Professor Douglas Kell CBE, DSc, MA, DPhil, FAAAS, FLSW, FSB
Research Chair in Systems Biology / Director of GeneMill Biochemistry, Cell and Systems Biology
- +44 (0)151 795 7772 Ext. 57772
- Work email Douglas.Kell@liverpool.ac.uk
- Personal Websitehttp://dbkgroup.org/
Publications
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2024
Increased Levels of Inflammatory and Endothelial Biomarkers in Blood of Long COVID Patients Point to Thrombotic Endothelialitis (Journal article)
Turner, S., Naidoo, C. A., Usher, T. J., Kruger, A., Venter, C., Laubscher, G. J., . . . Pretorius, E. (2023). Increased Levels of Inflammatory and Endothelial Biomarkers in Blood of Long COVID Patients Point to Thrombotic Endothelialitis. SEMINARS IN THROMBOSIS AND HEMOSTASIS. doi:10.1055/s-0043-1769014Uncertainties about the roles of anticoagulation and microclots in postacute sequelae of SARS-CoV-2 infection: comment from Kell et al. (Journal article)
Kell, D. B., Khan, M. A., Laubscher, G. J., & Pretorius, E. (2024). Uncertainties about the roles of anticoagulation and microclots in postacute sequelae of SARS-CoV-2 infection: comment from Kell et al.. Journal of thrombosis and haemostasis : JTH, 22(2), 565-568. doi:10.1016/j.jtha.2023.09.035Fibrinaloid Microclots and Atrial Fibrillation (Preprint)
Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID. (Journal article)
Kell, D. B., Khan, M. A., Kane, B., Lip, G. Y. H., & Pretorius, E. (2024). Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID.. Journal of personalized medicine, 14(2), 170. doi:10.3390/jpm14020170Herpesvirus Infection as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Preprint)
2023
Quantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome. (Journal article)
Roberts, I., Wright Muelas, M., Taylor, J. M., Davison, A. S., Winder, C. L., Goodacre, R., & Kell, D. B. (2023). Quantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome.. Metabolomics : Official journal of the Metabolomic Society, 19(11), 87. doi:10.1007/s11306-023-02048-0A Perspective on How Fibrinaloid Microclots and Platelet Pathology May be Applied in Clinical Investigations (Journal article)
Pretorius, E., & Kell, D. B. (2023). A Perspective on How Fibrinaloid Microclots and Platelet Pathology May be Applied in Clinical Investigations. SEMINARS IN THROMBOSIS AND HEMOSTASIS. doi:10.1055/s-0043-1774796Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model (Journal article)
Turner, S., Laubscher, G. J., Khan, M. A., Kell, D. B., & Pretorius, E. (2023). Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model. Heliyon, 9(9), e19605. doi:10.1016/j.heliyon.2023.e19605Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases? (Journal article)
Kell, D. B., & Pretorius, E. (2023). Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?. BIOCHEMICAL JOURNAL, 480(15), 1217-1240. doi:10.1042/BCJ20230241Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia (Journal article)
Kenny, L. C., Brown, L. W., Ortea, P., Tuytten, R., & Kell, D. B. (2023). Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia. BIOSCIENCE REPORTS, 43(7). doi:10.1042/BSR20230160Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses (Journal article)
Nunes, J. M., Kell, D. B., & Pretorius, E. (2023). Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses. BLOOD REVIEWS, 60. doi:10.1016/j.blre.2023.101075Data sharing: A Long COVID perspective, challenges, and road map for the future (Journal article)
Oladejo, S. O., Watson, L. R., Watson, B. W., Rajaratnam, K., Kotze, M. J., Kell, D. B., & Pretorius, E. (2023). Data sharing: A Long COVID perspective, challenges, and road map for the future. SOUTH AFRICAN JOURNAL OF SCIENCE, 119(5-6). doi:10.17159/sajs.2023/14719Long COVID: pathophysiological factors and abnormalities of coagulation (Journal article)
Turner, S., Khan, M. A., Putrino, D., Woodcock, A., Kell, D. B., & Pretorius, E. (2023). Long COVID: pathophysiological factors and abnormalities of coagulation. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 34(6), 321-344. doi:10.1016/j.tem.2023.03.002Alzheimer's Disease: A Systems View Provides a Unifying Explanation of Its Development (Journal article)
Grobler, C., van Tongeren, M., Gettemans, J., Kell, D. B., & Pretorius, E. (2023). Alzheimer's Disease: A Systems View Provides a Unifying Explanation of Its Development. Journal of Alzheimer's Disease, 91(1), 43-70. doi:10.3233/JAD-2207202022
Understanding Functional Redundancy and Promiscuity of Multidrug Transporters in E. coli under Lipophilic Cation Stress (Journal article)
Radi, M. S., Munro, L. J., Salcedo-Sora, J. E., Kim, S. H., Feist, A. M., & Kell, D. B. (2022). Understanding Functional Redundancy and Promiscuity of Multidrug Transporters in E. coli under Lipophilic Cation Stress. MEMBRANES, 12(12). doi:10.3390/membranes12121264Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness (Journal article)
Grobbelaar, L. M., Kruger, A., Venter, C., Burger, E. M., Laubscher, G. J., Maponga, T. G., . . . Pretorius, E. (2022). Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 48(07), 858-868. doi:10.1055/s-0042-1756306Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system (Journal article)
Kruger, A., Vlok, M., Turner, S., Venter, C., Laubscher, G. J., Kell, D. B., & Pretorius, E. (2022). Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system. CARDIOVASCULAR DIABETOLOGY, 21(1). doi:10.1186/s12933-022-01623-4The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications. (Journal article)
Kell, D. B., & Pretorius, E. (2022). The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.. The Biochemical journal, 479(16), 1653-1708. doi:10.1042/bcj20220154Dimethyl fumarate eliminates differentially culturable <i>Mycobacterium tuberculosis</i> in an intranasal murine model of tuberculosis (Journal article)
Glenn, S. M., Turapov, O., Makarov, V., Kell, D. B., & Mukamolova, G. V. (2022). Dimethyl fumarate eliminates differentially culturable <i>Mycobacterium tuberculosis</i> in an intranasal murine model of tuberculosis. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 12. doi:10.3389/fcimb.2022.957287Analysis of a Library of Escherichia coli Transporter Knockout Strains to Identify Transport Pathways of Antibiotics (Journal article)
Munro, L. J., & Kell, D. B. (2022). Analysis of a Library of Escherichia coli Transporter Knockout Strains to Identify Transport Pathways of Antibiotics. ANTIBIOTICS-BASEL, 11(8). doi:10.3390/antibiotics11081129Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC) (Journal article)
Pretorius, E., Venter, C., Laubscher, G. J., Kotze, M. J., Oladejo, S. O., Watson, L. R., . . . Kell, D. B. (2022). Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC). CARDIOVASCULAR DIABETOLOGY, 21(1). doi:10.1186/s12933-022-01579-5The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (Journal article)
Nunes, J. M., Kruger, A., Proal, A., Kell, D. B., & Pretorius, E. (2022). The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). PHARMACEUTICALS, 15(8). doi:10.3390/ph15080931Membrane transporter identification and modulation via adaptive laboratory evolution (Journal article)
Radi, M. S., SalcedoSora, J. E., Kim, S. H., Sudarsan, S., V. Sastry, A., Kell, D. B., . . . Feist, A. M. (2022). Membrane transporter identification and modulation via adaptive laboratory evolution. METABOLIC ENGINEERING, 72, 376-390. doi:10.1016/j.ymben.2022.05.004SpeedyGenesXL: an Automated, High-Throughput Platform for the Preparation of Bespoke Ultralarge Variant Libraries for Directed Evolution. (Journal article)
Sadler, J. C., Swainston, N., Dunstan, M. S., Currin, A., & Kell, D. B. (2022). SpeedyGenesXL: an Automated, High-Throughput Platform for the Preparation of Bespoke Ultralarge Variant Libraries for Directed Evolution.. Methods in molecular biology (Clifton, N.J.), 2461, 67-83. doi:10.1007/978-1-0716-2152-3_5Identification and Engineering of Transporters for Efficient Melatonin Production in <i>Escherichia coli</i> (Journal article)
Yang, L., Malla, S., Oezdemir, E., Kim, S. H., Lennen, R., Christensen, H. B., . . . Palsson, B. O. (2022). Identification and Engineering of Transporters for Efficient Melatonin Production in <i>Escherichia coli</i>. FRONTIERS IN MICROBIOLOGY, 13. doi:10.3389/fmicb.2022.880847Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation (Journal article)
Bunch, C. M., Moore, E. E., Moore, H. B., Neal, M. D., Thomas, A. V., Zackariya, N., . . . Walsh, M. M. (2022). Immuno-Thrombotic Complications of COVID-19: Implications for Timing of Surgery and Anticoagulation. FRONTIERS IN SURGERY, 9. doi:10.3389/fsurg.2022.889999Engineering precursor supply for the high-level production of ergothioneine in Saccharomyces cerevisiae. (Journal article)
van der Hoek, S. A., Rusnák, M., Wang, G., Stanchev, L. D., de Fátima Alves, L., Jessop-Fabre, M. M., . . . Borodina, I. (2022). Engineering precursor supply for the high-level production of ergothioneine in Saccharomyces cerevisiae.. Metabolic engineering, 70, 129-142. doi:10.1016/j.ymben.2022.01.012A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications (Journal article)
Kell, D. B., Laubscher, G. J., & Pretorius, E. (2022). A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications. BIOCHEMICAL JOURNAL, 479(4), 537-559. doi:10.1042/BCJ20220016The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation (Journal article)
Page, M. J., Kell, D. B., & Pretorius, E. (2022). The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation. Chronic Stress, 6, 247054702210763. doi:10.1177/24705470221076390Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome (Journal article)
Roberts, I., Muelas, M. W., Taylor, J. M., Davison, A. S., Xu, Y., Grixti, J. M., . . . Kell, D. B. (2022). Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome. METABOLOMICS, 18(1). doi:10.1007/s11306-021-01859-32021
Combined triple treatment of fibrin amyloid microclots and platelet pathology in individuals with Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) can resolve their persistent symptoms (Preprint)
Engineering ergothioneine production in Yarrowia lipolytica (Journal article)
van der Hoek, S. A., Rusnak, M., Jacobsen, I. H., Martinez, J. L., Kell, D. B., & Borodina, I. (2021). Engineering ergothioneine production in Yarrowia lipolytica. FEBS LETTERS. doi:10.1002/1873-3468.14239MassGenie: A Transformer-Based Deep Learning Method for Identifying Small Molecules from Their Mass Spectra (Journal article)
Shrivastava, A. D., Swainston, N., Samanta, S., Roberts, I., Wright Muelas, M., & Kell, D. B. (2021). MassGenie: A Transformer-Based Deep Learning Method for Identifying Small Molecules from Their Mass Spectra. BIOMOLECULES, 11(12). doi:10.3390/biom11121793TEG(R), Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy (Journal article)
Laubscher, G. J., Lourens, P. J., Venter, C., Kell, D. B., & Pretorius, E. (2021). TEG(R), Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy. JOURNAL OF CLINICAL MEDICINE, 10(22). doi:10.3390/jcm10225381Intelligent host engineering for metabolic flux optimisation in biotechnology (Journal article)
Munro, L. J., & Kell, D. B. (2021). Intelligent host engineering for metabolic flux optimisation in biotechnology. BIOCHEMICAL JOURNAL, 478(20), 3685-3721. doi:10.1042/BCJ20210535MassGenie: A Transformer-Based Deep Learning Method for Identifying Small Molecules From Their Mass Spectra (Preprint)
Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli (Journal article)
Salcedo-Sora, J. E., Robison, A. T. R., Zaengle-Barone, J., Franz, K. J., & Kell, D. B. (2021). Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli. MOLECULES, 26(19). doi:10.3390/molecules26195826The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes (Journal article)
Kell, D. B. (2021). The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes. MOLECULES, 26(18). doi:10.3390/molecules26185629Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin (Journal article)
Pretorius, E., Vlok, M., Venter, C., Bezuidenhout, J. A., Laubscher, G. J., Steenkamp, J., & Kell, D. B. (2021). Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin. CARDIOVASCULAR DIABETOLOGY, 20(1). doi:10.1186/s12933-021-01359-7SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 (Journal article)
Grobbelaar, L. M., Venter, C., Vlok, M., Ngoepe, M., Laubscher, G. J., Lourens, P. J., . . . Pretorius, E. (2021). SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19. BIOSCIENCE REPORTS, 41(8). doi:10.1042/BSR20210611An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters (Journal article)
Dvorak, V., Wiedmer, T., Ingles-Prieto, A., Altermatt, P., Batoulis, H., Baerenz, F., . . . Superti-Furga, G. (2021). An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters. FRONTIERS IN PHARMACOLOGY, 12. doi:10.3389/fphar.2021.722889Harnessing the yeast <i>Saccharomyces cerevisiae</i> for the production of fungal secondary metabolites (Journal article)
Wang, G., Kell, D. B., & Borodina, I. (2021). Harnessing the yeast <i>Saccharomyces cerevisiae</i> for the production of fungal secondary metabolites. MICROBIAL CELL FACTORIES-BOOK, 65(2), 277-291. doi:10.1042/EBC20200137MassGenie: a transformer-based deep learning method for identifying small molecules from their mass spectra (Preprint)
Persistent clotting protein pathology in Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin (Journal article)
Pretorius, E., Vlok, M., Venter, C., Bezuidenhout, J., Laubscher, G. J., Steenkamp, J., & Kell, D. (2021). Persistent clotting protein pathology in Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin. doi:10.1101/2021.05.21.21257578FragNet, a Contrastive Learning-Based Transformer Model for Clustering, Interpreting, Visualizing, and Navigating Chemical Space (Journal article)
Shrivastava, A. D., & Kell, D. B. (2021). FragNet, a Contrastive Learning-Based Transformer Model for Clustering, Interpreting, Visualizing, and Navigating Chemical Space. MOLECULES, 26(7). doi:10.3390/molecules26072065SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19 (Journal article)
Grobbelaar, L., Venter, C., Vlok, M., Ngoepe, M., Laubscher, G. J., Lourens, P. J., . . . Pretorius, E. (2021). SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19. doi:10.1101/2021.03.05.21252960A palette of fluorophores that are differentially accumulated by wild- type and mutant strains of Escherichia coli: surrogate ligands for profiling bacterial membrane transporters (Journal article)
Salcedo-Sora, J. E., Jindal, S., O'Hagan, S., & Kell, D. B. (2021). A palette of fluorophores that are differentially accumulated by wild- type and mutant strains of Escherichia coli: surrogate ligands for profiling bacterial membrane transporters. MICROBIOLOGY-SGM, 167(2). doi:10.1099/mic.0.001016A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation (Chapter)
Kell, D. B. (2021). A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation. In ADVANCES IN MICROBIAL PHYSIOLOGY, VOL 78 (Vol. 78, pp. 1-177). doi:10.1016/bs.ampbs.2021.01.0012020
Bacteria, Lipopolysaccharides, Amyloid and the Role of Iron Dysregulation in Parkinson’s Disease (Journal article)
Vuuren, M. J. V., Nell, T. A., Carr, J. A., Kell, D., & Pretorius, E. (2020). Bacteria, Lipopolysaccharides, Amyloid and the Role of Iron Dysregulation in Parkinson’s Disease. Biomolecules. doi:10.3390/biom11010030Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease (Journal article)
Vuuren, M. J. V., Nell, T. A., Carr, J. A., Kell, D. B., & Pretorius, E. (2021). Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease. BIOMOLECULES, 11(1). doi:10.3390/biom11010030Automating Cloning by Natural Transformation (Journal article)
Jiang, X., Palazzotto, E., Wybraniec, E., Munro, L. J., Zhang, H., Kell, D. B., . . . Lee, S. Y. (2020). Automating Cloning by Natural Transformation. ACS SYNTHETIC BIOLOGY, 9(12), 3228-3235. doi:10.1021/acssynbio.0c00240Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently (Journal article)
Kell, D. B., Samanta, S., & Swainston, N. (2020). Deep learning and generative methods in cheminformatics and chemical biology: navigating small molecule space intelligently. BIOCHEMICAL JOURNAL, 477(23), 4559-4580. doi:10.1042/BCJ20200781Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome (Journal article)
Roberts, I., Muelas, M. W., Taylor, J., Davison, A., Xu, Y., Grixti, J., . . . Kell, D. (2020). Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome. doi:10.1101/2020.12.09.20246389Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency (Journal article)
Bezuidenhout, J. A., Venter, C., Roberts, T. J., Tarr, G., Kell, D. B., & Pretorius, E. (2020). Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.577523The biology of ergothioneine, an antioxidant nutraceutical (Journal article)
Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., . . . Kell, D. B. (2020). The biology of ergothioneine, an antioxidant nutraceutical. NUTRITION RESEARCH REVIEWS, 33(2), 190-217. doi:10.1017/S0954422419000301Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products (Journal article)
O'Hagan, S., & Kell, D. B. (2020). Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products. MARINE DRUGS, 18(11). doi:10.3390/md18110582Prevalence of readily detected amyloid blood clots in 'unclotted' Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report (Journal article)
Pretorius, E., Venter, C., Laubscher, G. J., Lourens, P. J., Steenkamp, J., & Kell, D. B. (2020). Prevalence of readily detected amyloid blood clots in 'unclotted' Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report. Cardiovascular Diabetology, 19(1). doi:10.1186/s12933-020-01165-7Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19 (Journal article)
Venter, C., Bezuidenhout, J. A., Laubscher, G. J., Lourens, P. J., Steenkamp, J., Kell, D. B., & Pretorius, E. (2020). Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(21). doi:10.3390/ijms21218234Is<i>Porphyromonas gingivalis</i>involved in Parkinson's disease? (Journal article)
Olsen, I., Kell, D. B., & Pretorius, E. (2020). Is<i>Porphyromonas gingivalis</i>involved in Parkinson's disease?. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 39(11), 2013-2018. doi:10.1007/s10096-020-03944-2An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines (Journal article)
Muelas, M. W., Roberts, I., Mughal, F., O'Hagan, S., Day, P. J., & Kell, D. B. (2020). An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines. METABOLOMICS, 16(10). doi:10.1007/s11306-020-01725-8DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach (Journal article)
Khemchandani, Y., O'Hagan, S., Samanta, S., Swainston, N., Roberts, T. J., Bollegala, D., & Kell, D. B. (2020). DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach. Journal of Cheminformatics, 12(1). doi:10.1186/s13321-020-00454-3A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery (Journal article)
Salcedo-Sora, J. E., & Kell, D. B. (2020). A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery. ANTIBIOTICS-BASEL, 9(8). doi:10.3390/antibiotics9080508SBML Level 3: an extensible format for the exchange and reuse of biological models (Journal article)
