Dr Andrew Jackson BSc MSc DPhil

Senior Lecturer in Parasite Biology Infection Biology

    Publications

    Selected Publications

    1. The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. (Journal article - 2014)
    2. A Cell-surface Phylome for African Trypanosomes (Journal article - 2013)
    3. Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species (Journal article - 2012)
    4. The Evolution of Amastin Surface Glycoproteins in Trypanosomatid Parasites (Journal article - 2010)
    5. A comprehensive evaluation of rodent malaria parasite genomes and gene expression (Journal article - 2014)

    2018

    Comparative approaches to genome evolution in Blastocystis and Entamoeba (Thesis / Dissertation)

    Low, R. S. (2018, February 21). Comparative approaches to genome evolution in Blastocystis and Entamoeba.

    Sequence analysis of the merozoite surface protein 7 (PvMSP-7) multigene family: vaccine candidates for Plasmodium vivax (Thesis / Dissertation)

    Cheng, C. (2018, November 19). Sequence analysis of the merozoite surface protein 7 (PvMSP-7) multigene family: vaccine candidates for Plasmodium vivax.

    The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense (Journal article)

    Abbas, A. H., Pereira, S. S., D'Archivio, S., Wickstead, B., Morrison, L. J., Hall, N., . . . Jackson, A. P. (2018). The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense. GENOME BIOLOGY AND EVOLUTION, 10(9), 2458-2473. doi:10.1093/gbe/evy186

    DOI: 10.1093/gbe/evy186

    The effects of development and virulence on gene expression in the protozoan parasite Neospora caninum (Thesis / Dissertation)

    Unjit, K. I. T. T. I. C. H. A. I. (2018, June 28). The effects of development and virulence on gene expression in the protozoan parasite Neospora caninum.

    UDP-glycosyltransferase genes in trypanosomatid genomes have diversified independently to meet the distinct developmental needs of parasite adaptations (Journal article)

    Pereira, S. S., & Jackson, A. P. (2018). UDP-glycosyltransferase genes in trypanosomatid genomes have diversified independently to meet the distinct developmental needs of parasite adaptations. BMC EVOLUTIONARY BIOLOGY, 18. doi:10.1186/s12862-018-1149-6

    DOI: 10.1186/s12862-018-1149-6

    Variant Surface Glycoprotein Diversity in African Trypanosomes (Thesis / Dissertation)

    Silva Pereira, S. (2018, May 17). Variant Surface Glycoprotein Diversity in African Trypanosomes.

    Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs (Journal article)

    Pereira, S. S., Casas-Sanchez, A., Haines, L. R., Ogugo, M., Absolomon, K., Sanders, M., . . . Jackson, A. P. (2018). Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs. GENOME RESEARCH, 28(9), 1383-1394. doi:10.1101/gr.234146.118

    DOI: 10.1101/gr.234146.118

    2016

    Gene family phylogeny and the evolution of parasite cell surfaces (Journal article)

    Jackson, A. P. (2016). Gene family phylogeny and the evolution of parasite cell surfaces. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 209(1-2), 64-75. doi:10.1016/j.molbiopara.2016.03.007

    DOI: 10.1016/j.molbiopara.2016.03.007

    Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania (Journal article)

    Flegontov, P., Butenko, A., Firsov, S., Kraeva, N., Elias, M., Field, M. C., . . . Lukes, J. (2016). Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. SCIENTIFIC REPORTS, 6. doi:10.1038/srep23704

    DOI: 10.1038/srep23704

    Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism (Journal article)

    Jackson, A. P., Otto, T. D., Aslett, M., Armstrong, S. D., Bringaud, F., Schlacht, A., . . . Berriman, M. (2016). Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism. CURRENT BIOLOGY, 26(2), 161-172. doi:10.1016/j.cub.2015.11.055

    DOI: 10.1016/j.cub.2015.11.055

    Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole. (Journal article)

    Fougere, A., Jackson, A. P., Bechtsi, D. P., Braks, J. A. M., Annoura, T., Fonager, J., . . . Franke-Fayard, B. (2016). Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole. PLOS PATHOGENS, 12(11). doi:10.1371/journal.ppat.1005917

    DOI: 10.1371/journal.ppat.1005917

    2015

    Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty (Journal article)

    Carnes, J., Anupama, A., Balmer, O., Jackson, A., Lewis, M., Brown, R., . . . Schnaufer, A. (2015). Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty. PLOS NEGLECTED TROPICAL DISEASES, 9(1). doi:10.1371/journal.pntd.0003404

    DOI: 10.1371/journal.pntd.0003404

    Genome evolution in trypanosomatid parasites (Journal article)

    Jackson, A. P. (2015). Genome evolution in trypanosomatid parasites. PARASITOLOGY, 142, S40-S56. doi:10.1017/S0031182014000894

