Photo of Prof Sonia Rocha

Prof Sonia Rocha PhD, FRSB

Head of Department Biochemistry

    Publications

    2019

    JmjC histone demethylases act as chromatin oxygen sensors (Journal article)

    Batie, M., & Rocha, S. (2019). JmjC histone demethylases act as chromatin oxygen sensors. Molecular and Cellular Oncology. doi:10.1080/23723556.2019.1608501

    DOI: 10.1080/23723556.2019.1608501

    Hypoxia induces rapid changes to histone methylation and reprograms chromatin (Journal article)

    Batie, M., Frost, J., Frost, M., Wilson, J. W., Schofield, P., & Rocha, S. (2019). Hypoxia induces rapid changes to histone methylation and reprograms chromatin. SCIENCE, 363(6432), 1222-+. doi:10.1126/science.aau5870

    DOI: 10.1126/science.aau5870

    Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response: Supplementary material (Journal article)

    Batie, M., Frost, J., Frost, M., Wilson, J., Schofield, P., & Rocha, S. (2019). Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response: Supplementary material. doi:10.1101/513069

    DOI: 10.1101/513069

    RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response. (Journal article)

    Frost, J., Ciulli, A., & Rocha, S. (2019). RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.. Wellcome open research, 4, 17. doi:10.12688/wellcomeopenres.15044.1

    DOI: 10.12688/wellcomeopenres.15044.1

    2018

    TNFSF14/LIGHT, a Non-Canonical NF-kappa B Stimulus, Induces the HIF Pathway (Journal article)

    D'Ignazio, L., Batie, M., & Rocha, S. (2018). TNFSF14/LIGHT, a Non-Canonical NF-kappa B Stimulus, Induces the HIF Pathway. CELLS, 7(8). doi:10.3390/cells7080102

    DOI: 10.3390/cells7080102

    SINHCAF/FAM60A and SIN3A specifically repress HIF-2 alpha expression (Journal article)

    Biddlestone, J., Batie, M., Bandarra, D., Munoz, I., & Rocha, S. (2018). SINHCAF/FAM60A and SIN3A specifically repress HIF-2 alpha expression. BIOCHEMICAL JOURNAL, 475, 2073-2090. doi:10.1042/BCJ20170945

    DOI: 10.1042/BCJ20170945

    Hypoxia and Chromatin, a Focus on Transcriptional Repression Mechanisms (Journal article)

    Batie, M., del Peso, L., & Rocha, S. (2018). Hypoxia and Chromatin, a Focus on Transcriptional Repression Mechanisms. doi:10.20944/preprints201803.0004.v1

    DOI: 10.20944/preprints201803.0004.v1

    Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms. (Journal article)

    Batie, M., Del Peso, L., & Rocha, S. (2018). Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms.. Biomedicines, 6(2). doi:10.3390/biomedicines6020047

    DOI: 10.3390/biomedicines6020047

    2017

    Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. (Journal article)

    Maniaci, C., Hughes, S. J., Testa, A., Chen, W., Lamont, D. J., Rocha, S., . . . Ciulli, A. (2017). Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.. Nature communications, 8(1), 830. doi:10.1038/s41467-017-00954-1

    DOI: 10.1038/s41467-017-00954-1

    Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2 S ,4 R )-1-(( S )-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy- N -(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298) (Journal article)

    Soares, P., Gadd, M. S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., . . . Ciulli, A. (2018). Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).. Journal of medicinal chemistry, 61(2), 599-618. doi:10.1021/acs.jmedchem.7b00675

    DOI: 10.1021/acs.jmedchem.7b00675

    Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB. (Journal article)

    D'Ignazio, L., Batie, M., & Rocha, S. (2017). Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB.. Biomedicines, 5(2). doi:10.3390/biomedicines5020021

    DOI: 10.3390/biomedicines5020021

    Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB (Journal article)

    D'Ignazio, L., Batie, M., & Rocha, S. (2017). Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB. doi:10.20944/preprints201703.0240.v1

    DOI: 10.20944/preprints201703.0240.v1

    KDM2 Family Members are Regulated by HIF-1 in Hypoxia. (Journal article)

