Photo of Prof Pat Eyers

Prof Pat Eyers BSc/PhD

Professor of Cell Signalling Biochemistry

    Publications

    2019

    Structure-Based Design of Nucleoside-Derived Analogues as Sulfotransferase Inhibitors (Journal article)

    Kershaw, N., Byrne, D., Parsons, H., Berry, N., Fernig, D., Eyers, P., & Cosstick, R. (2019). Structure-Based Design of Nucleoside-Derived Analogues as Sulfotransferase Inhibitors. RSC Advances: an international journal to further the chemical sciences. doi:10.1039/C9RA07567D

    DOI: 10.1039/C9RA07567D

    Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors (Journal article)

    Kershaw, N. M., Byrne, D. P., Parsons, H., Berry, N. G., Fernig, D. G., Eyers, P. A., & Cosstick, R. (2019). Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors. RSC ADVANCES, 9(55), 32165-32173. doi:10.1039/c9ra07567d

    DOI: 10.1039/c9ra07567d

    Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation (Journal article)

    Hardman, G., Perkins, S., Brownridge, P., Clarke, C., Byrne, D., Campbell, A., . . . Eyers, C. (2019). Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation. The EMBO Journal.

    Emerging concepts in pseudoenzyme classification, evolution, and signaling (Journal article)

    Ribeiro, A. J. M., Das, S., Dawson, N., Zaru, R., Orchard, S., Thornton, J. M., . . . Eyers, P. A. (2019). Emerging concepts in pseudoenzyme classification, evolution, and signaling. SCIENCE SIGNALING, 12(594). doi:10.1126/scisignal.aat9797

    DOI: 10.1126/scisignal.aat9797

    Metabolic control of BRISC-SHMT2 assembly regulates immune signalling (Journal article)

    Walden, M., Tian, L., Ross, R. L., Sykora, U. M., Byrne, D. P., Hesketh, E. L., . . . Zeqiraj, E. (2019). Metabolic control of BRISC-SHMT2 assembly regulates immune signalling. NATURE, 570(7760), 194-+. doi:10.1038/s41586-019-1232-1

    DOI: 10.1038/s41586-019-1232-1

    Tracing the origin and evolution of pseudokinases across the tree of life (Journal article)

    Kwon, A., Scott, S., Taujale, R., Yeung, W., Kochut, K. J., Eyers, P. A., & Kannan, N. (2019). Tracing the origin and evolution of pseudokinases across the tree of life. SCIENCE SIGNALING, 12(578). doi:10.1126/scisignal.aav3810

    DOI: 10.1126/scisignal.aav3810

    Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer (Journal article)

    Cui, B., Eyers, P. A., Dobens, L. L., Tan, N. S., Mace, P. D., Link, W. A., . . . Hu, Z. (2019). Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer. ACTA PHARMACEUTICA SINICA B, 9(2), 443-454. doi:10.1016/j.apsb.2018.12.007

    DOI: 10.1016/j.apsb.2018.12.007

    Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of C17,C27-fragments (Journal article)

    Mears, P. R., Hoekman, S., Rye, C. E., Bailey, F. P., Byrne, D. P., Eyers, P. A., & Thomas, E. J. (2019). Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of C17,C27-fragments. ORGANIC & BIOMOLECULAR CHEMISTRY, 17(6), 1487-1505. doi:10.1039/c8ob03152e

    DOI: 10.1039/c8ob03152e

    Covalent Aurora A regulation by the metabolic integrator coenzyme A (Journal article)

    Tsuchiya, Y., Byrne, D. P., Burgess, S. G., Bormann, J., Bakovic, J., Huang, Y., . . . Gout, I. (2020). Covalent Aurora A regulation by the metabolic integrator coenzyme A. REDOX BIOLOGY, 28. doi:10.1016/j.redox.2019.101318

    DOI: 10.1016/j.redox.2019.101318

    2018

    A new consensus for evaluating CDKL5/STK9-dependent signalling mechanisms (Journal article)

    Eyers, P. A. (2018). A new consensus for evaluating CDKL5/STK9-dependent signalling mechanisms. EMBO JOURNAL, 37(24). doi:10.15252/embj.2018100848

    DOI: 10.15252/embj.2018100848

    Drug repurposing: progress, challenges and recommendations (Journal article)

    Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., . . . Pirmohamed, M. (2019). Drug repurposing: progress, challenges and recommendations. NATURE REVIEWS DRUG DISCOVERY, 18(1), 41-58. doi:10.1038/nrd.2018.168

    DOI: 10.1038/nrd.2018.168

    Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells (Journal article)

    Foulkes, D. M., Byrne, D. P., Yeung, W., Shrestha, S., Bailey, F. P., Ferries, S., . . . Eyers, P. A. (2018). Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. SCIENCE SIGNALING, 11(549). doi:10.1126/scisignal.aat7951

    DOI: 10.1126/scisignal.aat7951

    BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X-L (Journal article)

    Greaves, G., Milani, M., Butterworth, M., Carter, R. J., Byrne, D. P., Eyers, P. A., . . . Varadarajan, S. (2019). BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X-L. CELL DEATH AND DIFFERENTIATION, 26(6), 1037-1047. doi:10.1038/s41418-018-0183-7

    DOI: 10.1038/s41418-018-0183-7

    New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors (Journal article)

    Byrne, D. P., Li, Y., Ramakrishnan, K., Barsukov, I. L., Yates, E. A., Eyers, C. E., . . . Eyers, P. A. (2018). New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors. BIOCHEMICAL JOURNAL, 475, 2417-2433. doi:10.1042/BCJ20180265

    DOI: 10.1042/BCJ20180265

    DNA Binding and Phosphorylation Regulate the Core Structure of the NF-B p50 Transcription Factor (Journal article)

    Vonderach, M., Byrne, D. P., Barran, P. E., Eyers, P. A., & Eyers, C. E. (2019). DNA Binding and Phosphorylation Regulate the Core Structure of the NF-B p50 Transcription Factor. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 30(1), 128-138. doi:10.1007/s13361-018-1984-0

    DOI: 10.1007/s13361-018-1984-0

    New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors (Journal article)

    Byrne, D. P., Li, Y., Ngamlert, P., Ramakrishnan, K., Eyers, C. E., Wells, C., . . . Eyers, P. A. (2018). New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors. BIOCHEMICAL JOURNAL, 475, 2435-2455. doi:10.1042/BCJ20180266

    DOI: 10.1042/BCJ20180266

    Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinase (Journal article)

    Foulkes, D., Byrne, D., Bailey, F., Ferries, S., Eyers, C., Keeshan, K., . . . Eyers, P. (2018). Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinase. doi:10.1101/305243

    DOI: 10.1101/305243

    New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors (Journal article)

    Byrne, D. P., Li, Y., Ramakrishnan, K., Barsukov, I. L., Yates, E. A., Eyers, C. E., . . . Eyers, P. A. (n.d.). New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors. doi:10.1101/296533

    DOI: 10.1101/296533

    Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase (Journal article)

    Williams, R. M., Franke, B., Wilkinson, M., Fleming, J. R., Rigden, D. J., Benian, G. M., . . . Mayans, O. (2018). Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase. JOURNAL OF MOLECULAR BIOLOGY, 430(6), 793-805. doi:10.1016/j.jmb.2018.01.020

    DOI: 10.1016/j.jmb.2018.01.020

    Understanding protein-drug interactions using ion mobility-mass spectrometry (Journal article)

    Eyers, C. E., Vonderach, M., Ferries, S., Jeacock, K., & Eyers, P. A. (2018). Understanding protein-drug interactions using ion mobility-mass spectrometry. CURRENT OPINION IN CHEMICAL BIOLOGY, 42, 167-176. doi:10.1016/j.cbpa.2017.12.013

    DOI: 10.1016/j.cbpa.2017.12.013

    Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2 (Journal article)

    O'Connor, C., Yalla, K., Salomé, M., Moka, H. A., Castañeda, E. G., Eyers, P. A., & Keeshan, K. (2018). Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2.. Oncotarget, 9(19), 14977-14992. doi:10.18632/oncotarget.24525

    DOI: 10.18632/oncotarget.24525

    Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease (Journal article)

    Eyers, P. A. (2018). Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease. BIOCHEMICAL JOURNAL, 475, 185-189. doi:10.1042/BCJ20170870

    DOI: 10.1042/BCJ20170870

    Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint (Journal article)

