Professor Cheng-Hock Toh MBChB, MD, FRCP, FRCPath
Professor(Clin,Hcc) Clinical Infection, Microbiology & Immunology
- +44 (0)151 706 4324 / +44 (0)151 795 9637 / +44 (0)151 795 9637 Ext. 59637
- Work email C.H.Toh@liverpool.ac.uk
Publications
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2024
Shades of Grey-The brain in TTP. (Journal article)
Dutt, T., & Toh, C. -H. (2024). Shades of Grey-The brain in TTP.. British journal of haematology, 204(3), 757-758. doi:10.1111/bjh.19293Trauma-induced innate immune activation and disseminated intravascular coagulation. (Journal article)
Gando, S., Levi, M., & Toh, C. -H. (2024). Trauma-induced innate immune activation and disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 22(2), 337-351. doi:10.1016/j.jtha.2023.09.0282023
Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation. (Journal article)
Yong, J., & Toh, C. -H. (2023). Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation.. Blood, 142(25), 2133-2145. doi:10.1182/blood.2023021166Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia. (Journal article)
Abrams, S. T., Du, M., Shaw, R. J., Johnson, C., McGuinness, D., Schofield, J., . . . Toh, C. -H. (2023). Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00873-5. doi:10.1016/j.jtha.2023.12.008Are NETs a Novel, Exciting, Thrombosis Risk Marker? (Journal article)
Wang, G., Abrams, S. T., & Toh, C. -H. (2023). Are NETs a Novel, Exciting, Thrombosis Risk Marker?. Thrombosis and haemostasis. doi:10.1055/a-2187-0645How can we ensure that the right patient gets the right blood at the right time? (Journal article)
Toh, C. -H. (2023). How can we ensure that the right patient gets the right blood at the right time?. BMJ (Clinical research ed.), 383, 2446. doi:10.1136/bmj.p2446OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia (Journal article)
Schofield, J., Abrams, S., Alhamdi, Y., Ainsworth, S., Evans, C., Albulescu, L., . . . Toh, C. (2023). OC 78.5 Systemic Snakebite Envenoming Causes Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 100487. doi:10.1016/j.rpth.2023.100487PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia (Journal article)
Yong, J., Abrams, S., Alhamdi, Y., Wang, G., & Toh, C. (2023). PB0794 Fibrinogen Protects against Histone-Induced Thrombocytopaenia. Research and Practice in Thrombosis and Haemostasis, 7, 101370. doi:10.1016/j.rpth.2023.101370Delivering trials in the NHS: more than worth it. (Journal article)
Haynes, R., Mafham, M., Toh, C. H., & Landray, M. J. (2023). Delivering trials in the NHS: more than worth it.. Clinical medicine (London, England), 23(5), 525-526. doi:10.7861/clinmed.2023-0296How to approach acute thrombosis and thrombocytopenia (Journal article)
Schofield, J., & Toh, C. -H. (2023). How to approach acute thrombosis and thrombocytopenia. CLINICAL MEDICINE, 23(3), 234-241. doi:10.7861/clinmed2023-0076Cell-free histones and the cell-based model of coagulation. (Journal article)
Yong, J., Abrams, S. T., Wang, G., & Toh, C. -H. (2023). Cell-free histones and the cell-based model of coagulation.. Journal of thrombosis and haemostasis : JTH, S1538-7836(23)00340-9. doi:10.1016/j.jtha.2023.04.018A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Journal article)
Jorgensen, A. L., Orrell, C., Waitt, C., Toh, C. -H., Sekaggya-Wiltshire, C., Hughes, D. A., . . . Pirmohamed, M. (2023). A "Bundle of Care" to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study. JMIR RESEARCH PROTOCOLS, 12. doi:10.2196/46710A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study (Preprint) (Preprint)
Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis (Journal article)
Abrams, S. T. T., Alhamdi, Y., Zi, M., Guo, F., Du, M., Wang, G., . . . Toh, C. -H. (2023). Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4). doi:10.3390/ijms2404322536-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE. (Journal article)
Turpie, A. G. G., Farjat, A. E., Haas, S., Ageno, W., Weitz, J. I., Goldhaber, S. Z., . . . GARFIELD-VTE investigators. (2023). 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE.. Thrombosis research, 222, 31-39. doi:10.1016/j.thromres.2022.11.016Alan Randolph Giles, MD (1940-2022): dogged pioneer and esteemed hematologist (Journal article)
Senis, Y. A., Toh, C. -H., & Lillicrap, D. (2023). Alan Randolph Giles, MD (1940-2022): dogged pioneer and esteemed hematologist. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 21(2), 397-399. doi:10.1016/j.jtha.2022.10.026Tranexamic acid for safer surgery: does the evidence support preventative use? Response to <i>Br J Anaesth</i> 2023; 130: e23-e24 (Journal article)
Grocott, M. P. W., Murphy, M., Roberts, I., Sayers, R., & Toh, C. -H. (2023). Tranexamic acid for safer surgery: does the evidence support preventative use? Response to <i>Br J Anaesth</i> 2023; 130: e23-e24. BRITISH JOURNAL OF ANAESTHESIA, 130(2), E195-E196. doi:10.1016/j.bja.2022.11.0102022
The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction (Journal article)
Abrams, S. T. T., Wang, L., Yong, J., Yu, Q., Du, M., Alhamdi, Y., . . . Wang, G. (2022). The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction. BIOMEDICINES, 10(12). doi:10.3390/biomedicines10123256Tranexamic acid for safer surgery: the time is now (Journal article)
Grocott, M. P. W., Murphy, M., Roberts, I., Sayers, R., & Toh, C. -H. (2022). Tranexamic acid for safer surgery: the time is now. BRITISH JOURNAL OF ANAESTHESIA, 129(4), 459-461. doi:10.1016/j.bja.2022.06.024Tranexamic acid for safer surgery: the time is now (Journal article)
Grocott, M. P. W., Murphy, M., Roberts, I., Sayers, R., & Toh, C. -H. (2022). Tranexamic acid for safer surgery: the time is now. BRITISH JOURNAL OF SURGERY, 109(12), 1182-1183. doi:10.1093/bjs/znac252HaemSTAR-Growing Experience From a National, Trainee-led Research Network (Journal article)
Wilson, L., Doyle, A. J., Millen, E., Bull, T., Biss, T., Hart, D., . . . Nicolson, P. L. R. (2022). HaemSTAR-Growing Experience From a National, Trainee-led Research Network. HEMASPHERE, 6(9). doi:10.1097/HS9.0000000000000766GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements. (Journal article)
Dixon, P. H., Levine, A. P., Cebola, I., Chan, M. M. Y., Amin, A. S., Aich, A., . . . Williamson, C. (2022). GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements.. Nature communications, 13(1), 4840. doi:10.1038/s41467-022-29931-zThe Health and Care Act 2022: challenges and priorities for embedding research in the NHS (Journal article)
Toh, C. H., & Haynes, R. (2022). The Health and Care Act 2022: challenges and priorities for embedding research in the NHS. LANCET, 400(10349), 343-345. doi:10.1016/S0140-6736(22)01195-3The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia (Journal article)
Toh, C. -H., Wang, G., & Parker, A. L. (2022). The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia. CLINICAL MEDICINE, 22(2), 140-144. doi:10.7861/clinmed.2022-0006Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding. (Journal article)
Stapley, R. J., Poulter, N. S., Khan, A. O., Smith, C. W., Bignell, P., Fratter, C., . . . UK GAPP Study Group. (2022). Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding.. Journal of thrombosis and haemostasis : JTH, 20(2), 478-485. doi:10.1111/jth.15584Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis (Journal article)
Alsabani, M., Abrams, S. T., Cheng, Z., Morton, B., Lane, S., Alosaimi, S., . . . Toh, C. -H. (2022). Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis. British Journal of Anaesthesia, 128(2), 283-293. doi:10.1016/j.bja.2021.10.039A single 1 g/kg dose of intravenous immunoglobulin is a safe and effective treatment for immune thrombocytopenia; results of the first HaemSTAR 'Flash-Mob' retrospective study incorporating 961 patients (Journal article)
Nicolson, P. L. R., Perry, R., Buka, R. J., Fisher, A., Scott, G., Magill, L., . . . Hill, Q. A. (2022). A single 1 g/kg dose of intravenous immunoglobulin is a safe and effective treatment for immune thrombocytopenia; results of the first HaemSTAR 'Flash-Mob' retrospective study incorporating 961 patients. BRITISH JOURNAL OF HAEMATOLOGY, 196(2), 433-437. doi:10.1111/bjh.176922021
