Dr Urszula McClurg MSc, PhD

Tenure Track Research Fellow Biochemistry, Cell and Systems Biology

+44 (0)151 795 7735 Ext. 7735
Work email Urszula.Mcclurg@liverpool.ac.uk
Personal Websitehttps://www.mcclurglab.com/

Publications

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2024

Conference accessibility should be a universal concern. (Journal article)

McClurg, U. L. (2024). Conference accessibility should be a universal concern.. Nature cell biology, 26(3), 309. doi:10.1038/s41556-024-01346-6

DOI: 10.1038/s41556-024-01346-6

2023

Towards inclusive and sustainable scientific meetings. (Journal article)

Chalmers, S. B., Madgwick, S., Lloyd-Lewis, B., McClurg, U. L., Elias, S., Andersen, P., . . . Davis, F. M. (2023). Towards inclusive and sustainable scientific meetings.. Nature cell biology, 25(11), 1557-1560. doi:10.1038/s41556-023-01222-9

DOI: 10.1038/s41556-023-01222-9

ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression. (Journal article)

Scott, E., Archer Goode, E., Garnham, R., Hodgson, K., Orozco-Moreno, M., Turner, H., . . . Munkley, J. (2023). ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.. The Journal of pathology. doi:10.1002/path.6152

DOI: 10.1002/path.6152

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. (Journal article)

Zhang, J., Hu, Z., Chung, H. H., Tian, Y., Lau, K. W., Ser, Z., . . . Tee, W. -W. (2023). Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.. Nature communications, 14(1), 2439. doi:10.1038/s41467-023-38132-1

DOI: 10.1038/s41467-023-38132-1

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth (Journal article)

Scott, E., Hodgson, K., Calle, B., Turner, H., Cheung, K., Bermudez, A., . . . Munkley, J. (2023). Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. ONCOGENE, 42(12), 926-937. doi:10.1038/s41388-023-02604-x

DOI: 10.1038/s41388-023-02604-x

Cancer and meiotic gene expression: Two sides of the same coin? (Chapter)

Sou, I. F., Hamer, G., Tee, W. -W., Vader, G., & McClurg, U. L. (2023). Cancer and meiotic gene expression: Two sides of the same coin?. In Unknown Book (Vol. 151, pp. 43-68). doi:10.1016/bs.ctdb.2022.06.002

DOI: 10.1016/bs.ctdb.2022.06.002

2022

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth (Preprint)

DOI: 10.21203/rs.3.rs-2092111/v1

2021

Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 (Journal article)

Sandhu, S., Sou, I. F., Hunter, J. E., Salmon, L., Wilson, C. L., Perkins, N. D., . . . McClurg, U. L. (2021). Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12. COMMUNICATIONS BIOLOGY, 4(1). doi:10.1038/s42003-021-02887-4

DOI: 10.1038/s42003-021-02887-4

Meiosis initiation: a story of two sexes in all creatures great and small (Journal article)

Sou, I. F., Pryce, R. M., Tee, W. -W., & McClurg, U. L. (2021). Meiosis initiation: a story of two sexes in all creatures great and small. BIOCHEMICAL JOURNAL, 478(20), 3791-3805. doi:10.1042/BCJ20210412

DOI: 10.1042/bcj20210412

2020

Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability (Journal article)

Prendergast, L., McClurg, U. L., Hristova, R., Berlinguer-Palmini, R., Greener, S., Veitch, K., . . . Papamichos-Chronakis, M. (2020). Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability. Nature Communications, 11. doi:10.1038/s41467-020-18306-x

DOI: 10.1038/s41467-020-18306-x

Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (vol 11, 646, 2020) (Journal article)

Ndeh, D., Basle, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (vol 11, 646, 2020). NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18097-1

DOI: 10.1038/s41467-020-18097-1

Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (Journal article)

Ndeh, D., Baslé, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nature Communications, 11. doi:10.1038/s41467-020-14509-4

DOI: 10.1038/s41467-020-14509-4

2019

A pseudo-meiotic centrosomal function of TEX12 in cancer (Journal article)

Sandhu, S., Salmon, L. J., Hunter, J. E., Wilson, C. L., Perkins, N. D., Hunter, N., . . . McClurg, U. L. (2019). A pseudo-meiotic centrosomal function of TEX12 in cancer. doi:10.1101/509869

DOI: 10.1101/509869

2018

Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples (Journal article)

McClurg, U. L., McCracken, S. R., Butler, L., Riabowol, K. T., & Binda, O. (2018). Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples. BIO-PROTOCOL, 8(21). doi:10.21769/BioProtoc.3075

DOI: 10.21769/BioProtoc.3075

The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival (Journal article)

McClurg, U. L., Azizyan, M., Dransfield, D. T., Namdev, N., Chit, N. C. T. H., Nakjang, S., & Robson, C. N. (2018). The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival. Oncotarget, 9(38), 24992-25007. doi:10.18632/oncotarget.25167

DOI: 10.18632/oncotarget.25167

Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12 (Journal article)

McClurg, U. L., Chit, N. C. T. H., Azizyan, M., Edwards, J., Nabbi, A., Riabowol, K. T., . . . Robson, C. N. (2018). Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12. ONCOGENE, 37(34), 4679-4691. doi:10.1038/s41388-018-0283-3

DOI: 10.1038/s41388-018-0283-3

Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein (Journal article)

McClurg, U. L., Nabbi, A., Ricordel, C., Korolchuk, S., McCracken, S., Heer, R., . . . Binda, O. (2018). Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. British Journal of Cancer, 118, 713-726. doi:10.1038/bjc.2017.447