    Combes, G., Barysz, H., Garand, C., Braga, L. G., Alharbi, I., Thebault, P., . . . Elowe, S. (2018). Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint. CURRENT BIOLOGY, 28(6), 872-+. doi:10.1016/j.cub.2018.02.002

    DOI: 10.1016/j.cub.2018.02.002

    2017

    New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome (Journal article)

    Wilson, L. J., Linley, A., Hammond, D. E., Hood, F. E., Coulson, J. M., MacEwan, D. J., . . . Prior, I. A. (2018). New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome. CANCER RESEARCH, 78(1), 15-29. doi:10.1158/0008-5472.CAN-17-2291

    DOI: 10.1158/0008-5472.CAN-17-2291

    Extensive non-canonical phosphorylation in human cells revealed using strong-anion exchange-mediated phosphoproteomics (Journal article)

    Hardman, G., Perkins, S., Ruan, Z., Kannan, N., Brownridge, P., Byrne, D., . . . Eyers, C. (2017). Extensive non-canonical phosphorylation in human cells revealed using strong-anion exchange-mediated phosphoproteomics. doi:10.1101/202820

    DOI: 10.1101/202820

    Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics (Journal article)

    Bailey, F. P., Clarke, K., Kalirai, H., Kenyani, J., Shahidipour, H., Falciani, F., . . . Eyers, P. A. (2018). Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics. PIGMENT CELL & MELANOMA RESEARCH, 31(2). doi:10.1111/pcmr.12650

    DOI: 10.1111/pcmr.12650

    Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes (Journal article)

    Bury, L., Coelho, P. A., Simeone, A., Ferries, S., Eyers, C. E., Eyers, P. A., . . . Glover, D. M. (2017). Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes. JOURNAL OF CELL BIOLOGY, 216(11), 3571-3590. doi:10.1083/jcb.201606077

    DOI: 10.1083/jcb.201606077

    Live and let die: insights into pseudoenzyme mechanisms from structure (Journal article)

    Murphy, J. M., Mace, P. D., & Eyers, P. A. (2017). Live and let die: insights into pseudoenzyme mechanisms from structure. CURRENT OPINION IN STRUCTURAL BIOLOGY, 47, 95-104. doi:10.1016/j.sbi.2017.07.004

    DOI: 10.1016/j.sbi.2017.07.004

    Evaluation of Parameters for Confident Phosphorylation Site Localization Using an Orbitrap Fusion Tribrid Mass Spectrometer (Journal article)

    Ferries, S., Perkins, S., Brownridge, P. J., Camphell, A., Eyers, P. A., Jones, A. R., & Eyers, C. E. (2017). Evaluation of Parameters for Confident Phosphorylation Site Localization Using an Orbitrap Fusion Tribrid Mass Spectrometer. JOURNAL OF PROTEOME RESEARCH, 16(9), 3448-3459. doi:10.1021/acs.jproteome.7b00337

    DOI: 10.1021/acs.jproteome.7b00337

    DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis (Journal article)

    Milani, M., Byrne, D. P., Greaves, G., Butterworth, M., Cohen, G. M., Eyers, P. A., & Varadarajan, S. (2017). DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis. CELL DEATH & DISEASE, 8. doi:10.1038/cddis.2016.485

    DOI: 10.1038/cddis.2016.485

    Local protein kinase A action proceeds through intact holoenzymes (Journal article)

    Smith, F. D., Esseltine, J. L., Nygren, P. J., Veesler, D., Byrne, D. P., Vonderach, M., . . . Scott, J. D. (2017). Local protein kinase A action proceeds through intact holoenzymes. SCIENCE, 356(6344), 1288-+. doi:10.1126/science.aaj1669

    DOI: 10.1126/science.aaj1669

    The response of uveal melanoma (UM) cells to Bromodomain and Extra Terminal (BET) inhibitors (Conference Paper)

    Bailey, F. P., Kalirai, H., Shahidipour, H., Clarke, K., Coupland, S. E., & Eyers, P. A. (2017). The response of uveal melanoma (UM) cells to Bromodomain and Extra Terminal (BET) inhibitors. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from http://gateway.webofknowledge.com/

    Bio-Zombie: the rise of pseudoenzymes in biology (Journal article)