Keating, S. M., Waltemath, D., Koenig, M., Zhang, F., Draeger, A., Chaouiya, C., . . . Hucka, M. (2020). SBML Level 3: an extensible format for the exchange and reuse of biological models. MOLECULAR SYSTEMS BIOLOGY, 16(8). doi:10.15252/msb.20199110DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach (Journal article)
Khemchandani, Y., O'Hagan, S., Samanta, S., Swainston, N., Roberts, T., Bollegala, D., & Kell, D. (2020). DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach. doi:10.21203/rs.3.rs-32446/v2Prevalence of amyloid blood clots in COVID-19 plasma (Journal article)
Pretorius, E., Venter, C., Laubscher, G. J., Lourens, P. J., Steenkamp, J., & Kell, D. (2020). Prevalence of amyloid blood clots in COVID-19 plasma. doi:10.1101/2020.07.28.20163543VAE-Sim: A Novel Molecular Similarity Measure Based on a Variational Autoencoder. (Journal article)
Samanta, S., O'Hagan, S., Swainston, N., Roberts, T. J., & Kell, D. B. (2020). VAE-Sim: A Novel Molecular Similarity Measure Based on a Variational Autoencoder.. Molecules, 25(15). doi:10.3390/molecules25153446Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics (Journal article)
Nunes, J. M., Fillis, T., Page, M. J., Venter, C., Lancry, O., Kell, D. B., . . . Pretorius, E. (2020). Gingipain R1 and Lipopolysaccharide From<i>Porphyromonas gingivalis</i>Have Major Effects on Blood Clot Morphology and Mechanics. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01551Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes (Journal article)
Grobler, C., Maphumulo, S. C., Grobbelaar, L. M., Bredenkamp, J. C., Laubscher, G. J., Lourens, P. J., . . . Pretorius, E. (2020). Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(14). doi:10.3390/ijms21145168COVID-19: The Rollercoaster of Fibrin(ogen), D-dimer, von Willebrand Factor, P-selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes (Journal article)
Grobler, C., Bredenkamp, J., Grobbelaar, M., Maphumulo, S., Laubscher, J., Steenkamp, J., . . . Pretorius, E. (2020). COVID-19: The Rollercoaster of Fibrin(ogen), D-dimer, von Willebrand Factor, P-selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes. doi:10.20944/preprints202007.0142.v1The RESOLUTE consortium: unlocking SLC transporters for drug discovery (Journal article)
Superti-Furga, G., Lackner, D., Wiedmer, T., Ingles-Prieto, A., & Steppan, C. M. (2020). The RESOLUTE consortium: unlocking SLC transporters for drug discovery. NATURE REVIEWS DRUG DISCOVERY, 19(7), 429-430. doi:10.1038/d41573-020-00056-6VAE-Sim: a novel molecular similarity measure based on a variational autoencoder (Journal article)
Samanta, S., O’Hagan, S., Swainston, N., Roberts, T., & Kell, D. (2020). VAE-Sim: a novel molecular similarity measure based on a variational autoencoder. doi:10.1101/2020.06.26.172908A palette of fluorophores that are differentially accumulated by wild-type and mutant strains of<i>Escherichia coli</i>: surrogate ligands for bacterial membrane transporters (Journal article)
Salcedo-Sora, J. E., Jindal, S., O’Hagan, S., & Kell, D. (2020). A palette of fluorophores that are differentially accumulated by wild-type and mutant strains of<i>Escherichia coli</i>: surrogate ligands for bacterial membrane transporters. doi:10.1101/2020.06.15.152629DeepGraphMol, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach (Journal article)
Khemchandani, Y., O'Hagan, S., Samanta, S., Swainston, N., Roberts, T., Bollegala, D., & Kell, D. (2020). DeepGraphMol, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach. doi:10.21203/rs.3.rs-32446/v1An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines (Journal article)
Muelas, M. W., Roberts, I., Mughal, F., O’Hagan, S., Day, P., & Kell, D. (2020). An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines. doi:10.1101/2020.06.02.129239Author Correction: Hitchhiking into the cell. (Journal article)
Kell, D. B. (2020). Author Correction: Hitchhiking into the cell.. Nature chemical biology, 16(6), 710. doi:10.1038/s41589-020-0540-yThe Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria (Journal article)
Kell, D. B., Heyden, E. L., & Pretorius, E. (2020). The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria. Frontiers in Immunology, 11. doi:10.3389/fimmu.2020.01221DeepGraphMol, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach (Journal article)
Khemchandani, Y., O’Hagan, S., Samanta, S., Swainston, N., Roberts, T., Bollegala, D., & Kell, D. (2020). DeepGraphMol, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach. doi:10.1101/2020.05.25.114165Gingipain R1 and lipopolysaccharide from Porphyromonas gingivalis have major effects on blood clot morphology and mechanics (Preprint)
Hitchhiking into the cell (Journal article)
Kell, D. B. (2020). Hitchhiking into the cell. NATURE CHEMICAL BIOLOGY, 16(4), 367-368. doi:10.1038/s41589-020-0489-xL-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model (Journal article)
Williamson, R. D., McCarthy, F. P., Manna, S., Groarke, E., Kell, D. B., Kenny, L. C., & McCarthy, C. M. (2020). L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model. HYPERTENSION, 75(2), 561-568. doi:10.1161/HYPERTENSIONAHA.119.13929Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters (Journal article)
Mendes, P., Girardi, E., Superti-Furga, G., & Kell, D. (2020). Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters. doi:10.1101/2020.01.16.909507Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia (Journal article)
Morillon, A. -C., Williamson, R. D., Baker, P. N., Kell, D. B., Kenny, L. C., English, J. A., . . . McCarthy, C. (2020). Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia. PLOS ONE, 15(3). doi:10.1371/journal.pone.02309772019
The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data (Journal article)
Muelas, M. W., Mughal, F., O'Hagan, S., Day, P. J., & Kell, D. B. (2019). The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-54288-7A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study (Journal article)
Kell, D. (2019). A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study. Frontiers in Neurology. doi:10.3389/fneur.2019.01262Structural similarities between some common fluorophores used in biology and marketed drugs, endogenous metabolites, and natural products (Journal article)
O’Hagan, S., & Kell, D. (2019). Structural similarities between some common fluorophores used in biology and marketed drugs, endogenous metabolites, and natural products. doi:10.1101/834325Engineering the Yeast <i>Saccharomyces</i> <i>cerevisiae</i> for the Production of L-(+)-Ergothioneine (Journal article)
van der Hoek, S. A., Darbani, B., Zugaj, K. E., Prabhala, B. K., Biron, M. B., Randelovic, M., . . . Borodina, I. (2019). Engineering the Yeast <i>Saccharomyces</i> <i>cerevisiae</i> for the Production of L-(+)-Ergothioneine. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 7. doi:10.3389/fbioe.2019.00262A top priority in pre-eclampsia research: development of a reliable and inexpensive urinary screening test (Journal article)
Scioscia, M., Dekker, G. A., Chaouat, G., Dawonauth, L., Dechend, R., Goldman-Wohl, D., . . . Robillard, P. -Y. (2019). A top priority in pre-eclampsia research: development of a reliable and inexpensive urinary screening test. LANCET GLOBAL HEALTH, 7(10), E1312-E1313. doi:10.1016/S2214-109X(19)30319-5Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens (Journal article)
Adams, B., Nunes, M., Page, M., Roberts, T., Carr, J., Nell, T., . . . Pretorius, E. (2019). Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens. Frontiers in Aging Neuroscience. doi:10.3389/fnagi.2019.00210Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli (Journal article)
Jindal, S., Yang, L., Day, P. J., & Kell, D. B. (2019). Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli. BMC MICROBIOLOGY, 19. doi:10.1186/s12866-019-1561-0A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites (Journal article)
Zhang, S., Sakuma, M., Deora, G. S., Levy, C. W., Klausing, A., Breda, C., . . . Scrutton, N. S. (2019). A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. COMMUNICATIONS BIOLOGY, 2. doi:10.1038/s42003-019-0520-5GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries (Journal article)
Currin, A., Kwok, J., Sadler, J. C., Bell, E. L., Swainston, N., Ababi, M., . . . Kell, D. B. (2019). GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries. ACS SYNTHETIC BIOLOGY, 8(6), 1371-1378. doi:10.1021/acssynbio.9b00063Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by<i>Escherichia coli</i> (Journal article)
Jindal, S., Yang, L., Day, P., & Kell, D. (2019). Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by<i>Escherichia coli</i>. doi:10.1101/603688Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth. (Journal article)
Jindal, S., Thampy, H., Day, P. J. R., & Kell, D. B. (2019). Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth.. Microbiology, 165(4), 439-454. doi:10.1099/mic.0.000777Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation (Journal article)
Page, M. J., Thomson, G. J. A., Nunes, J. M., Engelbrecht, A. -M., Nell, T. A., de Villiers, W. J. S., . . . Pretorius, E. (2019). Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-39056-xBacterial Dysbiosis and Translocation in Psoriasis Vulgaris (Journal article)
Visser, M. J. E., Kell, D. B., & Pretorius, E. (2019). Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 9. doi:10.3389/fcimb.2019.00007Erythrocyte health and the possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura pathophysiology: Results from a pilot study (Conference Paper)
de Villiers, S., Bester, J., Kell, D. B., & Pretorius, E. (2019). Erythrocyte health and the possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura pathophysiology: Results from a pilot study. In CEPHALALGIA Vol. 39 (pp. 150-151). Retrieved from https://www.webofscience.com/2018
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals (Journal article)
Carbonell, P., Jervis, A. J., Robinson, C. J., Yan, C., Dunstan, M., Swainston, N., . . . Scrutton, N. S. (2018). An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals. COMMUNICATIONS BIOLOGY, 1. doi:10.1038/s42003-018-0076-9Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia (Journal article)
Pretorius, L., Kell, D. B., & Pretorius, E. (2018). Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia. FRONTIERS IN NEUROSCIENCE, 12. doi:10.3389/fnins.2018.00851Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson's Disease, Alzheimer's Disease and Type 2 Diabetes Mellitus (Journal article)
de Waal, G. M., Engelbrecht, L., Davis, T., de Villiers, W. J. S., Kell, D. B., & Pretorius, E. (2018). Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson's Disease, Alzheimer's Disease and Type 2 Diabetes Mellitus. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-35009-yUltra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting (Journal article)
Sadler, J. C., Currin, A., & Kell, D. B. (2018). Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting. ANALYST, 143(19), 4747-4755. doi:10.1039/c8an00851eThe Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia (Journal article)
Pretorius, E., Bester, J., Page, M. J., & Kell, D. B. (2018). The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia. FRONTIERS IN AGING NEUROSCIENCE, 10. doi:10.3389/fnagi.2018.00257No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases (Journal article)
Kell, D. B., & Pretorius, E. (2018). No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases. BIOLOGICAL REVIEWS, 93(3), 1518-1557. doi:10.1111/brv.12407PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts (Journal article)
Swainston, N., Dunstan, M., Jervis, A. J., Robinson, C. J., Carbonell, P., Williams, A. R., . . . Kell, D. B. (2018). PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts. Bioinformatics, 34(13), 2327-2329. doi:10.1093/bioinformatics/bty105Selenzyme: enzyme selection tool for pathway design (Journal article)
Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N. J., Scrutton, N. S., . . . Faulon, J. -L. (2018). Selenzyme: enzyme selection tool for pathway design. BIOINFORMATICS, 34(12), 2153-2154. doi:10.1093/bioinformatics/bty065Energetic evolution of cellular Transportomes (Journal article)
Darbani, B., Kell, D. B., & Borodina, I. (2018). Energetic evolution of cellular Transportomes. BMC GENOMICS, 19. doi:10.1186/s12864-018-4816-5To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin? (Journal article)
Kell, D. B., & Pretorius, E. (2018). To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 44(3), 224-238. doi:10.1055/s-0037-1604108Belief Book (Preprint)
Control of metabolite efflux in microbial cell factories: current advances and future prospects (Preprint)
Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase (Journal article)
Currin, A., Dunstan, M. S., Johannissen, L. O., Hollywood, K. A., Vinaixa, M., Jervis, A. J., . . . Scrutton, N. S. (2018). Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase. ACS CATALYSIS, 8(3), 2012-2020. doi:10.1021/acscatal.7b04115Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease (Journal article)
Pretorius, E., Page, M. J., Mbotwe, S., & Kell, D. B. (2018). Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease. PLOS ONE, 13(3). doi:10.1371/journal.pone.0192121The potential therapeutic effects of ergothioneine in pre-eclampsia (Journal article)
Kerley, R. N., McCarthy, C., Kell, D. B., & Kenny, L. C. (2018). The potential therapeutic effects of ergothioneine in pre-eclampsia. FREE RADICAL BIOLOGY AND MEDICINE, 117, 145-157. doi:10.1016/j.freeradbiomed.2017.12.030GeneGini: Assessment via the Gini Coefficient of Reference “Housekeeping” Genes and Diverse Human Transporter Expression Profiles (Journal article)
O'Hagan, S., Muelas, M. W., Day, P. J., Lundberg, E., & Kell, D. B. (2018). GeneGini: Assessment via the Gini Coefficient of Reference “Housekeeping” Genes and Diverse Human Transporter Expression Profiles. Cell Systems, 6(2), 230-244.E1. doi:10.1016/j.cels.2018.01.003Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries (Journal article)
O'Hagan, S., & Kell, D. B. (2018). Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries. BIOTECHNOLOGY JOURNAL, 13(1). doi:10.1002/biot.201700503Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains (Journal article)
Pretorius, E., Page, M. J., Hendricks, L., Nkosi, N. B., Benson, S. R., & Kell, D. B. (2018). Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 15(139). doi:10.1098/rsif.2017.0941Fast and Flexible Synthesis of Combinatorial Libraries for Directed Evolution (Chapter)
Sadler, J. C., Green, L., Swainston, N., Kell, D. B., & Currin, A. (2018). Fast and Flexible Synthesis of Combinatorial Libraries for Directed Evolution. In ENZYMES IN SYNTHETIC BIOLOGY (Vol. 608, pp. 59-79). doi:10.1016/bs.mie.2018.04.006Microcompartmentation (Chapter)
Jones, D. P. (n.d.). Microcompartmentation. In D. P. Jones (Ed.). CRC Press. doi:10.1201/97813510745752017
Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains (Journal article)
Pretorius, E., Page, M. J., Engelbrecht, L., Ellis, G. C., & Kell, D. B. (2017). Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains. CARDIOVASCULAR DIABETOLOGY, 16. doi:10.1186/s12933-017-0624-5Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father<sup>1</sup> (Journal article)
Kenny, L., & Kell, D. (2017). Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father<sup>1</sup>. doi:10.1101/198796PartsGenie: an integrated tool for optimising and sharing synthetic biology parts (Journal article)
Swainston, N., Dunstan, M., Jervis, A., Robinson, C., Carbonell, P., Williams, A., . . . Kell, D. (2017). PartsGenie: an integrated tool for optimising and sharing synthetic biology parts. doi:10.1101/189357Selenzyme: Enzyme selection tool for pathway design (Journal article)
Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N., Scrutton, N., . . . Faulon, J. -L. (2017). Selenzyme: Enzyme selection tool for pathway design. doi:10.1101/188979A Metabolic Reaction Balancing Web Service for Computational Systems Biology (Journal article)
Dobson, P., Mendes, P., Kell, D., & Swainston, N. (2017). A Metabolic Reaction Balancing Web Service for Computational Systems Biology. doi:10.1101/187328Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin (Journal article)
Kell, D. B. (2017). Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin. GENETIC PROGRAMMING AND EVOLVABLE MACHINES, 18(3), 373-378. doi:10.1007/s10710-017-9292-1Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities (Journal article)
Pretorius, E., Mbotwe, S., & Kell, D. B. (2017). Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-09860-4Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation (Journal article)
Glymenaki, M., Barnes, A., Hagan, S. O., Warhurst, G., McBain, A. J., Wilson, I. D., . . . Cruickshank, S. M. (2017). Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-08732-1Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3 x Tg Alzheimer mouse model (Journal article)
Esteve, C., Jones, E. A., Kell, D. B., Boutin, H., & McDonnell, L. A. (2017). Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3 x Tg Alzheimer mouse model. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1865(7), 747-754. doi:10.1016/j.bbapap.2017.04.002biochem4j: Integrated and extensible biochemical knowledge through graph databases (Journal article)
Swainston, N., Batista-Navarro, R., Carbonell, P., Dobson, P. D., Dunstan, M., Jervis, A. J., . . . Breitling, R. (n.d.). biochem4j: Integrated and extensible biochemical knowledge through graph databases. PLOS ONE, 12(7). doi:10.1371/journal.pone.0179130Novel ‘housekeeping’ genes and an unusually heterogeneous distribution of transporter expression profiles in human tissues and cell lines, assessed using the Gini coefficient (Journal article)
O’Hagan, S., Muelas, M. W., Day, P., Lundberg, E., & Kell, D. (2017). Novel ‘housekeeping’ genes and an unusually heterogeneous distribution of transporter expression profiles in human tissues and cell lines, assessed using the Gini coefficient. doi:10.1101/155697Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker<sup>™</sup>stains (Journal article)
Pretorius, E., Page, M., Hendricks, L., Nkosi, N., Benson, S., & Kell, D. (2017). Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker<sup>™</sup>stains. doi:10.1101/143867Commentary on "Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks" (Journal article)
Goodacre, R., & Kell, D. B. (2017). Commentary on "Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks". FEMS MICROBIOLOGY LETTERS, 364(10). doi:10.1093/femsle/fnx018Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson’s disease: implications for its aetiology (Journal article)
Pretorius, E., Mbotwe, S., & Kell, D. (2017). Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson’s disease: implications for its aetiology. doi:10.1101/124180Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine (Journal article)