    Batie, M., Druker, J., D'Ignazio, L., & Rocha, S. (2017). KDM2 Family Members are Regulated by HIF-1 in Hypoxia.. Cells, 6(1). doi:10.3390/cells6010008

    DOI: 10.3390/cells6010008

    2016

    Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. (Journal article)

    Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., . . . Ciulli, A. (2016). Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.. Nature communications, 7, 13312. doi:10.1038/ncomms13312

    DOI: 10.1038/ncomms13312

    Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation. (Journal article)

    Pinto, A. T., Pinto, M. L., Velho, S., Pinto, M. T., Cardoso, A. P., Figueira, R., . . . Rocha, S. (2016). Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation.. PloS one, 11(8), e0160891. doi:10.1371/journal.pone.0160891

    DOI: 10.1371/journal.pone.0160891

    Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities. (Journal article)

    Teresa Pinto, A., Laranjeiro Pinto, M., Patrícia Cardoso, A., Monteiro, C., Teixeira Pinto, M., Filipe Maia, A., . . . José Oliveira, M. (2016). Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.. Scientific reports, 6, 18765. doi:10.1038/srep18765

    DOI: 10.1038/srep18765

    Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines. (Journal article)

    Ono, M., Yamada, K., Bensaddek, D., Afzal, V., Biddlestone, J., Ortmann, B., . . . Lamond, A. I. (2016). Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines.. PloS one, 11(4), e0154759. doi:10.1371/journal.pone.0154759

    DOI: 10.1371/journal.pone.0154759

    The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors (Journal article)

    Wiechens, N., Singh, V., Gkikopoulos, T., Schofield, P., Rocha, S., & Owen-Hughes, T. (2016). The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors. PLOS GENETICS, 12(3). doi:10.1371/journal.pgen.1005940

    DOI: 10.1371/journal.pgen.1005940

    Hypoxia Induced NF-κB. (Journal article)

    D'Ignazio, L., & Rocha, S. (2016). Hypoxia Induced NF-κB.. Cells, 5(1). doi:10.3390/cells5010010

    DOI: 10.3390/cells5010010

    NF-κB and HIF crosstalk in immune responses. (Journal article)

    D'Ignazio, L., Bandarra, D., & Rocha, S. (2016). NF-κB and HIF crosstalk in immune responses.. The FEBS journal, 283(3), 413-424. doi:10.1111/febs.13578

    DOI: 10.1111/febs.13578

    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Journal article)

    Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., . . . Zughaier, S. M. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). AUTOPHAGY, 12(1), 1-222. doi:10.1080/15548627.2015.1100356

    DOI: 10.1080/15548627.2015.1100356

    CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. (Journal article)

    Ortmann, B., Bensaddek, D., Carvalhal, S., Moser, S. C., Mudie, S., Griffis, E. R., . . . Rocha, S. (2016). CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells.. Journal of cell science, 129(1), 191-205. doi:10.1242/jcs.179911

    DOI: 10.1242/jcs.179911

    Erratum (Journal article)

    Erratum (2016). Autophagy, 12(2), 443. doi:10.1080/15548627.2016.1147886

    DOI: 10.1080/15548627.2016.1147886

    2015

    The Prolylhydroxylase PHD2 Modulates Centromere Function through the Hydroxylation of CENP-N (Journal article)

    Moser, S., Bensaddek, D., Ortmann, B., Rocha, S., Lamond, A., & Swedlow, J. (2015). The Prolylhydroxylase PHD2 Modulates Centromere Function through the Hydroxylation of CENP-N. doi:10.1101/030452

    DOI: 10.1101/030452

    Spatio-Temporal Dynamics of Hypoxia during Radiotherapy. (Journal article)

    Kempf, H., Bleicher, M., & Meyer-Hermann, M. (2015). Spatio-Temporal Dynamics of Hypoxia during Radiotherapy.. PloS one, 10(8), e0133357. doi:10.1371/journal.pone.0133357

    DOI: 10.1371/journal.pone.0133357

    Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. (Journal article)

    Sun, Y., George, J., & Rocha, S. (2015). Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia.. PloS one, 10(4), e0123649. doi:10.1371/journal.pone.0123649