    Murphy, J. M., Farhan, H., & Eyers, P. A. (2017). Bio-Zombie: the rise of pseudoenzymes in biology. BIOCHEMICAL SOCIETY TRANSACTIONS, 45, 537-544. doi:10.1042/BST20160400

    DOI: 10.1042/BST20160400

    Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease. (Journal article)

    Eyers, P. A., Keeshan, K., & Kannan, N. (2017). Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease. TRENDS IN CELL BIOLOGY, 27(4), 284-298. doi:10.1016/j.tcb.2016.11.002

    DOI: 10.1016/j.tcb.2016.11.002

    Pseudokinases: update on their functions and evaluation as new drug targets (Journal article)

    Byrne, D. P., Foulkes, D. M., & Eyers, P. A. (2017). Pseudokinases: update on their functions and evaluation as new drug targets. FUTURE MEDICINAL CHEMISTRY, 9(2), 245-265. doi:10.4155/fmc-2016-0207

    DOI: 10.4155/fmc-2016-0207

    The evolving world of pseudoenzymes: proteins, prejudice and zombies (Journal article)

    Eyers, P. A., & Murphy, J. M. (2016). The evolving world of pseudoenzymes: proteins, prejudice and zombies. BMC BIOLOGY, 14. doi:10.1186/s12915-016-0322-x

    DOI: 10.1186/s12915-016-0322-x

    2016

    Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1) (Journal article)

    Caron, D., Byrne, D. P., Thebault, P., Soulet, D., Landry, C. R., Eyers, P. A., & Elowe, S. (2016). Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1). SCIENCE SIGNALING, 9(458). doi:10.1126/scisignal.aah3525

    DOI: 10.1126/scisignal.aah3525

    KinView: a visual comparative sequence analysis tool for integrated kinome research (Journal article)

    McSkimming, D. I., Dastgheib, S., Baffi, T. R., Byrne, D. P., Ferries, S., Scott, S. T., . . . Kannan, N. (2016). KinView: a visual comparative sequence analysis tool for integrated kinome research. MOLECULAR BIOSYSTEMS, 12(12), 3651-3665. doi:10.1039/c6mb00466k

    DOI: 10.1039/c6mb00466k

    Human CDK18 promotes replication stress signaling and genome stability (Journal article)

    Barone, G., Staples, C. J., Ganesh, A., Patterson, K. W., Bryne, D. P., Myers, K. N., . . . Collis, S. J. (2016). Human CDK18 promotes replication stress signaling and genome stability. NUCLEIC ACIDS RESEARCH, 44(18), 8772-8785. doi:10.1093/nar/gkw615

    DOI: 10.1093/nar/gkw615

    cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry (Journal article)

    Byrne, D. P., Vonderach, M., Ferries, S., Brownridge, P. J., Eyers, C. E., & Eyers, P. A. (2016). cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry. BIOCHEMICAL JOURNAL, 473, 3159-3175. doi:10.1042/BCJ20160648

    DOI: 10.1042/BCJ20160648

    'Up with the LRRK': a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement (Journal article)

    Eyers, P. A. (2016). 'Up with the LRRK': a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement. BIOCHEMICAL JOURNAL, 473, 2757-2762. doi:10.1042/BCJ20160671C

    DOI: 10.1042/BCJ20160671C

    Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C (Journal article)

    Liang, K. L., Paredes, R., Carmody, R., Eyers, P. A., Meyer, S., McCarthy, T. V., & Keeshan, K. (2016). Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17(9). doi:10.3390/ijms17091378

    DOI: 10.3390/ijms17091378

    The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumourgrowth (Journal article)

    Bago, R., Sommer, E., Castel, P., Crafter, C., Bailey, F. P., Shpiro, N., . . . Alessi, D. R. (2016). The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumourgrowth. EMBO JOURNAL, 35(17), 1902-1922. doi:10.15252/embj.201693929

    DOI: 10.15252/embj.201693929

    Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization (Journal article)

    Mohanty, S., Oruganty, K., Kwon, A., Byrne, D. P., Ferries, S., Ruan, Z., . . . Kannan, N. (2016). Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization. PLOS GENETICS, 12(2). doi:10.1371/journal.pgen.1005885