Transfusion 2024: A 5-year plan for clinical and laboratory transfusion in England (Journal article)
Allard, S., Cort, J., Howell, C., Sherliker, L., Miflin, G., & Toh, C. H. (2021). Transfusion 2024: A 5-year plan for clinical and laboratory transfusion in England. TRANSFUSION MEDICINE, 31(6), 400-408. doi:10.1111/tme.12827The art and science of the thrombosis with thrombocytopenia syndrome (Journal article)
Toh, C. -H. (2021). The art and science of the thrombosis with thrombocytopenia syndrome. CLINICAL MEDICINE, 21(6), E603. doi:10.7861/clinmed.2021-0525Circulating histones play a central role in COVID-19-associated coagulopathy and mortality (Journal article)
Shaw, R. J., Abrams, S. T., Austin, J., Taylor, J. M., Lane, S., Dutt, T., . . . Toh, C. -H. (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. HAEMATOLOGICA, 106(9), 2493-2498. doi:10.3324/haematol.2021.278492COVID-19 and immunothrombosis: emerging understanding and clinical management (Journal article)
Shaw, R. J., Bradbury, C., Abrams, S. T., Wang, G., & Toh, C. -H. (2021). COVID-19 and immunothrombosis: emerging understanding and clinical management. BRITISH JOURNAL OF HAEMATOLOGY, 194(3), 518-529. doi:10.1111/bjh.17664Intracranial hemorrhage in immune thrombotic thrombocytopenic purpura treated with caplacizumab (Journal article)
Schofield, J., Shaw, R. J., Lester, W., Thomas, W., Toh, C. -H., & Dutt, T. (2021). Intracranial hemorrhage in immune thrombotic thrombocytopenic purpura treated with caplacizumab. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 19(8), 1922-1925. doi:10.1111/jth.15363Research 2021: never the same again. (Journal article)
Toh, C. -H., & Stewart, P. (2021). Research 2021: never the same again.. Future healthcare journal, 8(2), e187. doi:10.7861/fhj.ed.8.2.2Real-world experience with caplacizumab in the management of acute TTP (Journal article)
Dutt, T., Shaw, R. J., Stubbs, M., Yong, J., Bailiff, B., Cranfield, T., . . . Scully, M. (2021). Real-world experience with caplacizumab in the management of acute TTP. BLOOD, 137(13), 1731-1740. doi:10.1182/blood.2020007599ADAMTS13 activity trends in TTP patients with COVID-19 infection (Conference Paper)
Shaw, R. J., Kenworthy, J., Lawrenson, A., Toh, C. -H., & Dutt, T. (2021). ADAMTS13 activity trends in TTP patients with COVID-19 infection. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 193 (pp. 211). Retrieved from https://www.webofscience.com/OPTIMISATION OF ORAL ANTICOAGULATION FOR STROKE PREVENTION: A SCOPING REVIEW OF FACTORS INFLUENCING UPTAKE AND IMPLEMENTATION IN EFFECTIVENESS STUDIES (Conference Paper)
Gibson, J., Weldon, J., Banerjee, A., Chauhan, U., Georgiou, R., Joshi, M., . . . Watkins, C. (2021). OPTIMISATION OF ORAL ANTICOAGULATION FOR STROKE PREVENTION: A SCOPING REVIEW OF FACTORS INFLUENCING UPTAKE AND IMPLEMENTATION IN EFFECTIVENESS STUDIES. In INTERNATIONAL JOURNAL OF STROKE Vol. 16 (pp. 37). Retrieved from https://www.webofscience.com/2020
Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway (Journal article)
Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation (Conference Paper)
Shaw, R. J., Austin, J., Taylor, J., Dutt, T., Wang, G., Abrams, S. T., & Toh, C. H. (2020). Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation. In BLOOD Vol. 136. doi:10.1182/blood-2020-142344Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway (Preprint)
The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development (Journal article)
Cheng, Z., Abrams, S. T., Austin, J., Toh, J., Wang, S. S., Wang, Z., . . . Wang, G. (2020). The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development. MEDIATORS OF INFLAMMATION, 2020. doi:10.1155/2020/7418342The Critical Roles and Mechanisms of Immune Cell Death in Sepsis (Journal article)
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Wang, Z., Yu, Q., . . . Wang, G. (2020). The Critical Roles and Mechanisms of Immune Cell Death in Sepsis. FRONTIERS IN IMMUNOLOGY, 11. doi:10.3389/fimmu.2020.01918Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort. (Journal article)
Thaventhiran, J. E. D., Lango Allen, H., Burren, O. S., Rae, W., Greene, D., Staples, E., . . . Smith, K. G. C. (2020). Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.. Nature, 584(7819), E2. doi:10.1038/s41586-020-2556-6Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE. (Journal article)
Weitz, J. I., Haas, S., Ageno, W., Goldhaber, S. Z., Turpie, A. G. G., Goto, S., . . . GARFIELD-VTE investigators. (2020). Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE.. Journal of thrombosis and thrombolysis, 50(2), 267-277. doi:10.1007/s11239-020-02180-xAssembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation (Journal article)
Abrams, S. T., Su, D., Sahraoui, Y., Lin, Z., Cheng, Z., Nesbitt, K., . . . Toh, C. -H. (2021). Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation. BLOOD, 137(1), 103-114. doi:10.1182/blood.2019002973Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria (Journal article)
Moxon, C. A., Alhamdi, Y., Storm, J., Toh, J. M. H., McGuinness, D., Ko, J. Y., . . . Toh, C. (n.d.). Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), 2851-2864. doi:10.1182/bloodadvances.2019001258Whole-genome sequencing of a sporadic primary immunodeficiency cohort (Journal article)
Thaventhiran, J. E. D., Allen, H. L., Burren, O. S., Rae, W., Greene, D., Staples, E., . . . Smith, K. G. C. (2020). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. NATURE, 583(7814), 90-+. doi:10.1038/s41586-020-2265-1Whole-genome sequencing of patients with rare diseases in a national health system (Journal article)
Turro, E., Astle, W. J., Megy, K., Graef, S., Greene, D., Shamardina, O., . . . Ouwehand, W. H. (2020). Whole-genome sequencing of patients with rare diseases in a national health system. NATURE, 583(7814), 96-+. doi:10.1038/s41586-020-2434-2Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis (Journal article)
Cheng, Z., Abrams, S. T., Toh, J., Wang, S. S., Downey, C., Ge, X., . . . Toh, C. -H. (2020). Complexes between C-Reactive Protein and Very Low Density Lipoprotein Delay Bacterial Clearance in Sepsis. Journal of Immunology, 204(10), 2712-2721. doi:10.4049/jimmunol.1900962Parasite histones mediate blood-brain barrier disruption in cerebral malaria. (Journal article)
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2020). Parasite histones mediate blood-brain barrier disruption in cerebral malaria.. Clinical medicine (London, England), 20(Suppl 2), s96-s97. doi:10.7861/clinmed.20-2-s96Blood works (Journal article)
Toh, C. -H., & Amberley, K. (2020). Blood works. BRITISH JOURNAL OF HAEMATOLOGY, 189(3), 391-392. doi:10.1111/bjh.16650A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit. (Journal article)
Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.. Clinical medicine (London, England), 20(Suppl 2), s114-s115. doi:10.7861/clinmed.20-2-s114A cross-sectional evaluation of five warfarin anticoagulation services in Uganda and South Africa (Journal article)
Semakula, J. R., Mouton, J. P., Jorgensen, A., Hutchinson, C., Allie, S., Semakula, L., . . . Cohen, K. (2020). A cross-sectional evaluation of five warfarin anticoagulation services in Uganda and South Africa. PLOS ONE, 15(1). doi:10.1371/journal.pone.0227458A novel assay of neutrophil extracellular traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies (Conference Paper)
Abrams, S., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2020). A novel assay of neutrophil extracellular traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 189 (pp. 42). Retrieved from https://www.webofscience.com/Patients with acute thrombotic thrombocytopenic purpura (TTP) should be managed in a critical care setting - A Single TTP Referral Centre Experience (Conference Paper)
Shaw, R. J., Garth, L., Toh, C. -H., & Dutt, T. (2020). Patients with acute thrombotic thrombocytopenic purpura (TTP) should be managed in a critical care setting - A Single TTP Referral Centre Experience. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 189 (pp. 268). Retrieved from https://www.webofscience.com/2019
