Dr Daniel Wootton MBChB DTM+H MRCP (Respiratory) PhD
NIHR Advanced Fellow, Senior Clinical Lecturer and Honorary Consultant Respiratory Physician Clinical Infection, Microbiology & Immunology
- +44 (0)151 795 9667
- Work email D.G.Wootton@liverpool.ac.uk
- ORCID0000-0002-5903-3881
Publications
Selected Publications
- Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins (Journal article - 2016)
- Household Air Pollution Causes Dose-Dependent Inflammation and Altered Phagocytosis in Human Macrophages (Journal article - 2015)
- Quantification of Efferocytosis by Single-cell Fluorescence Microscopy (Media - 2018)
- The association between pre-hospital antibiotic therapy and subsequent in-hospital mortality in adults presenting with community-acquired pneumonia: an observational study (Journal article - 2018)
- A <i>Haemophilus</i> sp. dominates the microbiota of sputum from UK adults with non-severe community acquired pneumonia and chronic lung disease (Journal article - 2019)
- The challenge of antimicrobial prescribing for hospital-acquired pneumonia (Journal article - 2020)
- Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study (Journal article - 2021)
- Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study (Journal article - 2021)
- The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA (Journal article - 2020)
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2024
Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin. (Journal article)
Bucci, T., Wat, D., Nazareth, D., Sibley, S., Wootton, D., Lip, G. Y., & Frost, F. (2024). Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin.. American journal of respiratory and critical care medicine. doi:10.1164/rccm.202309-1699lePrevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis. (Journal article)
van der Feltz-Cornelis, C., Turk, F., Sweetman, J., Khunti, K., Gabbay, M., Shepherd, J., . . . Banerjee, A. (2024). Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis.. General hospital psychiatry, 88, 10-22. doi:10.1016/j.genhosppsych.2024.02.009Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. (Journal article)
RECOVERY Collaborative Group., Horby, P. W., Peto, L., Staplin, N., Campbell, M., Pessoa-Amorim, G., . . . Landray, M. J. (2024). Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.. Nature communications, 15(1), 924. doi:10.1038/s41467-023-43644-xImmunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. (Journal article)
RECOVERY Collaborative Group. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.. The Lancet. Child & adolescent health, S2352-4642(23)00316-4. doi:10.1016/s2352-4642(23)00316-4Accelarated immune ageing is associated with COVID-19 disease severity. (Journal article)
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., . . . ISARIC4C investigators. (2024). Accelarated immune ageing is associated with COVID-19 disease severity.. Immunity & ageing : I & A, 21(1), 6. doi:10.1186/s12979-023-00406-zBarriers to healthcare access: findings from a co-produced Long Covid case-finding study (Preprint)
Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort. (Journal article)
Kirwan, P. D., Hall, V. J., Foulkes, S., Otter, A. D., Munro, K., Sparkes, D., . . . Hopkins, S. (2024). Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort.. The Lancet regional health. Europe, 36, 100809. doi:10.1016/j.lanepe.2023.1008092023
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. (Journal article)
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.. Nature communications, 14(1), 8487. doi:10.1038/s41467-023-42320-4Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study (Journal article)
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L. -P., . . . Williams, N. (2023). Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology, 53(1). doi:10.1093/ije/dyad165Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation (Preprint)
Clinical trials of pneumonia management assess heterogeneous outcomes and measurement instruments. (Journal article)
Mathioudakis, A. G., Fally, M., Hansel, J., Robey, R. C., Haseeb, F., Williams, T., . . . Pneumonia Outcomes Group. (2023). Clinical trials of pneumonia management assess heterogeneous outcomes and measurement instruments.. Journal of clinical epidemiology, 164, 88-95. doi:10.1016/j.jclinepi.2023.10.011Pathways to care for Long COVID and for long-term conditions from patients' and clinicians' perspective. (Journal article)
