Photo of Dr Joao Pedro De Magalhaes

Dr Joao Pedro De Magalhaes Ph.D.

Senior Lecturer Musculoskeletal Biology II

    Publications

    Selected Publications

    1. How ageing processes influence cancer (Journal article - 2013)
    2. Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes (Journal article - 2012)
    3. Insights into the Evolution of Longevity from the Bowhead Whale Genome (Journal article - 2015)
    4. A network pharmacology approach reveals new candidate caloric restriction mimetics in C-elegans (Journal article - 2015)
    5. Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging (Journal article - 2015)

    2018

    A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging (Journal article)

    de Magalhaes, J. P., Thompson, L., de Lima, I., Gaskill, D., Li, X., Thornton, D., . . . Palmer, D. (2018). A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging. GENETICS, 208(4), 1617-1630. doi:10.1534/genetics.118.300821

    DOI: 10.1534/genetics.118.300821

    A new approach for interpreting Random Forest models and its application to the biology of ageing (Journal article)

    Fabris, F., Doherty, A., Palmer, D., de Magalhaes, J. P., & Freitas, A. A. (2018). A new approach for interpreting Random Forest models and its application to the biology of ageing. BIOINFORMATICS, 34(14), 2449-2456. doi:10.1093/bioinformatics/bty087

    DOI: 10.1093/bioinformatics/bty087

    Biological Processes Modulating Longevity across Primates: A Phylogenetic Genome-Phenome Analysis (Journal article)

    Muntane, G., Farre, X., Rodriguez, J. A., Pegueroles, C., Hughes, D. A., de Magalhaes, J. P., . . . Navarro, A. (2018). Biological Processes Modulating Longevity across Primates: A Phylogenetic Genome-Phenome Analysis. MOLECULAR BIOLOGY AND EVOLUTION, 35(8), 1990-2004. doi:10.1093/molbev/msy105

    DOI: 10.1093/molbev/msy105

    Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome (Journal article)

    Tong, K. -L., Zuhdi, A. S. M., Ahmad, W. A. W., Vanhoutte, P. M., de Magalhaes, J. P., Mustafa, M. R., & Wong, P. -F. (2018). Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(5). doi:10.3390/ijms19051467

    DOI: 10.3390/ijms19051467

    Enhancing Epitranscriptome Module Detection from m(6)A-Seq Data Using Threshold-Based Measurement Weighting Strategy (Journal article)

    Chen, K., Wei, Z., Liu, H., de Magalhaes, J. P., Rong, R., Lu, Z., & Meng, J. (2018). Enhancing Epitranscriptome Module Detection from m(6)A-Seq Data Using Threshold-Based Measurement Weighting Strategy. BIOMED RESEARCH INTERNATIONAL. doi:10.1155/2018/2075173

    DOI: 10.1155/2018/2075173

    From humans to hydra: patterns of cancer across the tree of life (Journal article)

    Albuquerque, T. A. F., do Val, L. D., Doherty, A., & de Magalhaes, J. P. (2018). From humans to hydra: patterns of cancer across the tree of life. BIOLOGICAL REVIEWS, 93(3), 1715-1734. doi:10.1111/brv.12415

    DOI: 10.1111/brv.12415

    Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence (Journal article)

    Zhao, Y., Tyshkovskiy, A., Munoz-Espin, D., Tian, X., Serrano, M., de Magalhaes, J. P., . . . Gorbunova, V. (2018). Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(8), 1801-1806. doi:10.1073/pnas.1721160115

    DOI: 10.1073/pnas.1721160115

    Topological Characterization of Human and Mouse m(5)C Epitranscriptome Revealed by Bisulfite Sequencing (Journal article)

    Wei, Z., Panneerdoss, S., Timilsina, S., Zhu, J., Mohammad, T. A., Lu, Z. -L., . . . Meng, J. (2018). Topological Characterization of Human and Mouse m(5)C Epitranscriptome Revealed by Bisulfite Sequencing. INTERNATIONAL JOURNAL OF GENOMICS. doi:10.1155/2018/1351964

    DOI: 10.1155/2018/1351964

    Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization. (Journal article)

    Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., . . . Zhavoronkov, A. (2018). Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.. Oncotarget, 9(18), 14692-14722. doi:10.18632/oncotarget.24461

    DOI: 10.18632/oncotarget.24461

    2017

    A review of supervised machine learning applied to ageing research (Journal article)

    Fabris, F., de Magalhes, J. P., & Freitas, A. A. (2017). A review of supervised machine learning applied to ageing research. BIOGERONTOLOGY, 18(2), 171-188. doi:10.1007/s10522-017-9683-y

    DOI: 10.1007/s10522-017-9683-y

    Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans (Journal article)

    Nam, K., Lee, K. W., Chung, O., Yim, H. -S., Cha, S. -S., Lee, S. -W., . . . Jeong, J. -Y. (2017). Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans. SCIENTIFIC REPORTS, 7. doi:10.1038/srep40233

    DOI: 10.1038/srep40233

    Gene co-expression analysis for functional classification and gene-disease predictions. (Journal article)

    van Dam, S., Vosa, U., van der Graaf, A., Franke, L., & de Magalhaes, J. P. (2018). Gene co-expression analysis for functional classification and gene-disease predictions. BRIEFINGS IN BIOINFORMATICS, 19(4), 575-592. doi:10.1093/bib/bbw139

    DOI: 10.1093/bib/bbw139

    Human Ageing Genomic Resources: new and updated databases (Journal article)

    Tacutu, R., Thornton, D., Johnson, E., Budovsky, A., Barardo, D., Craig, T., . . . de Magalhaes, J. P. (2018). Human Ageing Genomic Resources: new and updated databases. NUCLEIC ACIDS RESEARCH, 46(D1), D1083-D1090. doi:10.1093/nar/gkx1042