    DOI: 10.1371/journal.pgen.1005885

    2015

    TRIBBLES: A Twist in the Pseudokinase Tail (Journal article)

    Eyers, P. A. (2015). TRIBBLES: A Twist in the Pseudokinase Tail. STRUCTURE, 23(11), 1974-1976. doi:10.1016/j.str.2015.10.003

    DOI: 10.1016/j.str.2015.10.003

    Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function (Journal article)

    Sawant, D. B., Majumder, S., Perkins, J. L., Yang, C. -H., Eyers, P. A., & Fisk, H. A. (2015). Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function. MOLECULAR BIOLOGY OF THE CELL, 26(21), 3741-3753. doi:10.1091/mbc.E14-07-1248

    DOI: 10.1091/mbc.E14-07-1248

    Tribbles pseudokinases: novel targets for chemical biology and drug discovery? (Journal article)

    Foulkes, D. M., Byrne, D. P., Bailey, F. P., & Eyers, P. A. (2015). Tribbles pseudokinases: novel targets for chemical biology and drug discovery?. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 1095-1103. doi:10.1042/BST20150109

    DOI: 10.1042/BST20150109

    The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner (Journal article)

    Bailey, F. P., Byrne, D. P., Oruganty, K., Eyers, C. E., Novotny, C. J., Shokat, K. M., . . . Eyers, P. A. (2015). The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. BIOCHEMICAL JOURNAL, 467, 47-62. doi:10.1042/BJ20141441

    DOI: 10.1042/BJ20141441

    2) Going for broke: targeting the human cancer pseudokinome. (Journal article)

    Bailey, F. P., Byrne, D. P., McSkimming, D., Kannan, N., & Eyers, P. A. (2015). 2) Going for broke: targeting the human cancer pseudokinome.. The Biochemical journal, 466(1), 201. doi:10.1042/bj4660201v

    DOI: 10.1042/bj4660201v

    Going for broke: targeting the human cancer pseudokinome (vol 465, pg 195, 2015) (Journal article)

    Bailey, F. P., Byrne, D. P., McSkimming, D., Kannan, N., & Eyers, P. A. (2015). Going for broke: targeting the human cancer pseudokinome (vol 465, pg 195, 2015). BIOCHEMICAL JOURNAL, 466, 201. Retrieved from http://gateway.webofknowledge.com/

    Going for broke: targeting the human cancer pseudokinome (Journal article)

    Bailey, F. P., Byrne, D. P., McSkimming, D., Kannan, N., & Eyers, P. A. (2015). Going for broke: targeting the human cancer pseudokinome. BIOCHEMICAL JOURNAL, 465, 195-211. doi:10.1042/BJ20141060

    DOI: 10.1042/BJ20141060

    TD-60 links RalA GTPase function to the CPC in mitosis (Journal article)

    Papini, D., Langemeyer, L., Abad, M. A., Kerr, A., Samejima, I., Eyers, P. A., . . . Earnshaw, W. C. (2015). TD-60 links RalA GTPase function to the CPC in mitosis. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms8678

    DOI: 10.1038/ncomms8678

    2014

    Day of the dead: pseudokinases and pseudophosphatases in physiology and disease (Journal article)

    Reiterer, V., Eyers, P. A., & Farhan, H. (2014). Day of the dead: pseudokinases and pseudophosphatases in physiology and disease. TRENDS IN CELL BIOLOGY, 24(9), 489-505. doi:10.1016/j.tcb.2014.03.008

    DOI: 10.1016/j.tcb.2014.03.008

    A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties (Journal article)

    Murphy, J. M., Zhang, Q., Young, S. N., Reese, M. L., Bailey, F. P., Eyers, P. A., . . . Lucet, I. S. (2014). A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. BIOCHEMICAL JOURNAL, 457, 323-334. doi:10.1042/BJ20131174

    DOI: 10.1042/BJ20131174

    DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B (Journal article)

    Zuazua-Villar, P., Rodriguez, R., Gagou, M. E., Eyers, P. A., & Meuth, M. (2014). DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B. CELL DEATH & DISEASE, 5. doi:10.1038/cddis.2014.231

    DOI: 10.1038/cddis.2014.231

    The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-Resistant Protein Kinase Alleles (Journal article)

