I have two key strands to my research interests. Firstly, I work on kinetoplastid parasites, a group of pathogens that cause devastating diseases in humans and animals in large parts of Africa, Asia and South America. I leverage comparative genomic approaches to investigate pathogenicity and understand host-restriction. I also work on one of the human diseases, Human African trypanosomiasis, a neglected tropical disease of sub-Saharan Africa that claims the lives of tens of thousands of people a year in some of the poorest and most remote areas of the world, significantly impacting on the economy and development of affected countries. As part of the Wellcome Trust-funded TrypanoGEN consortium, I am interested in understanding the genomic signatures that underlie human host susceptibility and disease progressions once infected with the Trypanosoma brucei parasite. Secondly, I focus on developing and maintaining database/data-mining infrastructure, combined with expertise in curation and annotation, to provide robust, scalable, cost-effective support for researchers working within the fungal and kinetoplastid global research communities as part of the EuPathDB project.
Research Group Membership
- Ensuring access and appropriate/ effective use of clinical and epidemiological datasets for enteric pathogens
- Overexpression of Hydrogel-Forming proteins in heterologous hosts
- MICA: Phenotyping immune responses in asthma and respiratory infections - a systems approach to understanding changes from childhood to adulthood.
- Fully Integrated, real-time detection, diagnosis and control of community infection outbreaks.
- Liverpool Health Genomics Laboratory
- Cost effective community access to intergrated information for microbial eukaryotis pathogen reesearch
- Assay Development Platforms
- OXITEC: Gene discovery in the diamondback moth for novel pest control
- Support to process high-throughput genomics projects
- Genetic markers for carbamazepine-induced hypersensitivty syndrome
- Integrated bioinformatics resources for kinetoplastid pathogens.
- Centre for synthetic biology of fine and speciality chemicals
- Centre for Genomic Research: Genomics Hub Renewal
- Liverpool GeneMill
- Establishing Single Molecule Real Time Sequencing for the North of the UK
- UNILEVER: Development of instrumental and bioinformatic pipelines to accelerate commercial applications of metagenomics approaches
- Establishing a single cell analysis facility for the UK scientific research community
- The In Vivo Transcriptome of Trypanosama Brucei as a Tool to Examine the Host-Parasite Interaction