Grixti, J. M., O'Hagan, S., Day, P. J., & Kell, D. B. (2017). Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00155A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease (Chapter)
Pretorius, E., Bester, J., & Kell, D. B. (2017). A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease. In HANDBOOK OF INFECTION AND ALZHEIMER'S DISEASE (Vol. 5, pp. 313-332). doi:10.3233/978-1-61499-706-313Microbes and Alzheimer's Disease (Chapter)
Itzhaki, R. F., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., . . . Whittum-Hudson, J. A. (2017). Microbes and Alzheimer's Disease. In HANDBOOK OF INFECTION AND ALZHEIMER'S DISEASE (Vol. 5, pp. 3-8). doi:10.3233/978-1-61499-706-3Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures (Journal article)
O'Hagan, S., & Kell, D. B. (2017). Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures. JOURNAL OF CHEMINFORMATICS, 9. doi:10.1186/s13321-017-0198-yConsensus rank orderings of molecular fingerprints illustrate the ‘most genuine’ similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates (Journal article)
O’Hagan, S., & Kell, D. (2017). Consensus rank orderings of molecular fingerprints illustrate the ‘most genuine’ similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates. doi:10.1101/110437Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability (Journal article)
Pretorius, E., Akeredolu, O. -O., Soma, P., & Kell, D. B. (2017). Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability. EXPERIMENTAL BIOLOGY AND MEDICINE, 242(4), 355-373. doi:10.1177/1535370216681549A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease (Book)
Pretorius, E., Bester, J., & Kell, D. B. (2017). A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease (Vol. 5). doi:10.3233/978-1-61499-706-1-313CodonGenie: optimised ambiguous codon design tools (Journal article)
Swainston, N., Currin, A., Green, L., Breitling, R., Day, P. J., & Kell, D. B. (2017). CodonGenie: optimised ambiguous codon design tools. PEERJ COMPUTER SCIENCE. doi:10.7717/peerj-cs.120Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates (Journal article)
O'Hagan, S., & Kell, D. B. (n.d.). Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates. ADMET and DMPK, 5(2), 85-125. doi:10.5599/admet.5.2.376Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father (Journal article)
Kenny, L. C., & Kell, D. B. (2018). Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father. FRONTIERS IN MEDICINE, 4. doi:10.3389/fmed.2017.00239Microbes and Alzheimer's Disease (Journal article)
Itzhaki, R. F., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., . . . Whittum-Hudson, J. A. (2017). Microbes and Alzheimer's Disease. Advances in Alzheimer's Disease, 5, 3-8. doi:10.3233/978-1-61499-706-1-3Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting (Journal article)
Kell, D. B., & Pretorius, E. (2017). Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 123, 16-41. doi:10.1016/j.pbiomolbio.2016.08.006SpeedyGenes: Exploiting an Improved Gene Synthesis Method for the Efficient Production of Synthetic Protein Libraries for Directed Evolution (Chapter)
Currin, A., Swainston, N., Day, P. J., & Kell, D. B. (2017). SpeedyGenes: Exploiting an Improved Gene Synthesis Method for the Efficient Production of Synthetic Protein Libraries for Directed Evolution. In SYNTHETIC DNA: METHODS AND PROTOCOLS (Vol. 1472, pp. 63-78). doi:10.1007/978-1-4939-6343-0_52016
SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production (Journal article)
Le Feuvre, R. A., Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A. J., . . . Turner, N. J. (2016). SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 1(4), 271-275. doi:10.1016/j.synbio.2016.07.001The metabolome 18 years on: a concept comes of age (Journal article)
Kell, D. B., & Oliver, S. G. (2016). The metabolome 18 years on: a concept comes of age. METABOLOMICS, 12(9). doi:10.1007/s11306-016-1108-4Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide (Journal article)
Pretorius, E., Mbotwe, S., Bester, J., Robinson, C. J., & Kell, D. B. (2016). Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 13(122). doi:10.1098/rsif.2016.0539MetMaxStruct: A Tversky-Similarity-Based Strategy for Analysing the (Sub)Structural Similarities of Drugs and Endogenous Metabolites (Journal article)
O'Hagan, S., & Kell, D. B. (2016). MetMaxStruct: A Tversky-Similarity-Based Strategy for Analysing the (Sub)Structural Similarities of Drugs and Endogenous Metabolites. FRONTIERS IN PHARMACOLOGY, 7. doi:10.3389/fphar.2016.00266Computing exponentially faster: implementing a non- deterministic universal Turing machine using DNA (Journal article)
Currin, A., Korovin, K., Ababi, M., Roper, K., Kell, D. B., Day, P. J., & King, R. D. (2017). Computing exponentially faster: implementing a non- deterministic universal Turing machine using DNA. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 14(128). doi:10.1098/rsif.2016.0990Recon 2.2: from reconstruction to model of human metabolism (Journal article)
Swainston, N., Smallbone, K., Hefzi, H., Dobson, P. D., Brewer, J., Hanscho, M., . . . Mendes, P. (2016). Recon 2.2: from reconstruction to model of human metabolism. METABOLOMICS, 12(7). doi:10.1007/s11306-016-1051-4A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease (Journal article)
Pretorius, E., Bester, J., & Kell, D. B. (2016). A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease. JOURNAL OF ALZHEIMERS DISEASE, 53(4), 1237-1256. doi:10.3233/JAD-160318SYNBIOCHEM - a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals (Journal article)
Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., . . . Turner, N. J. (2016). SYNBIOCHEM - a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals. BIOCHEMICAL SOCIETY TRANSACTIONS, 44, 675-677. doi:10.1042/BST20160009Microbes and Alzheimer's Disease (Journal article)
Itzhaki, R. F., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., . . . Whittum-Hudson, J. A. (2016). Microbes and Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE, 51(4), 979-984. doi:10.3233/JAD-160152Response to 'The Need for Speed', by Matsson <i>et al</i>. (Journal article)
Mendes, P., Oliver, S. G., & Kell, D. B. (2016). Response to 'The Need for Speed', by Matsson <i>et al</i>.. TRENDS IN PHARMACOLOGICAL SCIENCES, 37(4), 245-+. doi:10.1016/j.tips.2016.02.004Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness (Journal article)
Kell, D. B. (2016). Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness. NATURE REVIEWS DRUG DISCOVERY, 15(2). doi:10.1038/nrd.2015.44A Dormant Microbial Component in the Development of Preeclampsia (Journal article)
Kell, D. B., & Kenny, L. C. (2016). A Dormant Microbial Component in the Development of Preeclampsia. FRONTIERS IN MEDICINE, 3. doi:10.3389/fmed.2016.000602015
The transporter-mediated cellular uptake of pharmaceutical drugs is based on their metabolite-likeness and not on their bulk biophysical properties: Towards a systems pharmacology (Journal article)
Kell, D. B. (2015). The transporter-mediated cellular uptake of pharmaceutical drugs is based on their metabolite-likeness and not on their bulk biophysical properties: Towards a systems pharmacology. Perspectives in Science, 6, 66-83. doi:10.1016/j.pisc.2015.06.004Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS) (Journal article)
Bester, J., Soma, P., Kell, D. B., & Pretorius, E. (2015). Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS). ONCOTARGET, 6(34), 35284-35303. doi:10.18632/oncotarget.6074On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death (Journal article)
Kell, D. B., & Pretorius, E. (2015). On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death. INTEGRATIVE BIOLOGY, 7(11), 1339-1377. doi:10.1039/c5ib00158gFitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly (Journal article)
Mendes, P., Oliver, S. G., & Kell, D. B. (2015). Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly. TRENDS IN PHARMACOLOGICAL SCIENCES, 36(11), 710-723. doi:10.1016/j.tips.2015.07.006Software review: the KNIME workflow environment and its applications in genetic programming and machine learning (Journal article)
O'Hagan, S., & Kell, D. B. (2015). Software review: the KNIME workflow environment and its applications in genetic programming and machine learning. GENETIC PROGRAMMING AND EVOLVABLE MACHINES, 16(3), 387-391. doi:10.1007/s10710-015-9247-3Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology (Journal article)
Kell, D., Potgieter, M., & Pretorius, E. (n.d.). Individuality, phenotypic differentiation, dormancy and ‘persistence’ in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology. F1000Research, 4, 179. doi:10.12688/f1000research.6709.1The dormant blood microbiome in chronic, inflammatory diseases (Journal article)
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015). The dormant blood microbiome in chronic, inflammatory diseases. FEMS MICROBIOLOGY REVIEWS, 39(4), 567-591. doi:10.1093/femsre/fuv013Event-based text mining for biology and functional genomics (Journal article)
Ananiadou, S., Thompson, P., Nawaz, R., McNaught, J., & Kell, D. B. (2015). Event-based text mining for biology and functional genomics. BRIEFINGS IN FUNCTIONAL GENOMICS, 14(3), 213-230. doi:10.1093/bfgp/elu015A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs (vol 11, pg 323, 2015) (Journal article)
O'Hagan, S., Swainston, N., Handl, J., & Kell, D. B. (2015). A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs (vol 11, pg 323, 2015). METABOLOMICS, 11(2), 340. doi:10.1007/s11306-014-0745-8Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis (Journal article)
Kell, D. B., Swainston, N., Pir, P., & Oliver, S. G. (2015). Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis. TRENDS IN BIOTECHNOLOGY, 33(4), 237-246. doi:10.1016/j.tibtech.2015.02.001Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics (Journal article)
Pretorius, E., Bester, J., Vermeulen, N., Alummoottil, S., Soma, P., Buys, A. V., & Kell, D. B. (2015). Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics. CARDIOVASCULAR DIABETOLOGY, 14. doi:10.1186/s12933-015-0192-5Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently (Journal article)
Currin, A., Swainston, N., Day, P. J., & Kell, D. B. (2015). Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently. CHEMICAL SOCIETY REVIEWS, 44(5), 1172-1239. doi:10.1039/c4cs00351aThe virtue of innovation: innovation through the lenses of biological evolution (Journal article)
Kell, D. B., & Lurie-Luke, E. (2015). The virtue of innovation: innovation through the lenses of biological evolution. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12(103). doi:10.1098/rsif.2014.1183Molecular phenotyping of a UK population: defining the human serum metabolome (Journal article)
Dunn, W. B., Lin, W., Broadhurst, D., Begley, P., Brown, M., Zelena, E., . . . Kell, D. B. (2015). Molecular phenotyping of a UK population: defining the human serum metabolome. METABOLOMICS, 11(1), 9-26. doi:10.1007/s11306-014-0707-1The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen) (Journal article)
Kell, D. B., & Pretorius, E. (2015). The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen). INTEGRATIVE BIOLOGY, 7(1), 24-52. doi:10.1039/c4ib00173gA 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs (Journal article)
O'Hagan, S., Swainston, N., Handl, J., & Kell, D. B. (2015). A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs. METABOLOMICS, 11(2), 323-339. doi:10.1007/s11306-014-0733-zIndividuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology. (Journal article)
Kell, D., Potgieter, M., & Pretorius, E. (2015). Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology.. F1000Research, 4, 179. doi:10.12688/f1000research.6709.2The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities (Journal article)
O'Hagan, S., & Kell, D. B. (2015). The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities. PEERJ, 3. doi:10.7717/peerj.1405Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites (Journal article)
O'Hagan, S., & Kell, D. B. (2015). Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites. FRONTIERS IN PHARMACOLOGY, 6. doi:10.3389/fphar.2015.00105What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible? (Journal article)
Kell, D. B. (2015). What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?. TRENDS IN PHARMACOLOGICAL SCIENCES, 36(1), 15-21. doi:10.1016/j.tips.2014.10.0052014
Alignment by numbers: sequence assembly using compressed numerical representations (Journal article)
Tapinos, A., Constantinides, B., Kell, D., & Robertson, D. (2014). Alignment by numbers: sequence assembly using compressed numerical representations. doi:10.1101/011940Eryptosis as a marker of Parkinson's disease (Journal article)
Pretorius, E., Swanepoel, A. C., Buys, A. V., Vermeulen, N., Duim, W., & Kell, D. B. (2014). Eryptosis as a marker of Parkinson's disease. AGING-US, 6(10), 788-819. doi:10.18632/aging.100695GeneGenie: optimized oligomer design for directed evolution (Journal article)
Swainston, N., Currin, A., Day, P. J., & Kell, D. B. (2014). GeneGenie: optimized oligomer design for directed evolution. NUCLEIC ACIDS RESEARCH, 42(W1), W395-W400. doi:10.1093/nar/gku336Mental health: drug search on risky path (Journal article)
Kell, D. (2014). Mental health: drug search on risky path. NATURE, 508(7497), 458. doi:10.1038/508458dProfound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents (Journal article)
Pretorius, E., Bester, J., Vermeulen, N., Lipinski, B., Gericke, G. S., & Kell, D. B. (2014). Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents. PLOS ONE, 9(1). doi:10.1371/journal.pone.0085271Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases (Journal article)
Pretorius, E., & Kell, D. B. (2014). Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases. INTEGRATIVE BIOLOGY, 6(5), 486-510. doi:10.1039/c4ib00025kEvidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes (Journal article)
Anderson, S. G., Dunn, W. B., Banerjee, M., Brown, M., Broadhurst, D. I., Goodacre, R., . . . Cruickshank, J. K. (2014). Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes. PLOS ONE, 9(9). doi:10.1371/journal.pone.0103217How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion (Journal article)
Kell, D. B., & Oliver, S. G. (2014). How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion. FRONTIERS IN PHARMACOLOGY, 5. doi:10.3389/fphar.2014.00231Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery (Journal article)
Kell, D. B., & Goodacre, R. (2014). Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery. DRUG DISCOVERY TODAY, 19(2), 171-182. doi:10.1016/j.drudis.2013.07.014Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery (vol 19, pg 171, 2014) (Journal article)
Kell, D. B., & Goodacre, R. (2014). Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery (vol 19, pg 171, 2014). DRUG DISCOVERY TODAY, 19(11), 1828. doi:10.1016/j.drudis.2014.03.019Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells (Journal article)
Kell, D. B., & Pretorius, E. (2014). Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. METALLOMICS, 6(4), 748-773. doi:10.1039/c3mt00347gSpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution (Journal article)
Currin, A., Swainston, N., Day, P. J., & Kell, D. B. (2014). SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution. PROTEIN ENGINEERING DESIGN & SELECTION, 27(9), 273-280. doi:10.1093/protein/gzu029Yeast cells with impaired drug resistance accumulate glycerol and glucose (Journal article)
Dikicioglu, D., Oc, S., Rash, B. M., Dunn, W. B., Pir, P., Kell, D. B., . . . Oliver, S. G. (2014). Yeast cells with impaired drug resistance accumulate glycerol and glucose. MOLECULAR BIOSYSTEMS, 10(1), 93-102. doi:10.1039/c2mb25512j2013
Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it (Journal article)
Kell, D. B. (2013). Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it. FEBS JOURNAL, 280(23), 5957-5980. doi:10.1111/febs.12268Classroom orchestration: Synthesis (Journal article)
Roschelle, J., Dimitriadis, Y., & Hoppe, U. (2013). Classroom orchestration: Synthesis. COMPUTERS & EDUCATION, 69, 523-526. doi:10.1016/j.compedu.2013.04.010Path2Models: large-scale generation of computational models from biochemical pathway maps (Journal article)
Buechel, F., Rodriguez, N., Swainston, N., Wrzodek, C., Czauderna, T., Keller, R., . . . Le Novere, N. (2013). Path2Models: large-scale generation of computational models from biochemical pathway maps. BMC SYSTEMS BIOLOGY, 7. doi:10.1186/1752-0509-7-116A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes (Journal article)
Smallbone, K., Messiha, H. L., Carroll, K. M., Winder, C. L., Malys, N., Dunn, W. B., . . . Mendes, P. (2013). A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. FEBS LETTERS, 587(17), 2832-2841. doi:10.1016/j.febslet.2013.06.043An analysis of a 'community-driven' reconstruction of the human metabolic network (Journal article)
Swainston, N., Mendes, P., & Kell, D. B. (2013). An analysis of a 'community-driven' reconstruction of the human metabolic network. METABOLOMICS, 9(4), 757-764. doi:10.1007/s11306-013-0564-3A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text (Conference Paper)
Miwa, M., Ohta, T., Rak, R., Rowley, A., Kell, D. B., Pyysalo, S., & Ananiadou, S. (2013). A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text. In BIOINFORMATICS Vol. 29 (pp. 44-52). doi:10.1093/bioinformatics/btt227A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy (Journal article)
Pretorius, E., Vermeulen, N., Bester, J., Lipinski, B., & Kell, D. B. (2013). A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy. TOXICOLOGY MECHANISMS AND METHODS, 23(5), 352-359. doi:10.3109/15376516.2012.762082Genetics and iron in the systems biology of Parkinson's disease and some related disorders (Journal article)
Funke, C., Schneider, S. A., Berg, D., & Kell, D. B. (2013). Genetics and iron in the systems biology of Parkinson's disease and some related disorders. NEUROCHEMISTRY INTERNATIONAL, 62(5), 637-652. doi:10.1016/j.neuint.2012.11.015The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so (Journal article)
Kell, D. B., Dobson, P. D., Bilsland, E., & Oliver, S. G. (2013). The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. DRUG DISCOVERY TODAY, 18(5-6), 218-239. doi:10.1016/j.drudis.2012.11.008A community-driven global reconstruction of human metabolism (Journal article)
Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, A., Sahoo, S., Aurich, M. K., . . . Palsson, B. O. (2013). A community-driven global reconstruction of human metabolism. NATURE BIOTECHNOLOGY, 31(5), 419-+. doi:10.1038/nbt.2488High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease (Journal article)
Bester, J., Buys, A. V., Lipinski, B., Kell, D. B., & Pretorius, E. (2013). High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease. FRONTIERS IN AGING NEUROSCIENCE, 5. doi:10.3389/fnagi.2013.000882012
