Professor Cheng-Hock Toh MBChB, MD, FRCP, FRCPath
Professor(Clin,Hcc) Clinical Infection, Microbiology & Immunology
- +44 (0)151 706 4324 / +44 (0)151 795 9637 / +44 (0)151 795 9637 Ext. 59637
- Work email C.H.Toh@liverpool.ac.uk
Research
Research Interest 1
My research focus is on "Vascular and Haemostatic Dysfunction". The work encompasses molecular and biological scientific approaches to clinical diagnostic applications. In particular, we are interested in the mechanisms that link coagulation, inflammation and lipid metabolism. The disease areas of relevance are sepsis, disseminated intravascular coagulation and atherosclerosis.
Research Grants
Variability in response to warfarin: a prospective analysis of pharmacogenetic and environmental factors.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2004 - October 2009
Flexibility and Sustainability Funding for Dominic Banks
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
April 2011 - October 2011
Effects of activated protein C on complement activation in severe sepsis.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
April 2004 - September 2009
The role of microparticle-associated endothelial protein C receptor in disseminating activated protein C function.
WELLCOME TRUST (UK)
April 2006 - September 2009
Coagulant and inflammatory modulation by activated protein C-induced microparticle-associated endothelial protein C receptor.
BRITISH JOURNAL OF HAEMATOLOGY RESEARCH TRUST (UK)
September 2005 - August 2009
Ishtar Adnan Mohammed Alethari - Bench Fees
REPUBLIC OF IRAQ MINISTRY OF EDUCATION🚩
October 2014 - September 2017
The Role of Circulating Histones in the Cardiac Dysfunction of Sepsis.
BRITISH HEART FOUNDATION (UK)
September 2014 - August 2016
DISTINCTIVE - Diagnostic comparison of procalcitonin and the aPTT biphasic waveform in children with bacterial sepsis on the intensive care unit
ALDER HEY IMAGINE APPEAL (UK), DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2010 - August 2014
Developing a rapid, robust and comprehensive assay for histones and chromatin breakdown products via xMAP technology
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
March 2011 - September 2012
A prospective Study of the aPTT Waveform and Lipoprotein-Complexed C Reactive Protein Assays in the Early Diagnosis and Prognosis of Sepsis
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2007 - March 2009
The role of extracellular histones in the pathogenesis of haemophilic arthropathy.
PFIZER INC (USA)
November 2013 - October 2017
The regulation of pro-coagulant and pro-inflammatory properties of monocytes by microparticle-associated endothelial protein c receptor.
BRITISH HEART FOUNDATION (UK)
January 2008 - December 2009
The dynamic changes pf cytoskeleton of endothelial cells upon thrombin treatment
WELLCOME TRUST (UK)
June 2009 - August 2009
British Society for Haematology
BRITISH SOCIETY FOR HAEMATOLOGY (UK)
January 2014 - December 2014
A prospective study of the aPTT waveform and lipoprotein-complexed C reactive protein assays in the early diagnosis and prognosis of sepsis
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
July 2011 - December 2012
A pharmacogenomic approach to coumarin anticoagulant therapy (PACT)
EUROPEAN COMMISSION
October 2008 - March 2013
The Impact of continuous haemofiltration with high volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function- A pilot study
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
July 2010 - March 2012
Chronic lymphoproliferative disorders : The control of the migration, tissue localisation and survival of malignant B cells.
LEUKAEMIA RESEARCH FUND
January 2001 - December 2002
A Point-of-Care Test for Sepsis based on Calcium-induced Turbidity in Blood
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
February 2010 - September 2013
A Point-of-Care Test for Sepsis based on Calcium-induced Turbidity in Blood
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2011 - June 2014
Forging patient-related translational research between the University and NHS Trust (PhD Studentship).
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
September 2014 - December 2024
Bridging and accelerating the translation of novel scientific findings for health and wealth gain
MEDICAL RESEARCH COUNCIL
March 2014 - August 2015
The role of very low density lipoprotein in sepsis.
MEDICAL RESEARCH COUNCIL
May 2005 - May 2007
Development of a rapid salivary test to detect serious bacterial infection in children presenting to the accident and emergency department. SPICED.
DEPARTMENT OF HEALTH & SOCIAL CARE (UK)
September 2010 - May 2012
Endothelial Cell Protein C Receptor (EPCR) : A New Therapeutic and Diagnostic Target in the Inflammation-Thrombosis Link of Arterial Disease.
NATIONAL HEART RESEARCH FUND (UK)
July 2000 - June 2002
Bench fees to support PhD student
THE HIGHER COMMITTEE FOR EDUCATION DEVELOPMENT IN IRAQ (HCED) (IRAQ)
February 2014 - January 2015
Activated protein C on in vitro and in vivo cellular microparticles.
MEDICAL RESEARCH COUNCIL
July 2006 - July 2009
A complex of C-Reactive Protein (CPR) and very low density lipoprotein (VLDL): characterisation of a diagnostic marker linking systemic inflamation, lipid metabolism and coagulation pathways in the critically ill.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
April 2001 - March 2002
Toxic nuclear breakdown products and cardiomyocyte function.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
May 2013 - December 2023