Module Details

The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title Applied Analytical Chemistry
Code CHEM286
Coordinator Dr K Luzyanin
Chemistry
Konstantin.Luzyanin@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2021-22 Level 5 FHEQ Second Semester 7.5

Pre-requisites before taking this module (or general academic requirements):

CHEM170 Introductory Spectroscopy 

Aims

To provide students with an understanding of the applications of various analytical techniques and their role in modern research. This module will demonstrate the fundamental theoretical principles of selected instrumental analytical techniques (NMR spectroscopy, mass-spectrometry, ICP-OE(MS) spectroscopy, separation and hyphenated techniques) in the context of their roles in industrial and academic research, to include chemical and pharmaceutical analysis.


Learning Outcomes

(LO1) To be able to recognise the current trends in the application of the instrumental analytical methods

(LO2) Demonstrate awareness of the theoretical concepts of NMR spectroscopy, Mass-Spectrometry, Chromatography, hyphenated techniques GC/HPLC-MS, and ICP-based methods

(LO3) To be able to choose an appropriate technique in order to evaluate the structure, properties and potential applications of materials, or a multi-technique approach to find the solution of a selected experimental problem

(S1) Students will develop their chemistry-related cognitive ability and skills, relating to intellectual tasks, including problem solving as required by the Chemistry subject benchmark statement.

(S2) Students will improve their confidence in scientific communication and develop presentation skills of analytical data


Teaching and Learning Strategies

Teaching method 1. 16 Lectures
Description: lectures, some synchronous and some asynchronous

Teaching method 2. Workshops on case/problem-based learning in small groups
Description: 3 problem(case)-based learning workshops (two synchronous, one asynchronous) with summary presentation in small groups, two are assessed totalling 20% of the final mark.

Attendance Recorded: Yes
Note: In the preparatory stage, students work outside the class to finding a solution of a problem given. In class, students work in small groups overseen/guided by a demonstrator towards refining the solution found. Upon completion of this work, students will deliver a short presentation with the most important results.

Teaching method 3. Self-directed learning
Description: Self-directed learning using recorded lectures, additional recommended literature sources; preparatory work for the workshops.
Attendance Recorded: No


Syllabus

 

Introduction (lectures 1 and 2)
1. Analytical chemistry: absolute and relative analytical methods, calibration (external calibration, standard additions, internal calibration), characteristics of an analytical procedure (accuracy, precision, specificity and selectivity, linearity range, detection and quantitation limits, robustness).
2. Sample preparation in instrumental analytical chemistry; validation of analytical procedures.

Mass-spectrometry (lectures 3-5)
1. Fundamentals of mass-spectrometry. Ion sources: Electron Impaction Ionization (EI) and Chemical Ionization (CI), Electrospray ionization (ESI), Atmospheric Pressure Chemical Ionization (APCI) and Atmospheric Pressure Photo Ionization (API). Fast atom bombardment (FAB) and Matrix Assisted Laser Desorption Ionization (MALDI) mass-spectrometry. Mass spectrometry detectors: quadrupole, ion trap, time of flight (TOF).
2. Applications of mass-spectrometry in chemistry and biochemistry

NMR spectrosc opy (lectures 6-9)
1. Fundamentals of NMR spectroscopy; sensitivity, resolution, and scope; 1D and 2D NMR methods and techniques. Principal differences between solution and solid-state NMR (magic angle spinning, chemical shift anisotropy, quadrupolar and paramagnetic spins)
2. Applications of NMR spectroscopy
Applications of NMR spectroscopy in synthetic chemistry, catalysis, and materials study

Atomic spectroscopy (lectures 10-12)
1. Fundamentals of atomic spectroscopy: atomic absorption (AA) versus atomic emission (AE/OE); principles of AA, MP-AE, ICP-OE spectroscopy and ICP-MS techniques.
2. Applications of atomic spectroscopy methods in chemistry and materials studies

Separation science (lectures 13-14)
1. Fundamentals of chromatography
2. Liquid Chromatography: modes of separation, instrumentation used, HPLC vs UHPLC. Method development for LC: optimising separation conditions, selecting an appropriate column and dete ctor for the given analysis. LC detectors: UV (photodiode array versus single wave UV), fluorescence, refractive index, electrochemical methods of detection.
3. Gas Chromatography: modes of separation, instrumentation used. Method development for GC: optimising separation conditions, selecting an appropriate column and detector for the given analysis. GC detectors: flame ionisation detector, thermal conductivity detector.
4. Applications of chromatography in chemical and pharmaceutical analysis

Hyphenated Techniques (lectures 15-16)
1. Introduction to hyphenation (GC/MS, HPLC/MS, MS/MS). GC Interfaces: Electron Impact Ionization (EI) and Chemical Ionization (CI). HPLC Interfaces: Electrospray ionization (ESI), Atmospheric Pressure Chemical Ionization (APCI) and Atmospheric Pressure Photo Ionization (APPI).
2. Applications of hyphenated techniques in chemical and pharmaceutical analysis.


Recommended Texts

Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.

Teaching Schedule

  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 16

        6

22
Timetable (if known)              
Private Study 53
TOTAL HOURS 75

Assessment

EXAM Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
time-controlled on-line examination  1.5 hours + 1hour fo    80       
CONTINUOUS Duration Timing
(Semester)
% of
final
mark
Resit/resubmission
opportunity
Penalty for late
submission
Notes
2 problem/case-based learning workshops with summary presentation in small groups (2 x 10% each). Each workshop has a duration of 2h There is no re-submission opportunity. These assignments are not   2 hours    20