Photo of Prof Christiane Hertz-Fowler

Prof Christiane Hertz-Fowler

Interim Dean of Institute of Integrative Biology, Chair in Pathogen Genomics Functional and Comparative Genomics

Research

Research Interests

I have two key strands to my research interests. Firstly, I work on kinetoplastid parasites, a group of pathogens that cause devastating diseases in humans and animals in large parts of Africa, Asia and South America. I leverage comparative genomic approaches to investigate pathogenicity and understand host-restriction. I also work on one of the human diseases, Human African trypanosomiasis, a neglected tropical disease of sub-Saharan Africa that claims the lives of tens of thousands of people a year in some of the poorest and most remote areas of the world, significantly impacting on the economy and development of affected countries. As part of the Wellcome Trust-funded TrypanoGEN consortium, I am interested in understanding the genomic signatures that underlie human host susceptibility and disease progressions once infected with the Trypanosoma brucei parasite. Secondly, I focus on developing and maintaining database/data-mining infrastructure, combined with expertise in curation and annotation, to provide robust, scalable, cost-effective support for researchers working within the fungal and kinetoplastid global research communities as part of the EuPathDB project.

Research Grants

FungiDB: An integrated bioinformatics resource for fungi and oomycetes

WELLCOME TRUST (UK)

November 2018 - November 2023

SAVER - Sodium valproate for epigenetic reprogramming in the management of high risk oral epithelial dysplasia

DEPARTMENT OF HEALTH (UK) (NIHR)

January 2018 - June 2023

The NERC Biomolecular Analysis Facility (NBAF) at the University of Liverpool 2014-15 - PAYG Consumables

NATURAL ENVIRONMENT RESEARCH COUNCIL (NERC)

April 2014 - March 2021

The NERC Biomolecular Analysis Facility (NBAF) at the University of Liverpool 2014-15 - Main Budget

NATURAL ENVIRONMENT RESEARCH COUNCIL (NERC)

April 2016 - March 2018

Improving diagnosis of brain infections in Indonesia using novel and established molecular diagnostic tools.

DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY (BEIS) (UK)

April 2019 - April 2022

Ensuring access and appropriate/ effective use of clinical and epidemiological datasets for enteric pathogens

BILL & MELINDA GATES FOUNDATION (USA)

February 2017 - January 2020

Overexpression of Hydrogel-Forming proteins in heterologous hosts

UNILEVER PLC (UK)

July 2015 - January 2017

MICA: Phenotyping immune responses in asthma and respiratory infections - a systems approach to understanding changes from childhood to adulthood.

MEDICAL RESEARCH COUNCIL (MRC)

December 2015 - August 2017

Fully Integrated, real-time detection, diagnosis and control of community infection outbreaks.

WELLCOME TRUST (UK)

April 2013 - July 2018

Liverpool Health Genomics Laboratory

LIVERPOOL HEALTH PARTNERS (UK)

March 2015 - February 2018

Cost effective community access to intergrated information for microbial eukaryotis pathogen reesearch

WELLCOME TRUST (UK)

January 2016 - December 2019

Assay Development Platforms

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

February 2015 - November 2016

OXITEC: Gene discovery in the diamondback moth for novel pest control

INNOVATE UK (UK)

August 2011 - July 2014

Support to process high-throughput genomics projects

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

January 2014 - March 2015

Genetic markers for carbamazepine-induced hypersensitivty syndrome

EPILEPSY RESEARCH UK (UK)

June 2012 - November 2013

Integrated bioinformatics resources for kinetoplastid pathogens.

WELLCOME TRUST (UK)

October 2012 - November 2016

Centre for synthetic biology of fine and speciality chemicals

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

November 2014 - November 2019

Centre for Genomic Research: Genomics Hub Renewal

MEDICAL RESEARCH COUNCIL (MRC)

January 2013 - December 2014

Liverpool GeneMill

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

September 2014 - September 2015

Establishing Single Molecule Real Time Sequencing for the North of the UK

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

January 2014 - December 2016

UNILEVER: Development of instrumental and bioinformatic pipelines to accelerate commercial applications of metagenomics approaches

INNOVATE UK (UK)

September 2011 - November 2014

Establishing a single cell analysis facility for the UK scientific research community

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

January 2015 - January 2016

The In Vivo Transcriptome of Trypanosama Brucei as a Tool to Examine the Host-Parasite Interaction

ROYAL SOCIETY (CHARITABLE)

May 2012 - October 2014