Turk, F., Sweetman, J., Allsopp, G., Crooks, M., Cuthbertson, D. J., Gabbay, M., . . . STIMULATE-ICP Consortium. (2023). Pathways to care for Long COVID and for long-term conditions from patients' and clinicians' perspective.. Journal of evidence-based medicine, 16(4), 435-437. doi:10.1111/jebm.12563Long COVID research: an update from the PHOSP-COVID Scientific Summit. (Journal article)
Brightling, C. E., Evans, R. A., Singapuri, A., Smith, N., Wain, L. V., & PHOSP-COVID Collaborative Group. (2023). Long COVID research: an update from the PHOSP-COVID Scientific Summit.. The Lancet. Respiratory medicine, 11(11), e93-e94. doi:10.1016/s2213-2600(23)00341-7Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. (Journal article)
RECOVERY Collaborative Group. (2023). Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.. The lancet. Diabetes & endocrinology, S2213-8587(23)00253-X. doi:10.1016/s2213-8587(23)00253-x<i>Histoplasma</i> Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen. (Journal article)
Cornell, T. R., Jobe, D., Donkor, S., Wootton, D. G., Pinchbeck, G., Sutherland, J. S., & Scantlebury, C. E. (2023). <i>Histoplasma</i> Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen.. Open forum infectious diseases, 10(10), ofad510. doi:10.1093/ofid/ofad510Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study. (Journal article)
C-MORE/PHOSP-COVID Collaborative Group. (2023). Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.. The Lancet. Respiratory medicine, S2213-2600(23)00262-X. doi:10.1016/s2213-2600(23)00262-xOmicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history. (Journal article)
Hornsby, H., Nicols, A. R., Longet, S., Liu, C., Tomic, A., Angyal, A., . . . de Silva, T. I. (2023). Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history.. Nature communications, 14(1), 5065. doi:10.1038/s41467-023-40592-4Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study (Journal article)
Jackson, C., Stewart, I., Plekhanova, T., Cunningham, P. S., Hazel, A. L., Al-Sheklly, B., . . . PHOSP-COVID, S. C. G. (2023). Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. LANCET RESPIRATORY MEDICINE, 11(8), 673-684. doi:10.1016/S2213-2600(23)00124-8Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis (Journal article)
Dawson, C., Clunie, G., Evison, F., Duncan, S., Whitney, J., Houchen-Wolloff, L., . . . Wallace, S. (2023). Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis. BMJ OPEN RESPIRATORY RESEARCH, 10(1). doi:10.1136/bmjresp-2023-001647Long Covid active case finding study protocol: A co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways) (Journal article)
Alwan, N., Clutterbuck, D., Pantelic, M., Hayer, J., Fisher, L., Hishmeh, L., . . . STIMULATE-ICP, C. (2023). Long Covid active case finding study protocol: A co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways). PLOS ONE, 18(7). doi:10.1371/journal.pone.0284297SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease (Journal article)
Barnes, E., Goodyear, C. S., Willicombe, M., Gaskell, C., Siebert, S., de Silva, T. I., . . . McInnes, I. B. (2023). SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. NATURE MEDICINE, 29(7), 1760-+. doi:10.1038/s41591-023-02414-4Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease (Preprint)
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls (Journal article)
Zheng, B., Vivaldi, G., Daines, L., Leavy, O. C., Richardson, M., Elneima, O., . . . Zongo, O. (2023). Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls. The Lancet Regional Health - Europe, 29, 100635. doi:10.1016/j.lanepe.2023.100635Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial (Journal article)
Horby, P. W., Emberson, J. R., Basnyat, B., Campbell, M., Peto, L., Pessoa-Amorim, G., . . . Landray, M. J. (2023). Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 401(10387), 1499-1507. doi:10.1016/S0140-6736(23)00510-XResidual Lung Abnormalities after COVID-19 Hospitalization Interim Analysis of the UKILD Post-COVID-19 Study (Journal article)
Stewart, I., Jacob, J., George, P. M., Molyneaux, P. L., Porter, J. C., Allen, R. J., . . . Jenkins, G. R. (2023). Residual Lung Abnormalities after COVID-19 Hospitalization Interim Analysis of the UKILD Post-COVID-19 Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207(6), 693-703. doi:10.1164/rccm.202203-0564OCThe P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection. (Journal article)
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5Evolution of Long-Term Hybrid Immunity in Healthcare Workers after Different Covid-19 Vaccination Regimens: A Longitudinal Observational Cohort Study (Journal article)