    DOI: 10.1371/journal.pone.0123649

    Cezanne regulates E2F1-dependent HIF2α expression. (Journal article)

    Moniz, S., Bandarra, D., Biddlestone, J., Campbell, K. J., Komander, D., Bremm, A., & Rocha, S. (2015). Cezanne regulates E2F1-dependent HIF2α expression.. Journal of cell science, 128(16), 3082-3093. doi:10.1242/jcs.168864

    DOI: 10.1242/jcs.168864

    HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals. (Journal article)

    Bandarra, D., Biddlestone, J., Mudie, S., Müller, H. -A. J., & Rocha, S. (2015). HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals.. Disease models & mechanisms, 8(2), 169-181. doi:10.1242/dmm.017285

    DOI: 10.1242/dmm.017285

    The role of hypoxia in inflammatory disease (review). (Journal article)

    Biddlestone, J., Bandarra, D., & Rocha, S. (2015). The role of hypoxia in inflammatory disease (review).. International journal of molecular medicine, 35(4), 859-869. doi:10.3892/ijmm.2015.2079

    DOI: 10.3892/ijmm.2015.2079

    2014

    PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. (Journal article)

    Mudie, S., Bandarra, D., Batie, M., Biddlestone, J., Moniz, S., Ortmann, B., . . . Rocha, S. (2014). PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia.. Cell cycle (Georgetown, Tex.), 13(24), 3878-3891. doi:10.4161/15384101.2014.972889

    DOI: 10.4161/15384101.2014.972889

    Chromatin and oxygen sensing in the context of JmjC histone demethylases. (Journal article)

    Shmakova, A., Batie, M., Druker, J., & Rocha, S. (2014). Chromatin and oxygen sensing in the context of JmjC histone demethylases.. The Biochemical journal, 462(3), 385-395. doi:10.1042/BJ20140754

    DOI: 10.1042/BJ20140754

    SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells. (Journal article)

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Rocha, S., & Hay, R. T. (2014). SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells.. Journal of visualized experiments : JoVE, (87). doi:10.3791/51572

    DOI: 10.3791/51572

    Analysis of global RNA synthesis at the single cell level following hypoxia. (Journal article)

    Biddlestone, J., Druker, J., Shmakova, A., Ferguson, G., Swedlow, J. R., & Rocha, S. (2014). Analysis of global RNA synthesis at the single cell level following hypoxia.. Journal of visualized experiments : JoVE, (87). doi:10.3791/51420

    DOI: 10.3791/51420

    Grow₂: the HIF system, energy homeostasis and the cell cycle. (Journal article)

    Moniz, S., Biddlestone, J., & Rocha, S. (2014). Grow₂: the HIF system, energy homeostasis and the cell cycle.. Histology and histopathology, 29(5), 589-600. doi:10.14670/hh-29.10.589

    DOI: 10.14670/hh-29.10.589

    Cell cycle progression in response to oxygen levels. (Journal article)

    Ortmann, B., Druker, J., & Rocha, S. (2014). Cell cycle progression in response to oxygen levels.. Cellular and molecular life sciences : CMLS, 71(18), 3569-3582. doi:10.1007/s00018-014-1645-9

    DOI: 10.1007/s00018-014-1645-9

    Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner. (Journal article)

    Bremm, A., Moniz, S., Mader, J., Rocha, S., & Komander, D. (2014). Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.. EMBO reports, 15(12), 1268-1277. doi:10.15252/embr.201438850

    DOI: 10.15252/embr.201438850

    Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster. (Journal article)

    Bandarra, D., Biddlestone, J., Mudie, S., Muller, H. A., & Rocha, S. (2014). Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster.. Bioscience reports, 34(4). doi:10.1042/BSR20140095

    DOI: 10.1042/BSR20140095

    2013

    HIF-independent role of prolyl hydroxylases in the cellular response to amino acids. (Journal article)

    Durán, R. V., MacKenzie, E. D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S., . . . Gottlieb, E. (2013). HIF-independent role of prolyl hydroxylases in the cellular response to amino acids.. Oncogene, 32(38), 4549-4556. doi:10.1038/onc.2012.465

