Professor Helen Sharp B.Sc. (HONS) M.Phil. Ph.D. D.Clin.Psy.

Professor of Perinatal and Clinical Child Psychology Primary Care & Mental Health

Publications

2020

Sex differences in foetal origins of child emotional symptoms: a test of evolutionary hypotheses in a large, general population cohort (Journal article)

Braithwaite, E. C., Pickles, A., Wright, N., Sharp, H., & Hill, J. (2020). Sex differences in foetal origins of child emotional symptoms: a test of evolutionary hypotheses in a large, general population cohort. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 61(11), 1194-1202. doi:10.1111/jcpp.13229

DOI: 10.1111/jcpp.13229

2019

Sex-dependent associations between maternal prenatal cortisol and child callous-unemotional traits: Findings from the Wirral Child Health and Development Study (Journal article)

Wright, N., Pickles, A., Braithwaite, E. C., Sharp, H., & Hill, J. (2019). Sex-dependent associations between maternal prenatal cortisol and child callous-unemotional traits: Findings from the Wirral Child Health and Development Study. PSYCHONEUROENDOCRINOLOGY, 109. doi:10.1016/j.psyneuen.2019.104409

DOI: 10.1016/j.psyneuen.2019.104409

Mapping early environment using communication deviance: A longitudinal study of maternal sensitivity toward 6-month-old children (Journal article)

de Sousa, P., Sellwood, W., Fien, K., Sharp, H., Pickles, A., Hill, J., . . . Bentall, R. P. (2019). Mapping early environment using communication deviance: A longitudinal study of maternal sensitivity toward 6-month-old children. DEVELOPMENT AND PSYCHOPATHOLOGY, 31(4), 1501-1511. doi:10.1017/S0954579418001189

DOI: 10.1017/S0954579418001189

Mismatched Prenatal and Postnatal Maternal Depressive Symptoms and Child Behaviours: A Sex-Dependent Role for NR3C1 DNA Methylation in the Wirral Child Health and Development Study (Journal article)

Hill, J., Pickles, A., Wright, N., Quinn, J. P., Murgatroyd, C., & Sharp, H. (2019). Mismatched Prenatal and Postnatal Maternal Depressive Symptoms and Child Behaviours: A Sex-Dependent Role for NR3C1 DNA Methylation in the Wirral Child Health and Development Study. CELLS, 8(9). doi:10.3390/cells8090943

DOI: 10.3390/cells8090943

Distinct chromatin structures at the monoamine oxidase-A promoter correlate with allele-specific expression in SH-SY5Y cells (Journal article)

Manca, M., Pessoa, V., Myers, P., Pickles, A., Hill, J., Sharp, H., . . . Quinn, J. P. (2019). Distinct chromatin structures at the monoamine oxidase-A promoter correlate with allele-specific expression in SH-SY5Y cells. GENES BRAIN AND BEHAVIOR, 18(6). doi:10.1111/gbb.12483

DOI: 10.1111/gbb.12483

How does perinatal maternal mental health explain early social inequalities in child behavioural and emotional problems? Findings from the Wirral Child Health and Development Study. (Journal article)

Rutherford, C., Sharp, H., Hill, J., Pickles, A., & Taylor-Robinson, D. (2019). How does perinatal maternal mental health explain early social inequalities in child behavioural and emotional problems? Findings from the Wirral Child Health and Development Study.. PloS one, 14(5), e0217342. doi:10.1371/journal.pone.0217342

DOI: 10.1371/journal.pone.0217342

Predictions of children's emotionality from evolutionary and epigenetic hypotheses (Journal article)

Hill, J., Pickles, A., Wright, N., Braithwaite, E., & Sharp, H. (2019). Predictions of children's emotionality from evolutionary and epigenetic hypotheses. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-39513-7

DOI: 10.1038/s41598-019-39513-7

Callous-unemotional traits, low cortisol reactivity and physical aggression in children: findings from the Wirral Child Health and Development Study (Journal article)