Exploiting Genomic Knowledge in Optimising Molecular Breeding Programmes: Algorithms from Evolutionary Computing (Journal article)
O'Hagan, S., Knowles, J., & Kell, D. B. (2012). Exploiting Genomic Knowledge in Optimising Molecular Breeding Programmes: Algorithms from Evolutionary Computing. PLOS ONE, 7(11). doi:10.1371/journal.pone.0048862Reviews turn facts into understanding (Journal article)
Kell, D. B. (2012). Reviews turn facts into understanding. NATURE, 490(7418), 37. doi:10.1038/490037eThe metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy (Journal article)
Dunn, W. B., Brown, M., Worton, S. A., Davies, K., Jones, R. L., Kell, D. B., & Heazell, A. E. P. (2012). The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy. METABOLOMICS, 8(4), 579-597. doi:10.1007/s11306-011-0348-6Improving metabolic flux predictions using absolute gene expression data (Journal article)
Lee, D., Smallbone, K., Dunn, W. B., Murabito, E., Winder, C. L., Kell, D. B., . . . Swainston, N. (2012). Improving metabolic flux predictions using absolute gene expression data. BMC SYSTEMS BIOLOGY, 6. doi:10.1186/1752-0509-6-73Large-scale sequestration of atmospheric carbon via plant roots in natural and agricultural ecosystems: why and how (Journal article)
Kell, D. B. (2012). Large-scale sequestration of atmospheric carbon via plant roots in natural and agricultural ecosystems: why and how. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 367(1595), 1589-1597. doi:10.1098/rstb.2011.0244Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment (Journal article)
Dikicioglu, D., Dunn, W. B., Kell, D. B., Kirdar, B., & Oliver, S. G. (2012). Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment. MOLECULAR BIOSYSTEMS, 8(6), 1760-1774. doi:10.1039/c2mb05443dExtracting semantically enriched events from biomedical literature (Journal article)
Miwa, M., Thompson, P., McNaught, J., Kell, D. B., & Ananiadou, S. (2012). Extracting semantically enriched events from biomedical literature. BMC BIOINFORMATICS, 13. doi:10.1186/1471-2105-13-108Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability (Journal article)
Davey, H. M., Cross, E. J. M., Davey, C. L., Gkargkas, K., Delneri, D., Hoyle, D. C., . . . Griffith, G. W. (2012). Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability. ENVIRONMENTAL MICROBIOLOGY, 14(5), 1249-1260. doi:10.1111/j.1462-2920.2012.02705.xA systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation (Journal article)
Wang, Y., Paszek, P., Horton, C. A., Yue, H., White, M. R. H., Kell, D. B., . . . Broomhead, D. S. (2012). A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation. JOURNAL OF THEORETICAL BIOLOGY, 297, 137-147. doi:10.1016/j.jtbi.2011.12.014Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments? (Journal article)
Kell, D. B. (2012). Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?. BIOESSAYS, 34(3), 236-244. doi:10.1002/bies.201100144The genetic control of growth rate: a systems biology study in yeast (Journal article)
Pir, P., Gutteridge, A., Wu, J., Rash, B., Kell, D. B., Zhang, N., & Oliver, S. G. (2012). The genetic control of growth rate: a systems biology study in yeast. BMC SYSTEMS BIOLOGY, 6. doi:10.1186/1752-0509-6-4Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (vol 27, pg 1108, 2011) (Journal article)
Brown, M., Wedge, D. C., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., . . . Dunn, W. B. (2012). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (vol 27, pg 1108, 2011). BIOINFORMATICS, 28(1), 149. doi:10.1093/bioinformatics/btr6012011
Absolute Quantification of the Glycolytic Pathway in Yeast: DEPLOYMENT OF A COMPLETE QconCAT APPROACH (Journal article)
Carroll, K. M., Simpson, D. M., Eyers, C. E., Knight, C. G., Brownridge, P., Dunn, W. B., . . . Beynon, R. J. (2011). Absolute Quantification of the Glycolytic Pathway in Yeast: DEPLOYMENT OF A COMPLETE QconCAT APPROACH. MOLECULAR & CELLULAR PROTEOMICS, 10(12). doi:10.1074/mcp.M111.007633The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networks. (Journal article)
Swainston, N., Smallbone, K., Mendes, P., Kell, D., & Paton, N. (2011). The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networks.. Journal of integrative bioinformatics, 8(2), 186. doi:10.2390/biecoll-jib-2011-186Controlled vocabularies and semantics in systems biology (Journal article)
Courtot, M., Juty, N., Knuepfer, C., Waltemath, D., Zhukova, A., Draeger, A., . . . Le Novere, N. (2011). Controlled vocabularies and semantics in systems biology. MOLECULAR SYSTEMS BIOLOGY, 7. doi:10.1038/msb.2011.77Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast (Journal article)
Lanthaler, K., Bilsland, E., Dobson, P. D., Moss, H. J., Pir, P., Kell, D. B., & Oliver, S. G. (2011). Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. BMC BIOLOGY, 9. doi:10.1186/1741-7007-9-70Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing (Journal article)
Small, B. G., McColl, B. W., Allmendinger, R., Pahle, J., Lopez-Castejon, G., Rothwell, N. J., . . . Kell, D. B. (2011). Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing. NATURE CHEMICAL BIOLOGY, 7(12), 902-908. doi:10.1038/NCHEMBIO.689Concussion's impact (Journal article)
Kell, D. (2011). Concussion's impact. NEW SCIENTIST, 211(2831), 38. doi:10.1016/S0262-4079(11)62341-5Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration (Journal article)
Kell, D. B. (2011). Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration. ANNALS OF BOTANY, 108(3), 407-418. doi:10.1093/aob/mcr175Metabolic Profiling Uncovers a Phenotypic Signature of Small for Gestational Age in Early Pregnancy (Journal article)
Horgan, R. P., Broadhurst, D. I., Walsh, S. K., Dunn, W. B., Brown, M., Roberts, C. T., . . . Kenny, L. C. (2011). Metabolic Profiling Uncovers a Phenotypic Signature of Small for Gestational Age in Early Pregnancy. JOURNAL OF PROTEOME RESEARCH, 10(8), 3660-3673. doi:10.1021/pr2002897Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only (Journal article)
Kell, D. B., Dobson, P. D., & Oliver, S. G. (2011). Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. DRUG DISCOVERY TODAY, 16(15-16), 704-714. doi:10.1016/j.drudis.2011.05.010Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry (Journal article)
Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., . . . Goodacre, R. (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. NATURE PROTOCOLS, 6(7), 1060-1083. doi:10.1038/nprot.2011.335Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (Journal article)
Brown, M., Wedge, D. C., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., . . . Dunn, W. B. (2011). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. BIOINFORMATICS, 27(8), 1108-1112. doi:10.1093/bioinformatics/btr079Mining metabolites: extracting the yeast metabolome from the literature (Journal article)
Nobata, C., Dobson, P. D., Iqbal, S. A., Mendes, P., Tsujii, J., Kell, D. B., & Ananiadou, S. (2011). Mining metabolites: extracting the yeast metabolome from the literature. METABOLOMICS, 7(1), 94-101. doi:10.1007/s11306-010-0251-6Predicting the points of interaction of small molecules in the NF-κB pathway (Journal article)
Patel, Y., Heyward, C. A., White, M. R. H., & Kell, D. B. (2011). Predicting the points of interaction of small molecules in the NF-κB pathway. BMC SYSTEMS BIOLOGY, 5. doi:10.1186/1752-0509-5-32Interactions among oscillatory pathways in NF-kappa B signaling (Journal article)
Wang, Y., Paszek, P., Horton, C. A., Kell, D. B., White, M. R. H., Broomhead, D. S., & Muldoon, M. R. (2011). Interactions among oscillatory pathways in NF-kappa B signaling. BMC SYSTEMS BIOLOGY, 5. doi:10.1186/1752-0509-5-23Understanding the languages of cells: Network modelling in metabolic systems biology and biotechnology: why, how and whither (Journal article)
Kell, D. B. (2011). Understanding the languages of cells: Network modelling in metabolic systems biology and biotechnology: why, how and whither. The Biochemist, 33(1), 4-7. doi:10.1042/bio03301004SYSTEMS BIOLOGY Metabolites do social networking (Journal article)
Kell, D. B. (2011). SYSTEMS BIOLOGY Metabolites do social networking. NATURE CHEMICAL BIOLOGY, 7(1), 7-8. doi:10.1038/nchembio.5052010
Systematic integration of experimental data and models in systems biology (Journal article)
Li, P., Dada, J. O., Jameson, D., Spasic, I., Swainston, N., Carroll, K., . . . Paton, N. W. (2010). Systematic integration of experimental data and models in systems biology. BMC BIOINFORMATICS, 11. doi:10.1186/1471-2105-11-582Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples (Journal article)
Kell, D. B. (2010). Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. ARCHIVES OF TOXICOLOGY, 84(11), 825-889. doi:10.1007/s00204-010-0577-xFurther developments towards a genome-scale metabolic model of yeast (Journal article)
Dobson, P. D., Smallbone, K., Jameson, D., Simeonidis, E., Lanthaler, K., Pir, P., . . . Mendes, P. (2010). Further developments towards a genome-scale metabolic model of yeast. BMC SYSTEMS BIOLOGY, 4. doi:10.1186/1752-0509-4-145Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies (Journal article)
Horgan, R. P., Broadhurst, D. I., Dunn, W. B., Brown, M., Heazell, A. E. P., Kell, D. B., . . . Kenny, L. C. (2010). Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies. PLACENTA, 31(10), 893-901. doi:10.1016/j.placenta.2010.07.002Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers (Journal article)
Kenny, L. C., Broadhurst, D. I., Dunn, W., Brown, M., North, R. A., McCowan, L., . . . Baker, P. N. (2010). Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers. HYPERTENSION, 56(4), 741-749. doi:10.1161/HYPERTENSIONAHA.110.157297Utopia documents: linking scholarly literature with research data (Journal article)
Attwood, T. K., Kell, D. B., McDermott, P., Marsh, J., Pettifer, S. R., & Thorne, D. (2010). Utopia documents: linking scholarly literature with research data. BIOINFORMATICS, 26(18), i568-i574. doi:10.1093/bioinformatics/btq383Convergent evolution to an aptamer observed in small populations on DNA microarrays (Journal article)
Rowe, W., Platt, M., Wedge, D. C., Day, P. J. R., Kell, D. B., & Knowles, J. D. (2010). Convergent evolution to an aptamer observed in small populations on DNA microarrays. PHYSICAL BIOLOGY, 7(3). doi:10.1088/1478-3975/7/3/036007Enzyme kinetics informatics: from instrument to browser (Journal article)
Swainston, N., Golebiewski, M., Messiha, H. L., Malys, N., Kania, R., Kengne, S., . . . Rojas, I. (2010). Enzyme kinetics informatics: from instrument to browser. FEBS JOURNAL, 277(18), 3769-3779. doi:10.1111/j.1742-4658.2010.07778.xPredictive models for population performance on real biological fitness landscapes (Journal article)
Rowe, W., Wedge, D. C., Platt, M., Kell, D. B., & Knowles, J. (2010). Predictive models for population performance on real biological fitness landscapes. BIOINFORMATICS, 26(17), 2145-2152. doi:10.1093/bioinformatics/btq353Event extraction for systems biology by text mining the literature (Journal article)
Ananiadou, S., Pyysalo, S., Tsujii, J., & Kell, D. B. (2010). Event extraction for systems biology by text mining the literature. TRENDS IN BIOTECHNOLOGY, 28(7), 381-390. doi:10.1016/j.tibtech.2010.04.005Arcadia: a visualization tool for metabolic pathways (Journal article)
Villeger, A. C., Pettifer, S. R., & Kell, D. B. (2010). Arcadia: a visualization tool for metabolic pathways. BIOINFORMATICS, 26(11), 1470-1471. doi:10.1093/bioinformatics/btq154Analysis of a complete DNA-protein affinity landscape (Journal article)
Rowe, W., Platt, M., Wedge, D. C., Day, P. J., Kell, D. B., & Knowles, J. (2010). Analysis of a complete DNA-protein affinity landscape. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 7(44), 397-408. doi:10.1098/rsif.2009.0193Systems microbiology (Journal article)
Kell, D. B. (2010). Systems microbiology. Microbiology Today, 37(1), 14-15.BACTERIAL PHEROMONE AND USE THEREOF (Journal article)
MUKAMOLOVA GALINA V., KAPRELYANTS ARSENY S., YOUNG DANIELLE I., KELL DOUGLAS B., & YOUNG MICHAEL. (2010). BACTERIAL PHEROMONE AND USE THEREOF.(Journal article)
YOUNG DANIELLE I., YOUNG MICHAEL., MUKAMOLOVA GALINA V., KAPRELYANTS ARSENY S., & KELL DOUGLAS B. (2010). .2009
Calling International Rescue: knowledge lost in literature and data landslide! (Journal article)
Attwood, T. K., Kell, D. B., McDermott, P., Marsh, J., Pettifer, S. R., & Thorne, D. (2009). Calling International Rescue: knowledge lost in literature and data landslide!. BIOCHEMICAL JOURNAL, 424, 317-333. doi:10.1042/BJ20091474Real-time vapour sensing using an OFET-based electronic nose and genetic programming (Journal article)
Wedge, D. C., Das, A., Dost, R., Kettle, J., Madec, M. -B., Morrison, J. J., . . . Turner, M. L. (2009). Real-time vapour sensing using an OFET-based electronic nose and genetic programming. SENSORS AND ACTUATORS B-CHEMICAL, 143(1), 365-372. doi:10.1016/j.snb.2009.09.030Analysis of aptamer sequence activity relationships (Journal article)
Platt, M., Rowe, W., Knowles, J., Day, P. J., & Kell, D. B. (2009). Analysis of aptamer sequence activity relationships. INTEGRATIVE BIOLOGY, 1(1), 116-122. doi:10.1039/b814892aCalling International Rescue: Knowledge lost in literature and data landslide! (Journal article)
Attwood, T. K., Kell, D. B., McDermott, P., Marsh, J., Pettifer, S. R., & Thorne, D. (2009). Calling International Rescue: Knowledge lost in literature and data landslide!. The Biochemist, 31(6), 23-38. doi:10.1042/bio03106023Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia (Journal article)
Dunn, W. B., Brown, M., Worton, S. A., Crocker, I. P., Broadhurst, D., Horgan, R., . . . Heazell, A. E. P. (2009). Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia. PLACENTA, 30(11), 974-980. doi:10.1016/j.placenta.2009.08.008Matrix Method for Determining Steps Most Rate-Limiting to Metabolic Fluxes in Biotechnological Processes (Journal article)
Westerhoff, H. V., & Kell, D. B. (2009). Matrix Method for Determining Steps Most Rate-Limiting to Metabolic Fluxes in Biotechnological Processes. BIOTECHNOLOGY AND BIOENGINEERING, 104(1), 3-9. Retrieved from https://www.webofscience.com/The Systems Biology Graphical Notation (vol 27, pg 735, 2009) (Journal article)
Le Novere, N., Hucka, M., Mi, H., Moodie, S., Schreiber, F., Sorokin, A., . . . Kitano, H. (2009). The Systems Biology Graphical Notation (vol 27, pg 735, 2009). NATURE BIOTECHNOLOGY, 27(9), 864. doi:10.1038/nbt0909-864dDevelopment and Performance of a Gas Chromatography-Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum (Journal article)
Begley, P., Francis-McIntyre, S., Dunn, W. B., Broadhurst, D. I., Halsall, A., Tseng, A., . . . Kell, D. B. (2009). Development and Performance of a Gas Chromatography-Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum. ANALYTICAL CHEMISTRY, 81(16), 7038-7046. doi:10.1021/ac9011599Optimal construction of a fast and accurate polarisable water potential based on multipole moments trained by machine learning (Journal article)
Handley, C. M., Hawe, G. I., Kell, D. B., & Popelier, P. L. A. (2009). Optimal construction of a fast and accurate polarisable water potential based on multipole moments trained by machine learning. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 11(30), 6365-6376. doi:10.1039/b905748jJournal club. A systems biologist ponders how disparate ideas can sometimes come together beautifully. (Journal article)
Kell, D. (2009). Journal club. A systems biologist ponders how disparate ideas can sometimes come together beautifully.. Nature, 460(7256), 669. doi:10.1038/460669eThe Systems Biology Graphical Notation (Journal article)
Le Novere, N., Hucka, M., Mi, H., Moodie, S., Schreiber, F., Sorokin, A., . . . Kitano, H. (2009). The Systems Biology Graphical Notation. NATURE BIOTECHNOLOGY, 27(8), 735-741. doi:10.1038/nbt.1558Information management for high content live cell imaging (Journal article)
Jameson, D., Turner, D. A., Ankers, J., Kennedy, S., Ryan, S., Swainston, N., . . . Paton, N. W. (2009). Information management for high content live cell imaging. BMC BIOINFORMATICS, 10. doi:10.1186/1471-2105-10-226Deterministic mathematical models of the cAMP pathway in <i>Saccharomyces cerevisiae</i> (Journal article)
Williamson, T., Schwartz, J. -M., Kell, D. B., & Stateva, L. (2009). Deterministic mathematical models of the cAMP pathway in <i>Saccharomyces cerevisiae</i>. BMC SYSTEMS BIOLOGY, 3. doi:10.1186/1752-0509-3-70Aptamer evolution for array-based diagnostics (Journal article)
Platt, M., Rowe, W., Wedge, D. C., Kell, D. B., Knowles, J., & Day, P. J. R. (2009). Aptamer evolution for array-based diagnostics. ANALYTICAL BIOCHEMISTRY, 390(2), 203-205. doi:10.1016/j.ab.2009.04.013Visualising biological data: a semantic approach to tool and database integration (Conference Paper)
Pettifer, S., Thorne, D., McDermott, P., Marsh, J., Villeger, A., Kell, D. B., & Attwood, T. K. (2009). Visualising biological data: a semantic approach to tool and database integration. In BMC BIOINFORMATICS Vol. 10. doi:10.1186/1471-2105-10-S6-S19KiPar, a tool for systematic information retrieval regarding parameters for kinetic modelling of yeast metabolic pathways (Journal article)
Spasic, I., Simeonidis, E., Messiha, H. L., Paton, N. W., & Kell, D. B. (2009). KiPar, a tool for systematic information retrieval regarding parameters for kinetic modelling of yeast metabolic pathways. BIOINFORMATICS, 25(11), 1404-1411. doi:10.1093/bioinformatics/btp175Dormant microbes: time to revive some old ideas (Journal article)
Kell, D. (2009). Dormant microbes: time to revive some old ideas. NATURE, 458(7240), 831. doi:10.1038/458831bPulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription (Journal article)
Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Harper, C. V., Sillitoe, K., . . . White, M. R. H. (2009). Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription. SCIENCE, 324(5924), 242-246. doi:10.1126/science.1164860Low cost, portable, fast multiparameter data acquisition system for organic transistor odour sensors (Journal article)
Das, A., Dost, R., Richardson, T. H., Grell, M., Wedge, D. C., Kell, D. B., . . . Turner, M. L. (2009). Low cost, portable, fast multiparameter data acquisition system for organic transistor odour sensors. SENSORS AND ACTUATORS B-CHEMICAL, 137(2), 586-591. doi:10.1016/j.snb.2009.01.006<i>In silico</i> modelling of directed evolution: Implications for experimental design and stepwise evolution (Journal article)
Wedge, D. C., Rowe, W., Kell, D. B., & Knowles, J. (2009). <i>In silico</i> modelling of directed evolution: Implications for experimental design and stepwise evolution. JOURNAL OF THEORETICAL BIOLOGY, 257(1), 131-141. doi:10.1016/j.jtbi.2008.11.005Abstracts (Journal article)
Abstracts (2009). Reproductive Sciences, 16(S3), A67-A374. doi:10.1177/193371912009163s167Opinion (Journal article)
