Photo of Dr Raphael Levy

Dr Raphael Levy

Senior Lecturer Biochemistry

Research

Nanoparticles

It all starts with Nanoparticles ... but it doesn't end there!

We love nanoparticles because of their physical properties. Gold nanoparticles solutions look like red wine… and turn to blue upon aggregation. Iron oxide nanoparticles form ferrofluids which can be spectacular if you have a strong enough magnet.

These physical properties are not just fun: they can be harnessed for imaging and tracking of molecules and cells. Furthermore, the nanoparticles can be camouflaged so that they look similar to biomolecules. This can be achieved by attaching many small biomolecules to their surface.

The two main aims of our research are to prepare nanoparticles with advanced structures and functions and to develop biological imaging at various length scales. For this second aim, we do use nanoparticles but we do not restrict ourselves since there is a lot that can be done with other types of probes. The research is highly interdisciplinary (physics, chemistry and biology) and this is reflected both by the composition of the group and the breadth of our collaborations.

For more information, check the group website.

Research Grants

A multimodal imaging platform with real-time super-resolution for research across the life sciences

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

May 2018 - April 2019

Developing novel tools and technologies to assess the safety and efficacy of cell-based regenerative medicine therapies, focusing on kidney disease RenalToolBox

EUROPEAN COMMISSION

November 2018 - October 2022

Nanoparticle probes for the imaging of amyloid disease progression

ALZHEIMER'S RESEARCH (UK)

February 2018 - March 2019

3DBioNet: an integrated technological platform for the development of 3D cell culture models of human tissues

MEDICAL RESEARCH COUNCIL (MRC)

October 2018 - February 2022

Multimodal preclinical imaging probes to evaluate the safety and efficacy of regenerative medicine therapies

EUROPEAN COMMISSION

August 2016 - July 2018

Super-resolution optical fluctuations imaging (SOFI) to investigate the organisation of protein binding sites in the extracellular matrix on the nanometre scale.

CARL ZEISS LTD (UK)

October 2014 - September 2018

Nanoparticle-based electronic biosensor for diagnostics of cardiovascular disease. (NACARDIO)

EUROPEAN COMMISSION

October 2006 - December 2009

Real-Time Stem Cell Tracking Using Nanoprobes for Photoacoustic Imaging: Resolution and Sensitivity in a Single Technique

EUROPEAN COMMISSION

April 2014 - January 2017

Liverpool BioAFM: an integrated optical and atomic force microscope for research across the life sciences

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

January 2015 - January 2016

Development of live cell imaging from single cells to single molecules

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

September 2007 - August 2010

Regenerative Medicine Platform in Stem Cell Safety Science

MEDICAL RESEARCH COUNCIL (MRC)

June 2013 - March 2018

In vivo imaging technologies to assess the efficacy and safety of RMTs

MEDICAL RESEARCH COUNCIL (MRC)

October 2013 - March 2015

Nanoparticles, peptide self assembly. bionanotechnology, force spectroscopy

ROYAL SOCIETY (CHARITABLE)

April 2006 - March 2007

University of Liverpool Institutional Discipline Bridging.

MEDICAL RESEARCH COUNCIL (MRC)

October 2003 - October 2006

Value in People Award 2005.

WELLCOME TRUST (UK)

October 2005 - September 2009

Ultrastable targeted multifunctional hybrid nanomaterials for long-term stem cell tracking

ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL (EPSRC)

September 2010 - October 2014

Establishing a single cell analysis facility for the UK scientific research community

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

January 2015 - January 2016

Liverpool Imaging Partnership: Molecular physiology and drug response

MEDICAL RESEARCH COUNCIL (MRC)

February 2013 - February 2017

Biomimetic metal nanoparticles and photothermal imaging to explore the transcriptional network at a single molecule level in living cells

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

October 2006 - October 2011

Fluorescence Light Sheet Microscopy for Live 3D and 4D imaging

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

January 2014 - June 2014

Research Collaborations

Martin Volk

Project: Structure of peptides on nanoparticles
Internal

Experimental and theoretical investigation of the structure of peptides on nanoparticles (we co-supervise the work of PhD student Elena Colangelo).

Michael Sullivan

Project: Structure of peptides on nanoparticles
External: A* STAR (IHPC)

Experimental and theoretical investigation of the structure of peptides on nanoparticles (we co-supervise the work of PhD student Elena Colangelo).

David Paramelle

Project: Structure of peptides on nanoparticles
External: A* STAR (IMRE)

Experimental and theoretical investigation of the structure of peptides on nanoparticles (we co-supervise the work of PhD student Elena Colangelo).

Patricia Murray

Project: UK Regenerative Medicine Platform
Internal

Development of nanomaterials and imaging strategies for evaluating stem cell safety and tracking stem cells in pre-clinical models

Violaine See

Internal

Mathias Brust

Internal

Dave Fernig

Internal