Wright, N., Hill, J., Pickles, A., & Sharp, H. (2019). Callous-unemotional traits, low cortisol reactivity and physical aggression in children: findings from the Wirral Child Health and Development Study. TRANSLATIONAL PSYCHIATRY, 9. doi:10.1038/s41398-019-0406-9

DOI: 10.1038/s41398-019-0406-9

2018

Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology (Journal article)

Billingsley, K. J., Manca, M., Gianfrancesco, O., Collier, D., Sharp, H. M., Bubb, V. J., & Quinn, J. (2018). Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology. Schizophrenia Research, 199, 168-175. doi:10.1016/j.schres.2018.02.036

DOI: 10.1016/j.schres.2018.02.036

Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study (Journal article)

Braithwaite, E. C., Hill, J., Pickles, A., Glover, V., O'Donnell, K., & Sharp, H. (2018). Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 9(4), 425-431. doi:10.1017/S2040174418000181

DOI: 10.1017/S2040174418000181

Maternal sensitivity to distress, attachment and the development of callous-unemotional traits in young children (Journal article)

Wright, N., Hill, J., Sharp, H., & Pickles, A. (2018). Maternal sensitivity to distress, attachment and the development of callous-unemotional traits in young children. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 59(7), 790-800. doi:10.1111/jcpp.12867

DOI: 10.1111/jcpp.12867

The Regulation of Monoamine Oxidase A Gene Expression by Distinct Variable Number Tandem Repeats (Journal article)

Manca, M., Pessoa, V., Lopez, A. I., Harrison, P. T., Miyajima, F., Sharp, H., . . . Quinn, J. P. (2018). The Regulation of Monoamine Oxidase A Gene Expression by Distinct Variable Number Tandem Repeats. JOURNAL OF MOLECULAR NEUROSCIENCE, 64(3), 459-470. doi:10.1007/s12031-018-1044-z

DOI: 10.1007/s12031-018-1044-z

2017

Maternal mental health and child problem behaviours: disentangling the role of depression and borderline personality dysfunction (Journal article)

Huntley, F., Wright, N., Pickles, A., Sharp, H., & Hill, J. (2017). Maternal mental health and child problem behaviours: disentangling the role of depression and borderline personality dysfunction. BJPSYCH OPEN, 3(6), 300-305. doi:10.1192/bjpo.bp.117.005843

DOI: 10.1192/bjpo.bp.117.005843

Sex differences in the associations between vagal reactivity and oppositional defiant disorder symptoms (Journal article)

Vidal-Ribas, P., Pickles, A., Tibu, F., Sharp, H., & Hill, J. (2017). Sex differences in the associations between vagal reactivity and oppositional defiant disorder symptoms. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 58(9), 988-997. doi:10.1111/jcpp.12750

DOI: 10.1111/jcpp.12750

Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner (Journal article)

Braithwaite, E. C., Pickles, A., Sharp, H., Glover, V., O'Donnell, K. J., Tibu, F., & Hill, J. (2017). Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner. PHYSIOLOGY & BEHAVIOR, 175, 31-36. doi:10.1016/j.physbeh.2017.03.017

DOI: 10.1016/j.physbeh.2017.03.017

Prenatal anxiety, maternal stroking in infancy, and symptoms of emotional and behavioral disorders at 3.5 years (Journal article)

Pickles, A., Sharp, H., Hellier, J., & Hill, J. (2017). Prenatal anxiety, maternal stroking in infancy, and symptoms of emotional and behavioral disorders at 3.5 years. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 26(3), 325-334. doi:10.1007/s00787-016-0886-6

DOI: 10.1007/s00787-016-0886-6

2016

The Team of Life: A narrative approach to building resilience in UK school children (Journal article)

Eames, V., Shippen, C., & Sharp, H. (2016). The Team of Life: A narrative approach to building resilience in UK school children. Educational and Child Psychology, 33(2), 57-68.