Kell, D. (2009). Opinion. Food Science and Technology, 23(1), 17.Development of a Robust and Repeatable UPLC-MS Method for the Long-Term Metabolomic Study of Human Serum (Journal article)
Zelena, E., Dunn, W. B., Broadhurst, D., Francis-McIntyre, S., Carroll, K. M., Begley, P., . . . Kellt, D. B. (2009). Development of a Robust and Repeatable UPLC-MS Method for the Long-Term Metabolomic Study of Human Serum. ANALYTICAL CHEMISTRY, 81(4), 1357-1364. doi:10.1021/ac8019366Anaesthetic function (Journal article)
Kell, D. (2009). Anaesthetic function. NEW SCIENTIST, 201(2694), 27. doi:10.1016/S0262-4079(09)60363-8Implications of the Dominant Role of Transporters in Drug Uptake by Cells (Journal article)
Dobson, P. D., Lanthaler, K., Oliver, S. G., & Kell, D. B. (2009). Implications of the Dominant Role of Transporters in Drug Uptake by Cells. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 9(2), 163-181. doi:10.2174/156802609787521616Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape (Journal article)
Knight, C. G., Platt, M., Rowe, W., Wedge, D. C., Khan, F., Day, P. J. R., . . . Kell, D. B. (2009). Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape. NUCLEIC ACIDS RESEARCH, 37(1). doi:10.1093/nar/gkn899Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (Journal article)
Kell, D. B. (2009). Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC MEDICAL GENOMICS, 2. doi:10.1186/1755-8794-2-2'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries (Journal article)
Dobson, P. D., Patel, Y., & Kell, D. B. (2009). 'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries. DRUG DISCOVERY TODAY, 14(1-2), 31-40. doi:10.1016/j.drudis.2008.10.011Altered Plasma Metabolome in Early Pregnancy in Women Who Develop a Small for Gestational Age Baby (Conference Paper)
Horgan, R. P., Broadhurst, D. I., Brown, M. C., Warwick, B. D., Kell, D. B., Baker, P. N., & Kenny, L. C. (2009). Altered Plasma Metabolome in Early Pregnancy in Women Who Develop a Small for Gestational Age Baby. In REPRODUCTIVE SCIENCES Vol. 16 (pp. 137A-138A). Retrieved from https://www.webofscience.com/Altered plasma metabolome in early pregnancy in women who develop a small for gestational age baby (Conference Paper)
Horgan, R., Broadhurst, D., Brown, M., Dunn, W., Kell, D., Baker, P., & Kenny, L. (2009). Altered plasma metabolome in early pregnancy in women who develop a small for gestational age baby. In BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 116 (pp. 1409). Retrieved from https://www.webofscience.com/Changes in the Metabolic Profile of Placental Villous Explants Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies (Conference Paper)
Horgan, R. P., Brown, M. C., Dunn, W. B., Heazell, A. E., Kell, D. B., Baker, P. N., . . . Broadhurst, D. I. (2009). Changes in the Metabolic Profile of Placental Villous Explants Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies. In REPRODUCTIVE SCIENCES Vol. 16 (pp. 345A). Retrieved from https://www.webofscience.com/Clustering of NF-κB inhibitors by their interaction in the signaling pathway (Conference Paper)
Patel, Y., Heyward, C., & Kell, D. B. (2009). Clustering of NF-κB inhibitors by their interaction in the signaling pathway. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 237. Retrieved from https://www.webofscience.com/Early Pregnancy Prediction of Preeclampsia Using Metabolomic Biomarkers (Conference Paper)
Kenny, L. C., Broadhurst, D. I., Dunn, W., Brown, M., North, R. A., Cooper, G. J. S., . . . Baker, P. N. (2009). Early Pregnancy Prediction of Preeclampsia Using Metabolomic Biomarkers. In REPRODUCTIVE SCIENCES Vol. 16 (pp. 102A). Retrieved from https://www.webofscience.com/Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics (Journal article)
Brown, M., Dunn, W. B., Dobson, P., Patel, Y., Winder, C. L., Francis-McIntyre, S., . . . Kell, D. B. (2009). Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics. ANALYST, 134(7), 1322-1332. doi:10.1039/b901179jMetabolic Footprinting of Preeclamptic Placental Tissue Using UPLC/LTQ-Orbitrap Mass Spectrometry (Conference Paper)
Brown, M., Heazell, A., Dunn, W. B., Kenny, L. C., Broadhurst, D. I., Horgan, R., . . . Baker, P. N. (2009). Metabolic Footprinting of Preeclamptic Placental Tissue Using UPLC/LTQ-Orbitrap Mass Spectrometry. In REPRODUCTIVE SCIENCES Vol. 16 (pp. 342A). Retrieved from https://www.webofscience.com/(Journal article)
MUKAMOLOVA GALINA V., KAPRELYANTS ARSENY S., YOUNG DANIELLE., KELL DOUGLAS., & YOUNG MICHAEL. (2009). .2008
Rapid prediction of optimum population size in genetic programming using a novel genotype - Fitness correlation (Conference Paper)
Wedge, D. C., & Kell, D. B. (2008). Rapid prediction of optimum population size in genetic programming using a novel genotype - Fitness correlation. In GECCO'08: Proceedings of the 10th Annual Conference on Genetic and Evolutionary Computation 2008 (pp. 1315-1322).Q&A (Journal article)
Kell, P. D., & Reece, R. (2008). Q&A. The Biochemist, 30(6), 31-32. doi:10.1042/bio03006031Molecular Structure Elucidation Using Ant Colony Optimization: A Preliminary Study (Conference Paper)
Farrelly, C., Kell, D. B., & Knowles, J. (2008). Molecular Structure Elucidation Using Ant Colony Optimization: A Preliminary Study. In ANT COLONY OPTIMIZATION AND SWARM INTELLIGENCE, PROCEEDINGS Vol. 5217 (pp. 120-131). Retrieved from https://www.webofscience.com/Progress being made on standards for use in data sharing (Journal article)
Kell, D. B. (2008). Progress being made on standards for use in data sharing. NATURE, 456(7218), 29. doi:10.1038/456029cSensitivity Analysis and Robust Experimental Design of a Signal Transduction Pathway System (Conference Paper)
Yue, H., Brown, M., He, F., Jia, J., & Kell, D. B. (2008). Sensitivity Analysis and Robust Experimental Design of a Signal Transduction Pathway System. In INTERNATIONAL JOURNAL OF CHEMICAL KINETICS Vol. 40 (pp. 730-741). doi:10.1002/kin.20369A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology (Journal article)
Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., . . . Kell, D. B. (2008). A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. NATURE BIOTECHNOLOGY, 26(10), 1155-1160. doi:10.1038/nbt1492Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system (Journal article)
Dunn, W. B., Broadhurst, D., Brown, M., Baker, P. N., Redman, C. W. G., Kenny, L. C., & Kell, D. B. (2008). Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 871(2), 288-298. doi:10.1016/j.jchromb.2008.03.021Performing statistical analyses on quantitative data in Taverna workflows: An example using R and maxdBrowse to identify differentially-expressed genes from microarray data (Journal article)
Li, P., Castrillo, J. I., Velarde, G., Wassink, I., Soiland-Reyes, S., Owen, S., . . . Kell, D. B. (2008). Performing statistical analyses on quantitative data in Taverna workflows: An example using R and maxdBrowse to identify differentially-expressed genes from microarray data. BMC BIOINFORMATICS, 9. doi:10.1186/1471-2105-9-334Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers (Journal article)
Heazell, A. E. P., Brown, M., Dunn, W. B., Worton, S. A., Crocker, I. P., Baker, P. N., & Kell, D. B. (2008). Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. PLACENTA, 29(8), 691-698. doi:10.1016/j.placenta.2008.05.002Detection and identification of novel metabolomic biomarkers in preeclampsia (Journal article)
Kenny, L. C., Broadhurst, D., Brown, M., Dunn, W. B., Redman, C. W. G., Kill, D. B., & Baker, P. N. (2008). Detection and identification of novel metabolomic biomarkers in preeclampsia. REPRODUCTIVE SCIENCES, 15(6), 591-597. doi:10.1177/1933719108316908The markup is the model: Reasoning about systems biology models in the Semantic Web era (Journal article)
Kell, D. B., & Mendes, P. (2008). The markup is the model: Reasoning about systems biology models in the Semantic Web era. JOURNAL OF THEORETICAL BIOLOGY, 252(3), 538-543. doi:10.1016/j.jtbi.2007.10.023Bayesian inference of the sites of perturbations in metabolic pathways via Markov chain Monte Carlo (Journal article)
Jayawardhana, B., Kell, D. B., & Rattray, M. (2008). Bayesian inference of the sites of perturbations in metabolic pathways via Markov chain Monte Carlo. BIOINFORMATICS, 24(9), 1191-1197. doi:10.1093/bioinformatics/btn103Facilitating the development of controlled vocabularies for metabolomics technologies with text mining (Journal article)
Spasic, I., Schober, D., Sansone, S. -A., Rebholz-Schuhmann, D., Kell, D. B., & Paton, N. W. (2008). Facilitating the development of controlled vocabularies for metabolomics technologies with text mining. BMC BIOINFORMATICS, 9. doi:10.1186/1471-2105-9-S5-S5A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols (Journal article)
Dunn, W. B., Broadhurst, D., Ellis, D. I., Brown, M., Halsall, A., O'Hagan, S., . . . Kell, D. B. (2008). A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 37, 23-30. doi:10.1093/ije/dym281Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS (Journal article)
Lu, H., Dunn, W. B., Shen, H., Kell, D. B., & Liang, Y. (2008). Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 27(3), 215-227. doi:10.1016/j.trac.2007.11.004Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, <i>Stereum hirsutum</i> with its competitors <i>Coprinus micaceus</i> and <i>Coprinus disseminatus</i> (Journal article)
Peiris, D., Dunn, W. B., Brown, M., Kell, D. B., Roy, I., & Hedger, J. N. (2008). Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, <i>Stereum hirsutum</i> with its competitors <i>Coprinus micaceus</i> and <i>Coprinus disseminatus</i>. METABOLOMICS, 4(1), 52-62. doi:10.1007/s11306-007-0100-4Opinion - Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? (Journal article)
Dobson, P. D., & Kell, D. B. (2008). Opinion - Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?. NATURE REVIEWS DRUG DISCOVERY, 7(3), 205-220. doi:10.1038/nrd2438Information-theoretic sensitivity analysis:: a general method for credit assignment in complex networks (Journal article)
Luedtke, N., Panzeri, S., Brown, M., Broomhead, D. S., Knowles, J., Montemurro, M. A., & Kell, D. B. (2008). Information-theoretic sensitivity analysis:: a general method for credit assignment in complex networks. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 5(19), 223-235. doi:10.1098/rsif.2007.1079Automated manipulation of systems biology models using libSBML within Taverna workflows (Journal article)
Li, P., Oinn, T., Soiland, S., & Kell, D. B. (2008). Automated manipulation of systems biology models using libSBML within Taverna workflows. BIOINFORMATICS, 24(2), 287-289. doi:10.1093/bioinformatics/btm578Changes in metabolic profile of placental villous explants cultured in different oxygen tensions. (Conference Paper)
Heazell, A. E., Brown, M. C., Dunn, W. B., Worton, S. A., Robinson, N., Baker, P. N., & Kell, D. B. (2008). Changes in metabolic profile of placental villous explants cultured in different oxygen tensions.. In REPRODUCTIVE SCIENCES Vol. 15 (pp. 318A). Retrieved from https://www.webofscience.com/Defrosting the Digital Library: Bibliographic Tools for the Next Generation Web (Journal article)
Hull, D., Pettifer, S. R., & Kell, D. B. (2008). Defrosting the Digital Library: Bibliographic Tools for the Next Generation Web. PLOS COMPUTATIONAL BIOLOGY, 4(10). doi:10.1371/journal.pcbi.1000204Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures (Journal article)
Delneri, D., Hoyle, D. C., Gkargkas, K., Cross, E. J. M., Rash, B., Zeef, L., . . . Oliver, S. G. (2008). Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures. NATURE GENETICS, 40(1), 113-117. doi:10.1038/ng.2007.49Metabolic footprinting of placental explants using UPLC/LTQ-Orbitrap mass spectrometry. (Conference Paper)
Brown, M., Heazell, A., Dunn, W. B., Kenny, L. C., Worton, S., Kell, D. B., & Baker, P. N. (2008). Metabolic footprinting of placental explants using UPLC/LTQ-Orbitrap mass spectrometry.. In REPRODUCTIVE SCIENCES Vol. 15 (pp. 318A). Retrieved from https://www.webofscience.com/Metabolomic investigation of placental factors released in pre-eclampsia (Conference Paper)
Worlon, S. A., Brown, M., Dunn, W. B., Crocker, I. P., Baker, P. N., Kell, D. B., & Heazell, A. E. P. (2008). Metabolomic investigation of placental factors released in pre-eclampsia. In PLACENTA Vol. 29 (pp. A76). Retrieved from https://www.webofscience.com/The application of UPLC/LTQ-Orbitrap mass Spectrometry to human metabolite biomarker discovery. A case study: Pre-eclampsia. (Conference Paper)
Broadhurst, D. I., Brown, M., Dunn, W. B., Carroll, K. B., Redman, C. W., Baker, P. N., . . . Kenny, L. C. (2008). The application of UPLC/LTQ-Orbitrap mass Spectrometry to human metabolite biomarker discovery. A case study: Pre-eclampsia.. In REPRODUCTIVE SCIENCES Vol. 15 (pp. 208A). Retrieved from https://www.webofscience.com/The landscape adaptive particle swarm optimizer (Journal article)
Yisu, J., Knowles, J., Hongmei, L., Liang, Y., & Kell, D. B. (2008). The landscape adaptive particle swarm optimizer. APPLIED SOFT COMPUTING, 8(1), 295-304. doi:10.1016/j.asoc.2007.01.0092007
Improving Data Fitting of a Signal Transduction Model by Global Sensitivity Analysis (Conference Paper)
Jin, Y., Yue, H., Brown, M., Liang, Y., & Kell, D. B. (2007). Improving Data Fitting of a Signal Transduction Model by Global Sensitivity Analysis. In 2007 American Control Conference. IEEE. doi:10.1109/acc.2007.4282366Taverna/myGrid: Aligning a Workflow System with the Life Sciences Community (Chapter)
Oinn, T., Li, P., Kell, D. B., Goble, C., Goderis, A., Greenwood, M., . . . Zhao, J. (n.d.). Taverna/myGrid: Aligning a Workflow System with the Life Sciences Community. In Workflows for e-Science (pp. 300-319). Springer London. doi:10.1007/978-1-84628-757-2_19The methodologies of systems biology (Chapter)
Westerhoff, H. V., & Kell, D. B. (2007). The methodologies of systems biology. In Systems Biology (pp. 23-70). Elsevier. doi:10.1016/b978-044452085-2/50004-8Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate (Journal article)
Dunn, W. B., Broadhurst, D. I., Deepak, S. M., Buch, M. H., McDowell, G., Spasic, I., . . . Neyses, L. (2007). Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate. METABOLOMICS, 3(4), 413-426. doi:10.1007/s11306-007-0063-5The virtual human: Towards a global systems biology of multiscale, distributed biochemical network models (Journal article)
Kell, D. B. (2007). The virtual human: Towards a global systems biology of multiscale, distributed biochemical network models. IUBMB LIFE, 59(11), 689-695. doi:10.1080/15216540701694252Something from nothing - bridging the gap between constraint-based and kinetic modelling (Journal article)
Smallbone, K., Simeonidis, E., Broomhead, D. S., & Kell, D. B. (2007). Something from nothing - bridging the gap between constraint-based and kinetic modelling. FEBS JOURNAL, 274(21), 5576-5585. doi:10.1111/j.1742-4658.2007.06076.xProposed minimum reporting standards for data analysis in metabolomics (Journal article)
Goodacre, R., Broadhurst, D., Smilde, A. K., Kristal, B. S., Baker, J. D., Beger, R., . . . Wulfert, F. (2007). Proposed minimum reporting standards for data analysis in metabolomics. METABOLOMICS, 3(3), 231-241. doi:10.1007/s11306-007-0081-3Transcriptional and metabolic response of <i>Saccharomyces cerevisiae</i> to a nutritional perturbation when under stress (Conference Paper)
Dikicioglu, D., Rash, B., Dunn, W. B., Pir, P., Hayes, A., Kell, D. B., . . . Oliver, S. G. (2007). Transcriptional and metabolic response of <i>Saccharomyces cerevisiae</i> to a nutritional perturbation when under stress. In JOURNAL OF BIOTECHNOLOGY Vol. 131 (pp. S14-S15). doi:10.1016/j.jbiotec.2007.07.028Metabolic footprinting as a tool for discriminating between brewing yeasts (Journal article)
Pope, G. A., MacKenzie, D. A., Defemez, M., Aroso, M. A. M. M., Fuller, L. J., Mellon, F. A., . . . Roberts, I. N. (2007). Metabolic footprinting as a tool for discriminating between brewing yeasts. YEAST, 24(8), 667-679. doi:10.1002/yea.1499Peptide Detectability following ESI Mass Spectrometry: Prediction using Genetic Programming (Conference Paper)
Wedge, D. C., Kell, D. B., Gaskell, S. J., Lau, K. W., Hubbard, S. J., & Eyers, C. (2007). Peptide Detectability following ESI Mass Spectrometry: Prediction using Genetic Programming. In GECCO 2007: GENETIC AND EVOLUTIONARY COMPUTATION CONFERENCE, VOL 1 AND 2 (pp. 2219-+). Retrieved from https://www.webofscience.com/Metabolomic biomarkers: search, discovery and validation (Journal article)
Kell, D. B. (2007). Metabolomic biomarkers: search, discovery and validation. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 7(4), 329-333. doi:10.1586/14737159.7.4.329Growth control of the eukaryote cell: a systems biology study in yeast. (Journal article)
Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., . . . Oliver, S. G. (2007). Growth control of the eukaryote cell: a systems biology study in yeast.. Journal of biology, 6(2), 4. doi:10.1186/jbiol54The methodologies of systems biology (Chapter)
Westerhoff, H. V., & Kell, D. B. (2007). The methodologies of systems biology. In Systems Biology: Philosophical Foundations (pp. 23-70). doi:10.1016/B978-044452085-2/50004-8Multiobjective optimization in bioinformatics and computational biology (Journal article)
Handl, J., Kell, D. B., & Knowles, J. (2007). Multiobjective optimization in bioinformatics and computational biology. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 4(2), 279-292. doi:10.1109/TCBB.2007.070203Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics (Journal article)
Hagan, S. O., Dunn, W. B., Knowles, J. D., Broadhurst, D., Williams, R., Ashworth, J. J., . . . Kell, D. B. (2007). Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics. ANALYTICAL CHEMISTRY, 79(2), 464-476. doi:10.1021/ac061443+Statistical strategies for avoiding false discoveries in metabolomics and related experiments (Journal article)
Broadhurst, D. I., & Kell, D. B. (2006). Statistical strategies for avoiding false discoveries in metabolomics and related experiments. METABOLOMICS, 2(4), 171-196. doi:10.1007/s11306-006-0037-zImpaired endothelium-dependent vascular reactivity in patients with familial combined hyperlipidaemia. (Journal article)
De Michele, M., Iannuzzi, A., Salvato, A., Pauciullo, P., Gentile, M., Iannuzzo, G., . . . Rubba, P. (2007). Impaired endothelium-dependent vascular reactivity in patients with familial combined hyperlipidaemia.. Heart (British Cardiac Society), 93(1), 78-81. doi:10.1136/hrt.2006.093278Improving data fitting of a signal transduction model by global sensitivity analysis (Conference Paper)
Jin, Y., Yue, H., Brown, M., Liang, Y., & Kell, D. B. (2007). Improving data fitting of a signal transduction model by global sensitivity analysis. In 2007 AMERICAN CONTROL CONFERENCE, VOLS 1-13 (pp. 1379-1384). Retrieved from https://www.webofscience.com/Proximate parameter tuning for biochemical networks with uncertain kinetic parameters (Journal article)