DOI: 10.1038/bjc.2017.447

2017

The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration (Journal article)

Munkley, J., McClurg, U. L., Livermore, K. E., Ehrmann, I., Knight, B., Mccullagh, P., . . . Elliott, D. J. (2017). The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-05489-5

DOI: 10.1038/s41598-017-05489-5

ING3 promotes prostate cancer growth by activating the androgen receptor (Journal article)

Nabbi, A., McClurg, U. L., Thalappilly, S., Almami, A., Mobahat, M., Bismar, T. A., . . . Riabowol, K. T. (2017). ING3 promotes prostate cancer growth by activating the androgen receptor. BMC MEDICINE, 15. doi:10.1186/s12916-017-0854-0

DOI: 10.1186/s12916-017-0854-0

Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity (Journal article)

McClurg, U. L., Cork, D. M. W., Darby, S., Ryan-Munden, C. A., Nakjang, S., Cortes, L. M., . . . Robson, C. N. (2017). Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity. NUCLEIC ACIDS RESEARCH, 45(04), 1793-1804. doi:10.1093/nar/gkw1162

DOI: 10.1093/nar/gkw1162

2016

A novel anti-androgen candidate galeterone acts by targeting USP12, a deubiquitinating enzyme that controls prostate cancer growth and survival (Journal article)

McClurg, U., Dransfield, D., Namdev, N., Jacoby, D., Chit, N., Nakjang, S., . . . Robson, C. (2016). A novel anti-androgen candidate galeterone acts by targeting USP12, a deubiquitinating enzyme that controls prostate cancer growth and survival. European Journal of Cancer, 69, S25. doi:10.1016/s0959-8049(16)32654-5

DOI: 10.1016/s0959-8049(16)32654-5

Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells (Journal article)

Logan, I. R., McClurg, U. L., Jones, D. L., O'Neill, D. J., Shaheen, F. S., Lunec, J., . . . Robson, C. N. (2016). Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells. ONCOTARGET, 7(46), 74724-74733. doi:10.18632/oncotarget.12542

DOI: 10.18632/oncotarget.12542

The deubiquitinating enzyme USP12 controls prostate cancer cell survival by regulating the AR-AKT-p53 signalling network (Journal article)

McClurg, U. L., Chit, N. C. T. H., Nakjang, S., Edwards, J., McCracken, S. R., & Robson, C. N. (n.d.). The deubiquitinating enzyme USP12 controls prostate cancer cell survival by regulating the AR-AKT-p53 signalling network. Endocrine Abstracts. doi:10.1530/endoabs.42.p9

DOI: 10.1530/endoabs.42.p9

Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3 (Journal article)

Kim, S., Natesan, S., Cornilescu, G., Carlson, S., Tonelli, M., McClurg, U. L., . . . Glass, K. C. (2016). Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(35), 18326-18341. doi:10.1074/jbc.M115.690651

DOI: 10.1074/jbc.M115.690651

2015

Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer (Journal article)

McClurg, U. L., Harle, V. J., Nabbi, A., Batalha-Pereira, A., Walker, S., Coffey, K., . . . Robson, C. N. (2015). Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer. ONCOTARGET, 6(35), 37724-37736. doi:10.18632/oncotarget.6075

DOI: 10.18632/oncotarget.6075

The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells. (Journal article)

Munkley, J., Livermore, K. E., McClurg, U. L., Kalna, G., Knight, B., McCullagh, P., . . . Elliott, D. J. (2015). The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.. Oncoscience, 2(9), 755-764. doi:10.18632/oncoscience.243

DOI: 10.18632/oncoscience.243

Deubiquitinating enzymes as oncotargets (Journal article)

McClurg, U. L., & Robson, C. N. (2015). Deubiquitinating enzymes as oncotargets. ONCOTARGET, 6(12), 9657-9668. doi:10.18632/oncotarget.3922

DOI: 10.18632/oncotarget.3922

Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation (Journal article)

McClurg, U. L., Danjo, K., King, H. O., Scott, G. B., Robinson, P. A., & Crabtree, J. E. (2015). Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation. MICROBES AND INFECTION, 17(3), 205-214. doi:10.1016/j.micinf.2014.11.011

DOI: 10.1016/j.micinf.2014.11.011

2014

Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway (Journal article)

McClurg, U. L., Summerscales, E. E., Harle, V. J., Gaughan, L., & Robson, C. N. (2014). Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway. ONCOTARGET, 5(16), 7081-7092. doi:10.18632/oncotarget.2162

DOI: 10.18632/oncotarget.2162

Literature Search and Review (Journal article)

Davis, M. I., Lea, W., Simeonov, A., & Auld, D. (2014). Literature Search and Review. ASSAY and Drug Development Technologies, 12(2), 101-109. doi:10.1089/adt.2014.1202.lr

DOI: 10.1089/adt.2014.1202.lr

Two plasmid-encoded genes of enteropathogenic Escherichia coli strain K798 promote invasion and survival within HEp-2 cells (Journal article)

Burska, U. L., & Fletcher, J. N. (2014). Two plasmid-encoded genes of enteropathogenic Escherichia coli strain K798 promote invasion and survival within HEp-2 cells. APMIS, 122(10), 922-930. doi:10.1111/apm.12234

DOI: 10.1111/apm.12234

2013

Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor (Journal article)

Burska, U. L., Harle, V. J., Coffey, K., Darby, S., Ramsey, H., O'Neill, D., . . . Robson, C. N. (2013). Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(45), 32641-32650. doi:10.1074/jbc.M113.485912

DOI: 10.1074/jbc.M113.485912