Module Details

The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title ASYMMETRIC SYNTHESIS AND SYNTHETIC STRATEGY
Code CHEM433
Coordinator Dr C Aissa
Chemistry
Christophe.Aissa@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2017-18 Level 7 FHEQ First Semester 7.5

Pre-requisites before taking this module (or general academic requirements):

Either completion of year 3 of a MChem programme or BSc (Hons) in Chemistry  

Aims

The aim of this module is to further broaden and extend the knowledge of modern Organic Chemistry so that students will be able to enter directly into a PhD or embark on a career as a specialist chemist.


Learning Outcomes

By the end of the module students will have achieved a solid foundation in Organic Chemistry. In particular they will have a clear understanding of

(a) stereocontrolled synthesis

(b) main strategies in organic chemistry

and be able to give examples of their use in modern synthetic methodology.


Teaching and Learning Strategies

Lecture -


Syllabus

Asymmetric Synthesis
  • Cyclic control, reactions of endocyclic olefins
  • Thermodynamic and kinetic control in the formation of spiroketals
  • Acyclic control by 1,3-allylic strain
  • Acyclic control in nucleophilic attack of aldehydes and ketones
  • Zimmerman-Traxler transition state (aldol, pericyclic rearrangements, allylation reactions)
  • Chiral auxiliaries in aldol and other reactions

Main Group Organic Chemistry

  • Definition of retrosynthesic analysis. Basic principles of retrosynthesis
  • Disconnections, synthons, synthetic equivalents and reagents. The concept of umpolung.
  • Revision of key reactions in synthesis. Methods for the synthesis of dicarbonyl compounds. Methods for the synthesis of alkenes .
  • Functional group interconversions.
  • C-C bond disconnections.
  • Aromatic and heterocyclic compounds. Sp2-Sp2 coupling reactions.
  • Key ring-forming reactions.
  • Stereocontrol in synthesis.

Recommended Texts

Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.
Explanation of Reading List:

Teaching Schedule

  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 18

          18
Timetable (if known)              
Private Study 57
TOTAL HOURS 75

Assessment

EXAM Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
Unseen Written Exam  2 hours  Semester 1  100  Yes  Standard UoL penalty applies  Assessment 1 Notes (applying to all assessments) August resit opportunity for PGT students only where applicable. Integrated Master students resit at the next normal opportunity.  
CONTINUOUS Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes