Module Details

The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title Foundations of Medicinal Chemistry
Code CHEM141
Coordinator Dr G Nixon
Chemistry
G.L.Nixon@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2021-22 Level 4 FHEQ First Semester 15

Pre-requisites before taking this module (or general academic requirements):

 

Aims

The aim of this module is to provide students with an understanding of:
1. The key components of cells that act as the building blocks for the key macromolecular structures that are essential in medicinal chemistry.
2. How macromolecules interact with each other to allow for natural cellular processes (such as gene expression) that can be exploited by medicinal chemists.
3. The key drug targets in medicinal chemistry.


Learning Outcomes

(LO1) Upon successful completion of this module, a student will be able to demonstrate an understanding of the chemical components of cells.

(LO2) Upon successful completion of this module, a student will be able to demonstrate an understanding of the structure, chemical bonding and interactions of a range of cellular macromolecules that allow natural cellular processes to occur

(LO3) Upon successful completion of this module, a student will be able to demonstrate an understanding of the key drug targets in medicinal chemistry, including enzymes, receptors and nucleic acids

(S1) Problem solving skills


Teaching and Learning Strategies

The course will be taught through ~ 22 hours of online lectures via ~ 10-20 minute recordings. This will be supplemented by a number (~8) of face to face 1.5 hour long sessions delivered to groups of ~30 students and the assessment strategy detailed above.

Lectures: 22 hours
Tutorial: 12 hours
Self Directed Learning: 116 hours


Syllabus

 

The course will have the following syllabus, but there is likely to be overlap in the delivery of the two sections.

FOUNDATIONS OF CELL BIOLOGY
Topic 1 (Introduction to cell biology, chemical components of cells and related thermodynamics)
• Non-covalent interactions, energy and the properties of water.
• Unity and diversity of cells
• Model organisms
• How we look at cells
• Components of cells: Sugars, fatty acids, amino acids and nucleotides
• Macromolecules in cells: A focus on non-covalent interactions

Topic 2 (DNA, chromosomes, replication and repair)
• The structure and function of DNA
• The structure of eukaryotic chromosomes
• The regulation of chromosome structure
• DNA replication
• DNA repair
• Intercalators and alkylating reagents

Topic 3 (From DNA to protein: How ce lls read the genome)
• Transcription, Translation and Ribozymes

WHAT ARE THE PRINCIPLE DRUG TARGETS IN MEDICINAL CHEMISTRY? ENZYMES, RECEPTORS & NUCLEIC ACIDS

Topic 4 (Protein structure and function)
• The basics of protein structure
• Functions of proteins
• The shape and structure of proteins (Interesting examples, protein aggregates and assemblies)
• How proteins work (Antibodies, Lysozymes, Trypsin, Small molecule cofactors)
• How proteins are controlled (Allosteric proteins)

Topic 5 (Enzymes; Structure and function)
• Enzymes as catalysts
• How do enzymes catalyse reactions
• The active site of enzymes
• Substrate binding and binding interactions
• Acid-base catalysis
• Basic enzyme kinetics

Topic 6 (Enzymes as Drug Targets)
• Reversible inhibitors
 022; Irreversible inhibitors
• Allosteric inhibitors
• Uncompetitive and non-competitive
• Transition state inhibitors
• Suicide substrates
• Medicinal uses of enzyme inhibitors

Topic 7 (Receptors; Structure, function and signal transduction)
• Role of the receptor
• Neurotransmitters and hormones
• Receptor activation
• Ion channel receptors
• Ligand gated and voltage gated ion channels
• Protein coupled receptors

Topic 8 (Receptors as Drug Targets; Agonists and Antagonists)
• Design of agonists
• Binding groups
• The design of antagonists
• Examples of agonists and antagonists

Revision session delivered at the end of the module


Recommended Texts

Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.

Teaching Schedule

  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours     12

    22

34
Timetable (if known)              
Private Study 116
TOTAL HOURS 150

Assessment

EXAM Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
remote class test Word Processed short answer questions. A resit is available.  120 minutes    45       
CONTINUOUS Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
2 pieces of coursework completed during the semester. Standard UoL penalties apply for late submission. Resit available.      25       
3 online quizzes completed during the semester. Standard UoL penalties apply for late submission. Resit available      30