    DOI: 10.1093/nar/gkx1042

    Identification of polymorphisms in cancer patients that differentially affect survival with age (Journal article)

    Doherty, A., Kernogitski, Y., Kulminski, A. M., & de Magalhaes, J. P. (2017). Identification of polymorphisms in cancer patients that differentially affect survival with age. AGING-US, 9(10), 2114-+. doi:10.18632/aging.101305

    DOI: 10.18632/aging.101305

    Machine learning for predicting lifespan-extending chemical compounds (Journal article)

    Barardo, D. G., Newby, D., Thornton, D., Ghafourian, T., de Magalhaes, J. P., & Freitas, A. A. (2017). Machine learning for predicting lifespan-extending chemical compounds. AGING-US, 9(7), 1721-1737. doi:10.18632/aging.101264

    DOI: 10.18632/aging.101264

    Stress, cell senescence and organismal ageing (Journal article)

    de Magalhaes, J. P., & Passos, J. F. (2018). Stress, cell senescence and organismal ageing. MECHANISMS OF AGEING AND DEVELOPMENT, 170, 2-9. doi:10.1016/j.mad.2017.07.001

    DOI: 10.1016/j.mad.2017.07.001

    The Business of Anti-Aging Science (Journal article)

    de Magalhaes, J. P., Stevens, M., & Thornton, D. (2017). The Business of Anti-Aging Science. TRENDS IN BIOTECHNOLOGY, 35(11), 1062-1073. doi:10.1016/j.tibtech.2017.07.004

    DOI: 10.1016/j.tibtech.2017.07.004

    The DrugAge database of aging-related drugs. (Journal article)

    Barardo, D., Thornton, D., Thoppil, H., Walsh, M., Sharifi, S., Ferreira, S., . . . de Magalhaes, J. P. (2017). The DrugAge database of aging-related drugs. AGING CELL, 16(3), 594-597. doi:10.1111/acel.12585

    DOI: 10.1111/acel.12585

    2016

    A direct communication proposal to test the Zoo Hypothesis (Journal article)

    de Magalhaes, J. P. (2016). A direct communication proposal to test the Zoo Hypothesis. SPACE POLICY, 38, 22-26. doi:10.1016/j.spacepol.2016.06.001

    DOI: 10.1016/j.spacepol.2016.06.001

    Fish oil supplements, longevity and aging (Journal article)

    de Magalhaes, J. P., Mueller, M., Rainger, G. E., & Steegenga, W. (2016). Fish oil supplements, longevity and aging. AGING-US, 8(8), 1578-1582. doi:10.18632/aging.101021

    DOI: 10.18632/aging.101021

    Has gene duplication impacted the evolution of Eutherian longevity? (Journal article)

    Doherty, A., & de Magalhaes, J. P. (2016). Has gene duplication impacted the evolution of Eutherian longevity?. AGING CELL, 15(5), 978-980. doi:10.1111/acel.12503

    DOI: 10.1111/acel.12503

    Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an -glucosidase inhibitor or a Nrf2-inducer (Journal article)

    Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., . . . Harrison, D. E. (2016). Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an -glucosidase inhibitor or a Nrf2-inducer. AGING CELL, 15(5), 872-884. doi:10.1111/acel.12496

    DOI: 10.1111/acel.12496

    Reductions in hypothalamic Gfap expression, glial cells and alpha-tanycytes in lean and hypermetabolic Gnasxl-deficient mice (Journal article)

    Holmes, A. P., Wong, S. Q., Pulix, M., Johnson, K., Horton, N. S., Thomas, P., . . . Plagge, A. (2016). Reductions in hypothalamic Gfap expression, glial cells and alpha-tanycytes in lean and hypermetabolic Gnasxl-deficient mice. MOLECULAR BRAIN, 9. doi:10.1186/s13041-016-0219-1

    DOI: 10.1186/s13041-016-0219-1

    Systematic analysis of the gerontome reveals links between aging and age-related diseases. (Journal article)

    Fernandes, M., Wan, C., Tacutu, R., Barardo, D., Rajput, A., Wang, J., . . . de Magalhaes, J. P. (2016). Systematic analysis of the gerontome reveals links between aging and age-related diseasesSystematic analysis of the gerontome reveals links between aging and age-related diseases. HUMAN MOLECULAR GENETICS, 25(21), 4804-4818. doi:10.1093/hmg/ddw307

    Systematic analysis of the gerontome reveals links between aging and age-related diseases. (Journal article)

    Fernandes, M., Wan, C., Tacutu, R., Barardo, D., Rajput, A., Wang, J., . . . de Magalhães, J. P. (2016). Systematic analysis of the gerontome reveals links between aging and age-related diseases.. Human molecular genetics, 25(21), 4804-4818. doi:10.1093/hmg/ddw307

    2015

    A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels (Journal article)

    Monaco, G., van Dam, S., Ribeiro, J. L. C. N., Larbi, A., & de Magalhaes, J. P. (2015). A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels. BMC EVOLUTIONARY BIOLOGY, 15. doi:10.1186/s12862-015-0534-7

    DOI: 10.1186/s12862-015-0534-7

    A network pharmacology approach reveals new candidate caloric restriction mimetics in C-elegans (Journal article)

    Calvert, S., Tacutu, R., Sharifi, S., Teixeira, R., Ghosh, P., & de Magalhaes, J. P. (2016). A network pharmacology approach reveals new candidate caloric restriction mimetics in C-elegans. AGING CELL, 15(2), 256-266. doi:10.1111/acel.12432

    DOI: 10.1111/acel.12432

    Being cool: how body temperature influences ageing and longevity (Journal article)

