2023
Batie, M., Fasanya, T., Kenneth, N. S., & Rocha, S. (2023). Oxygen-regulated post-translation modifications as master signalling pathway in cells.. EMBO reports, e57849. doi:10.15252/embr.202357849DOI: 10.15252/embr.202357849
2022
Kataura, T., Sedlackova, L., Otten, E. G., Kumari, R., Shapira, D., Scialo, F., . . . Korolchuk, V. I. (2022). Autophagy promotes cell survival by maintaining NAD levels. DEVELOPMENTAL CELL, 57(22), 2584-+. doi:10.1016/j.devcel.2022.10.008DOI: 10.1016/j.devcel.2022.10.008
Hunter, J. E., Campbell, A. E., Butterworth, J. A., Sellier, H., Hannaway, N. L., Luli, S., . . . Perkins, N. D. (2022). Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance. BIOCHEMICAL JOURNAL, 479(19), 2087-2113. doi:10.1042/BCJ20220089DOI: 10.1042/BCJ20220089
Khazeem, M. M., Casement, J. W., Schlossmacher, G., Kenneth, N. S., Sumbung, N. K., Chan, J. Y. T., . . . Austin, C. A. (2022). TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells.. Molecular neurobiology, 59(10), 5987-6008. doi:10.1007/s12035-022-02949-6DOI: 10.1007/s12035-022-02949-6
Russell, L. G., Davis, L. A. K., Hunter, J. E., Perkins, N. D., & Kenneth, N. S. (2022). Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase.. Scientific reports, 12(1), 7943. doi:10.1038/s41598-022-11438-8DOI: 10.1038/s41598-022-11438-8
Batie, M., Kenneth, N. S., & Rocha, S. (2022). Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling. The Biochemical journal, 479(3), 245-257. doi:10.1042/BCJ20210554DOI: 10.1042/BCJ20210554
2021
Shmakova, A., Frost, M., Batie, M., Kenneth, N. S., & Rocha, S. (2021). PBRM1 Cooperates with YTHDF2 to Control HIF-1 alpha Protein Translation. CELLS, 10(6). doi:10.3390/cells10061425DOI: 10.3390/cells10061425
2020
Sedlackova, L., Otten, E., Scialo, F., Shapira, D., Kataura, T., Carroll, B., . . . Korolchuk, V. (2020). Autophagy promotes cell and organismal survival by maintaining NAD(H) pools. doi:10.1101/2020.01.31.928424DOI: 10.1101/2020.01.31.928424
2019
Ivanova, I. G., Park, C. V., & Kenneth, N. S. (2019). Translating the Hypoxic Response-the Role of HIF Protein Translation in the Cellular Response to Low Oxygen.. Cells, 8(2), E114. doi:10.3390/cells8020114DOI: 10.3390/cells8020114
2018
Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN (Journal article)
Hunter, J., Butterworth, J., Sellier, H., Luli, S., Floudas, A., Moore, A., . . . Perkins, N. (2018). Regulation of checkpoint kinase signalling and tumorigenesis by the NF-κB regulated gene, CLSPN. doi:10.1101/358291DOI: 10.1101/358291
Ivanova, I. G., Park, C. V., Yemm, A. I., & Kenneth, N. S. (2018). PERK/eIF2 alpha signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1 alpha translation. Nucleic Acids Research, 46(8), 3878-3890. doi:10.1093/nar/gky127DOI: 10.1093/nar/gky127
Carroll, B., Otten, E. G., Manni, D., Stefanatos, R., Menzies, F. M., Smith, G. R., . . . Korolchuk, V. I. (2018). Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nature Communications, 9. doi:10.1038/s41467-017-02746-zDOI: 10.1038/s41467-017-02746-z
2017
Park, C. V., Ivanova, I. G., & Kenneth, N. S. (2017). XIAP upregulates expression of HIF target genes by targeting HIF1 alpha for Lys(63)-linked polyubiquitination. Nucleic Acids Research, 45(16), 9336-9347. doi:10.1093/nar/gkx549DOI: 10.1093/nar/gkx549
2014
Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways (Journal article)
Kenneth, N. S., Hucks, G. E. J., Kocab, A. J., McCollom, A. L., & Duckett, C. S. (2014). Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways. CELL CYCLE, 13(6), 1006-1014. doi:10.4161/cc.27922DOI: 10.4161/cc.27922
2013
TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling (Journal article)
Kenneth, N. S., Mudie, S., Naron, S., & Rocha, S. (2013). TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling. BIOCHEMICAL JOURNAL, 449, 275-284. doi:10.1042/BJ20120625DOI: 10.1042/BJ20120625
2012
IAP proteins: regulators of cell migration and development (Journal article)
Kenneth, N. S., & Duckett, C. S. (2012). IAP proteins: regulators of cell migration and development. CURRENT OPINION IN CELL BIOLOGY, 24(6), 871-875. doi:10.1016/j.ceb.2012.11.004DOI: 10.1016/j.ceb.2012.11.004
IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function (Journal article)
IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function (2012). The EMBO journal, 31(11), 2660-2661. doi:10.1038/emboj.2012.135DOI: 10.1038/emboj.2012.135
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1 (Journal article)
Kenneth, N. S., Younger, J. M., Hughes, E. D., Marcotte, D., Barker, P. A., Saunders, T. L., & Duckett, C. S. (2012). An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. BIOCHEMICAL JOURNAL, 443, 355-359. doi:10.1042/BJ20120249DOI: 10.1042/BJ20120249
