway. Mol Membr Biol. 2001 Jul-Sep;18(3):229-36. PMID: 11681790 View Abstract on PubMed
Paraoan L, Grierson I, Maden BE.
Analysis of expressed sequence tags of retinal pigment epithelium: cystatin C is an abundant transcript.
Int J Biochem Cell Biol. 2000 32(4):417-26. doi: 10.1016/s1357-2725(99)00143-0.Abstract on PubMed: https://pubmed.ncbi.nlm.nih.gov/10762067/