    Keil, G., Cummings, E., & de Magalhaes, J. P. (2015). Being cool: how body temperature influences ageing and longevity. BIOGERONTOLOGY, 16(4), 383-397. doi:10.1007/s10522-015-9571-2

    DOI: 10.1007/s10522-015-9571-2

    Dissecting the role of microRNAs and their therapeutic potential in Alzheimer's disease (Conference Paper)

    Viegas, A. T., Carmona, V., Pereira de Almeida, L., de Magalhaes, J. P., Cardoso, A. L., & Grp, V. G. T. (2015). Dissecting the role of microRNAs and their therapeutic potential in Alzheimer's disease. In FEBS JOURNAL Vol. 282 (pp. 217). Retrieved from http://gateway.webofknowledge.com/

    GeneFriends: a human RNA-seq-based gene and transcript co-expression database (Journal article)

    van Dam, S., Craig, T., & de Magalhaes, J. P. (2015). GeneFriends: a human RNA-seq-based gene and transcript co-expression database. NUCLEIC ACIDS RESEARCH, 43(D1), D1124-D1132. doi:10.1093/nar/gku1042

    DOI: 10.1093/nar/gku1042

    Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease (Journal article)

    Moskalev, A., Chernyagina, E., de Magalhaes, J. P., Barardo, D., Thoppil, H., Shaposhnikov, M., . . . Zhavoronkov, A. (2015). Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. AGING-US, 7(9), 616-628. doi:10.18632/aging.100799

    DOI: 10.18632/aging.100799

    Insights into the Evolution of Longevity from the Bowhead Whale Genome (Journal article)

    Keane, M., Semeiks, J., Webb, A. E., Li, Y. I., Quesada, V., Craig, T., . . . de Magalhaes, J. P. (2015). Insights into the Evolution of Longevity from the Bowhead Whale Genome. CELL REPORTS, 10(1), 112-122. doi:10.1016/j.celrep.2014.12.008

    DOI: 10.1016/j.celrep.2014.12.008

    Insights on cryoprotectant toxicity from gene expression profiling of endothelial cells exposed to ethylene glycol (Journal article)

    Cordeiro, R. M., Stirling, S., Fahy, G. M., & de Magalhaes, J. P. (2015). Insights on cryoprotectant toxicity from gene expression profiling of endothelial cells exposed to ethylene glycol. CRYOBIOLOGY, 71(3), 405-412. doi:10.1016/j.cryobiol.2015.10.142

    DOI: 10.1016/j.cryobiol.2015.10.142

    Integrative Genomics of Aging (Chapter)

    De Magalhães, J. P., & Tacutu, R. (2015). Integrative Genomics of Aging. In Handbook of the Biology of Aging: Eighth Edition (pp. 263-285). doi:10.1016/B978-0-12-411596-5.00009-5

    DOI: 10.1016/B978-0-12-411596-5.00009-5

    Mathematical Study of Mortality Dynamics in Heterogeneous Population Composed of Subpopulations Following the Exponential Law (Journal article)

    Arnold (-Gaille), S., Vasiev, B., Avraam, D., & de Magalhaes, J. P. (2015). Mathematical Study of Mortality Dynamics in Heterogeneous Population Composed of Subpopulations Following the Exponential Law.

    Meet the Editorial Board Members. (Journal article)

    de Magalhães, J. P., & Pandey, G. K. (2015). Meet the Editorial Board Members.. Current Genomics, 16(3), 139-140. doi:10.2174/138920291603150409100245

    DOI: 10.2174/138920291603150409100245

    The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource (Journal article)

    Craig, T., Smelick, C., Tacutu, R., Wuttke, D., Wood, S. H., Stanley, H., . . . de Magalhaes, J. P. (2015). The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource. NUCLEIC ACIDS RESEARCH, 43(D1), D873-D878. doi:10.1093/nar/gku843

    DOI: 10.1093/nar/gku843

    The big, the bad and the ugly Extreme animals as inspiration for biomedical research (Journal article)

    de Magalhaes, J. P. (2015). The big, the bad and the ugly Extreme animals as inspiration for biomedical research. EMBO REPORTS, 16(7), 771-776. doi:10.15252/embr.201540606

    DOI: 10.15252/embr.201540606

    Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging (Journal article)

    Wood, S. H., van Dam, S., Craig, T., Tacutu, R., O'Toole, A., Merry, B. J., & de Magalhaes, J. P. (2015). Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging. GENOME BIOLOGY, 16. doi:10.1186/s13059-015-0847-2

    DOI: 10.1186/s13059-015-0847-2

    2014

    The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations (Journal article)

    Keane, M., Craig, T., Alfoeldi, J., Berlin, A. M., Johnson, J., Seluanov, A., . . . de Magalhaes, J. P. (2014). The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. BIOINFORMATICS, 30(24), 3558-3560. doi:10.1093/bioinformatics/btu579

    DOI: 10.1093/bioinformatics/btu579

    The Scientific Quest for Lasting Youth: Prospects for Curing Aging (Journal article)

    de Magalhaes, J. P. (2014). The Scientific Quest for Lasting Youth: Prospects for Curing Aging. REJUVENATION RESEARCH, 17(5), 458-467. doi:10.1089/rej.2014.1580

    DOI: 10.1089/rej.2014.1580

    Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research (Journal article)

    de Magalhaes, J. P. (2014). Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research. CELL CYCLE, 13(17), 2671-2673. doi:10.4161/15384101.2014.950151

    DOI: 10.4161/15384101.2014.950151

    2013

    A mathematical model of mortality dynamics across the lifespan combining heterogeneity and stochastic effects (Journal article)