Wilkinson, S. J., Benson, N., & Kell, D. B. (2008). Proximate parameter tuning for biochemical networks with uncertain kinetic parameters. MOLECULAR BIOSYSTEMS, 4(1), 74-97. doi:10.1039/b707506eSerum metabolomic analysis successfully discriminates heart failure patients from controls (Conference Paper)
Deepak, S., Dunn, W., Broadhurst, D., Buch, M., McDowell, G., Ellis, D., . . . Neyses, L. (2007). Serum metabolomic analysis successfully discriminates heart failure patients from controls. In HEART Vol. 93 (pp. A78-A79). Retrieved from https://www.webofscience.com/2006
Automated tracking of gene expression in individual cells and cell compartments (Journal article)
Shen, H., Nelson, G., Nelson, D. E., Kennedy, S., Spiller, D. G., Griffiths, T., . . . Kell, D. B. (2006). Automated tracking of gene expression in individual cells and cell compartments. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 3(11), 787-794. doi:10.1098/rsif.2006.0137Systems biology, metabolic modelling and metabolomics in drug discovery and development (Journal article)
Kell, D. B. (2006). Systems biology, metabolic modelling and metabolomics in drug discovery and development. DRUG DISCOVERY TODAY, 11(23-24), 1085-1092. doi:10.1016/j.drudis.2006.10.004Text mining and its potential applications in systems biology (Journal article)
Ananiadou, S., Kell, D. B., & Tsujii, J. -I. (2006). Text mining and its potential applications in systems biology. TRENDS IN BIOTECHNOLOGY, 24(12), 571-579. doi:10.1016/j.tibtech.2006.10.002Insights into the behaviour of systems biology models from dynamic sensitivty and identifiability analysis:: a case study of an NF-κB signalling pathway (Journal article)
Yue, H., Brown, M., Knowles, J., Wang, H., Broomhead, D. S., & Kell, D. B. (2006). Insights into the behaviour of systems biology models from dynamic sensitivty and identifiability analysis:: a case study of an NF-κB signalling pathway. MOLECULAR BIOSYSTEMS, 2(12), 640-649. doi:10.1039/b609442bMeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics (Journal article)
Spasic, I., Dunn, W. B., Velarde, G., Tseng, A., Jenkins, H., Hardy, N., . . . Kell, D. B. (2006). MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics. BMC BIOINFORMATICS, 7. doi:10.1186/1471-2105-7-281Metabolomics: The new science of metabolic integration (Conference Paper)
Kell, D. B. (2006). Metabolomics: The new science of metabolic integration. In JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY Vol. 40 (pp. 935). doi:10.1016/j.yjmcc.2006.03.055Automatic tracking of biological cells and compartments using particle filters and active contours (Journal article)
Shen, H., Nelson, G., Kennedy, S., Nelson, D., Johnson, J., Spiller, D., . . . Kell, D. B. (2006). Automatic tracking of biological cells and compartments using particle filters and active contours. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 82(1-2), 276-282. doi:10.1016/j.chemolab.2005.07.007Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles (Journal article)
Underwood, B. R., Broadhurst, D., Dunn, W. B., Ellis, D. I., Michell, A. W., Vacher, C., . . . Rubinsztein, D. C. (2006). Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. BRAIN, 129, 877-886. doi:10.1093/brain/awl027Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells (Conference Paper)
Kell, D. B. (2006). Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells. In FEBS JOURNAL Vol. 273 (pp. 873-894). doi:10.1111/j.1742-4658.2006.05136.xMuralytic activity of <i>Micrococcus luteus</i> Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation (Journal article)
Mukamolova, G. V., Murzin, A. G., Salina, E. G., Demina, G. R., Kell, D. B., Kaprelyants, A. S., & Young, M. (2006). Muralytic activity of <i>Micrococcus luteus</i> Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation. MOLECULAR MICROBIOLOGY, 59(1), 84-98. doi:10.1111/j.1365-2958.2005.04930.xRapid high-throughput detection of preeclampsia. (Conference Paper)
Kenny, L. C., Harding, K. E. L., Ellis, D. I., Broadhurst, D., Dunn, W. B., Kell, D. B., & Baker, P. N. (2006). Rapid high-throughput detection of preeclampsia.. In JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION Vol. 13 (pp. 124A-125A). Retrieved from https://www.webofscience.com/2005
maxdLoad2 and maxdBrowse: standards-compliant tools for microarray experimental annotation, data management and dissemination (Journal article)
Hancock, D., Wilson, M., Velarde, G., Morrison, N., Hayes, A., Hulme, H., . . . Brass, A. (2005). maxdLoad2 and maxdBrowse: standards-compliant tools for microarray experimental annotation, data management and dissemination. BMC BIOINFORMATICS, 6. doi:10.1186/1471-2105-6-264Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops (Journal article)
Catchpole, G. S., Beckmann, M., Enot, D. P., Mondhe, M., Zywicki, B., Taylor, J., . . . Draper, J. (2005). Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(40), 14458-14462. doi:10.1073/pnas.0503955102Synergistic control of oscillations in the NF-κB signalling pathway (Journal article)
Ihekwaba, A. E. C., Broomhead, D. S., Grimley, R., Benson, N., White, M. R. H., & Kell, D. B. (2005). Synergistic control of oscillations in the NF-κB signalling pathway. IEE PROCEEDINGS SYSTEMS BIOLOGY, 152(3), 153-160. doi:10.1049/ip-syb:20050050Computational cluster validation in post-genomic data analysis (Journal article)
Handl, J., Knowles, J., & Kell, D. B. (2005). Computational cluster validation in post-genomic data analysis. BIOINFORMATICS, 21(15), 3201-3212. doi:10.1093/bioinformatics/bti517A laser desorption ionisation mass spectrometry approach for high throughput metabolomics (Journal article)
Vaidyanathan, S., Jones, D., Broadhurst, D. I., Ellis, J., Jenkins, T., Dunn, W. B., . . . Goodacre, R. (2005). A laser desorption ionisation mass spectrometry approach for high throughput metabolomics. METABOLOMICS, 1(3), 243-250. doi:10.1007/s11306-005-0007-xMetabolic footprinting and systems biology: the medium is the message. (Journal article)
Kell, D. B., Brown, M., Davey, H. M., Dunn, W. B., Spasic, I., & Oliver, S. G. (2005). Metabolic footprinting and systems biology: the medium is the message.. Nature reviews. Microbiology, 3(7), 557-565. doi:10.1038/nrmicro1177Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning (Journal article)
Kenny, L. C., Dunn, W. B., Ellis, D. I., Myers, J., Baker, P. N., & Kell, D. B. (2005). Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning. METABOLOMICS, 1(3), 227-234. doi:10.1007/s11306-005-0003-1A general model of error-prone PCR (Journal article)
Pritchard, L., Corne, D., Kell, D., Rowland, J., & Winson, M. (2005). A general model of error-prone PCR. JOURNAL OF THEORETICAL BIOLOGY, 234(4), 497-509. doi:10.1016/j.jtbi.2004.12.005Metabolomics, machine learning and modelling: towards an understanding of the language of cells (Journal article)
Kell, D. B. (2005). Metabolomics, machine learning and modelling: towards an understanding of the language of cells. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 520-524. doi:10.1042/BST0330520A metabolome pipeline: from concept to data to knowledge (Journal article)
Brown, M., Dunn, W. B., Ellis, D. I., Goodacre, R., Handl, J., Knowles, J. D., . . . Kell, D. B. (2005). A metabolome pipeline: from concept to data to knowledge. METABOLOMICS, 1(1), 39-51. doi:10.1007/s11306-005-1106-4Alterations in placental hemodynamics in growth-restricted transgenic mice. (Conference Paper)
Kenny, L. C., Dunn, W. B., Ellis, D. I., Myers, J. E., Robinson, A. E., Kell, D. B., & Baker, P. N. (2005). Alterations in placental hemodynamics in growth-restricted transgenic mice.. In JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION Vol. 12 (pp. 199A). Retrieved from https://www.webofscience.com/Closed-loop, multiobjective optimization of analytical instrumentation: Gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations (Journal article)
O'Hagan, S., Dunn, W. B., Brown, M., Knowles, J. D., & Kell, D. B. (2005). Closed-loop, multiobjective optimization of analytical instrumentation: Gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. ANALYTICAL CHEMISTRY, 77(1), 290-303. doi:10.1021/ac049146xDOUGLAS KELL COMMENTS ON 'METHODOLOGY' DURING THE WORKSHOP. (Conference Paper)
Kell, D. B. (2005). DOUGLAS KELL COMMENTS ON 'METHODOLOGY' DURING THE WORKSHOP.. In NONLINEAR DIELECTRIC PHENOMENA IN COMPLEX LIQUIDS Vol. 157 (pp. 61). doi:10.1007/1-4020-2704-4_7Electrospray-ionization mass spectrometry of protein mixtures: Influence of instrumental settings and proteomic implications. (Conference Paper)
Vaidyanathan, S., Kell, D. B., & Goodacre, R. (2005). Electrospray-ionization mass spectrometry of protein mixtures: Influence of instrumental settings and proteomic implications.. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 229 (pp. U185). Retrieved from https://www.webofscience.com/Metabolic footprinting and systems biology: The medium is the message (Journal article)
Kell, D. B., Brown, M., Davey, H. M., Dunn, W. B., Spasic, I., & Oliver, S. G. (2005). Metabolic footprinting and systems biology: The medium is the message. NATURE REVIEWS MICROBIOLOGY, 3(7), 557-565. doi:10.1038/nrmicro1177Metabolomic investigations using laser desorption ionisation mass spectrometry on porous silicon (Conference Paper)
Vaidyanathan, S., Jones, D., Jenkins, T., Kell, D. B., & Goodacre, R. (2005). Metabolomic investigations using laser desorption ionisation mass spectrometry on porous silicon. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 229 (pp. U245). Retrieved from https://www.webofscience.com/Metabolomics, machine learning and modelling in systems biology: Towards an understanding of the language of cells (Conference Paper)
Kell, D. B. (2005). Metabolomics, machine learning and modelling in systems biology: Towards an understanding of the language of cells. In JOURNAL OF BIOTECHNOLOGY Vol. 118 (pp. S5). Retrieved from https://www.webofscience.com/Metabolomics, modelling and machine learning in systems biology; understanding complex systems using genetic programming to produce simple interpretable rules. The Theodor Bucher Lecture and Medal (Conference Paper)
Kell, D. B. (2005). Metabolomics, modelling and machine learning in systems biology; understanding complex systems using genetic programming to produce simple interpretable rules. The Theodor Bucher Lecture and Medal. In FEBS JOURNAL Vol. 272 (pp. 2). Retrieved from https://www.webofscience.com/NONLINEAR DIELECTRIC SPECTROSCOPY OF BIOLOGICAL SYSTEMS: PRINCIPLES AND APPLICATIONS (Conference Paper)
Kell, D. B., Woodward, A. M., Davies, E. A., Todd, R. W., Evans, M. F., & Rowland, J. J. (2005). NONLINEAR DIELECTRIC SPECTROSCOPY OF BIOLOGICAL SYSTEMS: PRINCIPLES AND APPLICATIONS. In NONLINEAR DIELECTRIC PHENOMENA IN COMPLEX LIQUIDS Vol. 157 (pp. 335-344). doi:10.1007/1-4020-2704-4_31Novel biomarkers for preeclampsia detected using metabolomics and machine learning. (Conference Paper)
Kenny, L. C., Dunn, W. B., Ellis, D. I., Myers, J. E., Robinson, A. E., Kell, D. B., & Baker, P. N. (2005). Novel biomarkers for preeclampsia detected using metabolomics and machine learning.. In JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION Vol. 12 (pp. 199A). Retrieved from https://www.webofscience.com/Vacuum packing: a model system for laboratory-scale silage fermentations (Journal article)
Johnson, H. E., Merry, R. J., Davies, D. R., Kell, D. B., Theodorou, M. K., & Griffith, G. W. (2005). Vacuum packing: a model system for laboratory-scale silage fermentations. JOURNAL OF APPLIED MICROBIOLOGY, 98(1), 106-113. doi:10.1111/j.1365-2672.2004.02444.x2004
A proposed framework for the description of plant metabolomics experiments and their results (Journal article)
Jenkins, H., Hardy, N., Beckmann, M., Draper, J., Smith, A. R., Taylor, J., . . . Kell, D. B. (2004). A proposed framework for the description of plant metabolomics experiments and their results. NATURE BIOTECHNOLOGY, 22(12), 1601-1606. doi:10.1038/nbt1041Differentiation of <i>Micromonospora</i> isolates from a coastal sediment in wales on the basis of Fourier transform infrared spectroscopy, 16S rRNA sequence analysis, and the amplified fragment length polymorphism technique (Journal article)
Zhao, H. J., Kassama, Y., Young, M., Kell, D. B., & Goodacre, R. (2004). Differentiation of <i>Micromonospora</i> isolates from a coastal sediment in wales on the basis of Fourier transform infrared spectroscopy, 16S rRNA sequence analysis, and the amplified fragment length polymorphism technique. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(11), 6619-6627. doi:10.1128/AEM.70.11.6619-6627.2004Oscillations in NF-κB signaling control the dynamics of gene expression (Journal article)
Nelson, D. E., Ihekwaba, A. E. C., Elliott, M., Johnson, J. R., Gibney, C. A., Foreman, B. E., . . . White, M. R. H. (2004). Oscillations in NF-κB signaling control the dynamics of gene expression. SCIENCE, 306(5696), 704-708. doi:10.1126/science.1099962Discrimination of modes of action of antifungal substances by use of metabolic footprinting (Journal article)
Allen, J., Davey, H. M., Broadhurst, D., Rowland, J. J., Oliver, S. G., & Kell, D. B. (2004). Discrimination of modes of action of antifungal substances by use of metabolic footprinting. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(10), 6157-6165. doi:10.1128/AEM.70.10.6157-6165.2004Selective detection of proteins in mixtures using electrospray ionization mass spectrometry: Influence of instrumental settings and implications for proteomics (Journal article)
Vaidyanathan, S., Kell, D. B., & Goodacre, R. (2004). Selective detection of proteins in mixtures using electrospray ionization mass spectrometry: Influence of instrumental settings and implications for proteomics. ANALYTICAL CHEMISTRY, 76(17), 5024-5032. doi:10.1021/ac049684+Selective detection of proteins in mixtures using electrospray ionization mass spectrometry: influence of instrumental settings and implications for proteomics. (Journal article)
Vaidyanathan, S., Kell, D. B., & Goodacre, R. (2004). Selective detection of proteins in mixtures using electrospray ionization mass spectrometry: influence of instrumental settings and implications for proteomics.. Analytical chemistry, 76(17), 5024-5032. doi:10.1021/ac049684+Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs (Journal article)
White, T. A., & Kell, D. B. (2004). Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs. COMPARATIVE AND FUNCTIONAL GENOMICS, 5(4), 304-327. doi:10.1002/cfg.411Metabolomics and systems biology: making sense of the soup (Journal article)
Kell, D. B. (2004). Metabolomics and systems biology: making sense of the soup. CURRENT OPINION IN MICROBIOLOGY, 7(3), 296-307. doi:10.1016/j.mib.2004.04.012Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: the roles of IKK and IkappaBalpha. (Journal article)
Ihekwaba, A. E. C., Broomhead, D. S., Grimley, R. L., Benson, N., & Kell, D. B. (2004). Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: the roles of IKK and IkappaBalpha.. Systems biology, 1(1), 93-103. doi:10.1049/sb:20045009Metabolomics by numbers: acquiring and understanding global metabolite data (Journal article)
Goodacre, R., Vaidyanathan, S., Dunn, W. B., Harrigan, G. G., & Kell, D. B. (2004). Metabolomics by numbers: acquiring and understanding global metabolite data. TRENDS IN BIOTECHNOLOGY, 22(5), 245-252. doi:10.1016/j.tibtech.2004.03.007Metabolomics by numbers: acquiring and understanding global metabolite data (Journal article)
GOODACRE, R. (2004). Metabolomics by numbers: acquiring and understanding global metabolite data. Trends in Biotechnology, 22(5), 245-252. doi:10.1016/s0167-7799(04)00081-2Single-nucleotide polymorphism detection using nanomolar nucleotides and single-molecule fluorescence (Journal article)
Twist, C. R., Winson, M. K., Rowland, J. J., & Kell, D. B. (2004). Single-nucleotide polymorphism detection using nanomolar nucleotides and single-molecule fluorescence. ANALYTICAL BIOCHEMISTRY, 327(1), 35-44. doi:10.1016/j.ab.2003.12.023High-throughput metabolic fingerprinting of legume silage fermentations via Fourier transform infrared spectroscopy and chemometrics (Journal article)
Johnson, H. E., Broadhurst, D., Kell, D. B., Theodorou, M. K., Merry, R. J., & Griffith, G. W. (2004). High-throughput metabolic fingerprinting of legume silage fermentations via Fourier transform infrared spectroscopy and chemometrics. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(3), 1583-1592. doi:10.1128/AEM.70.3.1583-1592.2004Functional genomic hypothesis generation and experimentation by a robot scientist (Journal article)
King, R. D., Whelan, K. E., Jones, F. M., Reiser, P. G. K., Bryant, C. H., Muggleton, S. H., . . . Oliver, S. G. (2004). Functional genomic hypothesis generation and experimentation by a robot scientist. NATURE, 427(6971), 247-252. doi:10.1038/nature02236Estimation of microbial viability using flow cytometry. (Journal article)
Davey, H. M., Kell, D. B., Weichart, D. H., & Kaprelyants, A. S. (2004). Estimation of microbial viability using flow cytometry.. Current protocols in cytometry, Chapter 11, Unit-11.3. doi:10.1002/0471142956.cy1103s29Fast automatic registration of images using the phase of a complex wavelet transform: application to proteome gels (Journal article)
Woodward, A. M., Rowland, J. J., & Kell, D. B. (2004). Fast automatic registration of images using the phase of a complex wavelet transform: application to proteome gels. ANALYST, 129(6), 542-552. doi:10.1039/b403134bHere is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era (Journal article)
Kell, D. B., & Oliver, S. G. (2004). Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. BIOESSAYS, 26(1), 99-105. doi:10.1002/bies.103852003
Explanatory optimization of protein mass spectrometry via genetic search (Journal article)
Vaidyanathan, S., Broadhurst, D. I., Kell, D. B., & Goodacre, R. (2003). Explanatory optimization of protein mass spectrometry via genetic search. ANALYTICAL CHEMISTRY, 75(23), 6679-6686. doi:10.1021/ac034669aFunctional genomics via metabolic footprinting:: monitoring metabolite secretion by <i>Escherichia coli</i> tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry (Journal article)
Kaderbhai, N. N., Broadhurst, D. I., Ellis, D. I., Goodacre, R., & Kell, D. B. (2003). Functional genomics via metabolic footprinting:: monitoring metabolite secretion by <i>Escherichia coli</i> tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry. COMPARATIVE AND FUNCTIONAL GENOMICS, 4(4), 376-391. doi:10.1002/cfg.302High-throughput classification of yeast mutants for functional genomics using metabolic footprinting (Journal article)
Allen, J., Davey, H. M., Broadhurst, D., Heald, J. K., Rowland, J. J., Oliver, S. G., & Kell, D. B. (2003). High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. NATURE BIOTECHNOLOGY, 21(6), 692-696. doi:10.1038/nbt823A systematic approach to modeling, capturing, and disseminating proteomics experimental data (Journal article)