Enabling an equitable spread of research access, involvement, and funding in the UK (Journal article)
Toh, C. -H. (2019). Enabling an equitable spread of research access, involvement, and funding in the UK. LANCET, 394(10214), 2048-2050. Retrieved from https://www.webofscience.com/A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies (Conference Paper)
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. doi:10.1182/blood-2019-128493A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies (Conference Paper)
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Cheng, Z., Lane, S., . . . Toh, C. -H. (2019). A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies. In BLOOD Vol. 134. Retrieved from https://www.webofscience.com/A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients (Journal article)
Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M., Lane, S., Welters, I. D., . . . Toh, C. -H. (2019). A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients. American journal of respiratory and critical care medicine, 200(07), 869-880. doi:10.1164/rccm.201811-2111ocThe European Hematology Exam: The Next Step toward the Harmonization of Hematology Training in Europe (Journal article)
Navarro, J. -T., Birgegard, G., Strivens, J., Hollegien, W. W. G., van Hattem, N., Saris, M. T., . . . Almeida, A. M. (2019). The European Hematology Exam: The Next Step toward the Harmonization of Hematology Training in Europe. HEMASPHERE, 3(5). doi:10.1097/HS9.0000000000000291Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses. (Journal article)
Cheng, Z., Abrams, S. T., Alhamdi, Y., Toh, J., Yu, W., Wang, G., & Toh, C. -H. (2019). Circulating Histones Are Major Mediators of Multiple Organ Dysfunction Syndrome in Acute Critical Illnesses.. Critical care medicine, 47(8), e677-e684. doi:10.1097/ccm.0000000000003839Disseminated intravascular coagulation - what can we do? (Journal article)
Toh, C. -H., Toh, J. M. H., & Abrams, S. T. (2019). Disseminated intravascular coagulation - what can we do?. HEMASPHERE, 3, 92-94. doi:10.1097/HS9.0000000000000232Germline selection shapes human mitochondrial DNA diversity (Journal article)
Wei, W., Tuna, S., Keogh, M. J., Smith, K. R., Aitman, T. J., Beales, P. L., . . . Chinnery, P. F. (2019). Germline selection shapes human mitochondrial DNA diversity. SCIENCE, 364(6442), 749-+. doi:10.1126/science.aau6520Sepsis-associated coagulopathy and the association of platelet count with mortality (Conference Paper)
Welters, I. D. M., Waite, A., Alhamdi, Y., Abrams, S., Toh, C., Iqbal, R., & Venugopal, N. (2019). Sepsis-associated coagulopathy and the association of platelet count with mortality. In Critical Care Vol. 23, Suppl 2 (pp. 146). Brussels: Springer Nature.Developing today's trainees to become tomorrow's clinical researchers - an innovative collaboration driving improvements in clinical training and research delivery. (Journal article)
Loizou, E., Karpha, I., Toh, C. -H., & Dutt, T. (2019). Developing today's trainees to become tomorrow's clinical researchers - an innovative collaboration driving improvements in clinical training and research delivery.. Future healthcare journal, 6(Suppl 1), 112. doi:10.7861/futurehosp.6-1-s112Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis (Journal article)
Rhodes, C. J., Batai, K., Bleda, M., Haimel, M., Southgate, L., Germain, M., . . . Winslow, C. (2019). Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. LANCET RESPIRATORY MEDICINE, 7(3), 227-238. doi:10.1016/S2213-2600(18)30409-0Parasite histones mediate leak and coagulopathy in cerebral malaria (Preprint)
Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry (Journal article)
Ageno, W., Haas, S., Weitz, J. I., Goldhaber, S. Z., Turpie, A. G. G., Goto, S., . . . Yang, Z. (2019). Characteristics and Management of Patients with Venous Thromboembolism: The GARFIELD-VTE Registry. THROMBOSIS AND HAEMOSTASIS, 119(2), 319-327. doi:10.1055/s-0038-1676611A HaemSTAR is born; a trainee-led, UK-wide research network in haematology (Journal article)
Nicolson, P. L. R., Desborough, M. J. R., Hart, D., Biss, T. T., Lowe, G. C., & Toh, C. -H. (2019). A HaemSTAR is born; a trainee-led, UK-wide research network in haematology. CLINICAL MEDICINE, 19(6), 532-533. doi:10.7861/clinmed.2019-0313DIAPH1-related disorder: audiological phenotype and comparison to MYH9-related disorder and Takenouchi-Kosaki syndrome (Conference Paper)
Westbury, S., Burney, C., Obaji, S., Collins, P., Toh, C. -H., & Mumford, A. (2019). DIAPH1-related disorder: audiological phenotype and comparison to MYH9-related disorder and Takenouchi-Kosaki syndrome. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 185 (pp. 134-135). Retrieved from https://www.webofscience.com/Parasite histones are associated with poor outcome in cerebral malaria (Conference Paper)
Moxon, C., Alhamdi, Y., Storm, J., Toh, J., Ko, J. Y., Murphy, G., . . . Toh, C. -H. (2019). Parasite histones are associated with poor outcome in cerebral malaria. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 185 (pp. 33). Retrieved from https://www.webofscience.com/2018
The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms (Journal article)
Ainsworth, S., Slagboom, J., Alomran, N., Pla, D., Alhamdi, Y., King, S. I., . . . Casewell, N. R. (2018). The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms. COMMUNICATIONS BIOLOGY, 1. doi:10.1038/s42003-018-0039-1Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation (Conference Paper)
Abrams, S. T., Su, D., Sahraoui, Y., Alhamdi, Y., Wang, G., & Toh, C. H. (2018). Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation. In BLOOD Vol. 132. doi:10.1182/blood-2018-99-116117Phenotype description and response to thrombopoietin receptor agonist in <i>DIAPH1</i>-related disorder (Journal article)
Westbury, S. K., Downes, K., Burney, C., Lozano, M. L., Obaji, S. G., Toh, C. H., . . . Mumford, A. D. (2018). Phenotype description and response to thrombopoietin receptor agonist in <i>DIAPH1</i>-related disorder. BLOOD ADVANCES, 2(18), 2341-2346. doi:10.1182/bloodadvances.2018020370Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data (vol 8, 1300, 2018) (Journal article)
Farmery, J. H. R., Smith, M. L., Lynch, A. G., Huissoon, A., Furnell, A., Mead, A., . . . Tan, Y. (2018). Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data (vol 8, 1300, 2018). SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-31524-0<i>De Novo</i> Truncating Mutations in <i>WASF1</i> Cause Intellectual Disability with Seizures (Journal article)
Ito, Y., Carss, K. J., Duarte, S. T., Hartley, T., Keren, B., Kurian, M. A., . . . Raymond, F. L. (2018). <i>De Novo</i> Truncating Mutations in <i>WASF1</i> Cause Intellectual Disability with Seizures. AMERICAN JOURNAL OF HUMAN GENETICS, 103(1), 144-153. doi:10.1016/j.ajhg.2018.06.001A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC diagnostic criteria: communication from the SSC of the ISTH (Journal article)
Suzuki, K., Wada, H., Imai, H., Iba, T., Thachil, J., & Toh, C. -H. (2018). A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC diagnostic criteria: communication from the SSC of the ISTH. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 16(7), 1442-1444. doi:10.1111/jth.14134Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4 (Journal article)
Qaddoori, Y., Abrams, S. T., Mould, P., Alhamdi, Y., Christmas, S. E., Wang, G., & Toh, C. -H. (2018). Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4. JOURNAL OF IMMUNOLOGY, 200(12), 4125-4133. doi:10.4049/jimmunol.1700779The European Hematology Curriculum: An Electronic Passport Promoting Professional Competence and Mobility (Journal article)
Almeida, A. M., Ar, C., Hellstrom-Lindberg, E., Hollegien, W. W. G., Navarro, J. T., Saris, M. T., . . . Toh, C. H. (2018). The European Hematology Curriculum: An Electronic Passport Promoting Professional Competence and Mobility. HEMASPHERE, 2(3). doi:10.1097/HS9.0000000000000049Circulating histones are major mediators of cardiac complications in sepsis (Conference Paper)