    Avraam, D., de Magalhaes, J. P., & Vasiev, B. (2013). A mathematical model of mortality dynamics across the lifespan combining heterogeneity and stochastic effects. EXPERIMENTAL GERONTOLOGY, 48(8), 801-811. doi:10.1016/j.exger.2013.05.054

    DOI: 10.1016/j.exger.2013.05.054

    A mathematical model of mortality dynamics across the lifespan combining heterogeneity and stochastic effects (Journal article)

    Avraam, D., de Magalhaes, J. P., & Vasiev, B. (2013). A mathematical model of mortality dynamics across the lifespan combining heterogeneity and stochastic effects. Experimental Gerontology, 48(8), 801-811. doi:10.1016/j.exger.2013.05.054

    DOI: 10.1016/j.exger.2013.05.054

    A-to-I RNA editing does not change with age in the healthy male rat brain (Journal article)

    Holmes, A. P., Wood, S. H., Merry, B. J., & de Magalhaes, J. P. (2013). A-to-I RNA editing does not change with age in the healthy male rat brain. BIOGERONTOLOGY, 14(4), 395-400. doi:10.1007/s10522-013-9433-8

    DOI: 10.1007/s10522-013-9433-8

    Accelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevity (Journal article)

    Li, Y., & de Magalhaes, J. P. (2013). Accelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevity. AGE, 35(2), 301-314. doi:10.1007/s11357-011-9361-y

    DOI: 10.1007/s11357-011-9361-y

    An analysis and validation pipeline for large-scale RNAi-based screens (Journal article)

    Plank, M., Hu, G., Silva, A. S., Wood, S. H., Hesketh, E. E., Janssens, G., . . . Church, G. M. (2013). An analysis and validation pipeline for large-scale RNAi-based screens. SCIENTIFIC REPORTS, 3. doi:10.1038/srep01076

    DOI: 10.1038/srep01076

    Endless paces of degeneration-applying comparative genomics to study evolution's moulding of longevity (Journal article)

    de Magalhaes, J. P., & Keane, M. (2013). Endless paces of degeneration-applying comparative genomics to study evolution's moulding of longevity. EMBO REPORTS, 14(8), 661-662. doi:10.1038/embor.2013.96

    DOI: 10.1038/embor.2013.96

    How ageing processes influence cancer (Journal article)

    de Magalhaes, J. P. (2013). How ageing processes influence cancer. NATURE REVIEWS CANCER, 13(5), 357-365. doi:10.1038/nrc3497

    DOI: 10.1038/nrc3497

    Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing (Journal article)

    Tacutu, R., Craig, T., Budovsky, A., Wuttke, D., Lehmann, G., Taranukha, D., . . . de Magalhaes, J. P. (2013). Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing. NUCLEIC ACIDS RESEARCH, 41(D1), D1027-D1033. doi:10.1093/nar/gks1155

    DOI: 10.1093/nar/gks1155

    LongevityMap: a database of human genetic variants associated with longevity (Journal article)

    Budovsky, A., Craig, T., Wang, J., Tacutu, R., Csordas, A., Lourenco, J., . . . de Magalhaes, J. P. (2013). LongevityMap: a database of human genetic variants associated with longevity. TRENDS IN GENETICS, 29(10), 559-560. doi:10.1016/j.tig.2013.08.003

    DOI: 10.1016/j.tig.2013.08.003

    MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging (Journal article)

    Keane, M., & de Magalhaes, J. P. (2013). MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging. MECHANISMS OF AGEING AND DEVELOPMENT, 134(7-8), 346-348. doi:10.1016/j.mad.2013.04.006

    DOI: 10.1016/j.mad.2013.04.006

    Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome (Journal article)

    Wood, S. H., Craig, T., Li, Y., Merry, B., & de Magalhães, J. P. (2013). Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome.

    2012

    A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms (Journal article)

    Plank, M., Wuttke, D., van Dam, S., Clarkea, S. A., & de Magalhaes, J. P. (2012). A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms. MOLECULAR BIOSYSTEMS, 8(4), 1339-1349. doi:10.1039/c2mb05255e

    DOI: 10.1039/c2mb05255e

    Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes (Journal article)

    Wuttke, D., Connor, R., Vora, C., Craig, T., Li, Y., Wood, S., . . . de Magalhaes, J. P. (2012). Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes. PLOS GENETICS, 8(8). doi:10.1371/journal.pgen.1002834

    DOI: 10.1371/journal.pgen.1002834

    Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes (Journal article)

    Wuttke, D., Connor, R., Vora, C., Craig, T., Li, Y., Wood, S., . . . de Magalhães, J. P. (2012). Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.

    GeneFriends: An online co-expression analysis tool to identify novel gene targets for aging and complex diseases (Journal article)

    van Dam, S., Cordeiro, R., Craig, T., van Dam, J., Wood, S. H., & de Magalhaes, J. P. (2012). GeneFriends: An online co-expression analysis tool to identify novel gene targets for aging and complex diseases. BMC GENOMICS, 13. doi:10.1186/1471-2164-13-535

    DOI: 10.1186/1471-2164-13-535

    Genome-Wide Patterns of Genetic Distances Reveal Candidate Loci Contributing to Human Population-Specific Traits (Journal article)

    de Magalhaes, J. P., & Matsuda, A. (2012). Genome-Wide Patterns of Genetic Distances Reveal Candidate Loci Contributing to Human Population-Specific Traits. ANNALS OF HUMAN GENETICS, 76, 142-158. doi:10.1111/j.1469-1809.2011.00695.x

    DOI: 10.1111/j.1469-1809.2011.00695.x

    Genome-environment interactions that modulate aging: powerful targets for drug discovery (Journal article)

    de Magalhães, J. P., Wuttke, D., Wood, S. H., Plank, M., & Vora, C. (2012). Genome-environment interactions that modulate aging: powerful targets for drug discovery.