    DOI: 10.1038/onc.2012.465

    FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21 (Journal article)

    Yamada, K., Ono, M., Bensaddek, D., Lamond, A. I., & Rocha, S. (2013). FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21. CELL CYCLE, 12(15), 2348-2354. doi:10.4161/cc.25511

    DOI: 10.4161/cc.25511

    PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192 (Journal article)

    Moser, S. C., Bensaddek, D., Ortmann, B., Maure, J. -F., Mudie, S., Blow, J. J., . . . Rocha, S. (2013). PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192. DEVELOPMENTAL CELL, 26(4), 381-392. doi:10.1016/j.devcel.2013.06.014

    DOI: 10.1016/j.devcel.2013.06.014

    The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability (Journal article)

    Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S., & Hay, R. T. (2013). The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. BIOCHEMICAL JOURNAL, 451, 185-194. doi:10.1042/BJ20130026

    DOI: 10.1042/BJ20130026

    Identification and Functional Characterization of FMN2, a Regulator of the Cyclin-Dependent Kinase Inhibitor p21 (Journal article)

    Yamada, K., Ono, M., Perkins, N. D., Rocha, S., & Lamond, A. I. (2013). Identification and Functional Characterization of FMN2, a Regulator of the Cyclin-Dependent Kinase Inhibitor p21. MOLECULAR CELL, 49(5), 922-933. doi:10.1016/j.molcel.2012.12.023

    DOI: 10.1016/j.molcel.2012.12.023

    TfR1 interacts with the IKK complex and is involved in IKK-NF-kappa B signalling (Journal article)

    Kenneth, N. S., Mudie, S., Naron, S., & Rocha, S. (2013). TfR1 interacts with the IKK complex and is involved in IKK-NF-kappa B signalling. BIOCHEMICAL JOURNAL, 449, 275-284. doi:10.1042/BJ20120625

    DOI: 10.1042/BJ20120625

    2012

    Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex (Journal article)

    Munoz, I. M., MacArtney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S., & Rouse, J. (2012). Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(39), 32346-32353. doi:10.1074/jbc.M112.382499

    DOI: 10.1074/jbc.M112.382499

    Proteomic screen reveals Fbw7 as a modulator of the NF-kappa B pathway (Journal article)

    Arabi, A., Ullah, K., Branca, R. M. M., Johansson, J., Bandarra, D., Haneklaus, M., . . . Sangfelt, O. (2012). Proteomic screen reveals Fbw7 as a modulator of the NF-kappa B pathway. NATURE COMMUNICATIONS, 3. doi:10.1038/ncomms1975

    DOI: 10.1038/ncomms1975

    IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function. (Journal article)

    Kenneth, N. S., Mudie, S., & Rocha, S. (2012). IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function.. The EMBO journal, 31(11), 2660-2661. doi:10.1038/emboj.2012.135

    DOI: 10.1038/emboj.2012.135

    Chromatin as an oxygen sensor and active player in the hypoxia response (Journal article)

    Melvin, A., & Rocha, S. (2012). Chromatin as an oxygen sensor and active player in the hypoxia response. CELLULAR SIGNALLING, 24(1), 35-43. doi:10.1016/j.cellsig.2011.08.019

    DOI: 10.1016/j.cellsig.2011.08.019

    2011

    The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH (Journal article)

    Melvin, A., Mudie, S., & Rocha, S. (2011). The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH. MOLECULAR BIOLOGY OF THE CELL, 22(21), 4171-4181. doi:10.1091/mbc.E11-02-0163

    DOI: 10.1091/mbc.E11-02-0163

    The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration (Journal article)

    Msaki, A., Sanchez, A. M., Koh, L. F., Barre, B., Rocha, S., Perkins, N. D., & Johnson, R. F. (2011). The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. MOLECULAR BIOLOGY OF THE CELL, 22(17), 3032-3040. doi:10.1091/mbc.E11-04-0280

    DOI: 10.1091/mbc.E11-04-0280

    NF-kappa B controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration (Journal article)