Wang, G., Alhamdi, Y., Abrams, S. T., & Toh, C. H. (2018). Circulating histones are major mediators of cardiac complications in sepsis. In CARDIOVASCULAR RESEARCH Vol. 114 (pp. S99). doi:10.1093/cvr/cvy060.294Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data (Journal article)
Farmery, J. H. R., Smith, M. L., & Lynch, A. G. (2018). Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-017-14403-yCase report: A successful pregnancy in Haemophillia A (Conference Paper)
Yong, J., & Toh, C. -H. (2018). Case report: A successful pregnancy in Haemophillia A. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 205). Retrieved from https://www.webofscience.com/Case report: a successful pregnancy in hemophilia A (Conference Paper)
Yong, J., & Toh, C. -H. (2018). Case report: a successful pregnancy in hemophilia A. In HAEMOPHILIA Vol. 24 (pp. 94). Retrieved from https://www.webofscience.com/Haematology Speciality Trainees Driving NIHR Clinical Research: The North-West Coast Clinical Research Network (NWC CRN) Experience (Conference Paper)
Loizou, E., Karpha, I., Nicholson, T., Toh, C. -H., & Dutt, T. (2018). Haematology Speciality Trainees Driving NIHR Clinical Research: The North-West Coast Clinical Research Network (NWC CRN) Experience. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 168). Retrieved from https://www.webofscience.com/Neutrophil Extracellular Traps (NETs) formation in Patients newly diagnosed with Myeloma: Findings from the Thromboprophylaxis in Multiple Myeloma (TiMM) Study (Conference Paper)
Sayar, Z., Abrams, S. T., Alsabani, M., Czuprynska, J., Benjamin, R., Patel, J. P., . . . Toh, C. H. (2018). Neutrophil Extracellular Traps (NETs) formation in Patients newly diagnosed with Myeloma: Findings from the Thromboprophylaxis in Multiple Myeloma (TiMM) Study. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 181 (pp. 140-141). Retrieved from https://www.webofscience.com/2017
Phenotypic Characterization of <i>EIF2AK4</i> Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension. (Journal article)
Hadinnapola, C., Bleda, M., Haimel, M., Screaton, N., Swift, A., Dorfmüller, P., . . . Morrell, N. W. (2017). Phenotypic Characterization of <i>EIF2AK4</i> Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.. Circulation, 136(21), 2022-2033. doi:10.1161/circulationaha.117.028351Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis (Journal article)
Szatmary, P., Liu, T., Abrams, S. T., Voronina, S., Wen, L., Chvanov, M., . . . Sutton, R. (2017). Systemic histone release disrupts plasmalemma and contributes to necrosis in acute pancreatitis. PANCREATOLOGY, 17(6), 884-892. doi:10.1016/j.pan.2017.10.002Extracellular histones inhibit complement activation through interactions with complement component C4b (Conference Paper)
Qaddoori, Y., Abrams, S. T., Su, D., Liu, T., Alhamdi, Y., Wang, G., & Toh, C. -H. (2017). Extracellular histones inhibit complement activation through interactions with complement component C4b. In MOLECULAR IMMUNOLOGY Vol. 89 (pp. 132). doi:10.1016/j.molimm.2017.06.067Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Alhamdi, Y., Lin, Z., . . . Toh, C. H. (2017). Accuracy of circulating histones in predicting persistent organ failure and mortality in patients with acute pancreatitis. BRITISH JOURNAL OF SURGERY, 104(9), 1215-1225. doi:10.1002/bjs.10538Circulating histones associate with severity and play important roles in acute pancreatitis (Journal article)
Lin, Z., Cheng, Z., Liu, T., Wang, G., Sutton, R., & Toh, C. -H. (2017). Circulating histones associate with severity and play important roles in acute pancreatitis. Pancreatology, 17(3), S33. doi:10.1016/j.pan.2017.05.102143 The roles and mechanisms of pore-forming toxins in cardiac injury (Journal article)
Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). 143 The roles and mechanisms of pore-forming toxins in cardiac injury. Heart, 103(Suppl 5), A107.1-A107. doi:10.1136/heartjnl-2017-311726.142Granulocyte colony-stimulating factor (G-CSF) increases histone-complexed DNA plasma levels in healthy volunteers (Journal article)
Schoergenhofer, C., Schwameis, M., Wohlfarth, P., Brostjan, C., Abrams, S. T., Toh, C. -H., & Jilma, B. (2017). Granulocyte colony-stimulating factor (G-CSF) increases histone-complexed DNA plasma levels in healthy volunteers. CLINICAL AND EXPERIMENTAL MEDICINE, 17(2), 243-249. doi:10.1007/s10238-016-0413-6Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis (Journal article)
Liu, T., Huang, W., Abrams, S., Wang, L., Szatmary, P., Alhamdi, Y., . . . Sutton, R. (2016). Elevated Circulating Histones Associate With Multiple Organ Dysfunction Syndromes in Acute Pancreatitis. PANCREAS, 45(10), 1520. Retrieved from https://www.webofscience.com/Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration (Journal article)
Arno, G., Carss, K. J., Hull, S., Zihni, C., Robson, A. G., Fiorentino, A., . . . Webster, A. R. (2017). Biallelic Mutation of <i>ARHGEF18</i>, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. AMERICAN JOURNAL OF HUMAN GENETICS, 100(2), 334-342. doi:10.1016/j.ajhg.2016.12.014Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (vol 36, pg 505, 2016) (Journal article)
Toh, C. -H., Alhamdi, Y., & Abrams, S. T. (2017). Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (vol 36, pg 505, 2016). ANNALS OF LABORATORY MEDICINE, 37(1), 95. doi:10.3343/alm.2017.37.1.95Recent advances in pathophysiology of disseminated intravascular coagulation: the role of circulating histones and neutrophil extracellular traps. (Journal article)
Alhamdi, Y., & Toh, C. -H. (2017). Recent advances in pathophysiology of disseminated intravascular coagulation: the role of circulating histones and neutrophil extracellular traps.. F1000Research, 6, 2143. doi:10.12688/f1000research.12498.1THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY (Conference Paper)
Wang, G., Alhamdi, Y., & Toh, C. -H. (2017). THE ROLES AND MECHANISMS OF PORE-FORMING TOXINS IN CARDIAC INJURY. In HEART Vol. 103 (pp. A107). Retrieved from https://www.webofscience.com/2016
Role of Coagulation Factor Concentrates in the Operating Room (Journal article)
Alhamdi, Y. A. T., & Toh, C. H. (n.d.). Role of Coagulation Factor Concentrates in the Operating Room. Europeam Medical Journal.Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation (Journal article)
Toh, C. -H., Alhamdi, Y., & Abrams, S. T. (2016). Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ANNALS OF LABORATORY MEDICINE, 36(6), 505-512. doi:10.3343/alm.2016.36.6.505Disseminated intravascular coagulation (Chapter)
Gando, S., Levi, M., & Toh, C. -H. (2016). Disseminated intravascular coagulation. In Unknown Book (Vol. 2). doi:10.1038/nrdp.2016.37Disseminated intravascular coagulation. (Journal article)
Gando, S., Levi, M., & Toh, C. -H. (2016). Disseminated intravascular coagulation.. Nature reviews. Disease primers, 2, 16037. doi:10.1038/nrdp.2016.37Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S., Alhamdi, Y., Lin, Z., . . . Toh, C. -H. (2016). Circulating histones accurately predict persistent organ failure and mortality in patients with acute pancreatitis within 24 h of admission. Pancreatology, 16(3), S100-S101. doi:10.1016/j.pan.2016.05.338The role of extracellular histones in haematological disorders (Journal article)
Alhamdi, Y., & Toh, C. -H. (2016). The role of extracellular histones in haematological disorders. BRITISH JOURNAL OF HAEMATOLOGY, 173(5), 805-811. doi:10.1111/bjh.14077Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness (Journal article)
Alhamdi, Y., Zi, M., Abrams, S., Liu, T., Su, D., Welters, I., . . . Toh, C. -H. (2016). Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness. Critical Care Medicine, 44(05), e278-e288. doi:10.1097/CCM.000000000000141336th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. (Journal article)
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016. (2016). Critical care (London, England), 20(Suppl 2), 94. doi:10.1186/s13054-016-1208-6Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements? (Conference Paper)
Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., & Welters, I. D. M. (2016). Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements?. In Critical Care Vol. 20 (pp. P127). Brussels: BioMed Central.Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill (Journal article)
Alhamdi, Y., Abrams, S., Lane, S., Wang, G., & Toh, C. -H. (2016). Histone-Associated Thrombocytopenia in Patients Who Are Critically Ill. JAMA: Journal of the American Medical Association, 315(8), 817-819. doi:10.1001/jama.2016.0136Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding (vol 13, pg 1653, 2015) (Journal article)
Moxon, C. A., Chisala, N. V., Mzikamanda, R., MacCormick, I., Harding, S., Downey, C., . . . Toh, C. H. (2016). Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding (vol 13, pg 1653, 2015). JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 14(2), 415. doi:10.1111/jth.13233A multi-factorial analysis of response to warfarin in a UK prospective cohort (Journal article)
Bourgeois, S., Jorgensen, A., Zhang, E. J., Hanson, A., Gillman, M. S., Bumpstead, S., . . . Pirmohamed, M. (2016). A multi-factorial analysis of response to warfarin in a UK prospective cohort. Genome Medicine: medicine in the post-genomic era, 8. doi:10.1186/s13073-015-0255-y36th International Symposium on Intensive Care and Emergency Medicine (vol 20, 94, 2016) (Journal article)
Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., & Welters, I. D. (2016). 36th International Symposium on Intensive Care and Emergency Medicine (vol 20, 94, 2016). CRITICAL CARE, 20. doi:10.1186/s13054-016-1358-6Arterial ischemic stroke in HIV Defining and classifying etiology for research studies (Journal article)
Benjamin, L. A., Bryer, A., Lucas, S., Stanley, A., Allain, T. J., Joekes, E., . . . Solomon, T. (2016). Arterial ischemic stroke in HIV Defining and classifying etiology for research studies. NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 3(4). doi:10.1212/NXI.0000000000000254EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT (Conference Paper)
Sahraoui, Y., Abrams, S., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). EXTRACELLULAR HISTONES ENHANCE FACTOR XA MEDIATED PROTHROMBIN ACTIVATION WITHOUT PHOSPHOLIPID REQUIREMENT. In HAEMATOLOGICA Vol. 101 (pp. 310). Retrieved from https://www.webofscience.com/Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2016). Early prediction of major clinical outcomes of patients with acute pancreatitis by circulating histones. Pancreatology, 16(1), S34. doi:10.1016/j.pan.2015.12.107Extracellular histones promote prothrombin activation in the absence of phospholipids (Conference Paper)
Sahraoui, Y., Abrams, S. T., Su, D., Alhamdi, Y., Foley, J., Wang, G., & Toh, C. H. (2016). Extracellular histones promote prothrombin activation in the absence of phospholipids. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness (Conference Paper)
Alhamdi, Y., Abrams, S. T., Lane, S., Wang, G., & Toh, C. H. (2016). Histone-associated thrombocytopaenia is a significant cause of thrombocytopaenia in critical illness. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 173 (pp. 19). Retrieved from https://www.webofscience.com/2015
Acquired coagulation disorders (Chapter)
Collins, P. W., Thachil, J., & Toh, C. -H. (2016). Acquired coagulation disorders. In POSTGRADUATE HAEMATOLOGY, 7TH EDITION (pp. 743-760). Retrieved from https://www.webofscience.com/Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis (Journal article)
Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis. Pancreas, 44(7), 1089-1095. doi:10.1097/MPA.0000000000000416Circulating histones are major mediators of cardiac injury in patients with sepsis (Journal article)
Alhamdi, Y., Abrams, S. T., Cheng, Z., Jing, S., Su, D., Liu, Z., . . . Toh,, C. -H. (2015). Circulating histones are major mediators of cardiac injury in patients with sepsis. Critical Care Medicine, 43(10), 2094-2103. doi:10.1097/CCM.0000000000001162(Journal article)
doi:10.1186/2197-425x-3-s1-a85Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding (Journal article)
Moxon, C. A., Chisala, N. V., Mzikamanda, R., MacCormick, I., Harding, S., Downey, C., . . . Toh, C. -H. (2015). Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13(9), 1653-1664. doi:10.1111/jth.13060Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis (Journal article)
Liu, T., Abrams, S., Szatmary, P., Cheng, Z., Huang, W., Ou, X., . . . Toh, C. -H. (2015). Circulating histones contribute to acute respiratory distress syndrome in acute pancreatitis. Pancreatology, 15(3), S63. doi:10.1016/j.pan.2015.05.242Thrombotic thrombocytopenic purpura specialist centres: providing better outcomes for patients with rare but life-threatening conditions. (Journal article)
Dutt, T., Martlew, V., Toh, C. H., & Jones, C. K. (2015). Thrombotic thrombocytopenic purpura specialist centres: providing better outcomes for patients with rare but life-threatening conditions.. Clinical medicine (London, England), 15 Suppl 3, s21. doi:10.7861/clinmedicine.15-3-s21Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection (Journal article)
Alhamdi, Y., Neill, D., Abrams, S., Malak, H., Yahya, R., Barrett-Jolley, R., . . . Toh, C. -H. (2015). Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathogens, 11(5). doi:10.1371/journal.ppat.1004836Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis (Journal article)
Ou, X., Cheng, Z., Liu, T., Tang, Z., Huang, W., Szatmary, P., . . . Wang, G. (2015). Circulating Histone Levels Reflect Disease Severity in Animal Models of Acute Pancreatitis.Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis (Journal article)
Szatmary, P., Liu, T., Abrams, S., Wen, L., Huang, W., Wang, G., . . . Sutton, R. (2015). Circulating Histones Target Acinar Cells and Exacerbate Injury in Experimental Acute Pancreatitis. PANCREAS, 44(8), 1418. Retrieved from https://www.webofscience.com/Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis (Journal article)
Alhamdi, Y., Abrams, S. T., Zi, M., Welters, I., Cartwright, E. J., Wang, G., & Toh, C. -H. (2015). Circulating histones disturb intracellular calcium homeostasis and cause calcium overload to induce cardiovascular abnormalities in sepsis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 159. Retrieved from https://www.webofscience.com/Developing a laboratory-based score to predict mortality in patients admitted to the ICU (Journal article)
Iqbal, A., Welters, I., Kolamunnage-Dona, R., Toh, C., & Downey, C. (n.d.). Developing a laboratory-based score to predict mortality in patients admitted to the ICU. Critical Care, 19(S1). doi:10.1186/cc14627Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones (Journal article)
Liu, T., Huang, W., Szatmary, P., Abrams, S. T., Greenhalf, W., Welters, I., . . . Toh, C. H. (2015). Early Prediction of Major Clinical Outcomes of Patients With Acute Pancreatitis by Circulating Histones. PANCREAS, 44(8), 1393. Retrieved from https://www.webofscience.com/Exploring the psychosocial implications of living and coping with sickle cell crisis: an interpretative phenomenological analysis (Conference Paper)
Barrow, E., Houghton, A., Simcox, D., & Toh, C. H. (2015). Exploring the psychosocial implications of living and coping with sickle cell crisis: an interpretative phenomenological analysis. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 103-104). Retrieved from https://www.webofscience.com/Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients (Journal article)
Alhamdi, Y., Abrams, S. T., Welters, I., Wang, G., & Toh, C. -H. (2015). Histone-associated thrombocytopenia: a new cause of thrombocytopenia in critically ill patients. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 94. Retrieved from https://www.webofscience.com/Neuro-imaging does not correlate with disease severity in acute thrombotic thrombocytopenia purpura (TTP), but may predict long term sequelae (Journal article)
Karpha, I., Kay-Jones, C., Burgiss, J., Martlew, V., Toh, C. H., Fitzsimmons, P., & Dutt, T. (2015). Neuro-imaging does not correlate with disease severity in acute thrombotic thrombocytopenia purpura (TTP), but may predict long term sequelae. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13, 470. Retrieved from https://www.webofscience.com/Patients with suspected TTP should be acutely managed in a critical care setting (Conference Paper)
