Dr Daniel Wootton MBChB DTM+H PhD

Senior Fellow in Infection and Honorary Consultant Respiratory Physician Clinical Infection, Microbiology and Immunology

    Publications

    2018

    Quantification of Efferocytosis by Single-cell Fluorescence Microscopy (Journal article)

    Taruc, K., Yin, C., Wootton, D. G., & Heit, B. (2018). Quantification of Efferocytosis by Single-cell Fluorescence Microscopy. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (138). doi:10.3791/58149

    DOI: 10.3791/58149

    The association between pre-hospital antibiotic therapy and subsequent in-hospital mortality in adults presenting with community-acquired pneumonia: an observational study. (Journal article)

    Chakrabarti, B., Wootton, D., Lane, S., Kanwar, E., Somers, J., Proctor, J., . . . Woodhead, M. (2018). The association between pre-hospital antibiotic therapy and subsequent in-hospital mortality in adults presenting with community-acquired pneumonia: an observational study.. Pneumonia (Nathan Qld.), 10, 2. doi:10.1186/s41479-018-0047-4

    DOI: 10.1186/s41479-018-0047-4

    2017

    A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days (Journal article)

    Wootton, D. G., Dickinson, L., Pertinez, H., Court, J., Eneje, O., Keogan, L., . . . Diggle, P. J. (2017). A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days. EUROPEAN RESPIRATORY JOURNAL, 49(6). doi:10.1183/13993003.02170-2016

    DOI: 10.1183/13993003.02170-2016

    Studying the association between mortality in patients requiring hospital admission for Community Acquired Pneumonia and pre-hospital antibiotic treatment in primary care (Conference Paper)

    Wootton, D. G. (n.d.). Studying the association between mortality in patients requiring hospital admission for Community Acquired Pneumonia and pre-hospital antibiotic treatment in primary care.

    Studying the association between mortality in patients requiring hospital admission for Community Acquired Pneumonia and pre-hospital antibiotic treatment in primary care (Conference Paper)

    Wootton, D. G. (2017). Studying the association between mortality in patients requiring hospital admission for Community Acquired Pneumonia and pre-hospital antibiotic treatment in primary care. In European Respiratory Journal. Milan, Italy: European Respiratory Society. doi:10.1183/1393003.congress-2017.PA4525

    DOI: 10.1183/1393003.congress-2017.PA4525

    2016

    P214 Arrhythmias in pneumonia: a review of incidence, outcomes and management (vol 70, pg A184, 2015) (Presentation material)

    Cox, D. R., Wootton, D. G., & Blakey, J. (2016). P214 Arrhythmias in pneumonia: a review of incidence, outcomes and management (vol 70, pg A184, 2015). doi:10.1136/thoraxjnl-2015-207770.350corr1

    DOI: 10.1136/thoraxjnl-2015-207770.350corr1

    Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins (Journal article)

    Wootton, D. G., Diggle, P. J., Court, J., Eneje, O., Keogan, L., Macfarlane, L., . . . Gordon, S. B. (2016). Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins. THORAX, 71(11), 1052-+. doi:10.1136/thoraxjnl-2016-208505

    DOI: 10.1136/thoraxjnl-2016-208505

    2015

    Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation (Journal article)

    Lim, W. S., Brittain, C., Duley, L., Edwards, S., Gordon, S., Montgomery, A., . . . Wootton, D. (2015). Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation. HEALTH TECHNOLOGY ASSESSMENT, 19(16), 1-+. doi:10.3310/hta19160

    DOI: 10.3310/hta19160

    Household Air Pollution Causes Dose-Dependent Inflammation and Altered Phagocytosis in Human Macrophages (Journal article)

    Rylance, J., Fullerton, D. G., Scriven, J., Aljurayyan, A. N., Mzinza, D., Barrett, S., . . . Gordon, S. B. (2015). Household Air Pollution Causes Dose-Dependent Inflammation and Altered Phagocytosis in Human Macrophages. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 52(5), 584-593. doi:10.1165/rcmb.2014-0188OC

    DOI: 10.1165/rcmb.2014-0188OC

    The Genus Haemophilus Was Dominant In A Cohort With Community Acquired Pneumonia And Low Species Diversity Was Related To Age And Prior Pulmonary Disease (Conference Paper)

    Wootton, D. G., Cox, M. J., Hickey, G. L., Eneje, O., Court, J., Macfarlane, L., . . . Gordon, S. B. (2015). The Genus Haemophilus Was Dominant In A Cohort With Community Acquired Pneumonia And Low Species Diversity Was Related To Age And Prior Pulmonary Disease. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 191. Retrieved from http://gateway.webofknowledge.com/

    2014

    Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield (Journal article)

    Collins, A. M., Rylance, J., Wootton, D. G., Wright, A. D., Wright, A. K. A., Fullerton, D. G., & Gordon, S. B. (2014). Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (85). doi:10.3791/4345

    DOI: 10.3791/4345

    Bronchoalveolar lavage (BAL) for research; obtaining adequate sample yield. (Journal article)

    Collins, A. M., Rylance, J., Wootton, D. G., Wright, A. D., Wright, A. K. A., Fullerton, D. G., & Gordon, S. B. (2014). Bronchoalveolar lavage (BAL) for research; obtaining adequate sample yield.. Journal of visualized experiments : JoVE, (85).