    Mauro, C., Leow, S. C., Anso, E., Rocha, S., Thotakura, A. K., Tornatore, L., . . . Franzoso, G. (2011). NF-kappa B controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. NATURE CELL BIOLOGY, 13(10), 1272-U234. doi:10.1038/ncb2324

    DOI: 10.1038/ncb2324

    [Erratum: Volume 10, Issue 6, pp. 879–82] Mechanism of hypoxia-induced NFkB. (Journal article)

    Melvin, A., Mudie, S., & Rocha, S. (2011). [Erratum: Volume 10, Issue 6, pp. 879–82] Mechanism of hypoxia-induced NFkB.. Cell cycle (Georgetown, Tex.), 10(12), 2041. doi:10.4161/cc.10.12.16720

    DOI: 10.4161/cc.10.12.16720

    Antagonistic crosstalk between APC and HIF-1 alpha (Journal article)

    Naethke, I., & Rocha, S. (2011). Antagonistic crosstalk between APC and HIF-1 alpha. CELL CYCLE, 10(10), 1545-1547. doi:10.4161/cc.10.10.15638

    DOI: 10.4161/cc.10.10.15638

    HIF-1 alpha depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs (Journal article)

    Culver, C., Melvin, A., Mudie, S., & Rocha, S. (2011). HIF-1 alpha depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs. CELL CYCLE, 10(8), 1249-1260. doi:10.4161/cc.10.8.15326

    DOI: 10.4161/cc.10.8.15326

    Mechanism of hypoxia-induced NF kappa B (Journal article)

    Melvin, A., Mudie, S., & Rocha, S. (2011). Mechanism of hypoxia-induced NF kappa B. CELL CYCLE, 10(6), 879-882. doi:10.4161/cc.10.6.14910

    DOI: 10.4161/cc.10.6.14910

    Evolutionary Conserved Regulation of HIF-1 beta by NF-kappa B (Journal article)

    van Uden, P., Kenneth, N. S., Webster, R., Mueller, H. A., Mudie, S., & Rocha, S. (2011). Evolutionary Conserved Regulation of HIF-1 beta by NF-kappa B. PLOS GENETICS, 7(1). doi:10.1371/journal.pgen.1001285

    DOI: 10.1371/journal.pgen.1001285

    2010

    Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1 alpha Have an Antagonistic Connection (Journal article)

    Newton, I. P., Kenneth, N. S., Appleton, P. L., Naethke, I., & Rocha, S. (2010). Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1 alpha Have an Antagonistic Connection. MOLECULAR BIOLOGY OF THE CELL, 21(21), 3630-3638. doi:10.1091/mbc.E10-04-0312

    DOI: 10.1091/mbc.E10-04-0312

    Mechanism of Hypoxia-Induced NF-kappa B (Journal article)

    Culver, C., Sundqvist, A., Mudie, S., Melvin, A., Xirodimas, D., & Rocha, S. (2010). Mechanism of Hypoxia-Induced NF-kappa B. MOLECULAR AND CELLULAR BIOLOGY, 30(20), 4901-4921. doi:10.1128/MCB.00409-10

    DOI: 10.1128/MCB.00409-10

    IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function (Journal article)

    Kenneth, N. S., Mudie, S., & Rocha, S. (2010). IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function. EMBO JOURNAL, 29(17), 2966-2978. doi:10.1038/emboj.2010.171

    DOI: 10.1038/emboj.2010.171

    2009

    SWI/SNF Regulates the Cellular Response to Hypoxia (Journal article)

    Kenneth, N. S., Mudie, S., van Uden, P., & Rocha, S. (2009). SWI/SNF Regulates the Cellular Response to Hypoxia. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(7), 4123-4131. doi:10.1074/jbc.M808491200

    DOI: 10.1074/jbc.M808491200

    2008

    Regulation of gene expression by hypoxia (Journal article)

    Kenneth, N. S., & Rocha, S. (2008). Regulation of gene expression by hypoxia. BIOCHEMICAL JOURNAL, 414, 19-29. doi:10.1042/BJ20081055