Burgess, J. L., Jones, C. K., Karpha, I., Martlew, V. J., Toh, C. H., & Dutt, T. (2015). Patients with suspected TTP should be acutely managed in a critical care setting. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 45). Retrieved from https://www.webofscience.com/Short and long term neurological complications of thrombotic thrombocytopenic purpura (TTP) (Conference Paper)
Karpha, I., Kay-Jones, C., Burgiss, J., Martlew, V. J., Toh, C. H., Fitzsimmons, P., & Dutt, T. (2015). Short and long term neurological complications of thrombotic thrombocytopenic purpura (TTP). In BRITISH JOURNAL OF HAEMATOLOGY Vol. 169 (pp. 48). Retrieved from https://www.webofscience.com/(Journal article)
doi:10.1186/2197-425x-3-s1-a913(Journal article)
doi:10.1186/2197-425x-3-s1-a1382014
Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells (Journal article)
Mu, X., Pan, C., Zheng, S., Alhamdi, Y., Sun, B., Shi, Q., . . . Wang, G. (2014). Protective Effects of Carbon Monoxide-Releasing Molecule-2 on the Barrier Function of Intestinal Epithelial Cells. PLOS ONE, 9(8). doi:10.1371/journal.pone.0104032A Master Class for European Hematology (Journal article)
Toh, C. H., Strivens, J., Guenova, M., & Modok, S. (2014). A Master Class for European Hematology. HAEMATOLOGICA, 99(6), 949-951. doi:10.3324/haematol.2014.107540Survey of professional competence in hematology in Europe (Journal article)
Lindberg, E. H., Almeida, A., Enoksson, F., de Wit, T. D., Strivens, J., Naeve, A., & Toh, C. -H. (2014). Survey of professional competence in hematology in Europe. HAEMATOLOGICA, 99(3), 404-408. doi:10.3324/haematol.2014.104299Persistent Endothelial Activation and Inflammation After <i>Plasmodium falciparum</i> Infection in Malawian Children (Journal article)
Moxon, C. A., Chisala, N. V., Wassmer, S. C., Taylor, T. E., Seydel, K. B., Molyneux, M. E., . . . Heyderman, R. S. (2014). Persistent Endothelial Activation and Inflammation After <i>Plasmodium falciparum</i> Infection in Malawian Children. JOURNAL OF INFECTIOUS DISEASES, 209(4), 610-615. doi:10.1093/infdis/jit419Role of sequestration-induced loss of protein C receptors in coagulation and inflammation in cerebral malaria (Conference Paper)
Moxon, C., Wassmer, S., Milner, D. J., Chisala, N., Taylor, T., Seydel, K., . . . Heyderman, R. (2014). Role of sequestration-induced loss of protein C receptors in coagulation and inflammation in cerebral malaria. In LANCET Vol. 383 (pp. 75). Retrieved from https://www.webofscience.com/HYPOMAGNESAEMIA IN CRITICAL CARE (Conference Paper)
Homer, L. E., Kolammunage-Dona, R., Steele, T., Toh, C. -H., Downey, C., & Welters, I. D. (2014). HYPOMAGNESAEMIA IN CRITICAL CARE. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S196-S197). Retrieved from https://www.webofscience.com/LOW SERUM PHOSPHATE LEVELS IN CRITICAL ILLNESS (Conference Paper)
Agarwal, K., Kolammunage-Dona, R., Steele, T., Toh, C. H., Downey, C., & Welters, I. D. (2014). LOW SERUM PHOSPHATE LEVELS IN CRITICAL ILLNESS. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S178). Retrieved from https://www.webofscience.com/SEVERE HYPONATRAEMIA IN CRITICAL ILLNESS (Conference Paper)
Lee, S. D., Gilmartin, M., Nee, A., Steele, T., Toh, C. H., & Welters, I. (2014). SEVERE HYPONATRAEMIA IN CRITICAL ILLNESS. In INTENSIVE CARE MEDICINE Vol. 40 (pp. S196). Retrieved from https://www.webofscience.com/Safe implementation of the new oral anticoagulants (NOACs) requires patient monitoring (Journal article)
Loizou, E., Toh, C. -H., & Dutt, T. (2014). Safe implementation of the new oral anticoagulants (NOACs) requires patient monitoring. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 12, 9. Retrieved from https://www.webofscience.com/The Role of Neutrophil Extracellular Traps in Acute Pancreatitis (Journal article)
Szatmary, P., Liu, T., Wen, L., Huang, W., Awais, M., Wang, G., . . . Sutton, R. (2014). The Role of Neutrophil Extracellular Traps in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis (Journal article)
Szatmary, P., Liu, T., Huang, W., Wang, G., Latawiec, D., Davies, K., . . . Sutton, R. (2014). Use of Citrullinated Histones and Circulating Nucleosomes in Early Prediction of Organ Failure in Acute Pancreatitis. PANCREAS, 43(8), 1413. Retrieved from https://www.webofscience.com/2013
A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)
Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2294-2303. doi:10.1056/NEJMoa1311386A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)
Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. New England Journal of Medicine, 369(24), 2294-2303. doi:10.1056/nejmoa1311386Current consideration and management of disseminated intravascular coagulation. (Journal article)
Toh, C. H., & Alhamdi, Y. (2013). Current consideration and management of disseminated intravascular coagulation.. Hematology. American Society of Hematology. Education Program, 2013, 286-291. doi:10.1182/asheducation-2013.1.286Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response (Conference Paper)
Abrams, S. T., Zhang, N., Wang, G., & Toh, C. -H. (2013). Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response. In BLOOD Vol. 122. doi:10.1182/blood.V122.21.457.457Human CRP Defends against the Toxicity of Circulating Histones (Journal article)
Abrams, S. T., Zhang, N., Dart, C., Wang, S. S., Thachil, J., Guan, Y., . . . Toh, C. -H. (2013). Human CRP Defends against the Toxicity of Circulating Histones. JOURNAL OF IMMUNOLOGY, 191(5), 2495-2502. doi:10.4049/jimmunol.1203181Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children (Journal article)
Moxon, C. A., Wassmer, S. C., Milner, D. A. J., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. BLOOD, 122(5), 842-851. doi:10.1182/blood-2013-03-490219A European strategy for targeted education in hematology. (Journal article)
Strivens, J., Hellström-Lindberg, E., Bjerrum, O. W., & Toh, C. -H. (2013). A European strategy for targeted education in hematology.. Haematologica, 98(7), 1000-1002. doi:10.3324/haematol.2013.090423Assessment and clinical course of hypocalcemia in critical illness (Journal article)
Steele, T., Kolamunnage-Dona, R., Downey, C., Toh, C. -H., & Welters, I. (2013). Assessment and clinical course of hypocalcemia in critical illness. CRITICAL CARE, 17(3). doi:10.1186/cc12756Albumin-adjusted calcium concentration should not be used to identify hypocalcaemia in critical illness (Journal article)
Steele, T., Kolamunnage-Dona, R., Downey, C., Toh, C., & Welters, I. (2013). Albumin-adjusted calcium concentration should not be used to identify hypocalcaemia in critical illness. Critical Care, 17(S2). doi:10.1186/cc12384Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. (Journal article)
Wada, H., Thachil, J., Di Nisio, M., Mathew, P., Kurosawa, S., Gando, S., . . . The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis. (2013). Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines.. Journal of thrombosis and haemostasis : JTH. doi:10.1111/jth.12155Circulating Histones Are Mediators of Trauma-associated Lung Injury (Journal article)
Abrams, S. T., Zhang, N., Manson, J., Liu, T., Dart, C., Baluwa, F., . . . Toh, C. -H. (2013). Circulating Histones Are Mediators of Trauma-associated Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(2), 160-169. doi:10.1164/rccm.201206-1037OCA Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study (Journal article)
Pirmohamed, M., Burnside, G., Stoddern, J., Prince, C., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study. CIRCULATION, 128(24), 2710-2711. Retrieved from https://www.webofscience.com/Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway (Conference Paper)
Alhamdi, Y., Wang, G., & Toh, C. -H. (2013). Activated protein C (APC) and thrombin modulate cardiomyocytes contractility via a protease activated receptor-1 (PAR1)-cardiac troponin I (CTI) pathway. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 38). Retrieved from https://www.webofscience.com/Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation (Conference Paper)
