Publications

 

September 2017 - February 2018

Deep Sequencing of RNA from Blood and Oral Swab Samples Reveals the Presence of Nucleic Acid from a Number of Pathogens in Patients with Acute Ebola Virus Disease and Is Consistent with Bacterial Translocation across the Gut

Miles W. Carroll, Sam Haldenby, Natasha Y. Rickett, Bernadett Palyi, Isabel Garcia-Dorival,, Xuan Lui, Gary Barker, Joseph Akori Bore, Fara Raymond Koundouno

ABSTRACT - In this study, samples from the 2013–2016 West African Ebola virus outbreak from patients in Guinea with Ebola virus disease (EVD) were analyzed to discover and classify what other pathogens were present. Throat swabs were taken from deceased EVD patients, and peripheral blood samples were analyzed that had been taken from patients when they presented at the treatment center with acute illness

Optimised conditions for handling and transport of male Anopheles arabiensis: effects of low temperature, compaction, and ventilation on male quality

Nicole J. Culbert, Rosemary S. Lees, Marc J.B. Vreysen, Alistair C. Darby, Jeremie R.L. Gilles

ABSTRACT - Developing optimal conditions for handling and transport of sterile male mosquitoes, prior to their release, is critical for the sterile insect technique (SIT) to be successful. No data currently exist for Anopheles arabiensis Patton (Diptera: Culicidae) concerning the effects of chilling at different temperatures and for different time lengths on subsequent survival.

Identification of heparin modifications and polysaccharide inhibitors of Plasmodium falciparum merozoite invasion that have potential for novel drug development

Michelle J. Boyle, Mark Skidmore, Benjamin Dickerman, Lynsay Cooperc, Antony Devlinc, Edwin Yates, Paul Horrocks, Craig Freeman, Wengang Chai and James G. Beeson

ABSTRACT - Despite recent successful control efforts, malaria remains a leading global health burden. Alarmingly, resistance to current antimalarials is increasing, and the development of new drug families is needed to maintain malaria control.

 

August 2017

Composition and diversity of mucosa-associated microbiota along the entire length of the pig gastrointestinal tract; dietary influences
Kelly, J., Daly, K., Moran, A.W., Ryan, S., Bravo, D., Shirazi-Beechey, S.P. (2017) Composition and diversity of mucosa-associated microbiota along the entire length of the pig gastrointestinal tract; dietary influences. Environmental Microbiology. doi: 10.1111/1462-2920.13619

How do epidemics become endemic? Lessons from shigellosis in men who have sex with men
Baker, K. (2017) How do epidemics become endemic? Lessons from shigellosis in men who have sex with men. Microbiology Today.

Shigatoxin encoding Bacteriophage φ24B modulates bacterial metabolism to raise antimicrobial tolerance
Holt, G.S., Lodge, J.K., McCarthy, A.J., Graham, A.K., Young, G., Bridge, S.H., Brown, A.K., Veses-Garcia, M., Lanyon, C.V., Sails, A., Allison, H.E., Smith, D.L. (2017) Shigatoxin encoding Bacteriophage φ24B modulates bacterial metabolism to raise antimicrobial tolerance. Scientific Reports. doi: 10.1038/srep40424

Evolutionary interplay between structure, energy and epistasis in the coat protein of the fX174 phage family
Redondo, R.A.F., De Vladar, H.P., Włodarski, T., Bollback, J.P. (2017) Evolutionary interplay between structure, energy and epistasis in the coat protein of the fX174 phage family. Journal of the Royal Society Interface. doi: 10.1098/rsif.2016.0139

The diversity-generating benefits of a prokaryotic adaptive immune system
van Houte, S., Ekroth, A.K.E., Broniewski, J.M., Chabas, H., Ashby, B., Bondy-Donomy, J., Gandon, S., Boots, M., Paterson, S., Buckling, A., Westra, E.R. (2016). The diversity-generating benefits of a prokaryotic adaptive immune system. Nature. doi:10.1038/nature17436