Photo of Dr Raphael Levy

Dr Raphael Levy

Senior Lecturer Biochemistry

Research

Nanoparticles

It all starts with Nanoparticles ... but it doesn't end there!

We love nanoparticles because of their physical properties. Gold nanoparticles solutions look like red wine… and turn to blue upon aggregation. Iron oxide nanoparticles form ferrofluids which can be spectacular if you have a strong enough magnet.

These physical properties are not just fun: they can be harnessed for imaging and tracking of molecules and cells. Furthermore, the nanoparticles can be camouflaged so that they look similar to biomolecules. This can be achieved by attaching many small biomolecules to their surface.

The two main aims of our research are to prepare nanoparticles with advanced structures and functions and to develop biological imaging at various length scales. For this second aim, we do use nanoparticles but we do not restrict ourselves since there is a lot that can be done with other types of probes. The research is highly interdisciplinary (physics, chemistry and biology) and this is reflected both by the composition of the group and the breadth of our collaborations.

For more information, check the group website.

Research Group Membership
Research Grants
  • Multimodal preclinical imaging probes to evaluate the safety and efficacy of regenerative medicine therapies
  • Super-resolution optical fluctuations imaging (SOFI) to investigate the organisation of protein binding sites in the extracellular matrix on the nanometre scale.
  • Nanoparticle-based electronic biosensor for diagnostics of cardiovascular disease. (NACARDIO)
  • Real-Time Stem Cell Tracking Using Nanoprobes for Photoacoustic Imaging: Resolution and Sensitivity in a Single Technique
  • Liverpool BioAFM: an integrated optical and atomic force microscope for research across the life sciences
  • Development of live cell imaging from single cells to single molecules
  • Regenerative Medicine Platform in Stem Cell Safety Science
  • In vivo imaging technologies to assess the efficacy and safety of RMTs
  • Nanoparticles, peptide self assembly. bionanotechnology, force spectroscopy
  • University of Liverpool Institutional Discipline Bridging.
  • Value in People Award 2005.
  • Ultrastable targeted multifunctional hybrid nanomaterials for long-term stem cell tracking
  • Establishing a single cell analysis facility for the UK scientific research community
  • Liverpool Imaging Partnership: Molecular physiology and drug response
  • Biomimetic metal nanoparticles and photothermal imaging to explore the transcriptional network at a single molecule level in living cells
  • Fluorescence Light Sheet Microscopy for Live 3D and 4D imaging
Research Collaborations

Martin Volk

Project: Structure of peptides on nanoparticles
Internal

Experimental and theoretical investigation of the structure of peptides on nanoparticles (we co-supervise the work of PhD student Elena Colangelo).

Michael Sullivan

Project: Structure of peptides on nanoparticles
External: A* STAR (IHPC)

Experimental and theoretical investigation of the structure of peptides on nanoparticles (we co-supervise the work of PhD student Elena Colangelo).

David Paramelle

Project: Structure of peptides on nanoparticles
External: A* STAR (IMRE)

Experimental and theoretical investigation of the structure of peptides on nanoparticles (we co-supervise the work of PhD student Elena Colangelo).

Patricia Murray

Project: UK Regenerative Medicine Platform
Internal

Development of nanomaterials and imaging strategies for evaluating stem cell safety and tracking stem cells in pre-clinical models

Violaine See

Internal

Mathias Brust

Internal

Dave Fernig

Internal


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