Module Details
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title Pharmacological Chemistry
Code CHEM038
Coordinator Dr JW Gaynor
Chemistry
J.W.Gaynor@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2018-19 Level 5 FHEQ Second Semester 15

Pre-requisites before taking this module (or general academic requirements):
LIFE104 Other Chemistry based modules can replace the necessity for LIFE104. It is possible for students to take CHEM038 without taking the pre-requisite (LIFE104), but they must have a very good Chemistry A level grade (or equivalent), be prepared to undertake additional independent study, and it must be a requirement of their chosen degree path. 

Aims

The aim of this module is to offer students a grounding in organic chemistry and spectroscopy that is directly relevant to Pharmacology. There will be a particular emphasis on relating each topic studied to pharmacological examples.

Learning Outcomes
Upon successful completion of this module, a student will be able to demonstrate an understanding of the structure and bonding in a range of molecules, from simple organics to larger biologically relevant structures.
Upon successful completion of this module, a student will be able to demonstrate an understanding of the significant role of stereochemistry and conformation in a pharmacological setting

Upon successful completion of this module, a student will be able to demonstrate an understanding of an array of chemical reactions

Upon successful completion of this module, a student will be able to demonstrate an understanding of a range of spectroscopic methods

Upon successful completion of this module, a student will be able to demonstrate an understanding of the chemical principles in both the synthesis of biologically relevant structures and their interactions with small molecules

Upon successful completion of this module, a student will be able to apply these concepts and principles to process and solve unseen organic chemistry problems.

Teaching and Learning Strategies

Lecture - Lectures

This refers to timetabled lectures

Workshop - Workshops

This refers to problem solving workshops

Assessment - Class test and final exam

This refers to scheduled time for end of module summative assessment

Syllabus
1 
Structure, bonding and basic reactivity
• General revision of various concepts
 
Stereochemistry
• Absolute configuration
• Diastereoisomers
• Conformation of cyclic systems, including hexoses and pentoses
 
Chemical reactions
• Substitution and elimination reactions
• Alkene addition
• Carbonyl chemistry
• C-C bond forming reactions (aldol/Claisen) leading to Robinson annulations
 
Aromatics
• Chemistry of benzene
• Chemistry of substituted benzene
• Nucleophilic aromatic su bstitution
• Chemistry of heterocycles (ie, pyridines and pyrroles)
 
Biological Chemistry
• Carbohydrates and metabolism (sugars, glycosides and metabolism)
• Nucleic acids and DNA with a look at nucleoside analogues as antiviral agents
• Amino acids and proteins: Synthesis and interactions
 
Spectroscopy
• Mass spectrometry / LCMS
• Ultraviolet-visible spectroscopy
• Infrared spectroscopy
• Nuclear magnetic resonance
• Fluorescence spectroscopy
 
Revision

Recommended Texts
Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
Explanation of Reading List:

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 32
Lectures
        8
Workshops
5
Class test and final exam
45
Timetable (if known) This refers to timetabled lectures
  		        This refers to problem solving workshops
This refers to scheduled time for end of module summative assessment
  		 
Private Study 105
TOTAL HOURS 150

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Unseen Written Exam  180  Semester 2  80  Yes  Standard UoL penalty applies  Written exam 
Unseen Written Exam  60  Semester 2: week 7-9 (variable  10  Yes  Standard UoL penalty applies  Class test 
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Coursework  5 pieces of workshop  Workshops to take places throu  10  No reassessment opportunity  Standard UoL penalty applies  Workshop There is no reassessment opportunity, Work completed in workshops is primarily formative in nature and hence learning outcomes are covered by the formal resit examination which would contribute 90% (formal exam & workshops) of the resit marks if a students failed this component. Notes (applying to all assessments) Class test: Students who fail the class test will be given a resit opportunity during the final week of the semester. The maximum mark that can be achieved in the class test resit will be 40%. The class test will be given on pro-forma styles so cannot be marked anonymously. // Workshops: The 5 pieces of workshop material will be assessed via a mixture of face-to-face in class discussion, submission with written feedback for later reflection and the use of online tests. It is not possible to mark this work anonymously. // Written exam (end of course): The final exam will consist of free-answer questions.