Moore, S., Kronsteiner, B., Longet, S., Adele, S., Deeks, A., Liu, C., . . . Consortium, P. I. T. C. H. (2023). Evolution of Long-Term Hybrid Immunity in Healthcare Workers after Different Covid-19 Vaccination Regimens: A Longitudinal Observational Cohort Study. Med. doi:10.1016/j.medj.2023.02.004Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens (Journal article)
Moore, S. C., Kronsteiner, B., Longet, S., Adele, S., Deeks, A. S., Liu, C., . . . PITCH, C. (2023). Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens. MED, 4(3), 191-+. doi:10.1016/j.medj.2023.02.004Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (Journal article)
McAuley, H. J. C., Evans, R. A., Bolton, C. E., Brightling, C. E., Chalmers, J. D., Docherty, A. B., . . . Zongo, O. (2023). Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. eClinicalMedicine, 57, 101896. doi:10.1016/j.eclinm.2023.101896Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study. (Journal article)
Dennis, A., Cuthbertson, D. J., Wootton, D., Crooks, M., Gabbay, M., Eichert, N., . . . Banerjee, A. (2023). Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study.. Journal of the Royal Society of Medicine, 1410768231154703. doi:10.1177/01410768231154703Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study. (Journal article)
Turtle, L., Thorpe, M., Drake, T. M., Swets, M., Palmieri, C., Russell, C. D., . . . Docherty, A. B. (2023). Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.. PLoS medicine, 20(1), e1004086. doi:10.1371/journal.pmed.1004086SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (Journal article)
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Openshaw, P. J. M. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBIOMEDICINE, 87. doi:10.1016/j.ebiom.2022.1044022022
The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study (Preprint)
A COMPARISON OF WEEKEND AND WEEKDAY HOSPITAL ADMISSIONS DUE TO COMMUNITY ACQUIRED PNEUMONIA IN THE NORTH WEST OF ENGLAND: AN ANALYSIS OF THE ADVANCING QUALITY PNEUMONIA PROGRAM DATASET (Conference Paper)
Chakrabarti, B., Wickham, S., Jenks, T., Higgins, J., Pearce, B., & Wootton, D. G. (2022). A COMPARISON OF WEEKEND AND WEEKDAY HOSPITAL ADMISSIONS DUE TO COMMUNITY ACQUIRED PNEUMONIA IN THE NORTH WEST OF ENGLAND: AN ANALYSIS OF THE ADVANCING QUALITY PNEUMONIA PROGRAM DATASET. In THORAX Vol. 77 (pp. A69). doi:10.1136/thorax-2022-BTSabstracts.118STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol (Journal article)
van der Feltz-Cornelis, C. M., Sweetman, J., Allsopp, G., Attree, E., Crooks, M. G., Cuthbertson, D. J., . . . STIMULATE-ICP, C. (2022). STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol. PLOS ONE, 17(11). doi:10.1371/journal.pone.0277936Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study (Journal article)
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19. (Journal article)
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (Journal article)
Evans, R. A., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J. C., Shikotra, A., . . . Brightling, C. E. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. LANCET RESPIRATORY MEDICINE, 10(8), 761-775. doi:10.1016/S2213-2600(22)00127-8STIMULATE-ICP-CAREINEQUAL (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways) study protocol: Defining usual care and examining inequalities in Long Covid support (Journal article)
Ramasawmy, M., Mu, Y., Clutterbuck, D., Pantelic, M., Lip, G. Y. H., van der Feltz-cornelis, C., . . . Lorgelly, P. (2022). STIMULATE-ICP-CAREINEQUAL (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways) study protocol: Defining usual care and examining inequalities in Long Covid support. PLOS ONE, 17(8). doi:10.1371/journal.pone.0271978Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis (Journal article)
Horby, P. W., Emberson, J. R., Mafham, M., Campbell, M., Peto, L., Pessoa-Amorim, G., . . . Landray, M. J. (2022). Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. LANCET, 400(10349), 359-368. Retrieved from https://www.webofscience.com/Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study (Journal article)
Plekhanova, T., Rowlands, A. V., Evans, R. A., Edwardson, C. L., Bishop, N. C., Bolton, C. E., . . . Yates, T. (2022). Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study. INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY, 19(1). doi:10.1186/s12966-022-01333-wComparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naive and convalescent healthcare workers (Journal article)
Phillips, E., Adele, S., Malone, T., Deeks, A., Stafford, L., Dobson, S. L., . . . Dunachie, S. J. (2022). Comparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naive and convalescent healthcare workers. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. doi:10.1093/cei/uxac042Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (Journal article)
Narhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Docherty, A. B. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. LANCET DIGITAL HEALTH, 4(4). Retrieved from https://www.webofscience.com/Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (Journal article)
Horby, P. W., Mafham, M., Peto, L., Campbell, M., Pessoa-Amorim, G., Spata, E., . . . Landray, M. J. (2022). Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 399(10325), 665-676. Retrieved from https://www.webofscience.com/Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a prospective, multicentre study (Preprint)
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. (Journal article)
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (Journal article)
Horby, P. W., Pessoa-Amorim, G., Staplin, N., Emberson, J. R., Campbell, M., Spata, E., . . . Landray, M. J. (2022). Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 399(10320), 143-151. doi:10.1016/S0140-6736(21)01825-0T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study (Journal article)
Angyal, A., Longet, S., Moore, S. C., Payne, R. P., Harding, A., Tipton, T., . . . de, S. T. I. (2022). T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study. LANCET MICROBE, 3(1), E21-E31. doi:10.1016/S2666-5247(21)00275-52021
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells (Journal article)
de, S. T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. ISCIENCE, 24(11). doi:10.1016/j.isci.2021.103353Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine (Journal article)
Payne, R. P., Longet, S., Austin, J. A., Skelly, D. T., Dejnirattisai, W., Adele, S., . . . Dunachie, S. (2021). Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. CELL, 184(23), 5699-+. doi:10.1016/j.cell.2021.10.011Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study (Journal article)
Evans, R. A., McAuley, H., Harrison, E. M., Shikotra, A., Singapuri, A., Sereno, M., . . . Brightling, C. E. (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. LANCET RESPIRATORY MEDICINE, 9(11), 1275-1287. doi:10.1016/S2213-2600(21)00383-0A prenylated dsRNA sensor protects against severe COVID-19 (Journal article)
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. SCIENCE, 374(6567). doi:10.1126/science.abj3624Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study (Journal article)
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ OPEN, 11(10). doi:10.1136/bmjopen-2021-055435Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID) (Journal article)
Wild, J. M., Porter, J. C., Molyneaux, P. L., George, P. M., Stewart, I., Allen, R. J., . . . Jenkins, R. G. (2021). Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID). BMJ Open Respiratory Research, 8(1), e001049. doi:10.1136/bmjresp-2021-001049Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study (Journal article)
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Ho, A. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. LANCET MICROBE, 2(8), E354-E365. doi:10.1016/S2666-5247(21)00090-2Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study (Journal article)
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Semple, M. G. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. LANCET, 398(10296), 223-237. Retrieved from https://www.webofscience.com/Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial (Journal article)
Horby, P. W., Landray, M. J., & Grp, R. E. C. O. V. E. R. Y. C. (2021). Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. LANCET, 397(10289), 2049-2059. doi:10.1016/S0140-6736(21)00897-7Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (Journal article)
Horby, P. W., & Landray, M. J. (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 397(10285), 1637-1645. Retrieved from https://www.webofscience.com/Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study (Journal article)