2015

Psychometric Properties of the Parent-Infant Caregiving Touch Scale (Journal article)

Koukounari, A., Pickles, A., Hill, J., & Sharp, H. (2015). Psychometric Properties of the Parent-Infant Caregiving Touch Scale. FRONTIERS IN PSYCHOLOGY, 6. doi:10.3389/fpsyg.2015.01887

DOI: 10.3389/fpsyg.2015.01887

The Specific Role of Relationship Life Events in the Onset of Depression during Pregnancy and the Postpartum (Journal article)

Wright, N., Hill, J., Pickles, A., & Sharp, H. (2015). The Specific Role of Relationship Life Events in the Onset of Depression during Pregnancy and the Postpartum. PLOS ONE, 10(12). doi:10.1371/journal.pone.0144131

DOI: 10.1371/journal.pone.0144131

Reduced Face Preference in Infancy: A Developmental Precursor to Callous-Unemotional Traits? (Journal article)

Bedford, R., Pickles, A., Sharp, H., Wright, N., & Hill, J. (2015). Reduced Face Preference in Infancy: A Developmental Precursor to Callous-Unemotional Traits?. Biological Psychiatry, 78(2), 144-150. doi:10.1016/j.biopsych.2014.09.022

DOI: 10.1016/j.biopsych.2014.09.022

Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene (Journal article)

Murgatroyd, C., Quinn, J., Sharp, H., Pickles, A., & Hill, J. (2015). Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene. Translational Psychiatry, 5. doi:10.1038/tp.2014.140

DOI: 10.1038/tp.2014.140

Maternal antenatal anxiety, postnatal stroking and emotional problems in children: outcomes predicted from pre- and postnatal programming hypotheses (Journal article)

Sharp, H., Hill, J., Hellier, J., & Pickles, A. (2015). Maternal antenatal anxiety, postnatal stroking and emotional problems in children: outcomes predicted from pre- and postnatal programming hypotheses. Psychological Medicine, 45(2), 269-283. doi:10.1017/S0033291714001342

DOI: 10.1017/S0033291714001342

Conduct Disorders (Chapter 19) (Chapter)

Hill, J., & Sharp, H. (2015). Conduct Disorders (Chapter 19). In P. Luyten, L. C. Mayes, P. Fonagy, M. Target, & S. J. Blatt (Eds.), Handbook of contemporary psychodynamic approaches to psychopathology.. New York/London: The Guilford Press.

2014

Evidence for sex differences in fetal programming of stress reactivity in infancy (Journal article)

Tibu, F., Hill, J., Sharp, H., Marshall, K., Glover, V., & Pickles, A. (2014). Evidence for sex differences in fetal programming of stress reactivity in infancy. Development and Psychopathology, 26(4 pt1), 879-888. doi:10.1017/S0954579414000194

DOI: 10.1017/S0954579414000194

2013

Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness (Journal article)

Pickles, A., Hill, J., Breen, G., Quinn, J., Abbott, K., Jones, H., & Sharp, H. (2013). Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 54(12), 1308-1317. doi:10.1111/jcpp.12081

DOI: 10.1111/jcpp.12081

Evidence for interplay between genes and maternal stress in utero: monoamine oxidase A polymorphism moderates effects of life events during pregnancy on infant negative emotionality at 5weeks (Journal article)

Hill, J., Breen, G., Quinn, J., Tibu, F., Sharp, H., & Pickles, A. (2013). Evidence for interplay between genes and maternal stress in utero: monoamine oxidase A polymorphism moderates effects of life events during pregnancy on infant negative emotionality at 5weeks. GENES BRAIN AND BEHAVIOR, 12(4), 388-396. doi:10.1111/gbb.12033

DOI: 10.1111/gbb.12033

2012

Frequency of Infant Stroking Reported by Mothers Moderates the Effect of Prenatal Depression on Infant Behavioural and Physiological Outcomes (Journal article)