Taylor, C. F., Paton, N. W., Garwood, K. L., Kirby, P. D., Stead, D. A., Yin, Z. K., . . . Oliver, S. G. (2003). A systematic approach to modeling, capturing, and disseminating proteomics experimental data. NATURE BIOTECHNOLOGY, 21(3), 247-254. doi:10.1038/nbt0303-247Adoption of the transiently non-culturable state - a bacterial survival strategy? (Book)
Mukamolova, G. V., Kaprelyants, A. S., Kell, D. B., & Young, M. (2003). Adoption of the transiently non-culturable state - a bacterial survival strategy? (Vol. 47). doi:10.1016/S0065-2911(03)47002-1Assessing contributions to fitness of individual genes via genome-wide competition analysis. (Conference Paper)
Delneri, D., Leong, H. S., Hayes, A., Davey, H. M., Kell, D. B., & Oliver, S. G. (2003). Assessing contributions to fitness of individual genes via genome-wide competition analysis.. In YEAST Vol. 20 (pp. S337). Retrieved from https://www.webofscience.com/Landscape state machines: Tools for evolutionary algorithm performance analyses and landscape/algorithm mapping (Journal article)
Corne, D., Oates, M., & Kell, D. (2003). Landscape state machines: Tools for evolutionary algorithm performance analyses and landscape/algorithm mapping. APPLICATIONS OF EVOLUTIONARY COMPUTING, 2611, 187-198. Retrieved from https://www.webofscience.com/Metabolic footprinting: a high-throughput, high-information approach to cellular characterisation and functional genomics. (Conference Paper)
Kell, D. B., Allen, J. K., Davey, H. M., Broadhurst, D. I., Rowland, J. J., & Oliver, S. G. (2003). Metabolic footprinting: a high-throughput, high-information approach to cellular characterisation and functional genomics.. In YEAST Vol. 20 (pp. S335). Retrieved from https://www.webofscience.com/2002
Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of <i>Streptomyces coelicolor</i> (Journal article)
Hesketh, A. R., Chandra, G., Shaw, A. D., Rowland, J. J., Kell, D. B., Bibb, M. J., & Chater, K. F. (2002). Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of <i>Streptomyces coelicolor</i>. MOLECULAR MICROBIOLOGY, 46(4), 917-932. doi:10.1046/j.1365-2958.2002.03219.xA family of autocrine growth factors in <i>Mycobacterium tuberculosis</i> (Journal article)
Mukamolova, G. V., Turapov, O. A., Young, D. I., Kaprelyants, A. S., Kell, D. B., & Young, M. (2002). A family of autocrine growth factors in <i>Mycobacterium tuberculosis</i>. MOLECULAR MICROBIOLOGY, 46(3), 623-635. doi:10.1046/j.1365-2958.2002.03184.xThe <i>rpf</i> gene of <i>Micrococcus luteus</i> encodes an essential secreted growth factor (Journal article)
Mukamolova, G. V., Turapov, O. A., Kazarian, K., Telkov, M., Kaprelyants, A. S., Kell, D. B., & Young, M. (2002). The <i>rpf</i> gene of <i>Micrococcus luteus</i> encodes an essential secreted growth factor. MOLECULAR MICROBIOLOGY, 46(3), 611-621. doi:10.1046/j.1365-2958.2002.03183.xGenotype-phenotype mapping: genes as computer programs (Journal article)
Kell, D. B. (2002). Genotype-phenotype mapping: genes as computer programs. TRENDS IN GENETICS, 18(11), 555-559. doi:10.1016/S0168-9525(02)02765-8Metabolic profiling using direct infusion electrospray ionisation mass spectrometry for the characterisation of olive oils (Journal article)
Goodacre, R., Vaidyanathan, S., Bianchi, G., & Kell, D. B. (2002). Metabolic profiling using direct infusion electrospray ionisation mass spectrometry for the characterisation of olive oils. ANALYST, 127(11), 1457-1462. doi:10.1039/b206037jMetabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules. (Journal article)
Kell, D. B. (2002). Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules.. MOLECULAR BIOLOGY REPORTS, 29(1-2), 237-241. doi:10.1023/A:1020342216314Schemes of flux control in a model of <i>Saccharomyces</i> <i>cerevisiae</i> glycolysis (Journal article)
Pritchard, L., & Kell, D. B. (2002). Schemes of flux control in a model of <i>Saccharomyces</i> <i>cerevisiae</i> glycolysis. EUROPEAN JOURNAL OF BIOCHEMISTRY, 269(16), 3894-3904. doi:10.1046/j.1432-1033.2002.03055.xSample preparation in matrix-assisted laser desorption ionization mass spectrometry of whole bacterial cells and the detection of high mass (>20 kDa) proteins (Journal article)
Vaidyanathan, S., Winder, C. L., Wade, S. C., Kell, D. B., & Goodacre, R. (2002). Sample preparation in matrix-assisted laser desorption ionization mass spectrometry of whole bacterial cells and the detection of high mass (>20 kDa) proteins. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 16(13), 1276-1286. doi:10.1002/rcm.713The cytochrome p450 complement (CYPome) of <i>Streptomyces coelicolor</i> A3(2) (Journal article)
Lamb, D. C., Skaug, T., Song, H. L., Jackson, C. J., Podust, L. M., Waterman, M. R., . . . Kelly, S. L. (2002). The cytochrome p450 complement (CYPome) of <i>Streptomyces coelicolor</i> A3(2). JOURNAL OF BIOLOGICAL CHEMISTRY, 277(27), 24000-24005. doi:10.1074/jbc.M111109200Rapid and quantitative detection of the microbial spoilage of meat by Fourier transform infrared spectroscopy and machine learning (Journal article)
Ellis, D. I., Broadhurst, D., Kell, D. B., Rowland, J. J., & Goodacre, R. (2002). Rapid and quantitative detection of the microbial spoilage of meat by Fourier transform infrared spectroscopy and machine learning. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 68(6), 2822-2828. doi:10.1128/AEM.68.6.2822-2828.2002Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: Application to gibberellic acid production (Journal article)
McGovern, A. C., Broadhurst, D., Taylor, J., Kaderbhai, N., Winson, M. K., Small, D. A., . . . Goodacre, R. (2002). Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: Application to gibberellic acid production. Biotechnology and Bioengineering, 78(5), 527-538. doi:10.1002/bit.10226.absMonitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: Application to gibberellic acid production (Journal article)
McGovern, A. C., Broadhurst, D., Taylor, J., Kaderbhai, N., Winson, M. K., Small, D. A., . . . Goodacre, R. (2002). Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: Application to gibberellic acid production. BIOTECHNOLOGY AND BIOENGINEERING, 78(5), 527-538. Retrieved from https://www.webofscience.com/Formation and resuscitation of 'non-culturable' cells of <i>Rhodococcus rhodochrous</i> and <i>Mycobacterium tuberculosis</i> in prolonged stationary phase (Journal article)
Shleeva, M. O., Bagramyan, K., Telkov, M. V., Mukamolova, G. V., Young, M., Kell, D. B., & Kaprelyants, A. S. (2002). Formation and resuscitation of 'non-culturable' cells of <i>Rhodococcus rhodochrous</i> and <i>Mycobacterium tuberculosis</i> in prolonged stationary phase. MICROBIOLOGY-SGM, 148, 1581-1591. doi:10.1099/00221287-148-5-1581Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification (Journal article)
Vaidyanathan, S., Kell, D. B., & Goodacre, R. (2002). Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 13(2), 118-128. doi:10.1016/S1044-0305(01)00339-7Differentiation of <i>Phytophthora infestans</i> sporangia from other airborne biological particles by flow Cytometry (Journal article)
Day, J. P., Kell, D. B., & Griffith, G. W. (2002). Differentiation of <i>Phytophthora infestans</i> sporangia from other airborne biological particles by flow Cytometry. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 68(1), 37-45. doi:10.1128/AEM.68.1.37-45.2002Comprehensive Natural Products Chemistry, Volume 4: Amino Acids, Peptides, Porphyrins and Alkaloids (Journal article)
Kell, D. (2002). Comprehensive Natural Products Chemistry, Volume 4: Amino Acids, Peptides, Porphyrins and Alkaloids. Phytochemistry, 59(2), 231-232. doi:10.1016/s0031-9422(01)00374-0Metabolic Control Analysis and engineering of the yeast sterol biosynthetic pathway (Journal article)
Groeneveld, P., Rolley, N., Kell, D. B., Kelly, S. L., & Kelly, D. E. (2002). Metabolic Control Analysis and engineering of the yeast sterol biosynthetic pathway. MOLECULAR BIOLOGY REPORTS, 29(1-2), 27-29. doi:10.1023/A:1020342032302On Fitness Distributions and Expected Fitness Gain of Mutation Rates in Parallel Evolutionary Algorithms (Conference Paper)
Corne, D. W., Oates, M. J., & Kell, D. B. (2002). On Fitness Distributions and Expected Fitness Gain of Mutation Rates in Parallel Evolutionary Algorithms. In Unknown Conference (pp. 132-141). Springer Berlin Heidelberg. doi:10.1007/3-540-45712-7_13Rapid, high-throughput microbial characterization by metabolite and protein profiling of whole cells using soft-ionization mass spectrometry. (Conference Paper)
Vaidyanathan, S., Kell, D. B., & Goodacre, R. (2002). Rapid, high-throughput microbial characterization by metabolite and protein profiling of whole cells using soft-ionization mass spectrometry.. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 224 (pp. U199). Retrieved from https://www.webofscience.com/Use of flow cytometry in the detection of plant pathogenic spores (Conference Paper)
Griffith, G. W., Day, J. P., & Kell, D. B. (2002). Use of flow cytometry in the detection of plant pathogenic spores. In BCPC CONFERENCE - PESTS & DISEASES 2002, VOLS 1 AND 2 (pp. 417-424). Retrieved from https://www.webofscience.com/2001
Don't cut the cable (Journal article)
Kell, D. (2001). Don't cut the cable. NEW SCIENTIST, 172(2319), 54. Retrieved from https://www.webofscience.com/Discrimination of aerobic endospore-forming bacteria via electrospray-ionization mass spectrometry of whole cell suspensions (Journal article)
Vaidyanathan, S., Rowland, J. J., Kell, D. B., & Goodacre, R. (2001). Discrimination of aerobic endospore-forming bacteria via electrospray-ionization mass spectrometry of whole cell suspensions. ANALYTICAL CHEMISTRY, 73(17), 4134-4144. doi:10.1021/ac0103524Characterization of an autostimulatory substance produced by <i>Escherichia coli</i> (Journal article)
Weichart, D. H., & Kell, D. B. (2001). Characterization of an autostimulatory substance produced by <i>Escherichia coli</i>. MICROBIOLOGY-SGM, 147, 1875-1885. doi:10.1099/00221287-147-7-1875Genomic computing. Explanatory analysis of plant expression profiling data using machine learning (Journal article)
Kell, D. B., Darby, R. M., & Draper, J. (2001). Genomic computing. Explanatory analysis of plant expression profiling data using machine learning. PLANT PHYSIOLOGY, 126(3), 943-951. doi:10.1104/pp.126.3.943MEG (Model Extender for Gepasi): a program for the modelling of complex, heterogeneous, cellular systems (Journal article)
Mendes, P., & Kell, D. B. (2001). MEG (Model Extender for Gepasi): a program for the modelling of complex, heterogeneous, cellular systems. BIOINFORMATICS, 17(3), 288-289. doi:10.1093/bioinformatics/17.3.288Macromolecular interactions: tracing the roots (Journal article)
Clegg, J., Kell, D., Knull, H., Welch, G. R., & Wilson, J. (2001). Macromolecular interactions: tracing the roots. TRENDS IN BIOCHEMICAL SCIENCES, 26(2), 91. doi:10.1016/S0968-0004(00)01739-4A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations (Journal article)
Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N. S., Hayes, A., Walsh, M. C., . . . Oliver, S. G. (2001). A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. NATURE BIOTECHNOLOGY, 19(1), 45-50. doi:10.1038/83496Chemometric criteria for the characterisation of Italian protected denomination of origin (DOP) olive oils from their metabolic profiles (Journal article)
Bianchi, G., Giansante, L., Shaw, A., & Kell, D. B. (2001). Chemometric criteria for the characterisation of Italian protected denomination of origin (DOP) olive oils from their metabolic profiles. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 103(3), 141-150. Retrieved from https://www.webofscience.com/ELECTRODE WITH PROTECTIVE COATING (Journal article)
KELL Douglas Bruce., WOODWARD Andrew Michael., DENYER Stephen., OLLIFF Cedric., & DAVIES Elizabeth. (2001). ELECTRODE WITH PROTECTIVE COATING.Histometrics: Improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging (Journal article)
Woodward, A. M., Kaderbhai, N., Kaderbhai, M., Shaw, A., Rowland, J., & Kell, D. B. (2001). Histometrics: Improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging. PROTEOMICS, 1(11), 1351-1358. Retrieved from https://www.webofscience.com/Spectral analysis via supervised genetic search with application-specific mutations (Conference Paper)
Taylor, J., Rowland, J. J., & Kell, D. B. (2001). Spectral analysis via supervised genetic search with application-specific mutations. In PROCEEDINGS OF THE 2001 CONGRESS ON EVOLUTIONARY COMPUTATION, VOLS 1 AND 2 (pp. 481-486). Retrieved from https://www.webofscience.com/2000
Culturability of <i>Mycobacterium tuberculosis</i> cells isolated from murine macrophages:: a bacterial growth factor promotes recovery (Journal article)
Biketov, S., Mukamolova, G. V., Potapov, V., Gilenkov, E., Vostroknutova, G., Kell, D. B., . . . Kaprelyants, A. S. (2000). Culturability of <i>Mycobacterium tuberculosis</i> cells isolated from murine macrophages:: a bacterial growth factor promotes recovery. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 29(4), 233-240. doi:10.1111/j.1574-695X.2000.tb01528.xCulturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery (Journal article)
Biketov, S. (2000). Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery. FEMS Immunology and Medical Microbiology, 29(4), 233-240. doi:10.1016/s0928-8244(00)00210-8On-line, real-time measurements of cellular biomass using dielectric spectroscopy (Journal article)
Yardley, Y. E., Kell, D. B., Barrett, J., & Davey, C. L. (2000). On-line, real-time measurements of cellular biomass using dielectric spectroscopy. BIOTECHNOLOGY & GENETIC ENGINEERING REVIEWS, VOL 17, 17, 3-35. doi:10.1080/02648725.2000.10647986Bacterial dormancy and culturability: the role of autocrine growth factors - Commentary (Journal article)
Kell, D. B., & Young, M. (2000). Bacterial dormancy and culturability: the role of autocrine growth factors - Commentary. CURRENT OPINION IN MICROBIOLOGY, 3(3), 238-243. doi:10.1016/S1369-5274(00)00082-5Screen idols: faster, smaller, cheaper and smarter. (Conference Paper)
Kell, D. B. (2000). Screen idols: faster, smaller, cheaper and smarter.. In Trends in biotechnology Vol. 18 (pp. 186-187). doi:10.1016/s0167-7799(99)01382-7Efficient improvement of silage additives by using genetic algorithms (Journal article)
Davies, Z. S., Gilbert, R. J., Merry, R. J., Kell, D. B., Theodorou, M. K., & Griffith, G. W. (2000). Efficient improvement of silage additives by using genetic algorithms. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 66(4), 1435-1443. doi:10.1128/AEM.66.4.1435-1443.2000Website review - The Kyoto Encyclopedia of Genes and Genomes - KEGG - http://www.genome.ad.jp/kegg (Journal article)
Wixon, J., & Kell, D. (2000). Website review - The Kyoto Encyclopedia of Genes and Genomes - KEGG - http://www.genome.ad.jp/kegg. YEAST, 17(1), 48-55. doi:3.0.CO;2-H">10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-HDOI: 10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H
On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning (Journal article)
Kell, D. B., & King, R. D. (2000). On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning. TRENDS IN BIOTECHNOLOGY, 18(3), 93-98. doi:10.1016/S0167-7799(99)01407-9Correction of the influence of baseline artefacts and electrode polarisation on dielectric spectra (Journal article)
Yardley, J. E., Todd, R., Nicholson, D. J., Barrett, J., Kell, D. B., & Davey, C. L. (2000). Correction of the influence of baseline artefacts and electrode polarisation on dielectric spectra. BIOELECTROCHEMISTRY, 51(1), 53-65. doi:10.1016/S0302-4598(99)00069-0Non-linear dielectric spectroscopy: antifouling and stabilisation of electrodes by a polymer coating (Journal article)
Woodward, A. M., Davies, E. A., Denyer, S., Olliff, C., & Kell, D. B. (2000). Non-linear dielectric spectroscopy: antifouling and stabilisation of electrodes by a polymer coating. BIOELECTROCHEMISTRY, 51(1), 13-20. doi:10.1016/S0302-4598(00)00063-5A portable flow cytometer for the detection and identification of microorganisms (Conference Paper)
Davey, H. M., & Kell, D. B. (2000). A portable flow cytometer for the detection and identification of microorganisms. In RAPID METHODS FOR ANALYSIS OF BIOLOGICAL MATERIALS IN THE ENVIRONMENT Vol. 30 (pp. 159-167). Retrieved from https://www.webofscience.com/BACTERIAL PHEROMONES AND USES THEREFOR (Journal article)
KAPRELYANTS Arseny S.., KELL Douglas B.., MUKAMOLOVA Galina V.., YOUNG Danielle I.., & YOUNG Michael. (2000). BACTERIAL PHEROMONES AND USES THEREFOR.Detection of the dipicolinic acid biomarker in <i>Bacillus</i> spores using Curie-point pyrolysis mass spectrometry and fourier transform infrared spectroscopy (Journal article)
Goodacre, R., Shann, B., Gilbert, R. J., Timmins, É., McGovern, A. C., Alsberg, B. K., . . . Logan, N. A. (2000). Detection of the dipicolinic acid biomarker in <i>Bacillus</i> spores using Curie-point pyrolysis mass spectrometry and fourier transform infrared spectroscopy. ANALYTICAL CHEMISTRY, 72(1), 119-127. doi:10.1021/ac990661iDormancy in non-sporulating bacteria: Its significance for environmental monitoring (Conference Paper)
Kaprelyants, A. S., Mukamolova, G. V., Votyakova, T. V., Davey, H. M., & Kell, D. B. (2000). Dormancy in non-sporulating bacteria: Its significance for environmental monitoring. In RAPID METHODS FOR ANALYSIS OF BIOLOGICAL MATERIALS IN THE ENVIRONMENT Vol. 30 (pp. 49-65). Retrieved from https://www.webofscience.com/Intelligent systems for the characterization of microorganisms from hyperspectral data (Conference Paper)
Goodacre, R., Burton, R., Kaderbhai, N., Timmins, E. M., Woodward, A., Rooney, P. J., & Kell, D. B. (2000). Intelligent systems for the characterization of microorganisms from hyperspectral data. In RAPID METHODS FOR ANALYSIS OF BIOLOGICAL MATERIALS IN THE ENVIRONMENT Vol. 30 (pp. 111-136). Retrieved from https://www.webofscience.com/Rapid analysis of high-dimensional bioprocesses using multivariate spectroscopies and advanced chemometrics. (Journal article)
Shaw, A. D., Winson, M. K., Woodward, A. M., McGovern, A. C., Davey, H. M., Kaderbhai, N., . . . Rowland, J. J. (2000). Rapid analysis of high-dimensional bioprocesses using multivariate spectroscopies and advanced chemometrics.. Advances in biochemical engineering/biotechnology, 66, 83-113. doi:10.1007/3-540-48773-5_3Snapshots of systems -: <i>Metabolic control analysis and biotechnology in the post-genomic era</i> (Conference Paper)
Kell, D. B., & Mendes, P. (2000). Snapshots of systems -: <i>Metabolic control analysis and biotechnology in the post-genomic era</i>. In TECHNOLOGICAL AND MEDICAL IMPLICATIONS OF METABOLIC CONTROL ANALYSIS Vol. 74 (pp. 3-25). Retrieved from https://www.webofscience.com/The use of nonlinear dielectric spectroscopy to monitor the bioelectromagnetic effects of a weak pulsed magnetic field in real time (Journal article)