Dennis, A., Wamil, M., Alberts, J., Oben, J., Cuthbertson, D. J., Wootton, D., . . . Investigators, C. O. V. E. R. S. C. A. N. S. (2021). Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study. BMJ Open, 11(3). doi:10.1136/bmjopen-2020-048391A rapid assessment of wastewater for genomic surveillance of SARS-CoV-2 variants at sewershed scale in Louisville, KY. (Preprint)
Dexamethasone in Hospitalized Patients with Covid-19 (Journal article)
Wootton, D., & The RECOVERY Collaborative Group. (2021). Dexamethasone in Hospitalized Patients with Covid-19. New England Journal of Medicine, 384(8), 693-704. doi:10.1056/nejmoa2021436Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (Journal article)
Horby, P. W., Roddick, A., Spata, E., Staplin, N., Emberson, J., Pessoa-Amorim, G., . . . Yates, H. (2021). Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. LANCET, 397(10274), 605-612. doi:10.1016/S0140-6736(21)00149-5PREDICTORS OF AND TIME FRAME FOR READMISSION FOLLOWING HOSPITALISATION WITH COMMUNITY ACQUIRED PNEUMONIA (Conference Paper)
Chakrabarti, B., Lane, S., Jenks, T., Higgins, J., Kanwar, E., Allen, M., & Wootton, D. G. (2021). PREDICTORS OF AND TIME FRAME FOR READMISSION FOLLOWING HOSPITALISATION WITH COMMUNITY ACQUIRED PNEUMONIA. In THORAX Vol. 76 (pp. A61-A62). doi:10.1136/thorax-2020-BTSabstracts.106THE UTILITY OF ESTABLISHED PROGNOSTIC SCORES IN COVID-19 HOSPITAL ADMISSIONS: A COLLABORATIVE TRAINEE-LED, MULTI-CENTRE PROSPECTIVE EVALUATION OF CURB-65, NEWS2, AND QSOFA (Conference Paper)
Frost, F., Bradley, P., Tharmaratnam, K., & Wootton, D. (2021). THE UTILITY OF ESTABLISHED PROGNOSTIC SCORES IN COVID-19 HOSPITAL ADMISSIONS: A COLLABORATIVE TRAINEE-LED, MULTI-CENTRE PROSPECTIVE EVALUATION OF CURB-65, NEWS2, AND QSOFA. In THORAX Vol. 76 (pp. A57-A58). doi:10.1136/thorax-2020-BTSabstracts.1002020
The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA (Journal article)
Bradley, P., Frost, F., Tharmaratnam, K., & Wootton, D. G. (2020). The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA. BMJ Open Respiratory Research, 7(1). doi:10.1101/2020.07.15.20154815Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA (Journal article)
Bradley, P., Frost, F., Tharmaratnam, K., & Wootton, D. G. (2020). Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA. BMJ OPEN RESPIRATORY RESEARCH, 7(1). doi:10.1136/bmjresp-2020-000729Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 (Journal article)
Horby, P., Mafham, M., Linsell, L., Bell, J. L., Staplin, N., Emberson, J. R., . . . Landray, M. J. (2020). Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19. NEW ENGLAND JOURNAL OF MEDICINE, 383(21), 2030-2040. doi:10.1056/NEJMoa2022926The challenge of antimicrobial prescribing for hospital-acquired pneumonia (Journal article)
Wootton, D., Aston, S., & Felton, T. (2020). The challenge of antimicrobial prescribing for hospital-acquired pneumonia. Journal of Hospital Infection, 104(2), 198-199. doi:10.1016/j.jhin.2019.11.002Antimicrobial prescribing for hospital-acquired pneumonia. (Journal article)
Felton, T., & Wootton, D. (2020). Antimicrobial prescribing for hospital-acquired pneumonia.. British journal of hospital medicine (London, England : 2005), 81(1), 1-3. doi:10.12968/hmed.2019.03252019
PREDICTORS OF 30 DAY READMISSION FOLLOWING HOSPITALIZATION WITH COMMUNITY ACQUIRED PNEUMONIA (Conference Paper)
Chakrabarti, B., Jenks, T., Lane, S., Higgins, J., Kanwar, E., & Wootton, D. G. (2019). PREDICTORS OF 30 DAY READMISSION FOLLOWING HOSPITALIZATION WITH COMMUNITY ACQUIRED PNEUMONIA. In THORAX Vol. 74 (pp. A68). doi:10.1136/thorax-2019-BTSabstracts2019.113Community-acquired pneumonia due to drug-resistant Enterobacteriaceae: A global perspective (Journal article)
Aston, S. J., & Wootton, D. G. (2019). Community-acquired pneumonia due to drug-resistant Enterobacteriaceae: A global perspective. Respirology. doi:10.1111/resp.13720A <i>Haemophilus</i> sp. dominates the microbiota of sputum from UK adults with non-severe community acquired pneumonia and chronic lung disease (Journal article)
Wootton, D. G., Cox, M. J., Gloor, G. B., Litt, D., Hoschler, K., German, E., . . . Gordon, S. B. (2019). A <i>Haemophilus</i> sp. dominates the microbiota of sputum from UK adults with non-severe community acquired pneumonia and chronic lung disease. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-018-38090-52018
Quantification of Efferocytosis by Single-cell Fluorescence Microscopy (Media)
Taruc, K., Yin, C., Wootton, D. G., & Heit, B. (2018). Quantification of Efferocytosis by Single-cell Fluorescence Microscopy. doi:10.3791/58149The association between pre-hospital antibiotic therapy and subsequent in-hospital mortality in adults presenting with community-acquired pneumonia: an observational study (Journal article)