    DOI: 10.1042/BJ20081055

    Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. (Journal article)

    van Uden, P., Kenneth, N. S., & Rocha, S. (2008). Regulation of hypoxia-inducible factor-1alpha by NF-kappaB.. The Biochemical journal, 412(3), 477-484. doi:10.1042/BJ20080476

    DOI: 10.1042/BJ20080476

    2007

    Gene regulation under low oxygen: holding your breath for transcription (Journal article)

    Rocha, S. (2007). Gene regulation under low oxygen: holding your breath for transcription. TRENDS IN BIOCHEMICAL SCIENCES, 32(8), 389-397. doi:10.1016/j.tibs.2007.06.005

    DOI: 10.1016/j.tibs.2007.06.005

    Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1 (Journal article)

    Roche, K. C., Rocha, S., Bracken, C. P., & Perkins, N. D. (2007). Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1. ONCOGENE, 26(31), 4523-4530. doi:10.1038/sj.onc.1210233

    DOI: 10.1038/sj.onc.1210233

    2006

    SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes (Journal article)

    Fujii, M., Lyakh, L. A., Bracken, C. P., Fukuoka, J., Hayakawa, M., Tsukiyama, T., . . . Roberts, A. B. (2006). SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. MOLECULAR CELL, 24(5), 771-783. doi:10.1016/j.molcel.2006.11.006

    DOI: 10.1016/j.molcel.2006.11.006

    Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappa B subunit (Journal article)

    Schumm, K., Rocha, S., Caamano, J., & Perkins, N. D. (2006). Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappa B subunit. EMBO JOURNAL, 25(20), 4820-4832. doi:10.1038/sj.emboj.7601343

    DOI: 10.1038/sj.emboj.7601343

    Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappa B transactivation (Journal article)

    Campbell, K. J., Witty, J. M., Rocha, S., & Perkins, N. D. (2006). Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappa B transactivation. CANCER RESEARCH, 66(2), 929-935. doi:10.1158/0008-5472.CAN-05-2234

    DOI: 10.1158/0008-5472.CAN-05-2234

    2005

    Regulation of NF-kappa B and p53 through activation of ATR and Chk1 by the ARF tumour suppressor (Journal article)

    Rocha, S., Garrett, M. D., Campbell, K. J., Schumm, K., & Perkins, N. D. (2005). Regulation of NF-kappa B and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO JOURNAL, 24(6), 1157-1169. doi:10.1038/sj.emboj.7600608

    DOI: 10.1038/sj.emboj.7600608

    ARF the integrator - Linking NF-kappa B, p53 and checkpoint kinases (Journal article)

    Rocha, S., & Perkins, N. D. (2005). ARF the integrator - Linking NF-kappa B, p53 and checkpoint kinases. CELL CYCLE, 4(6), 756-759. doi:10.4161/cc.4.6.1739

    DOI: 10.4161/cc.4.6.1739

    2004

    Active repression of antiapoptotic gene expression by ReIA(p65) NF-kappa B (Journal article)

    Campbell, K. J., Rocha, S., & Perkins, N. D. (2004). Active repression of antiapoptotic gene expression by ReIA(p65) NF-kappa B. MOLECULAR CELL, 13(6), 853-865. doi:10.1016/S1097-2765(04)00131-5

    DOI: 10.1016/S1097-2765(04)00131-5

    2003

    The p53-inhibitor Pifithrin-alpha inhibits Firefly Luciferase activity in vivo and in vitro (Journal article)

    Rocha, S., Campbell, K. J., Roche, K. C., & Perkins, N. D. (2003). The p53-inhibitor Pifithrin-alpha inhibits Firefly Luciferase activity in vivo and in vitro. BMC MOLECULAR BIOLOGY, 4. doi:10.1186/1471-2199-4-9

    DOI: 10.1186/1471-2199-4-9

    p53 Represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappa B subunit with histone deacetylase 1 (Journal article)

    Rocha, S., Martin, A. M., Meek, D. W., & Perkins, N. D. (2003). p53 Represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappa B subunit with histone deacetylase 1. MOLECULAR AND CELLULAR BIOLOGY, 23(13), 4713-4727. doi:10.1128/MCB.23.13.4713-4727.2003