    Mutational Bias Plays an Important Role in Shaping Longevity-Related Amino Acid Content in Mammalian mtDNA-Encoded Proteins (Journal article)

    Carlos Aledo, J., Valverde, H., & de Magalhaes, J. P. (2012). Mutational Bias Plays an Important Role in Shaping Longevity-Related Amino Acid Content in Mammalian mtDNA-Encoded Proteins. JOURNAL OF MOLECULAR EVOLUTION, 74(5-6), 332-341. doi:10.1007/s00239-012-9510-7

    DOI: 10.1007/s00239-012-9510-7

    Osh6 links yeast vacuolar functions to lifespan extension and TOR (Journal article)

    Wuttke, D., & de Magalhaes, J. P. (2012). Osh6 links yeast vacuolar functions to lifespan extension and TOR. CELL CYCLE, 11(13), 2419-2420. doi:10.4161/cc.21069

    DOI: 10.4161/cc.21069

    Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks (Journal article)

    Tacutu, R., Shore, D. E., Budovsky, A., de Magalhaes, J. P., Ruvkun, G., Fraifeld, V. E., & Curran, S. P. (2012). Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PLOS ONE, 7(10). doi:10.1371/journal.pone.0048282

    DOI: 10.1371/journal.pone.0048282

    Programmatic features of aging originating in development: aging mechanisms beyond molecular damage? (Journal article)

    de Magalhaes, J. P. (2012). Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?. FASEB JOURNAL, 26(12), 4821-4826. doi:10.1096/fj.12-210872

    DOI: 10.1096/fj.12-210872

    The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease (Journal article)

    Johnson, A. A., Akman, K., Calimport, S. R. G., Wuttke, D., Stolzing, A., & de Magalhaes, J. P. (2012). The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease. REJUVENATION RESEARCH, 15(5), 483-494. doi:10.1089/rej.2012.1324

    DOI: 10.1089/rej.2012.1324

    Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome (Journal article)

    Wood, S. H., Craig, T., Li, Y., Merry, B., & de Magalhaes, J. P. (2013). Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome. AGE, 35(3), 763-776. doi:10.1007/s11357-012-9410-1

    DOI: 10.1007/s11357-012-9410-1

    2011

    A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related (Journal article)

    Freitas, A. A., Vasieva, O., & de Magalhaes, J. P. (2011). A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related. BMC GENOMICS, 12. doi:10.1186/1471-2164-12-27

    DOI: 10.1186/1471-2164-12-27

    A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related (Journal article)

    Freitas, A. A., Vasieva, O., & de Magalhães, J. P. (2011). A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related. BMC Genomics, 12(1). doi:10.1186/1471-2164-12-27

    DOI: 10.1186/1471-2164-12-27

    A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related (Journal article)

    Freitas, A. A., Vasieva, O., & de Magalhaes, J. P. (2011). A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related. BMC Genomics.

    A review and appraisal of the DNA damage theory of ageing (Journal article)

    Freitas, A. A., & de Magalhaes, J. P. (2011). A review and appraisal of the DNA damage theory of ageing. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 728(1-2), 12-22. doi:10.1016/j.mrrev.2011.05.001

    DOI: 10.1016/j.mrrev.2011.05.001

    A role for Ras signaling in modulating mammalian aging by the GH/IGF1 axis (Journal article)

    de Magalhaes, J. P. (2011). A role for Ras signaling in modulating mammalian aging by the GH/IGF1 axis. AGING-US, 3(4), 336-337. doi:10.18632/aging.100309

    DOI: 10.18632/aging.100309

    Gathering insights on disease etiology from gene expression profiles of healthy tissues (Journal article)

    Silva, A. S., Wood, S. H., van Dam, S., Berres, S., McArdle, A., & de Magalhaes, J. P. (2011). Gathering insights on disease etiology from gene expression profiles of healthy tissues. BIOINFORMATICS, 27(23), 3300-3305. doi:10.1093/bioinformatics/btr559

    DOI: 10.1093/bioinformatics/btr559

    Gathering insights on disease etiology from gene expression profiles of healthy tissues (Journal article)

    Silva, A. S., Wood, S. H., van Dam, S., Berres, S., McArdle, A., & de Magalhães, J. P. (2011). Gathering insights on disease etiology from gene expression profiles of healthy tissues. Bioinformatics, 27(23), 3300-3305. doi:10.1093/bioinformatics/btr559

    DOI: 10.1093/bioinformatics/btr559

    Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery (Journal article)

    de Magalhaes, J. P., Wuttke, D., Wood, S. H., Plank, M., & Vora, C. (2012). Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery. PHARMACOLOGICAL REVIEWS, 64(1), 88-101. doi:10.1124/pr.110.004499

    DOI: 10.1124/pr.110.004499

    Mitochondrially encoded methionine is inversely related to longevity in mammals (Journal article)

    Carlos Aledo, J., Li, Y., Pedro de Magalhaes, J., Ruiz-Camacho, M., & Antonio Perez-Claros, J. (2011). Mitochondrially encoded methionine is inversely related to longevity in mammals. AGING CELL, 10(2), 198-207. doi:10.1111/j.1474-9726.2010.00657.x

    DOI: 10.1111/j.1474-9726.2010.00657.x

    Paternal genome effects on aging: Evidence for a role of Rasgrf1 in longevity determination? (Journal article)

    de Magalhaes, J. P. (2011). Paternal genome effects on aging: Evidence for a role of Rasgrf1 in longevity determination?. MECHANISMS OF AGEING AND DEVELOPMENT, 132(1-2), 72-73. doi:10.1016/j.mad.2010.11.004

