Module Details
The information contained in this module specification was correct at the time of publication but may be subject to change, either during the session because of unforeseen circumstances, or following review of the module at the end of the session. Queries about the module should be directed to the member of staff with responsibility for the module.
Title CHEM038 - Organic Chemistry for Pharmacology
Code CHEM038
Coordinator Dr JW Gaynor
Chemistry
J.W.Gaynor@liverpool.ac.uk
Year CATS Level Semester CATS Value
Session 2019-20 Level 5 FHEQ Second Semester 15

Pre-requisites before taking this module (or general academic requirements):
 

Aims

The aim of this module is to offer students a grounding in organic chemistry and spectroscopy that is directly relevant to Pharmacology.
There will be a particular emphasis on relating each topic studied to pharmacological examples.

Learning Outcomes

(LO1) Upon successful completion of this module, a student will be able to demonstrate an understanding of the structure and bonding in a range of molecules, from simple organics to larger biologically relevant structures.

(LO2) Upon successful completion of this module, a student will be able to demonstrate an understanding of the significant role of stereochemistry and conformation in a pharmacological setting

(LO3) Upon successful completion of this module, a student will be able to demonstrate an understanding of an array of chemical reactions

(LO4) Upon successful completion of this module, a student will be able to demonstrate an understanding of a range of spectroscopic methods

(LO5) Upon successful completion of this module, a student will be able to demonstrate an understanding of the chemical principles in both the synthesis of biologically relevant structures and their interactions with small molecules

(LO6) Upon successful completion of this module, a student will be able to apply these concepts and principles to process and solve unseen organic chemistry problems.

(S1) Improving own learning/performance - Reflective practice

(S2) Critical thinking and problem solving - Problem identification

(S3) Personal attributes and qualities - Resilience

(S4) Students will develop independent learning and self-evaluation skills

Teaching and Learning Strategies

The course will be taught through a series of lectures (32) which are supported by 5x2 hour workshops throughout the term to give students the opportunity to obtain immediate and directed feedback. A mid-term class test will allow students to see how they are progressing.

Syllabus
 

Structure, bonding and basic reactivity
• General revision of various concepts

Stereochemistry
• Absolute configuration
• Diastereoisomers
• Conformation of cyclic systems, including hexoses and pentoses

Chemical reactions
• Substitution and elimination reactions
• Alkene addition
• Carbonyl chemistry
• C-C bond forming reactions (aldol/Claisen)

Aromatics
• Chemistry of benzene
• Chemistry of substituted benzene
• Nucleophilic aromatic substitution
• Chemistry of heterocycles (i.e., pyridines and pyrroles)

Biological Chemistry
• Carbohydrates and metabolism (sugars, glycosides and metabolism)
• Nucleic acids and DNA with a look at nucleoside analogues as antiviral agents
• Amino acids and proteins: Synth esis and interactions

Spectroscopy
• Mass spectrometry
• Ultraviolet-visible spectroscopy
• Infrared spectroscopy
• Nuclear magnetic resonance

Recommended Texts
Reading lists are managed at readinglists.liverpool.ac.uk. Click here to access the reading lists for this module.

Teaching Schedule
  Lectures Seminars Tutorials Lab Practicals Fieldwork Placement Other TOTAL
Study Hours 32

         10

 42
Timetable (if known)              
Private Study 108
TOTAL HOURS 150

Assessment
EXAM Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Class test Students who fail the class test will be given a resit opportunity during the final week of the semester. The maximum mark that can be achieved in the class test resit will be 40% (except   60 minutes    10       
Written exam The final exam will consist of free-answer questions.  180 minutes    80       
CONTINUOUS Duration Timing
(Semester)		 % of
final
mark		 Resit/resubmission
opportunity		 Penalty for late
submission		 Notes
Workshop Workshop material will be assessed via a mixture of face-to-face in-class discussion, submission with written feedback for later reflection and the use of online tests. Where appropriate,   5 in-class and 1 onl    10