Direct Regulation of tRNA and 5S rRNA Gene Transcription by Polo-like Kinase 1 (Journal article)
Fairley, J. A., Mitchell, L. E., Berg, T., Kenneth, N. S., von Schubert, C., Sillje, H. H. W., . . . White, R. J. (2012). Direct Regulation of tRNA and 5S rRNA Gene Transcription by Polo-like Kinase 1. MOLECULAR CELL, 45(4), 541-552. doi:10.1016/j.molcel.2011.11.030DOI: 10.1016/j.molcel.2011.11.030
2011
Evolutionary Conserved Regulation of HIF-1β by NF-κB (Journal article)
van Uden, P., Kenneth, N. S., Webster, R., Mueller, H. A., Mudie, S., & Rocha, S. (2011). Evolutionary Conserved Regulation of HIF-1β by NF-κB. PLOS GENETICS, 7(1). doi:10.1371/journal.pgen.1001285DOI: 10.1371/journal.pgen.1001285
2010
Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection (Journal article)
Newton, I. P., Kenneth, N. S., Appleton, P. L., Naethke, I., & Rocha, S. (2010). Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection. MOLECULAR BIOLOGY OF THE CELL, 21(21), 3630-3638. doi:10.1091/mbc.E10-04-0312DOI: 10.1091/mbc.E10-04-0312
IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function (Journal article)
Kenneth, N. S., Mudie, S., & Rocha, S. (2010). IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function. EMBO JOURNAL, 29(17), 2966-2978. doi:10.1038/emboj.2010.171DOI: 10.1038/emboj.2010.171
Mechanisms of RNA polymerase III transcriptional activation by c-Myc. (Journal article)
Kenneth, N. S. (2010). Mechanisms of RNA polymerase III transcriptional activation by c-Myc..
2009
SWI/SNF Regulates the Cellular Response to Hypoxia (Journal article)
Kenneth, N. S., Mudie, S., van Uden, P., & Rocha, S. (2009). SWI/SNF Regulates the Cellular Response to Hypoxia. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(7), 4123-4131. doi:10.1074/jbc.M808491200DOI: 10.1074/jbc.M808491200
Regulation by c-Myc of ncRNA expression (Journal article)
Kenneth, N. S., & White, R. J. (2009). Regulation by c-Myc of ncRNA expression. CURRENT OPINION IN GENETICS & DEVELOPMENT, 19(1), 38-43. doi:10.1016/j.gde.2008.11.012DOI: 10.1016/j.gde.2008.11.012
2008
Regulation of gene expression by hypoxia (Journal article)
Kenneth, N. S., & Rocha, S. (2008). Regulation of gene expression by hypoxia. BIOCHEMICAL JOURNAL, 414, 19-29. doi:10.1042/BJ20081055DOI: 10.1042/BJ20081055
Regulation of hypoxia-inducible factor-1α by NF-κB (Journal article)
van Uden, P., Kenneth, N. S., & Rocha, S. (2008). Regulation of hypoxia-inducible factor-1α by NF-κB. BIOCHEMICAL JOURNAL, 412, 477-484. doi:10.1042/BJ20080476DOI: 10.1042/BJ20080476
Recruitment of RNA polymerase III <i>in vivo</i> (Journal article)
Kenneth, N. S., Marshall, L., & White, R. J. (2008). Recruitment of RNA polymerase III <i>in vivo</i>. NUCLEIC ACIDS RESEARCH, 36(11), 3757-3764. doi:10.1093/nar/gkn272DOI: 10.1093/nar/gkn272
2007
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription (Journal article)
Kenneth, N. S., Ramsbottom, B. A., Gomez-Roman, N., Marshall, L., Cole, P. A., & White, R. J. (2007). TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(38), 14917-14922. doi:10.1073/pnas.0702909104DOI: 10.1073/pnas.0702909104
2006
Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes (Journal article)
Ernens, I., Goodfellow, S. J., Innes, F., Kenneth, N. S., Derblay, L. E., White, R. J., & Scott, P. H. (2006). Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. NUCLEIC ACIDS RESEARCH, 34(1), 286-294. doi:10.1093/nar/gkj402DOI: 10.1093/nar/gkj402
Activation by c-Myc of transcription by RNA polymerases I, II and III (Journal article)
Gomez-Roman, N., Felton-Edkins, Z. A., Kenneth, N. S., Goodfellow, S. J., Athineos, D., Zhang, J. X., . . . White, R. J. (2006). Activation by c-Myc of transcription by RNA polymerases I, II and III. TRANSCRIPTION, 73, 141-154. doi:10.1042/bss0730141DOI: 10.1042/bss0730141
2005
Human La is found at RNA polymerase III-transcribed genes <i>in vivo</i> (Journal article)
Fairley, J. A., Kantidakis, T., Kenneth, N. S., Intine, R. V., Maraia, R. J., & White, R. J. (2005). Human La is found at RNA polymerase III-transcribed genes <i>in vivo</i>. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(51), 18350-18355. doi:10.1073/pnas.0506415102DOI: 10.1073/pnas.0506415102
2003
Direct Regulation of RNA Polymerase III Transcription by RB, p53 and c-Myc (Journal article)
Felton-Edkins, Z. A., Kenneth, N. S., Brown, T. R. P., Daly, N. L., Gomez-Roman, N., Grandori, C., . . . White, R. J. (2003). Direct Regulation of RNA Polymerase III Transcription by RB, p53 and c-Myc. CELL CYCLE, 2(3), 181-184. doi:10.4161/cc.2.3.375DOI: 10.4161/cc.2.3.375