    DOI: 10.1016/j.mad.2010.11.004

    RNA Sequencing Reveals Differential Expression of Mitochondrial and Oxidation Reduction Genes in the Long-Lived Naked Mole-Rat When Compared to Mice (Journal article)

    Yu, C., Li, Y., Holmes, A., Szafranski, K., Faulkes, C. G., Coen, C. W., . . . Church, G. M. (2011). RNA Sequencing Reveals Differential Expression of Mitochondrial and Oxidation Reduction Genes in the Long-Lived Naked Mole-Rat When Compared to Mice. PLOS ONE, 6(11). doi:10.1371/journal.pone.0026729

    DOI: 10.1371/journal.pone.0026729

    The Biology of Ageing: A Primer (Chapter)

    de Magalhães, J. P. (2011). The Biology of Ageing: A Primer. In I. Stuart-Hamilton (Ed.), An Introduction to Gerontology (pp. 21-47). Cambridge: Cambridge University Press,.

    The biology of ageing: A primer (Chapter)

    De Magalhães, J. P. (2011). The biology of ageing: A primer. In An Introduction to Gerontology (pp. 24-47). doi:10.1017/CBO9780511973697.002

    DOI: 10.1017/CBO9780511973697.002

    2010

    Age-related gene-specific changes of A-to-I mRNA editing in the human brain (Journal article)

    Nicholas, A., de Magalhaes, J. P., Kraytsberg, Y., Richfield, E. K., Levanon, E. Y., & Khrapko, K. (2010). Age-related gene-specific changes of A-to-I mRNA editing in the human brain. MECHANISMS OF AGEING AND DEVELOPMENT, 131(6), 445-447. doi:10.1016/j.mad.2010.06.001

    DOI: 10.1016/j.mad.2010.06.001

    Bioinformatics in aging research: a workshop report. (Conference Paper)

    Fuellen, G., Adjaye, J., de Grey, A., Lepperdinger, G., de Magalhães, J. P., Sühnel, J., & Wipat, A. (2010). Bioinformatics in aging research: a workshop report.. In Rejuvenation research Vol. 13 (pp. 763-767). doi:10.1089/rej.2010.1125

    DOI: 10.1089/rej.2010.1125

    Cell resilience in species life spans: a link to inflammation? (Journal article)

    Finch, C. E., Morgan, T. E., Longo, V. D., & de Magalhaes, J. P. (2010). Cell resilience in species life spans: a link to inflammation?. AGING CELL, 9(4), 519-526. doi:10.1111/j.1474-9726.2010.00578.x

    DOI: 10.1111/j.1474-9726.2010.00578.x

    Cell resilience in species life spans: a link to inflammation? (Journal article)

    Finch, C. E., Morgan, T. E., Longo, V. D., & de Magalhaes, J. P. (2010). Cell resilience in species life spans: a link to inflammation?. Aging cell, 9(4), 519-526.

    Ecological, biomedical and epidemiological approaches to understanding oxidative balance and ageing: what they can teach each other (Journal article)

    Cohen, A. A., de Magalhaes, J. P., & Gohil, K. (2010). Ecological, biomedical and epidemiological approaches to understanding oxidative balance and ageing: what they can teach each other. FUNCTIONAL ECOLOGY, 24(5), 997-1006. doi:10.1111/j.1365-2435.2010.01761.x

    DOI: 10.1111/j.1365-2435.2010.01761.x

    Next-generation sequencing in aging research: Emerging applications, problems, pitfalls and possible solutions (Journal article)

    de Magalhaes, J. P., Finch, C. E., & Janssens, G. (2010). Next-generation sequencing in aging research: Emerging applications, problems, pitfalls and possible solutions. AGEING RESEARCH REVIEWS, 9(3), 315-323. doi:10.1016/j.arr.2009.10.006

    DOI: 10.1016/j.arr.2009.10.006

    Systems Biology and Longevity: An Emerging Approach to Identify Innovative Anti-Aging Targets and Strategies (Journal article)

    Cevenini, E., Bellavista, E., Tieri, P., Castellani, G., Lescai, F., Francesconi, M., . . . Franceschi, C. (2010). Systems Biology and Longevity: An Emerging Approach to Identify Innovative Anti-Aging Targets and Strategies. CURRENT PHARMACEUTICAL DESIGN, 16(7), 802-813. doi:10.2174/138161210790883660

    DOI: 10.2174/138161210790883660

    2009

    A database of vertebrate longevity records and their relation to other life-history traits (Journal article)

    de Magalhaes, J. P., & Costa, J. (2009). A database of vertebrate longevity records and their relation to other life-history traits. JOURNAL OF EVOLUTIONARY BIOLOGY, 22(8), 1770-1774. doi:10.1111/j.1420-9101.2009.01783.x

    DOI: 10.1111/j.1420-9101.2009.01783.x

    Ageing research in the post-genome era: new technologies for an old problem. (Journal article)

    de Magalhães, J. P. (2009). Ageing research in the post-genome era: new technologies for an old problem.. SEB experimental biology series, 62, 99-115.

    Meta-analysis of age-related gene expression profiles identifies common signatures of aging (Journal article)

    de Magalhaes, J. P., Curado, J., & Church, G. M. (2009). Meta-analysis of age-related gene expression profiles identifies common signatures of aging. BIOINFORMATICS, 25(7), 875-881. doi:10.1093/bioinformatics/btp073

    DOI: 10.1093/bioinformatics/btp073

    Meta-analysis of age-related gene expression profiles identifies common signatures of aging (Journal article)

    de Magalhães, J. P., Curado, J., & Church, G. M. (2009). Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics.

