Photo of Dr Nigel Jones

Dr Nigel Jones BSc, PhD

Senior Lecturer Biochemistry

    Biography

    Personal Statement

    My research interests focus on cellular processes involved in the detection, processing or tolerance of DNA damage and the role of the DNA damage response in preventing cancer. The DNA damage response (DDR) is vital in protecting cells from the genetic changes or mutations that lead to the development of cancer and includes a variety of DNA repair mechanisms that remove DNA damage arising from a variety of endogenous and exogenous sources. Two particular areas of interest are the human genetic disorder Fanconi anaemia (eg: DOI: 10.1038/sj.onc.1211034) and the role of the dinucleotide Ap4A in the DDR (eg: DOI: 10.1016/j.dnarep.2015.06.008).

    Short CV: BSc in Genetics/Microbiology, University of Wales Swansea (1982). PhD in cellular and molecular biology at the MRC Radiobiology Unit, Harwell (1987). Postdoctoral fellow with Dr Larry Thompson at Lawrence Livermore National Laboratory, California (USA) working on human DNA repair genes (1987-1988). Postdoctoral fellow and MRC grant holder with Profs. James Parry and Ray Waters, Swansea University working on DNA repair mechanisms, genetic toxicology and human biomonitoring (1989-1995). University of Liverpool (1995-present). Previous roles at UoL include programme director for Genetics for ~ 10 years. In 2017, I was appointed a Trustee of the UK charity Fanconi Hope. Fanconi Hope is a national charitable trust set up in 2008 by parents of FA-affected children and clinicians with an interest in FA to provide guidance and information for patients, families, clinicians and researchers http://www.fanconihope.org/

    Current teaching responsibilities include coordinator for 2nd year module LIFE208 (Molecular and Medical Genetics) and 3rd year module LIFE321 (Human and Clinical Genetics), lectures in LIFE302 (Genes and Cancer) and workshops on Genetic Toxicology in LIFE319.

    Personal Distinctions

    • Session Chair and Summariser (Interstrand Cross-Link Repair) and Speaker (Invitation to Speak, Fanconi Anemia Research Fund (FARF) (Toronto) 2015)
    • Selected Short Talk (Invitation to Speak, EU Integrated Project on DNA Repair Conference at Egmond van Zee 2016)
    • Session Chair and Summariser (Centrosome and Spindle Assembly) and Speaker (Invitation to Speak, Fanconi Anemia Research Fund (FARF) (Houston) 2013)
    • Symposium Speaker (Invitation to Speak, Fanconi Anemia Research Fund (FARF) (Denver) 2012)
    • Symposium Speaker (Invitation to Speak, Fanconi Anemia Research Fund (USA) 2011)
    • Conference Speaker (Invitation to Speak, UK Fanconi Anaemia Network 2010)
    • Symposium Speaker (Invitation to Speak, Fanconi Anaemia Research Fund (FARF) 2010)
    • Session Chair and Summarizer, Session on Cancer in Fanconi Anemia (Invitation to Speak, Fanconi Anemia Research Fund 2009)
    • Conference Speaker (Invitation to Speak, American Society for Microbiology (ASM) 2009)
    • Symposium Speaker (Invitation to Speak, Fanconi Anemia Research Fund 2009)
    • Symposium Speaker (Invitation to Speak, Fanconi Anemia Research Fund (FARF) 2008)
    • Invited Seminar (Invitation to Speak, UMDNJ New Jersey Medical School 2008)
    • Conference Speaker (Invitation to Speak, Genome Stability Network 2006)
    • Symposium Speaker (Invitation to Speak, Fanconi Anemia Research Fund 2006)
    • Selected Short Talk (Invitation to Speak, EU Integrated Project on DNA Repair 2006)
    • Symposium Speaker (Invitation to Speak, Fanconi Anemia Research Fund 2005)
    • Conference Speaker (Invitation to Speak, Royal Society of Chemistry 2005)
    • Symposium Speaker (Invitation to Speak, Fanconi Anemia Research Fund (FARF) 2004)
    • Symposium Speaker (Invitation to Speak, Fanconi Anemia Research Fund (FARF) 2002)
    • Symposium Speaker (Invitation to Speak, United Kingdom Environmental Mutagen Society 2002)

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