Chakrabarti, B., Wootton, D. G., Lane, S., Kanwar, E., Somers, J., Proctor, J., . . . Woodhead, M. (2018). The association between pre-hospital antibiotic therapy and subsequent in-hospital mortality in adults presenting with community-acquired pneumonia: an observational study. Pneumonia, 10. doi:10.1186/s41479-018-0047-42017
A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days (Journal article)
Wootton, D. G., Dickinson, L., Pertinez, H., Court, J., Eneje, O., Keogan, L., . . . Diggle, P. J. (2017). A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days. European Respiratory Journal, 49(6). doi:10.1183/13993003.02170-20162016
Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins (Journal article)
Wootton, D. G., Diggle, P. J., Court, J., Eneje, O., Keogan, L., Macfarlane, L., . . . Gordon, S. B. (2016). Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins. Thorax, 71(11), 1052-1054. doi:10.1136/thoraxjnl-2016-208505P214 Arrhythmias in pneumonia: a review of incidence, outcomes and management (vol 70, pg A184, 2015) (Presentation material)
Cox, D. R., Wootton, D. G., & Blakey, J. (2016). P214 Arrhythmias in pneumonia: a review of incidence, outcomes and management (vol 70, pg A184, 2015). doi:10.1136/thoraxjnl-2015-207770.350corr12015
The Genus Haemophilus Was Dominant In A Cohort With Community Acquired Pneumonia And Low Species Diversity Was Related To Age And Prior Pulmonary Disease (Conference Paper)
Wootton, D. G., Cox, M. J., Hickey, G. L., Eneje, O., Court, J., Macfarlane, L., . . . Gordon, S. B. (2015). The Genus Haemophilus Was Dominant In A Cohort With Community Acquired Pneumonia And Low Species Diversity Was Related To Age And Prior Pulmonary Disease. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 191. Retrieved from https://www.webofscience.com/Household Air Pollution Causes Dose-Dependent Inflammation and Altered Phagocytosis in Human Macrophages (Journal article)
Rylance, J., Fullerton, D. G., Scriven, J., Aljurayyan, A. N., Mzinza, D., Barrett, S., . . . Gordon, S. B. (2015). Household Air Pollution Causes Dose-Dependent Inflammation and Altered Phagocytosis in Human Macrophages. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 52(5), 584-593. doi:10.1165/rcmb.2014-0188OCBlinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation (Journal article)
Lim, W. S., Brittain, C., Duley, L., Edwards, S., Gordon, S., Montgomery, A., . . . Wootton, D. (2015). Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial 'in hibernation', ready for rapid activation. HEALTH TECHNOLOGY ASSESSMENT, 19(16), 1-+. doi:10.3310/hta191602014
Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield (Journal article)
Collins, A. M., Rylance, J., Wootton, D. G., Wright, A. D., Wright, A. K. A., Fullerton, D. G., & Gordon, S. B. (2014). Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (85). doi:10.3791/4345Feasibility study for early supported discharge in adults with respiratory infection in the UK (Journal article)
Collins, A. M., Eneje, O. J., Hancock, C. A., Wootton, D. G., & Gordon, S. B. (2014). Feasibility study for early supported discharge in adults with respiratory infection in the UK. BMC PULMONARY MEDICINE, 14. doi:10.1186/1471-2466-14-25The diagnosis of pneumonia requires a chest radiograph (x-ray)-yes, no or sometimes? (Journal article)
Wootton, D., & Feldman, C. (2014). The diagnosis of pneumonia requires a chest radiograph (x-ray)-yes, no or sometimes?. Pneumonia (Nathan Qld.), 5(Suppl 1), 1-7. doi:10.15172/pneu.2014.5/464The pathophysiology of pneumococcal pneumonia (Chapter)
Wootton, D. G., Aston, S. J., & Gordon, S. B. (2014). The pathophysiology of pneumococcal pneumonia. In COMMUNITY-ACQUIRED PNEUMONIA (pp. 42-63). doi:10.1183/1025448x.100033132012
Pneumococcal Specific Lung T Cells Produce Interleukin-17 That Can Increase Uptake Of Pneumococci By Human Alveolar Macrophages (Conference Paper)
Wright, A., Bangert, M., Ferreira, D. M., Collins, A., Wootton, D. G., Wright, A. D., & Gordon, S. B. (2012). Pneumococcal Specific Lung T Cells Produce Interleukin-17 That Can Increase Uptake Of Pneumococci By Human Alveolar Macrophages. In A21. FIRST RESPONDERS: MUCOSAL INNATE IMMUNITY. American Thoracic Society. doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1076DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1076