    The Human Ageing Genomic Resources: online databases and tools for biogerontologists (Journal article)

    de Magalhaes, J. P., Budovsky, A., Lehmann, G., Costa, J., Li, Y., Fraifeld, V., & Church, G. M. (2009). The Human Ageing Genomic Resources: online databases and tools for biogerontologists. AGING CELL, 8(1), 65-72. doi:10.1111/j.1474-9726.2008.00442.x

    DOI: 10.1111/j.1474-9726.2008.00442.x

    The Human Ageing Genomic Resources: online databases and tools for biogerontologists (Journal article)

    de Magalhães, J. P., Budovsky, A., Lehmann, G., Costa, J., Li, Y., Fraifeld, V., & Church, G. M. (2009). The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell, 8(1), 65-72. doi:10.1111/j.1474-9726.2008.00442.x

    DOI: 10.1111/j.1474-9726.2008.00442.x

    2008

    Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity (Journal article)

    de Magalhaes, J. P., & Faragher, R. G. A. (2008). Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. BIOESSAYS, 30(6), 567-578. doi:10.1002/bies.20760

    DOI: 10.1002/bies.20760

    2007

    A proposal to sequence genomes of unique interest for research on aging (Journal article)

    de Magalhaes, J. P., Sedivy, J. M., Finch, C. E., Austad, S. N., & Church, G. M. (2007). A proposal to sequence genomes of unique interest for research on aging. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 62(6), 583-584. Retrieved from http://gateway.webofknowledge.com/

    An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts (Journal article)

    de Magalhaes, J. P., Costa, J., & Church, G. M. (2007). An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 62(2), 149-160. Retrieved from http://gateway.webofknowledge.com/

    2006

    Cells discover fire: Employing reactive oxygen species in development and consequences for aging (Journal article)

    de Magalhaes, J. P., & Church, G. (2006). Cells discover fire: Employing reactive oxygen species in development and consequences for aging. EXPERIMENTAL GERONTOLOGY, 41(1), 1-10. doi:10.1016/j.exger.2005.09.002

    DOI: 10.1016/j.exger.2005.09.002

    Species Selection in Comparative Studies of Aging and Antiaging Research (Chapter)

    de Magalhães, J. P. (2006). Species Selection in Comparative Studies of Aging and Antiaging Research. In Handbook of Models for Human Aging (pp. 9-20). doi:10.1016/B978-012369391-4/50003-5

    DOI: 10.1016/B978-012369391-4/50003-5

    2005

    Cognitive aging as an extension of brain development: A model linking learning, brain plasticity, and neurodegeneration (Journal article)

    de Magalhaes, J. P., & Sandberg, A. (2005). Cognitive aging as an extension of brain development: A model linking learning, brain plasticity, and neurodegeneration. MECHANISMS OF AGEING AND DEVELOPMENT, 126(10), 1026-1033. doi:10.1016/j.mad.2005.04.004

    DOI: 10.1016/j.mad.2005.04.004

    Genomes optimize reproduction: Aging as a consequence of the developmental program (Journal article)

    de Magalhaes, J. P., & Church, G. M. (2005). Genomes optimize reproduction: Aging as a consequence of the developmental program. PHYSIOLOGY, 20, 252-259. doi:10.1152/physiol.00010.2005

    DOI: 10.1152/physiol.00010.2005

    Human disease-associated mitochondrial mutations fixed in nonhuman primates (Journal article)

    de Magalhaes, J. P. (2005). Human disease-associated mitochondrial mutations fixed in nonhuman primates. JOURNAL OF MOLECULAR EVOLUTION, 61(4), 491-497. doi:10.1007/s00239-004-0258-6

    DOI: 10.1007/s00239-004-0258-6

    Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations (Journal article)

    de Magalhaes, J. P. (2005). Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations. AGEING RESEARCH REVIEWS, 4(1), 1-22. doi:10.1016/j.arr.2004.05.003

    DOI: 10.1016/j.arr.2004.05.003

    The influence of genes on the aging process of mice: A statistical assessment of the genetics of aging (Journal article)

    de Magalhaes, J. P., Cabral, J. A. S., & Magalhaes, D. (2005). The influence of genes on the aging process of mice: A statistical assessment of the genetics of aging. GENETICS, 169(1), 265-274. doi:10.1534/genetics.104.032292

    DOI: 10.1534/genetics.104.032292

    2004

    Alice's dilemma (Journal article)

    de Magalhaes, J. P. (2004). Alice's dilemma. FUTURES, 36(1), 85-89. doi:10.1016/S0016-3287(03)00141-1

    DOI: 10.1016/S0016-3287(03)00141-1

    From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing (Journal article)

    de Magalhaes, J. P. (2004). From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. EXPERIMENTAL CELL RESEARCH, 300(1), 1-10. doi:10.1016/j.yexcr.2004.07.006

    DOI: 10.1016/j.yexcr.2004.07.006

    GenAge: a genomic and proteomic network map of human ageing (Journal article)

    de Magalhaes, J. P., & Toussaint, O. (2004). GenAge: a genomic and proteomic network map of human ageing. FEBS LETTERS, 571(1-3), 243-247. doi:10.1016/j.febslet.2004.07.006

    DOI: 10.1016/j.febslet.2004.07.006

    Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase (Journal article)

    de Magalhaes, J. P., Chainiaux, F., de Longueville, F., Mainfroid, V., Migeot, V., Marcq, L., . . . Toussaint, O. (2004). Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. EXPERIMENTAL GERONTOLOGY, 39(9), 1379-1389. doi:10.1016/j.exger.2004.06.004

    DOI: 10.1016/j.exger.2004.06.004

    HAGR: the human ageing genomic resources (Journal article)

    de Magalhaes, J. P., Costa, J., & Toussaint, O. (2005). HAGR: the human ageing genomic resources. NUCLEIC ACIDS RESEARCH, 33, D537-D543. doi:10.1093/nar/gki017