Abrams, S. T., Manson, J., Liu, T., Baluwa, F., Barrera, V., Brohi, K., . . . Toh, C. H. (2013). Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 22). Retrieved from https://www.webofscience.com/Adherence and variability in warfarin dose requirements: assessment in a prospective cohort (Journal article)
Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199Circulating histone-induced thrombosis leads to circulatory and respiratory failure (Conference Paper)
Abrams, S. T., Manson, J., Liu, T., Alhamdi, Y., Brohi, K., Wang, G., & Toh, C. H. (2013). Circulating histone-induced thrombosis leads to circulatory and respiratory failure. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 128). Retrieved from https://www.webofscience.com/Improving specificity for diagnosing heparin-induced thrombocytopenia through repeated testing (Conference Paper)
Vithanarachchi, S., Saminaden, L., Downey, C., Toh, C. H., & Dutt, T. (2013). Improving specificity for diagnosing heparin-induced thrombocytopenia through repeated testing. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 542). Retrieved from https://www.webofscience.com/Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. (Journal article)
Moxon, C. A., Wassmer, S. C., Milner, D. A. J., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.. Blood, 122(5), 842-845. doi:10.1182/blood-2013-03-490219Loss of protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria (Conference Paper)
Moxon, C. A., Wassmer, S. C., Milner, D. A., Chisala, N. V., Taylor, T. E., Seydel, K. B., . . . Heyderman, R. S. (2013). Loss of protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 4). Retrieved from https://www.webofscience.com/Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients (Conference Paper)
Thachil, J., Barrera, V., Djebabri, B., Abrams, S. T., Wang, G., & Toh, C. H. (2013). Platelet surface high mobility group box protein-1 binds receptor for advanced glycation endproducts in plasma or on monocytes in septic patients. In JOURNAL OF THROMBOSIS AND HAEMOSTASIS Vol. 11 (pp. 71). Retrieved from https://www.webofscience.com/2012
Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma/acute coagulopathy of trauma-shock. (Journal article)
Gando, S., Wada, H., Kim, H. K., Kurosawa, S., Nielsen, J. D., Thachil, J., . . . Scientific and Standardization Committee on DIC of the ISTH. (2012). Comparison of disseminated intravascular coagulation in trauma with coagulopathy of trauma/acute coagulopathy of trauma-shock.. Journal of thrombosis and haemostasis : JTH, 10(12), 2593-2595. doi:10.1111/jth.12011415 Activated Protein C (APC) Alleviates Endoplasmic Reticulum (ER) Stress and ER Stress-Linked Apoptosis in Endothelial Cells (Journal article)
Alhamdi, Y. A., Wang, G., & Toh, C. (2012). 415 Activated Protein C (APC) Alleviates Endoplasmic Reticulum (ER) Stress and ER Stress-Linked Apoptosis in Endothelial Cells. Canadian Journal of Cardiology, 28(5), S255. doi:10.1016/j.cjca.2012.07.390The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation]. (Journal article)
Thachil, J., Toh, C. H., Levi, M., & Watson, H. G. (2012). The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation].. British journal of haematology, 157(4), 493-494. doi:10.1111/j.1365-2141.2011.09019.xCurrent concepts in the management of disseminated intravascular coagulation. (Journal article)
Thachil, J., & Toh, C. H. (2012). Current concepts in the management of disseminated intravascular coagulation.. Thrombosis research, 129 Suppl 1, S54-S59. doi:10.1016/s0049-3848(12)70017-82011
Lipoproteins, statins and septic haematology patients. (Journal article)
Thachil, J., Abrams, S., Downey, C., & Toh, C. H. (2011). Lipoproteins, statins and septic haematology patients.. British journal of haematology, 155(1), 122-123. doi:10.1111/j.1365-2141.2011.08642.xReduction of circulating histone toxicity is a major function of C-reactive protein after extensive tissue damage (Preprint)
The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis (Journal article)
Perez-Casal, M., Thompson, V., Downey, C., Welters, I., Wyncoll, D., Thachil, J., & Toh, C. H. (2011). The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. CRITICAL CARE, 15(4). doi:10.1186/cc10356Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis (Journal article)
Paize, F., Carrol, E., Downey, C., Parry, C. M., Green, G., Diggle, P., . . . Toh, C. -H. (2011). Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis. PEDIATRIC CRITICAL CARE MEDICINE, 12(6), E322-E329. doi:10.1097/PCC.0b013e3182231034Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis. (Journal article)
Paize, F., Carrol, E., Downey, C., Parry, C. M., Green, G., Diggle, P., . . . Toh, C. H. (2011). Diagnostic efficacy of activated partial thromboplastin time waveform and procalcitonin analysis in pediatric meningococcal sepsis.. Pediatr Crit Care Med, 12(6), e322-e329.The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis (Journal article)
Pérez-Casal, M., Thompson, V., Downey, C., Welters, I., Wyncoll, D., Thachil, J., & Toh, C. (2011). The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. Critical Care, 15(4), R195. doi:10.1186/cc103562010
Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation. (Journal article)
Kim, S. Y., Kim, J. -E., Kim, H. K., Han, K. -S., & Toh, C. H. (2010). Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation.. American journal of clinical pathology, 134(4), 634-647. doi:10.1309/ajcp88jylrcsrxppModified non-overt DIC diagnostic criteria predict the early phase of overt-DIC. (Journal article)
Wada, H., Hatada, T., Okamoto, K., Uchiyama, T., Kawasugi, K., Mayumi, T., . . . Japanese Society of Thrombosis Hemostasis/DIC subcommittee. (2010). Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC.. American journal of hematology, 85(9), 691-694. doi:10.1002/ajh.21783Application of the international normalized ratio in the scoring system for disseminated intravascular coagulation. (Journal article)
Kim, H. K., Hong, K. H., Toh, C. H., & Scientific and Standardization Committee on DIC of The International Society on THrombosis and Haemostasis. (2010). Application of the international normalized ratio in the scoring system for disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 8(5), 1116-1118. doi:10.1111/j.1538-7836.2010.03834.xAppropriate use of D-dimer in hospital patients. (Journal article)
Thachil, J., Fitzmaurice, D. A., & Toh, C. H. (2010). Appropriate use of D-dimer in hospital patients.. The American journal of medicine, 123(1), 17-19. doi:10.1016/j.amjmed.2009.09.011Non-malignant haematology research in the UK: looking forward to new opportunities. (Journal article)
Collins, P. W., Baglin, T. P., Dang, R., Evans, G., Greaves, M., Laffan, M., . . . Toh, C. H. (2010). Non-malignant haematology research in the UK: looking forward to new opportunities.. Br J Haematol, 150(6), 732-736.2009
Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)
Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of <i>CYP4F2</i> genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study (Journal article)
Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5Disseminated intravascular coagulation in obstetric disorders and its acute haematological management. (Journal article)
Thachil, J., & Toh, C. -H. (2009). Disseminated intravascular coagulation in obstetric disorders and its acute haematological management.. Blood reviews, 23(4), 167-176. doi:10.1016/j.blre.2009.04.002Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. (Journal article)
Levi, M., Toh, C. H., Thachil, J., & Watson, H. G. (2009). Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology.. British journal of haematology, 145(1), 24-33. doi:10.1111/j.1365-2141.2009.07600.xMicroparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects. (Journal article)
Pérez-Casal, M., Downey, C., Cutillas-Moreno, B., Zuzel, M., Fukudome, K., & Toh, C. H. (2009). Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects.. Haematologica, 94(3), 387-394. doi:10.3324/haematol.13547Guidelines for the diagnosis and management of disseminated intravascular coagulation. (Journal article)
