Molecular Biology and Molecular Mechanisms of Disease

About our research

Our research aims to further the understanding of fundamental molecular processes and pathways underlying physiology of various eye tissues in health, ageing and degeneration.

Studying gene expression and regulation in pigmented cells of the eye (retinal pigment epithelial, trabecular meshwork, uveal melanocytes) and focusing on fundamental cellular processes of proteolysis, apoptosis and cellular signalling, the group has identified and characterised key molecular determinants of normal and pathological states of specific eye tissues. The findings have relevance for major eye diseases (age-related macular degeneration, proliferative vitreoretinal disease, uveal melanoma and glaucoma) and wider implications for age-related degenerative processes, proliferative pathology and cancer. Through this we can support progress in their diagnosis and treatment.


Luminita Group 2019

Out and about … November 2019. Luminita with (left to right) Umar Sharif, Lewis Kelly, Dhanach Dhirachaikulpanich, Neil Saptarshi, Kaiyue Teng, Kasit Chatsirisupachai, Emil Carlsson. 


MSB Lumi GRoupPic

Luminita with (l to r) Kaiyue Teng, Wasu Supharattanasitthi, Samantha McDonnell, Neil Saptarshi, Emil Carlsson, Umar Sharif, Sean Duffy – November 2018



‌‌December 2017 - Ocular Molecular Biology and Mechanisms of Disease Group


Welcoming visitors from Thailand and Germany in the new labs, May 2017. 

First Winter in Apex II 2015

Together in the office at the end of 2014.


 In the lab...


With Lamb Banana

... and with the Royal Hospital Lamb Banana.


Bowling team represented by 3 continents (Asia, Europe and South America), 3 European countries (Germany, Romania and UK) and 3 UK counties (Merseyside, Greater Manchester and West Yorkshire).