    DOI: 10.1128/MCB.23.13.4713-4727.2003

    p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor (Journal article)

    Rocha, S., Campbell, K. J., & Perkins, N. D. (2003). p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor. MOLECULAR CELL, 12(1), 15-25. doi:10.1016/S1097-2765(03)00223-5

    DOI: 10.1016/S1097-2765(03)00223-5

    Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionising radiation (Journal article)

    Hostanska, K., Vuong, V., Rocha, S., Soengas, M. S., Glanzmann, C., Saller, R., . . . Pruschy, M. (2003). Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionising radiation. BRITISH JOURNAL OF CANCER, 88(11), 1785-1792. doi:10.1038/sj.bjc.6600982

    DOI: 10.1038/sj.bjc.6600982

    2002

    NF-κB Function in Inflammation, Cellular Stress and Disease (Journal article)

    Chapman, N. R., Rocha, S., Adcock, I. M., & Perkins, N. D. (2002). NF-κB Function in Inflammation, Cellular Stress and Disease. Unknown Journal, 61-73. doi:10.1016/s1568-1254(02)80007-9

    DOI: 10.1016/s1568-1254(02)80007-9

    2001

    The phosphatidylinositide 3 '-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C (Journal article)

    Tenzer, A., Zingg, D., Rocha, S., Hemmings, B., Fabbro, D., Glanzmann, C., . . . Prusch, M. (2001). The phosphatidylinositide 3 '-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. CANCER RESEARCH, 61(22), 8203-8210. Retrieved from http://gateway.webofknowledge.com/

    Key targets for the execution of radiation-induced tumor cell apoptosis: The role of p53 and caspases (Journal article)

    Pruschy, M., Rocha, S., Zaugg, K., Tenzer, A., Hess, C., Fisher, D. E., . . . Bodis, S. (2001). Key targets for the execution of radiation-induced tumor cell apoptosis: The role of p53 and caspases. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 49(2), 561-567. doi:10.1016/S0360-3016(00)01480-2

    DOI: 10.1016/S0360-3016(00)01480-2

    Overexpression of Bcl-2 enhances sensitivity of L929 cells to a lipophilic cationic photosensitiser. (Journal article)

    Klein, S. D., Walt, H., Rocha, S., Ghafourifar, P., Pruschy, M., Winterhalter, K. H., & Richter, C. (2001). Overexpression of Bcl-2 enhances sensitivity of L929 cells to a lipophilic cationic photosensitiser.. Cell death and differentiation, 8(2), 204-206. doi:10.1038/sj.cdd.4400814

    DOI: 10.1038/sj.cdd.4400814

    Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412 (Journal article)

    Zaugg, K., Rocha, S., Resch, H., Hegyi, I., Oehler, C., Glanzmann, C., . . . Pruschy, M. (2001). Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412. CANCER RESEARCH, 61(2), 732-738. Retrieved from http://gateway.webofknowledge.com/

    2000

    Protein kinase C inhibitor and irradiation-induced apoptosis: Relevance of the cytochrome c-mediated caspase-9 death pathway (Journal article)

    Rocha, S., Soengas, M. S., Lowe, S. W., Glanzmann, C., Fabbro, D., Winterhalter, K., . . . Pruschy, M. (2000). Protein kinase C inhibitor and irradiation-induced apoptosis: Relevance of the cytochrome c-mediated caspase-9 death pathway. CELL GROWTH & DIFFERENTIATION, 11(9), 491-499. Retrieved from http://gateway.webofknowledge.com/

    1999

    Ceramide induces cytochrome c release from isolated mitochondria - Importance of mitochondrial redox state (Journal article)

    Ghafourifar, P., Klein, S. D., Schucht, O., Schenk, U., Pruschy, M., Rocha, S., & Richter, C. (1999). Ceramide induces cytochrome c release from isolated mitochondria - Importance of mitochondrial redox state. JOURNAL OF BIOLOGICAL CHEMISTRY, 274(10), 6080-6084. doi:10.1074/jbc.274.10.6080

    DOI: 10.1074/jbc.274.10.6080