Levi, M., Toh, C. H., Thachil, J., & Watson, H. G. (2009). Guidelines for the diagnosis and management of disseminated intravascular coagulation.. Br J Haematol, 94, 387-394.2007
The formation of a Ca2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform (Journal article)
Nesheim, M., Samis, J., Walker, J., Fischer, T., Tejidor, L., Jones, G., . . . Toh, C. H. (2007). The formation of a Ca2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform. BMC Pharmacology, 7(S1). doi:10.1186/1471-2210-7-s1-p42The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview. (Journal article)
Toh, C. H., & Hoots, W. K. (2007). The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview.. J Thromb Haemost, 5, 604-606.2006
Disseminated intravascular coagulation (Chapter)
Toh, C. H. (2006). Disseminated intravascular coagulation. In N. S. Young, S. L. Gerson, & K. A. High (Eds.), Clinical Hematology (Vol. 1, pp. 1134-1143). Philadelphia: Elsevier.2005
Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells. (Journal article)
Farahani, M., Treweeke, A. T., Toh, C. H., Till, K. J., Harris, R. J., Cawley, J. C., . . . Chen, H. (2005). Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells.. Leukemia, 19(4), 524-530. doi:10.1038/sj.leu.2403631Activated protein C induces the release of microparticle-associated endothelial protein C receptor. (Journal article)
Pérez-Casal, M., Downey, C., Fukudome, K., Marx, G., & Toh, C. H. (2005). Activated protein C induces the release of microparticle-associated endothelial protein C receptor.. Blood, 105(4), 1515-1522. doi:10.1182/blood-2004-05-1896Back to the future testing in disseminated intravascular coagulation (Journal article)
Toh, C. H., & Downey, C. (2005). Back to the future testing in disseminated intravascular coagulation. Unknown Journal, 16(8), 535-542.Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation. (Journal article)
Toh, C. H., & Downey, C. (2005). Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation.. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 16(1), 69-74. doi:10.1097/00001721-200501000-00011The use of clot waveform analysis in sepsis (Journal article)
Toh, C. H. (2005). The use of clot waveform analysis in sepsis. Unknown Journal, 4, 103-107.(Journal article)
Marx, G., Swaraj, S., Breen, A., Ritchie, G., Shenkin, A., Toh, C., & Leuwer, M. (2005). Unknown Title. Critical Care, 9(Suppl 1), P167. doi:10.1186/cc32302004
Thrombin activatable fibrinolysis inhibitor and its fibrinolytic effect in normal pregnancy. (Journal article)
Mousa, H. A., Downey, C., Alfirevic, Z., & Toh, C. -H. (2004). Thrombin activatable fibrinolysis inhibitor and its fibrinolytic effect in normal pregnancy.. Thrombosis and haemostasis, 92(5), 1025-1031. doi:10.1160/th04-06-0387Temporal changes in factors associated with neutrophil elastase and coagulation in intensive care patients with a biphasic waveform and disseminated intravascular coagulation. (Journal article)
Samis, J. A., Stewart, K. A., Toh, C. H., Day, A., Downey, C., & Nesheim, M. E. (2004). Temporal changes in factors associated with neutrophil elastase and coagulation in intensive care patients with a biphasic waveform and disseminated intravascular coagulation.. Journal of thrombosis and haemostasis : JTH, 2(9), 1535-1544. doi:10.1111/j.1538-7836.2004.00826.xProthrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein. (Journal article)
Dennis, M. W., Downey, C., Brufatto, N., Nesheim, M. E., Stevenson, K., & Toh, C. H. (2004). Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein.. Thrombosis and haemostasis, 91(3), 522-530. doi:10.1160/th03-08-0548Computational aspects of protein functionality (Journal article)
Paton, R., & Toh, C. H. (2004). Computational aspects of protein functionality. Unknown Journal, 5, 85-90.2003
Acquired activated protein C resistance may be a risk factor for recurrent fetal loss. (Journal article)
Dawood, F., Farquharson, R., Quenby, S., & Toh, C. H. (2003). Acquired activated protein C resistance may be a risk factor for recurrent fetal loss.. Fertility and sterility, 80(3), 649-650. doi:10.1016/s0015-0282(03)00972-5A Longitudinal Study of Maternal Dose Response to Low Molecular Weight Heparin in Pregnancy (Journal article)
Sephton, V., Farquharson, R. G., Topping, J., Quenby, S. M., Cowan, C., Back, D. J., & Toh, C. H. (2003). A Longitudinal Study of Maternal Dose Response to Low Molecular Weight Heparin in Pregnancy. Obstetrics & Gynecology, 101(6), 1307-1311. doi:10.1097/00006250-200306000-00028A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy (Journal article)
Sephton, V., Farquharson, R. G., Topping, J., Quenby, S. M., Cowan, C., Back, D. J., & Toh, C. H. (2003). A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy. OBSTETRICS AND GYNECOLOGY, 101(6), 1307-1311. doi:10.1016/S0029-7844(03)00340-5Characterisation of thrombin activatable fibrinolysis inhibitor in normal and acquired haemostatic dysfunction (Journal article)
Toh, C. H. (2003). Characterisation of thrombin activatable fibrinolysis inhibitor in normal and acquired haemostatic dysfunction. Unknown Journal, 14(Suppl), 69-72.DIC 2002: a review on disseminated intravascular coagulation (Journal article)
Toh, C. H., & Dennis, M. (2003). DIC 2002: a review on disseminated intravascular coagulation. Unknown Journal, 8(2), 65-71.Disseminated intravascular coagulation: Old disease, new hope (Journal article)
Toh, C. H., & Dennis, M. (2003). Disseminated intravascular coagulation: Old disease, new hope. Unknown Journal, 327(7421), 974-977.Early identification of sepsis and mortality risks through simple, rapid clot-waveform analysis - Implications of lipoprotein-complexed C reactive protein formation (Journal article)
Toh, C. H., Ticknor, L. O., Downey, C., Giles, A. R., Paton, R. C., & Wenstone, R. (2003). Early identification of sepsis and mortality risks through simple, rapid clot-waveform analysis - Implications of lipoprotein-complexed C reactive protein formation. INTENSIVE CARE MEDICINE, 29(1), 55-61. doi:10.1007/s00134-002-1557-2Lipoprotein-complexed C reactive protein: new wave in sepsis management (Journal article)
Toh, C. H., & Breen, A. (2003). Lipoprotein-complexed C reactive protein: new wave in sepsis management. Unknown Journal, 13, 17-21.2002
Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca<SUP>++</SUP>-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation (Journal article)
Toh, C. H., Samis, J., Downey, C., Walker, J., Becker, L., Brufatto, N., . . . Nesheim, M. (2002). Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca<SUP>++</SUP>-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation. BLOOD, 100(7), 2522-2529. doi:10.1182/blood.V100.7.2522Lipoprotein-complexed C-reactive protein and the biphasic transmittance waveform in critically ill patients. (Journal article)
Nesheim, M., Samis, J., Walker, J., Becker, L., Brufatto, N., Fischer, T., . . . Toh, C. H. (2002). Lipoprotein-complexed C-reactive protein and the biphasic transmittance waveform in critically ill patients.. Blood reviews, 16 Suppl 1, S15-S22.2001
The formation of a CA2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform (Journal article)
Nesheim, M., Samis, J., Walker, J., Fischer, T., Tejidor, L., Jones, G., . . . Toh, C. H. (2001). The formation of a CA2+-dependent complex of C-reactive protein and very low density lipoprotein causes the biphasic transmittance waveform. BMC News and views, 1(S2). doi:10.1186/2048-4623-1-s2-007Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. (Journal article)
Taylor, F. B., Toh, C. H., Hoots, W. K., Wada, H., Levi, M., & Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). (2001). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.. Thrombosis and haemostasis, 86(5), 1327-1330.Aberrant dimerization of von Willebrand factor as the result of mutations in the carboxy-terminal region: identification of 3 mutations in members of 3 different families with type 2A (phenotype IID) von Willebrand disease. (Journal article)
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