Photo of Prof Christiane Hertz-Fowler

Prof Christiane Hertz-Fowler

Interim Head of Institute of Integrative Biology, Chair in Pathogen Genomics Functional and Comparative Genomics


    Research Interests

    I have two key strands to my research interests. Firstly, I work on kinetoplastid parasites, a group of pathogens that cause devastating diseases in humans and animals in large parts of Africa, Asia and South America. I leverage comparative genomic approaches to investigate pathogenicity and understand host-restriction. I also work on one of the human diseases, Human African trypanosomiasis, a neglected tropical disease of sub-Saharan Africa that claims the lives of tens of thousands of people a year in some of the poorest and most remote areas of the world, significantly impacting on the economy and development of affected countries. As part of the Wellcome Trust-funded TrypanoGEN consortium, I am interested in understanding the genomic signatures that underlie human host susceptibility and disease progressions once infected with the Trypanosoma brucei parasite. Secondly, I focus on developing and maintaining database/data-mining infrastructure, combined with expertise in curation and annotation, to provide robust, scalable, cost-effective support for researchers working within the fungal and kinetoplastid global research communities as part of the EuPathDB project.

    Research Grants
    • Ensuring access and appropriate/ effective use of clinical and epidemiological datasets for enteric pathogens
    • Overexpression of Hydrogel-Forming proteins in heterologous hosts
    • MICA: Phenotyping immune responses in asthma and respiratory infections - a systems approach to understanding changes from childhood to adulthood.
    • Fully Integrated, real-time detection, diagnosis and control of community infection outbreaks.
    • Liverpool Health Genomics Laboratory
    • Cost effective community access to intergrated information for microbial eukaryotis pathogen reesearch
    • Assay Development Platforms
    • OXITEC: Gene discovery in the diamondback moth for novel pest control
    • Support to process high-throughput genomics projects
    • Genetic markers for carbamazepine-induced hypersensitivty syndrome
    • Integrated bioinformatics resources for kinetoplastid pathogens.
    • Centre for synthetic biology of fine and speciality chemicals
    • Centre for Genomic Research: Genomics Hub Renewal
    • Liverpool GeneMill
    • Establishing Single Molecule Real Time Sequencing for the North of the UK
    • UNILEVER: Development of instrumental and bioinformatic pipelines to accelerate commercial applications of metagenomics approaches
    • Establishing a single cell analysis facility for the UK scientific research community
    • The In Vivo Transcriptome of Trypanosama Brucei as a Tool to Examine the Host-Parasite Interaction

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