Sharp, H., Pickles, A., Meaney, M., Marshall, K., Tibu, F., & Hill, J. (2012). Frequency of Infant Stroking Reported by Mothers Moderates the Effect of Prenatal Depression on Infant Behavioural and Physiological Outcomes. PLOS ONE, 7(10). doi:10.1371/journal.pone.0045446

DOI: 10.1371/journal.pone.0045446

2010

Adversity and sex differences in social and emotional sensitivity in children, a possible mechanism for sex differences in psychiatric disorders (Journal article)

Hill, J., Sharp, H., & Murray, L. (2010). Adversity and sex differences in social and emotional sensitivity in children, a possible mechanism for sex differences in psychiatric disorders. Nature Precedings.

Maternal and infant negative emotionality as predictors of mothers' capacity to preserve mind-mindedness during the still face (Conference Paper)

Hill, J., Sharp, H., Pickles, A., Marshall, K., Kelly, J., Bensinyor, M., & Hulbert, A. (2010). Maternal and infant negative emotionality as predictors of mothers' capacity to preserve mind-mindedness during the still face. In INFANT MENTAL HEALTH JOURNAL Vol. 31 (pp. 110). Retrieved from http://gateway.webofknowledge.com/

Maternal emotion recognition during pregnancy and infant emotional negativity in early infancy (Conference Paper)

Hill, J., Sharp, H., Pickles, A., Marks, K., Sadler, C., Appleton, J., & Tibu, F. (2010). Maternal emotion recognition during pregnancy and infant emotional negativity in early infancy. In INFANT MENTAL HEALTH JOURNAL Vol. 31 (pp. 110-111). Retrieved from http://gateway.webofknowledge.com/

Prenatal maternal psychosocial stress and preterm delivery: Interactions with infant gender? (Conference Paper)

Sharp, H., Lunt, K., Thompson, B., Bedwell, C., Jones, H., Pickles, A., & Hill, J. (2010). Prenatal maternal psychosocial stress and preterm delivery: Interactions with infant gender?. In INFANT MENTAL HEALTH JOURNAL Vol. 31 (pp. 111). Retrieved from http://gateway.webofknowledge.com/

Sex differences in children's social and emotional sensitivity in response to an adversity; a possible mechanism for sex differences in psychopathology (Conference Paper)

Hill, J., Sharp, H., & Murray, L. (2010). Sex differences in children's social and emotional sensitivity in response to an adversity; a possible mechanism for sex differences in psychopathology. In INFANT MENTAL HEALTH JOURNAL Vol. 31 (pp. 110). Retrieved from http://gateway.webofknowledge.com/

2009

The dynamics of threat, fear and intentionality in the conduct disorders: longitudinal findings in the children of women with post-natal depression (Chapter)

Hill, J., Murray, L., Leidecker, V., & Sharp, H. (2009). The dynamics of threat, fear and intentionality in the conduct disorders: longitudinal findings in the children of women with post-natal depression. In S. Hodgins, E. Viding, & A. Plodowski (Eds.), Persistent Violent Offenders: Neuroscience and Rehabilitation. (pp. 101-122). Oxford: Oxford University Press.

2008

The dynamics of threat, fear and intentionality in the conduct disorders: longitudinal findings in the children of women with post-natal depression (Journal article)

Hill, J., Murray, L., Leidecker, V., & Sharp, H. (2008). The dynamics of threat, fear and intentionality in the conduct disorders: longitudinal findings in the children of women with post-natal depression. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 363(1503), 2529-2541. doi:10.1098/rstb.2008.0036

DOI: 10.1098/rstb.2008.0036

2005

The Antenatal Maternal Orientation Measure (Chapter)

Sharp, H. M. (2005). The Antenatal Maternal Orientation Measure. In J. Raphael-Leff (Ed.), Psychological Processes in Childbearing (pp. 586-590). London: Chapman and Hall.

