Dr Leonard Daly BSc

Research Associate Biochemistry, Cell and Systems Biology

+44 (0)151 794 5344 Ext. 5344
Work email Leonard.Daly@liverpool.ac.uk

Publications

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2024

Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs (Journal article)

Omar, M. H., Byrne, D. P., Shrestha, S., Lakey, T. M., Lee, K. -S., Lauer, S. M., . . . Scott, J. D. (2024). Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs. Science Advances, 10(8). doi:10.1126/sciadv.adl1258

DOI: 10.1126/sciadv.adl1258

2023

Custom Workflow for the Confident Identification of Sulfotyrosine-Containing Peptides and Their Discrimination from Phosphopeptides. (Journal article)

Daly, L. A., Byrne, D. P., Perkins, S., Brownridge, P. J., McDonnell, E., Jones, A. R., . . . Eyers, C. E. (2023). Custom Workflow for the Confident Identification of Sulfotyrosine-Containing Peptides and Their Discrimination from Phosphopeptides.. Journal of proteome research, 22(12), 3754-3772. doi:10.1021/acs.jproteome.3c00425

DOI: 10.1021/acs.jproteome.3c00425

Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases. (Journal article)

Venkat, A., Watterson, G., Byrne, D. P., O'Boyle, B., Shrestha, S., Gravel, N., . . . Kannan, N. (2023). Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases.. eLife, 12, RP87958. doi:10.7554/elife.87958

DOI: 10.7554/elife.87958

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases (Journal article)

Venkat, A., Watterson, G., Byrne, D. P., O'Boyle, B., Shrestha, S., Gravel, N., . . . Kannan, N. (n.d.). Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases. eLife, 12. doi:10.7554/elife.87958.3

DOI: 10.7554/elife.87958.3

Considerations for defining+80 Da mass shifts in mass spectrometry-based proteomics: phosphorylation and beyond (Journal article)

Daly, L. A., Clarke, C. J., Po, A., Oswald, S. O., & Eyers, C. E. (2023). Considerations for defining+80 Da mass shifts in mass spectrometry-based proteomics: phosphorylation and beyond. CHEMICAL COMMUNICATIONS, 59(77), 11484-11499. doi:10.1039/d3cc02909c

DOI: 10.1039/d3cc02909c

Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases. (Journal article)

DOI: 10.1101/2023.03.29.534689

A bespoke analytical workflow for the confident identification of sulfopeptides and their discrimination from phosphopeptides (Preprint)

DOI: 10.1101/2023.07.15.549150

Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases (Journal article)

Venkat, A., Watterson, G., Byrne, D. P., O’Boyle, B., Shrestha, S., Gravel, N., . . . Kannan, N. (2023). Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases. doi:10.7554/elife.87958.1

DOI: 10.7554/elife.87958.1

Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2 (Journal article)

Byrne, D. P., Shrestha, S., Daly, L. A., Marensi, V., Ramakrishnan, K., Eyers, C. E., . . . Eyers, P. A. (2023). Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2. BIOCHEMICAL JOURNAL, 480(2), 141-160. doi:10.1042/BCJ20220474

DOI: 10.1042/BCJ20220474

2022

Evolutionary and cellular analysis of the dark pseudokinase PSKH2 (Preprint)

DOI: 10.1101/2022.09.10.507278

Mislocalization of protein kinase A drives pathology in Cushing?s syndrome (Journal article)

Omar, M. H., Byrne, D. P., Jones, K. N., Lakey, T. M., Collins, K. B., Lee, K. -S., . . . Scott, J. D. (2022). Mislocalization of protein kinase A drives pathology in Cushing?s syndrome. CELL REPORTS, 40(2). doi:10.1016/j.celrep.2022.111073

DOI: 10.1016/j.celrep.2022.111073

Mechanism of glycogen synthase inactivation and interaction with glycogenin (Journal article)

Marr, L., Biswas, D., Daly, L. A., Browning, C., Vial, S. C. M., Maskell, D. P., . . . Zeqiraj, E. (2022). Mechanism of glycogen synthase inactivation and interaction with glycogenin. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-31109-6

DOI: 10.1038/s41467-022-31109-6

2021

Displacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing’s syndrome (Preprint)

DOI: 10.1101/2021.10.18.464848

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential (Journal article)

Meyer, B., Chiaravalli, J., Gellenoncourt, S., Brownridge, P., Bryne, D. P., Daly, L. A., . . . Emmott, E. (2021). Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25796-w

DOI: 10.1038/s41467-021-25796-w

Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1 alpha/2 alpha (Journal article)

Daly, L. A., Brownridge, P. J., Batie, M., Rocha, S., See, V., & Eyers, C. E. (2021). Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1 alpha/2 alpha. SCIENCE SIGNALING, 14(692). doi:10.1126/scisignal.abf6685

DOI: 10.1126/scisignal.abf6685

2020

The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity (Journal article)

Albanese, A., Daly, L. A., Mennerich, D., Kietzmann, T., & See, V. (2021). The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(1). doi:10.3390/ijms22010268

DOI: 10.3390/ijms22010268

Oxygen-dependent changes in HIF binding partners and post-translational modifications regulate stability and transcriptional activity (Preprint)

DOI: 10.1101/2020.11.12.379768

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential (Preprint)

DOI: 10.1101/2020.09.16.297945

Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity (Journal article)

Byrne, D. P., Shrestha, S., Galler, M., Cao, M., Daly, L. A., Campbell, A. E., . . . Eyers, P. A. (2020). Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity. Science Signaling, 13(639). doi:10.1126/scisignal.aax2713

DOI: 10.1126/scisignal.aax2713

Identification and characterisation of the post-translational modifications that regulate the Hypoxia Inducible Factors, HIF-1α and HIF-2α. (Thesis / Dissertation)

Daly, L. (2020, January 17). Identification and characterisation of the post-translational modifications that regulate the Hypoxia Inducible Factors, HIF-1α and HIF-2α..