    Efferocytosis Is Impaired By Smoking But Improved By Prior Statin Use In Patients Recovering From Community Acquired Pneumonia (Conference Paper)

    Wootton, D. G., Diggle, P. J., Woodhead, M., & Gordon, S. B. (2014). Efferocytosis Is Impaired By Smoking But Improved By Prior Statin Use In Patients Recovering From Community Acquired Pneumonia. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 189. Retrieved from http://gateway.webofknowledge.com/

    Feasibility study for early supported discharge in adults with respiratory infection in the UK (Journal article)

    Collins, A. M., Eneje, O. J., Hancock, C. A., Wootton, D. G., & Gordon, S. B. (2014). Feasibility study for early supported discharge in adults with respiratory infection in the UK. BMC PULMONARY MEDICINE, 14. doi:10.1186/1471-2466-14-25

    DOI: 10.1186/1471-2466-14-25

    The diagnosis of pneumonia requires a chest radiograph (x-ray)–yes, no or sometimes? (Journal article)

    Wootton, D., & Feldman, C. (2014). The diagnosis of pneumonia requires a chest radiograph (x-ray)–yes, no or sometimes?. Pneumonia, 5(S1), 1-7. doi:10.15172/pneu.2014.5/464

    DOI: 10.15172/pneu.2014.5/464

    The pathophysiology of pneumococcal pneumonia (Chapter)

    Wootton, D. G., Aston, S. J., & Gordon, S. B. (2014). The pathophysiology of pneumococcal pneumonia. In Unknown Book (Vol. 63, pp. 42-63). doi:10.1183/1025448x.10003313

    DOI: 10.1183/1025448x.10003313

    2012

    Supported home-care schemes: the key to increasing outpatient care? (Journal article)

    Collins, A. M., Wilks, S., Wootton, D., & Gordon, S. B. (2012). Supported home-care schemes: the key to increasing outpatient care?. European Respiratory Journal, 39(2), 508. doi:10.1183/09031936.00165911

    DOI: 10.1183/09031936.00165911

    Using the BTS CAP audit to evaluate local data (Journal article)

    Singh, B., Wootton, D. G., Brown, J., Chakrabarti, B., Cooke, R. P. D., & Gordon, S. B. (2012). Using the BTS CAP audit to evaluate local data. Thorax, 67(9), 832.1-832. doi:10.1136/thoraxjnl-2011-200876

    DOI: 10.1136/thoraxjnl-2011-200876

    2011

    P251 Junior doctors' interpretation of CXRs is more consistent than consultants in the context of possible pneumonia (Presentation material)

    Singh, B., Curtis, J., Gordon, S. B., Diggle, P. J., & Wootton, D. G. (2011). P251 Junior doctors' interpretation of CXRs is more consistent than consultants in the context of possible pneumonia. doi:10.1136/thoraxjnl-2011-201054c.251

    DOI: 10.1136/thoraxjnl-2011-201054c.251

    2009

    Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi (Journal article)

    Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., . . . Lalloo, D. G. (2009). Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. MALARIA JOURNAL, 8. doi:10.1186/1475-2875-8-204

    DOI: 10.1186/1475-2875-8-204

    Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria (Journal article)

    Miller, A. K., Bandyopadhyay, N., Wootton, D. G., Duparc, S., Kirby, P. L., Winstanley, P. A., & Ward, S. A. (2009). Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. European Journal of Clinical Pharmacology, 65(10), 977-987. doi:10.1007/s00228-009-0672-1

    DOI: 10.1007/s00228-009-0672-1

    2008

    Open-Label Comparative Clinical Study of Chlorproguanil−Dapsone Fixed Dose Combination (Lapdap™) Alone or with Three Different Doses of Artesunate for Uncomplicated Plasmodium falciparum Malaria (Journal article)

    Wootton, D. G., Opara, H., Biagini, G. A., Kanjala, M. K., Duparc, S., Kirby, P. L., . . . Winstanley, P. A. (2008). Open-Label Comparative Clinical Study of Chlorproguanil−Dapsone Fixed Dose Combination (Lapdap™) Alone or with Three Different Doses of Artesunate for Uncomplicated Plasmodium falciparum Malaria. PLoS ONE, 3(3), e1779. doi:10.1371/journal.pone.0001779

    DOI: 10.1371/journal.pone.0001779

    2007

    Austrian's syndrome: The first described case of pneumococcal meningitis pneumonia and endocarditis in an injecting drug user (Journal article)

    Beadsworth, M. B. J., Wooton, D., Chenzbraun, A., & Beeching, N. J. (2007). Austrian's syndrome: The first described case of pneumococcal meningitis pneumonia and endocarditis in an injecting drug user. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 18(8), 605-606. doi:10.1016/j.ejim.2007.03.012

    DOI: 10.1016/j.ejim.2007.03.012

    2006

    Malaria: clinical features and recommended management (Journal article)

    Wootton, D., Beeching, N., & Lalloo, D. (2006). Malaria: clinical features and recommended management. Prescriber, 17(21), 44-52. doi:10.1002/psb.437

    DOI: 10.1002/psb.437

    Undated

    Recovery from community acquired pneumonia (Thesis / Dissertation)

    Wootton, D. (n.d.). Recovery from community acquired pneumonia. (PhD Thesis, University of Liverpool).
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