Davies, E., Woodward, A., & Kell, D. (2000). The use of nonlinear dielectric spectroscopy to monitor the bioelectromagnetic effects of a weak pulsed magnetic field in real time. BIOELECTROMAGNETICS, 21(1), 25-33. doi:3.0.CO;2-9">10.1002/(SICI)1521-186X(200001)21:1<25::AID-BEM5>3.0.CO;2-9DOI: 10.1002/(SICI)1521-186X(200001)21:1<25::AID-BEM5>3.0.CO;2-9
1999
Intelligent systems for the characterisation and quantification of microbial systems from advanced analytical techniques (Conference Paper)
Goodacre, R., McGovern, A. C., Timmins, E. M., Winson, M. K., Kaderbhai, N., Broadhurst, D., . . . Kell, D. B. (1999). Intelligent systems for the characterisation and quantification of microbial systems from advanced analytical techniques. In ENVIRONMENTAL MONITORING AND REMEDIATION TECHNOLOGIES II Vol. 3853 (pp. 174-184). doi:10.1117/12.372851Use of <SUP>13</SUP>C nuclear magnetic resonance distortionless enhancement by polarization transfer pulse sequence and multivariate analysis to discriminate olive oil cultivars (Journal article)
Vlahov, G., Shaw, A. D., & Kell, D. B. (1999). Use of <SUP>13</SUP>C nuclear magnetic resonance distortionless enhancement by polarization transfer pulse sequence and multivariate analysis to discriminate olive oil cultivars. JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 76(10), 1223-1231. doi:10.1007/s11746-999-0098-zScreensavers: trends in high-throughput analysis. (Journal article)
Kell, D. (1999). Screensavers: trends in high-throughput analysis.. Trends in biotechnology, 17(3), 89-91. doi:10.1016/s0167-7799(98)01273-6Rapid analysis of the expression of heterologous proteins in <i>Escherichia coli</i> using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics:: application to α2-interferon production (Journal article)
McGovern, A. C., Ernill, R., Kara, B. V., Kell, D. B., & Goodacre, R. (1999). Rapid analysis of the expression of heterologous proteins in <i>Escherichia coli</i> using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics:: application to α2-interferon production. JOURNAL OF BIOTECHNOLOGY, 72(3), 157-167. doi:10.1016/S0168-1656(99)00128-5Characterisation of intact microorganisms using electrospray ionisation mass spectrometry (Journal article)
Goodacre, R. (1999). Characterisation of intact microorganisms using electrospray ionisation mass spectrometry. FEMS Microbiology Letters, 176(1), 17-24. doi:10.1016/s0378-1097(99)00212-8Characterisation of intact microorganisms using electrospray ionisation mass spectrometry (Journal article)
Goodacre, R., Heald, J. K., & Kell, D. B. (1999). Characterisation of intact microorganisms using electrospray ionisation mass spectrometry. FEMS MICROBIOLOGY LETTERS, 176(1), 17-24. doi:10.1016/S0378-1097(99)00212-8Stimulation of the multiplication of <i>Micrococcus luteus</i> by an autocrine growth factor (Journal article)
Mukamolova, G. V., Kormer, S. S., Kell, D. B., & Kaprelyants, A. S. (1999). Stimulation of the multiplication of <i>Micrococcus luteus</i> by an autocrine growth factor. ARCHIVES OF MICROBIOLOGY, 172(1), 9-14. doi:10.1007/s002030050733Genetic programming as an analytical tool for non-linear dielectric spectroscopy (Journal article)
Woodward, A. M., Gilbert, R. J., & Kell, D. B. (1999). Genetic programming as an analytical tool for non-linear dielectric spectroscopy. BIOELECTROCHEMISTRY AND BIOENERGETICS, 48(2), 389-396. doi:10.1016/S0302-4598(99)00022-7Revolutionary ideas come round again (Journal article)
Kell, D. B. (1999). Revolutionary ideas come round again. NATURE, 397(6721), 644. doi:10.1038/17672A weak pulsed magnetic field affects adenine nucleotide oscillations, and related parameters in aggregating <i>Dictyostelium discoideum</i> amoebae (Journal article)
Davies, E., Olliff, C., Wright, I., Woodward, A., & Kell, D. (1999). A weak pulsed magnetic field affects adenine nucleotide oscillations, and related parameters in aggregating <i>Dictyostelium discoideum</i> amoebae. BIOELECTROCHEMISTRY AND BIOENERGETICS, 48(1), 149-162. doi:10.1016/S0302-4598(98)00237-2Variable selection and multivariate methods for the identification of microorganisms by flow cytometry (Journal article)
Davey, H. M., Jones, A., Shaw, A. D., & Kell, D. B. (1999). Variable selection and multivariate methods for the identification of microorganisms by flow cytometry. CYTOMETRY, 35(2), 162-168. doi:3.0.CO;2-U">10.1002/(SICI)1097-0320(19990201)35:2<162::AID-CYTO8>3.0.CO;2-UDOI: 10.1002/(SICI)1097-0320(19990201)35:2<162::AID-CYTO8>3.0.CO;2-U
Capacitance measurement of a dielectric medium (Journal article)
DAVEY CHRISTOPHER LYNDON., & KELL DOUGLAS BRUCE. (1999). Capacitance measurement of a dielectric medium.Intercellular signalling and the multiplication of prokaryotes: Bacterial cytokines (Conference Paper)
Kaprelyants, A. S., Mukamolova, G. V., Kormer, S. S., Weichart, D. H., Young, M., & Kell, D. B. (1999). Intercellular signalling and the multiplication of prokaryotes: Bacterial cytokines. In MICROBIAL SIGNALLING AND COMMUNICATION Vol. 57 (pp. 33-69). Retrieved from https://www.webofscience.com/Noninvasive, on-line monitoring of the biotransformation by yeast of glucose to ethanol using dispersive Raman spectroscopy and chemometrics (Journal article)
Shaw, A. D., Kaderbhai, N., Jones, A., Woodward, A. M., Goodacre, R., Rowland, J. J., & Kell, D. B. (1999). Noninvasive, on-line monitoring of the biotransformation by yeast of glucose to ethanol using dispersive Raman spectroscopy and chemometrics. APPLIED SPECTROSCOPY, 53(11), 1419-1428. doi:10.1366/0003702991945777Use of <sup>13</sup>C nuclear magnetic resonance distortionless enhancement by polarization transfer pulse sequence and multivariate analysis to discriminate olive oil cultivars (Journal article)
Vlahov, G., Shaw, A. D., & Kell, D. B. (1999). Use of <sup>13</sup>C nuclear magnetic resonance distortionless enhancement by polarization transfer pulse sequence and multivariate analysis to discriminate olive oil cultivars. JAOCS, Journal of the American Oil Chemists' Society, 76(10), 1223-1231. doi:10.1007/s11746-999-0098-z1998
A DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics) approach for the rapid analysis of microbial fermentation products: Quantification of aristeromycin and neplanocin A in Streptomyces citricolor broths. (Conference Paper)
Winson, M. K., Todd, M., Rudd, B. A. M., Jones, A., Alsberg, B. K., Woodward, A. M., . . . Kell, D. B. (1998). A DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics) approach for the rapid analysis of microbial fermentation products: Quantification of aristeromycin and neplanocin A in Streptomyces citricolor broths.. In NEW FRONTIERS IN SCREENING FOR MICROBIAL BIOCATALYSTS Vol. 53 (pp. 185-191). Retrieved from https://www.webofscience.com/DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics). A novel, rapid, hyperspectral, FT-IR-based approach to screening for biocatalytic activity and metabolite overproduction (Journal article)
Kell, D. B., Winson, M. K., Goodacre, R., Woodward, A. M., Alsberg, B. K., Jones, A., . . . Rowland, J. J. (1998). DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics). A novel, rapid, hyperspectral, FT-IR-based approach to screening for biocatalytic activity and metabolite overproduction. NEW FRONTIERS IN SCREENING FOR MICROBIAL BIOCATALYSTS, 53, 61-75. Retrieved from https://www.webofscience.com/From code to mode for orphan genes (Conference Paper)
Kell, D. (1998). From code to mode for orphan genes. In Trends in Biotechnology Vol. 16 (pp. 491-493). Elsevier BV. doi:10.1016/s0167-7799(98)01254-2Research on the heterogeneity of a Micrococcus luteus culture during an extended stationary phase: Subpopulation separation and characterization (Journal article)
Votyakova, T. V., Mukamolova, G. V., Shtein-Margolina, V. A., Popov, V. I., Davey, H. M., Kell, D. B., & Kaprel'yants, A. S. (1998). Research on the heterogeneity of a Micrococcus luteus culture during an extended stationary phase: Subpopulation separation and characterization. MICROBIOLOGY, 67(1), 71-77. Retrieved from https://www.webofscience.com/Rheological phenomena occurring during the shearing flow of mayonnaise (Journal article)
Goshawk, J. A., Binding, D. M., Kell, D. B., & Goodacre, R. (1998). Rheological phenomena occurring during the shearing flow of mayonnaise. JOURNAL OF RHEOLOGY, 42(6), 1537-1553. doi:10.1122/1.550967On resuscitation from the dormant state of Micrococcus luteus (Journal article)
Mukamolova, G. V., Yanopolskaya, N. D., Kell, D. B., & Kaprelyants, A. S. (1998). On resuscitation from the dormant state of Micrococcus luteus. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 73(3), 237-243. doi:10.1023/A:1000881918216Variable selection in discriminant partial least-squares analysis (Journal article)
Alsberg, B. K., Kell, D. B., & Goodacre, R. (1998). Variable selection in discriminant partial least-squares analysis. ANALYTICAL CHEMISTRY, 70(19), 4126-4133. doi:10.1021/ac980506oSystematic functional analysis of the yeast genome (Journal article)
Oliver, S. G., Winson, M. K., Kell, D. B., & Baganz, F. (1998). Systematic functional analysis of the yeast genome. TRENDS IN BIOTECHNOLOGY, 16(9), 373-378. doi:10.1016/S0167-7799(98)01214-1Viability and activity in readily culturable bacteria: a review and discussion of the practical issues (Journal article)
Kell, D. B., Kaprelyants, A. S., Weichart, D. H., Harwood, C. R., & Barer, M. R. (1998). Viability and activity in readily culturable bacteria: a review and discussion of the practical issues. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 73(2), 169-187. doi:10.1023/A:1000664013047Microbial stress and culturability: conceptual and operational domains (Journal article)
Barer, M. R., Kaprelyants, A. S., Weichart, D. H., Harwood, C. R., & Kell, D. B. (1998). Microbial stress and culturability: conceptual and operational domains. MICROBIOLOGY-SGM, 144, 2009-2010. doi:10.1099/00221287-144-8-2009A bacterial cytokine (Journal article)
Mukamolova, G. V., Kaprelyants, A. S., Young, D. I., Young, M., & Kell, D. B. (1998). A bacterial cytokine. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(15), 8916-8921. doi:10.1073/pnas.95.15.8916Quantification of microbial productivity via multi-angle light scattering and supervised learning (Journal article)
Jones, A., Young, D., Taylor, J., Kell, D. B., & Rowland, J. J. (1998). Quantification of microbial productivity via multi-angle light scattering and supervised learning. BIOTECHNOLOGY AND BIOENGINEERING, 59(2), 131-143. doi:3.0.CO;2-I">10.1002/(SICI)1097-0290(19980720)59:2<131::AID-BIT1>3.0.CO;2-IDOI: 10.1002/(SICI)1097-0290(19980720)59:2<131::AID-BIT1>3.0.CO;2-I
Variable selection in wavelet regression models (Journal article)
Alsberg, B. K., Woodward, A. M., Winson, M. K., Rowland, J. J., & Kell, D. B. (1998). Variable selection in wavelet regression models. ANALYTICA CHIMICA ACTA, 368(1-2), 29-44. doi:10.1016/S0003-2670(98)00194-9Rapid identification of urinary tract infection bacteria using hyperspectral whole-organism fingerprinting and artificial neural networks (Journal article)
Goodacre, R., Timmins, É., Burton, R., Kaderbhai, N., Woodward, A. M., Kell, D. B., & Rooney, P. J. (1998). Rapid identification of urinary tract infection bacteria using hyperspectral whole-organism fingerprinting and artificial neural networks. MICROBIOLOGY-SGM, 144, 1157-1170. doi:10.1099/00221287-144-5-1157The effect of heteroscedastic noise on the chemometric modelling of frequency domain data (Journal article)
Woodward, A. M., Alsberg, B. K., & Kell, D. B. (1998). The effect of heteroscedastic noise on the chemometric modelling of frequency domain data. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 40(1), 101-107. doi:10.1016/S0169-7439(97)00078-6Rapid analysis of microbial systems using vibrational spectroscopy and supervised learning methods: application to the discrimination between methicillin-resistant and methicillin-susceptible Staphylococcus aureus. (Conference Paper)
Goodacre, R., Rooney, P. J., & Kell, D. B. (1998). Rapid analysis of microbial systems using vibrational spectroscopy and supervised learning methods: application to the discrimination between methicillin-resistant and methicillin-susceptible Staphylococcus aureus.. In INFRARED SPECTROSCOPY: NEW TOOL IN MEDICINE, PROCEEDINGS OF Vol. 3257 (pp. 220-229). doi:10.1117/12.306087The deconvolution of pyrolysis mass spectra using genetic programming: application to the identification of some Eubacterium species (Journal article)
Taylor, J. (1998). The deconvolution of pyrolysis mass spectra using genetic programming: application to the identification of some Eubacterium species. FEMS Microbiology Letters, 160(2), 237-246. doi:10.1016/s0378-1097(98)00038-xThe deconvolution of pyrolysis mass spectra using genetic programming:: application to the identification of some <i>Eubacterium</i> species (Journal article)
Taylor, J., Goodacre, R., Wade, W. G., Rowland, J. J., & Kell, D. B. (1998). The deconvolution of pyrolysis mass spectra using genetic programming:: application to the identification of some <i>Eubacterium</i> species. FEMS MICROBIOLOGY LETTERS, 160(2), 237-246. doi:10.1016/S0378-1097(98)00038-XBACTERIAL PHEROMONES AND USES THEREFOR (Journal article)
MUKAMOLOVA GALINA V., KAPRELYANTS ARSENY S., YOUNG DANIELLE I., KELL DOUGLAS B., & YOUNG MICHAEL. (1998). BACTERIAL PHEROMONES AND USES THEREFOR.Dielectric estimation of microbial biomass using the Aber instruments biomass monitor (Journal article)
Kell, D., & Todd, R. W. (1998). Dielectric estimation of microbial biomass using the Aber instruments biomass monitor. TRENDS IN BIOTECHNOLOGY, 16(4), 149-150. doi:10.1016/S0167-7799(98)01175-5Discrimination between methicillin-resistant and methicillin-susceptible <i>Staphylococcus aureus</i> using pyrolysis mass spectrometry and artificial neural networks (Journal article)
Goodacre, R., Rooney, P. J., & Kell, D. B. (1998). Discrimination between methicillin-resistant and methicillin-susceptible <i>Staphylococcus aureus</i> using pyrolysis mass spectrometry and artificial neural networks. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 41(1), 27-34. doi:10.1093/jac/41.1.27Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation (Journal article)
Mendes, P., & Kell, D. B. (1998). Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation. BIOINFORMATICS, 14(10), 869-883. doi:10.1093/bioinformatics/14.10.869The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements - I. Quantifying the effects on electrode polarisation of factors likely to occur during fermentations (Journal article)
Davey, C. L., & Kell, D. B. (1998). The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements - I. Quantifying the effects on electrode polarisation of factors likely to occur during fermentations. BIOELECTROCHEMISTRY AND BIOENERGETICS, 46(1), 91-103. doi:10.1016/S0302-4598(98)00131-7The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements: (II) Reduction in the contribution of electrode polarisation to dielectric spectra using a two-frequency method (Journal article)
Davey, C. L., & Kell, D. B. (1998). The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements: (II) Reduction in the contribution of electrode polarisation to dielectric spectra using a two-frequency method. BIOELECTROCHEMISTRY AND BIOENERGETICS, 46(1), 105-114. doi:10.1016/S0302-4598(98)00132-91997
Genetic programming: A novel method for the quantitative analysis of pyrolysis mass spectral data (Journal article)
Gilbert, R. J., Goodacre, R., Woodward, A. M., & Kell, D. B. (1997). Genetic programming: A novel method for the quantitative analysis of pyrolysis mass spectral data. ANALYTICAL CHEMISTRY, 69(21), 4381-4389. doi:10.1021/ac970460jCheques and balances (Journal article)
Kell, D. B. (1997). Cheques and balances. NATURE, 389(6648), 224. doi:10.1038/38374Classification of pyrolysis mass spectra by fuzzy multivariate rule induction-comparison with regression, K-nearest neighbour, neural and decision-tree methods (Conference Paper)
Alsberg, B. K., Goodacre, R., Rowland, J. J., & Kell, D. B. (1997). Classification of pyrolysis mass spectra by fuzzy multivariate rule induction-comparison with regression, K-nearest neighbour, neural and decision-tree methods. In ANALYTICA CHIMICA ACTA Vol. 348 (pp. 389-407). doi:10.1016/S0003-2670(97)00064-0Diffuse reflectance absorbance spectroscopy taking in chemometrics (DRASTIC). A hyperspectral FT-IR-based approach to rapid screening for metabolite overproduction (Conference Paper)
Winson, M. K., Goodacre, R., Timmins, E. M., Jones, A., Alsberg, B. K., Woodward, A. M., . . . Kell, D. B. (1997). Diffuse reflectance absorbance spectroscopy taking in chemometrics (DRASTIC). A hyperspectral FT-IR-based approach to rapid screening for metabolite overproduction. In ANALYTICA CHIMICA ACTA Vol. 348 (pp. 273-282). doi:10.1016/S0003-2670(97)00237-7Discrimination of the variety and region of origin of extra virgin olive oils using C-13 NMR and multivariate calibration with variable reduction (Conference Paper)
Shaw, A. D., diCamillo, A., Vlahov, G., Jones, A., Bianchi, G., Rowland, J., & Kell, D. B. (1997). Discrimination of the variety and region of origin of extra virgin olive oils using C-13 NMR and multivariate calibration with variable reduction. In ANALYTICA CHIMICA ACTA Vol. 348 (pp. 357-374). doi:10.1016/S0003-2670(97)00037-8Genetic algorithms as a method for variable selection in multiple linear regression and partial least squares regression, with applications to pyrolysis mass spectrometry (Conference Paper)
Broadhurst, D., Goodacre, R., Jones, A., Rowland, J. J., & Kell, D. B. (1997). Genetic algorithms as a method for variable selection in multiple linear regression and partial least squares regression, with applications to pyrolysis mass spectrometry. In ANALYTICA CHIMICA ACTA Vol. 348 (pp. 71-86). doi:10.1016/S0003-2670(97)00065-2On mass spectrometer instrument standardization and interlaboratory calibration transfer using neural networks (Conference Paper)
Goodacre, R., Timmins, E. M., Jones, A., Kell, D. B., Maddock, J., Heginbothom, M. L., & Magee, J. T. (1997). On mass spectrometer instrument standardization and interlaboratory calibration transfer using neural networks. In ANALYTICA CHIMICA ACTA Vol. 348 (pp. 511-532). doi:10.1016/S0003-2670(97)00062-7Enantioselectivity of sulcatone reduction by some anaerobic bacteria (Journal article)
Tidswell, E. C., Salter, G. J., Kell, D. B., & Morris, J. G. (1997). Enantioselectivity of sulcatone reduction by some anaerobic bacteria. ENZYME AND MICROBIAL TECHNOLOGY, 21(2), 143-147. doi:10.1016/S0141-0229(96)00264-5Fluorescent brighteners: Novel stains for the flow cytometric analysis of microorganisms (Journal article)
Davey, H. M., & Kell, D. B. (1997). Fluorescent brighteners: Novel stains for the flow cytometric analysis of microorganisms. CYTOMETRY, 28(4), 311-315. doi:3.0.CO;2-E">10.1002/(SICI)1097-0320(19970801)28:4<311::AID-CYTO6>3.0.CO;2-EDOI: 10.1002/(SICI)1097-0320(19970801)28:4<311::AID-CYTO6>3.0.CO;2-E