    Bailey, F. P., Andreev, V. I., & Eyers, P. A. (2014). The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-Resistant Protein Kinase Alleles. PROTEIN KINASE INHIBITORS IN RESEARCH AND MEDICINE, 548, 117-146. doi:10.1016/B978-0-12-397918-6.00005-7

    DOI: 10.1016/B978-0-12-397918-6.00005-7

    2013

    A robust methodology to subclassify pseudokinases based on their nucleotide binding properties (Journal article)

    Murphy, J. E. A. (2013). A robust methodology to subclassify pseudokinases based on their nucleotide binding properties. Biochemical Journal. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24107129

    Dawn of the dead: protein pseudokinases signal new adventures in cell biology (Journal article)

    Eyers, P. A., & Murphy, J. M. (2013). Dawn of the dead: protein pseudokinases signal new adventures in cell biology. Biochemical Society Transactions, 41, 969-974.

    Getting to grips with drug-resistance in the human protein kinase superfamily (Journal article)

    Eyers, P. A. (2013). Getting to grips with drug-resistance in the human protein kinase superfamily. European Pharmaceutical Review, 18, 49-54.

    Rheo-stating mitosis (Journal article)

    Eyers, P. A. (2013). Rheo-stating mitosis. Chemistry and Biology, 20, 142-143.

    2012

    A framework for identification of actionable cancer genome dependencies in small cell lung cancer (Journal article)

    Sos, M. L., Dietlein, F., Peifer, M., Balke-Want, H., Muller, C., Koker, M., . . . Thomas, R. K. (2012). A framework for identification of actionable cancer genome dependencies in small cell lung cancer. PNAS, 109, 17034-17039.

    2011

    Aurora A and Aurora B jointly coordinate chromosome segregation (Journal article)

    Hegarat, N., Smith, E., Nayak, G., Takeda, S., Eyers, P. A., & Hochegger, H. (2011). Aurora A and Aurora B jointly coordinate chromosome segregation. J Cell Biol, 195, 1103-1113.

    Phosphorylation by Protein Kinase A (PKA) enables forward transport of K2P3.1 and K2P9.1, two pore domain potassium channels (Journal article)

    Mant, A., Elliott, D., Eyers, P., & O'Kelly, I. M. (2011). Phosphorylation by Protein Kinase A (PKA) enables forward transport of K2P3.1 and K2P9.1, two pore domain potassium channels. J Biol Chem, 286, 14110-14119.

    2010

    Biophysical and X-ray Crystallographic Analysis of Mps1 Kinase Inhibitor Complexes, (Journal article)

    Chu, M. L. H., Lang, Z., Chavas, L. M. G., Neres, J., Fedorova, O. S., Tabernero, L., . . . Eyers, P. A. (2010). Biophysical and X-ray Crystallographic Analysis of Mps1 Kinase Inhibitor Complexes,. Biochemistry, 49(8), 1689-1701. doi:10.1021/bi901970c

    DOI: 10.1021/bi901970c

    Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237 (Journal article)

    Sloane, D. A., Trikic, M. Z., Chu, M. L. H., Lamers, M. B. A. C., Mason, C. S., Mueller, I., . . . Eyers, P. A. (2010). Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237. ACS Chemical Biology, 5(6), 563-576. doi:10.1021/cb100053q

    DOI: 10.1021/cb100053q

    2009

    Discovery and exploitation of inhibitor-resistant Aurora and Polo kinase mutants for the analysis of mitotic networks (Journal article)

    Scutt, P. J., Chu, M. L. H., Sloane, D. A., Cherry, M., Bignell, C. R., Williams, D. H., & Eyers, P. A. (2009). Discovery and exploitation of inhibitor-resistant Aurora and Polo kinase mutants for the analysis of mitotic networks. J Biol Chem, 284, 15880-15893.

    Rigorous Determination of the Stoichiometry of Protein Phosphorylation Using Mass Spectrometry (Journal article)

    Johnson, H., Eyers, C. E., Eyers, P. A., Beynon, R. J., & Gaskell, S. J. (2009). Rigorous Determination of the Stoichiometry of Protein Phosphorylation Using Mass Spectrometry. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(12), 2211-2220. doi:10.1016/j.jasms.2009.08.009

    DOI: 10.1016/j.jasms.2009.08.009