    DOI: 10.1093/nar/gki017

    How bioinformatics can help reverse engineer human aging (Journal article)

    de Magalhaes, J. P., & Toussaint, O. (2004). How bioinformatics can help reverse engineer human aging. AGEING RESEARCH REVIEWS, 3(2), 125-141. doi:10.1016/j.arr.2003.08.006

    DOI: 10.1016/j.arr.2003.08.006

    No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2 (Journal article)

    de Magalhaes, J. P., Migeot, V., Mainfroid, V., de Longueville, F., Remacle, J., & Toussaint, O. (2004). No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2. STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE, 1019, 375-378. doi:10.1196/annals.1297.066

    DOI: 10.1196/annals.1297.066

    Telomeres and telomerase: A modern fountain of youth? (Journal article)

    de Magalhaes, J. P., & Toussaint, O. (2004). Telomeres and telomerase: A modern fountain of youth?. REJUVENATION RESEARCH, 7(2), 126-133. doi:10.1089/1549168041553044

    DOI: 10.1089/1549168041553044

    2003

    Is mammalian aging genetically controlled? (Journal article)

    de Magalhaes, J. P. (2003). Is mammalian aging genetically controlled?. BIOGERONTOLOGY, 4(2), 119-120. doi:10.1023/A:1023356005749

    DOI: 10.1023/A:1023356005749

    Winning the war against aging (Journal article)

    de Magalhaes, J. P. (2003). Winning the war against aging. FUTURIST, 37(2), 48-50. Retrieved from http://gateway.webofknowledge.com/

    2002

    From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing (Journal article)

    Toussaint, O., Remacle, J., Dierick, J. F., Pascal, T., Frippiat, C., Zdanov, S., . . . Chainiaux, F. (2002). From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 34(11), 1415-1429. doi:10.1016/S1357-2725(02)00034-1

    DOI: 10.1016/S1357-2725(02)00034-1

    Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts (Journal article)

    de Magalhaes, J. P., Chainiaux, F., Remacle, J., & Toussaint, O. (2002). Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts. FEBS LETTERS, 523(1-3), 157-162. doi:10.1016/S0014-5793(02)02973-3

    DOI: 10.1016/S0014-5793(02)02973-3

    The evolution of mammalian aging (Journal article)

    de Magalhaes, J. P., & Toussaint, O. (2002). The evolution of mammalian aging. EXPERIMENTAL GERONTOLOGY, 37(6), 769-775. doi:10.1016/S0531-5565(02)00008-6

    DOI: 10.1016/S0531-5565(02)00008-6

    The one-man rule (Journal article)

    de Magalhaes, J. P. (2002). The one-man rule. FUTURIST, 36(6), 41-45. Retrieved from http://gateway.webofknowledge.com/

    UVB-induced premature senescence of human diploid skin fibroblasts (Journal article)

    Chainiaux, F., Magalhaes, J. P., Eliaers, F., Remacle, J., & Toussaint, O. (2002). UVB-induced premature senescence of human diploid skin fibroblasts. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 34(11), 1331-1339. doi:10.1016/S1357-2725(02)00022-5

    DOI: 10.1016/S1357-2725(02)00022-5

    2001

    Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence (Journal article)

    Dumont, P., Royer, V., Pascal, T., Dierick, J. F., Chainiaux, F., Frippiat, C., . . . Toussaint, O. (2001). Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence. FEBS LETTERS, 502(3), 109-112. doi:10.1016/S0014-5793(01)02679-5

    DOI: 10.1016/S0014-5793(01)02679-5

    Hormesis: a quest for virtuality? (Journal article)

    Toussaint, O., Remacle, J., Dierick, J. F., Pascal, T., Frippiat, C., Magalhaes, J. P., & Chainaux, F. (2001). Hormesis: a quest for virtuality?. HUMAN & EXPERIMENTAL TOXICOLOGY, 20(6), 311-314. doi:10.1191/096032701701547990

    DOI: 10.1191/096032701701547990

    Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts (Journal article)

    Frippiat, C., Chen, Q. M., Zdanov, S., Magalhaes, J. P., Remacle, J., & Toussaint, O. (2001). Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(4), 2531-2537. doi:10.1074/jbc.M006809200

    DOI: 10.1074/jbc.M006809200

    2000

    Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging (Journal article)

    de Magalhaes, J. P., & Church, G. M. (2007). Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging. MECHANISMS OF AGEING AND DEVELOPMENT, 128(5-6), 355-364. doi:10.1016/j.mad.2007.03.004

    DOI: 10.1016/j.mad.2007.03.004

    Predicting the Pro-Longevity or Anti-Longevity Effect of Model Organism Genes with New Hierarchical Feature Selection Methods (Journal article)

    Wan, C., Freitas, A. A., & de Magalhaes, J. P. (2015). Predicting the Pro-Longevity or Anti-Longevity Effect of Model Organism Genes with New Hierarchical Feature Selection Methods. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 12(2), 262-275. doi:10.1109/TCBB.2014.2355218

    DOI: 10.1109/TCBB.2014.2355218

    Stress-induced premature senescence as alternative toxicological method for testing the long-term effects of molecules under development in the industry (Journal article)

    Toussaint, O., Dumont, P., Dierick, J. F., Pascal, T., Frippiat, C., Chainiaux, F., . . . Remacle, J. (2000). Stress-induced premature senescence as alternative toxicological method for testing the long-term effects of molecules under development in the industry. BIOGERONTOLOGY, 1(2), 179-183. doi:10.1023/A:1010035712199

    DOI: 10.1023/A:1010035712199

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