2004

An empirical evaluation of a psychoanalytic theory of mothering orientation: implications for the antenatal prediction of postnatal depression (Journal article)

Sharp, H. M., & Bramwell, R. (2004). An empirical evaluation of a psychoanalytic theory of mothering orientation: implications for the antenatal prediction of postnatal depression. JOURNAL OF REPRODUCTIVE AND INFANT PSYCHOLOGY, 22(2), 71-89. doi:10.1080/0264683042000205945

DOI: 10.1080/0264683042000205945

2000

Obsessive-Compulsive Disorder with Delusions (Journal article)

Fear, C., Sharp, H., & Healy, D. (2000). Obsessive-Compulsive Disorder with Delusions. Psychopathology, 33(2), 55-61. doi:10.1159/000029121

DOI: 10.1159/000029121

1998

Symptoms or side effects? Methodological hazards and therapeutic principles (Journal article)

Sharp, H. M., Healy, D., & Fear, C. F. (1998). Symptoms or side effects? Methodological hazards and therapeutic principles. Human Psychopharmacology: Clinical and Experimental, 13(7), 467-475.

The Leicester 500 Project. Social support and the development of postnatal depressive symptoms, a prospective cohort survey (Journal article)

BRUGHA, T. S., SHARP, H. M., COOPER, S. -A., WEISENDER, C., BRITTO, D., SHINKWIN, R., . . . KIRWAN, P. H. (1998). The Leicester 500 Project. Social support and the development of postnatal depressive symptoms, a prospective cohort survey. Psychological Medicine, 28(1), 63-79. doi:10.1017/s0033291797005655

DOI: 10.1017/s0033291797005655

1997

Attributional style and delusions: an investigation based on delusional content (Journal article)

Sharp, H. M., Fear, C. F., & Healy, D. (1997). Attributional style and delusions: an investigation based on delusional content. European Psychiatry, 12, 1-7.

1996

Interpersonal sensitivity predicts depressive symptom response to the circadian rhythm disruption of nightwork (Journal article)

Adeniran, R., Healy, D., Sharp, H., Williams, J. M. G., Minors, D., & Waterhouse, J. M. (1996). Interpersonal sensitivity predicts depressive symptom response to the circadian rhythm disruption of nightwork. Psychological Medicine, 26(6), 1211-1221.

Delusional phenomenology—Dimensions of change (Journal article)

Sharp, H. M., Fear, C. F., Williams, J. M. G., Healy, D., Lowe, C. F., Yeadon, H., & Holden, R. (1996). Delusional phenomenology—Dimensions of change. Behaviour Research and Therapy, 34(2), 123-142. doi:10.1016/0005-7967(95)00059-3

DOI: 10.1016/0005-7967(95)00059-3

Cognitive Processes in Delusional Disorders (Journal article)

Fear, C., Sharp, H., & Healy, D. (1996). Cognitive Processes in Delusional Disorders. British Journal of Psychiatry, 168(1), 61-67. doi:10.1192/bjp.168.1.61

DOI: 10.1192/bjp.168.1.61

1995

Obsessive-Compulsive and Delusional Disorders: notes on their history, nosology and interface. (Journal article)

Fear, C. F., Sharp, H. M., & Healy, D. (1995). Obsessive-Compulsive and Delusional Disorders: notes on their history, nosology and interface.. Journal of Serotonin Research, 1(Suppl.), 1-18.

1993

ALTERNATING FLUENCY IN PARKINSONS-DISEASE - AN EVALUATION OF THE ATTENTIONAL CONTROL-THEORY OF COGNITIVE IMPAIRMENT (Journal article)

DOWNES, J. J., SHARP, H. M., COSTALL, B. M., SAGAR, H. J., & HOWE, J. (1993). ALTERNATING FLUENCY IN PARKINSONS-DISEASE - AN EVALUATION OF THE ATTENTIONAL CONTROL-THEORY OF COGNITIVE IMPAIRMENT. BRAIN, 116, 887-902. doi:10.1093/brain/116.4.887

DOI: 10.1093/brain/116.4.887