    DOI: 10.1017/S0031182014000894

    Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax (Journal article)

    Jackson, A. P., Goyard, S., Xia, D., Foth, B. J., Sanders, M., Wastling, J. M., . . . Berriman, M. (2015). Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax. PLOS NEGLECTED TROPICAL DISEASES, 9(8). doi:10.1371/journal.pntd.0003975

    DOI: 10.1371/journal.pntd.0003975

    Preface: the evolution of parasite genomes and the origins of parasitism (Journal article)

    Jackson, A. P. (2015). Preface: the evolution of parasite genomes and the origins of parasitism. PARASITOLOGY, 142, S1-S5. doi:10.1017/S0031182014001516

    DOI: 10.1017/S0031182014001516

    2014

    A comprehensive evaluation of rodent malaria parasite genomes and gene expression (Journal article)

    Otto, T. D., Boehme, U., Jackson, A. P., Hunt, M., Franke-Fayard, B., Hoeijmakers, W. A. M., . . . Janse, C. J. (2014). A comprehensive evaluation of rodent malaria parasite genomes and gene expression. BMC BIOLOGY, 12. doi:10.1186/s12915-014-0086-0

    DOI: 10.1186/s12915-014-0086-0

    The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction (Journal article)

    Jackson, A. P., Otto, T. D., Darby, A., Ramaprasad, A., Xia, D., Eduardo Echaide, I., . . . Pain, A. (2014). The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. NUCLEIC ACIDS RESEARCH, 42(11), 7113-7131. doi:10.1093/nar/gku322

    DOI: 10.1093/nar/gku322

    The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. (Journal article)

    Jackson, A. P., Otto, T. D., Darby, A., Ramaprasad, A., Xia, D., Echaide, I. E., . . . Pain, A. (2014). The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.. Nucleic Acids Research, 42(11), 7113-7131.

    2013

    A Cell-surface Phylome for African Trypanosomes (Journal article)

    Jackson, A. P., Allison, H. C., Barry, J. D., Field, M. C., Hertz-Fowler, C., & Berriman, M. (2013). A Cell-surface Phylome for African Trypanosomes. PLOS NEGLECTED TROPICAL DISEASES, 7(3). doi:10.1371/journal.pntd.0002121

    DOI: 10.1371/journal.pntd.0002121

    The Evolution of Antigenic Variation in African Trypanosomes (Chapter)

    Jackson, A. P., & Barry, J. D. (2013). The Evolution of Antigenic Variation in African Trypanosomes. In Evolution of Virulence in Eukaryotic Microbes (pp. 324-336). doi:10.1002/9781118308165.ch17

    DOI: 10.1002/9781118308165.ch17

    2012

    Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species (Journal article)

    Jackson, A. P., Berry, A., Aslett, M., Allison, H. C., Burton, P., Vavrova-Anderson, J., . . . Berriman, M. (2012). Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(9), 3416-3421. doi:10.1073/pnas.1117313109

    DOI: 10.1073/pnas.1117313109

    Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS). (Journal article)

    Lawton, J., Brugat, T., Yan, Y. X., Reid, A. J., Böhme, U., Otto, T. D., . . . Langhorne, J. (2012). Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).. BMC genomics, 13, 125. doi:10.1186/1471-2164-13-125

    DOI: 10.1186/1471-2164-13-125

    GeneDB--an annotation database for pathogens. (Journal article)

    Logan-Klumpler, F. J., De Silva, N., Boehme, U., Rogers, M. B., Velarde, G., McQuillan, J. A., . . . Berriman, M. (2012). GeneDB--an annotation database for pathogens.. Nucleic acids research, 40(Database issue), D98-108. doi:10.1093/nar/gkr1032

    DOI: 10.1093/nar/gkr1032

    Origins of variant surface glycoproteins in Trypanosoma brucei (Chapter)

    Jackson, A. P., & Barry, J. D. (2012). Origins of variant surface glycoproteins in Trypanosoma brucei. In D. L. Sibley, B. J. Howlett, & J. Heitman (Eds.), Evolution of Virulence in Eukaryotic Microbes (pp. 324-337). Hoboken: Wiley-Blackwell.

    2010

    Leishmania-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition (Journal article)

    Depledge, D. P., MacLean, L. M., Hodgkinson, M. R., Smith, B. A., Jackson, A. P., Ma, S., . . . Smith, D. F. (2010). Leishmania-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition. PLOS NEGLECTED TROPICAL DISEASES, 4(9). doi:10.1371/journal.pntd.0000829

    DOI: 10.1371/journal.pntd.0000829

    The Evolution of Amastin Surface Glycoproteins in Trypanosomatid Parasites (Journal article)

    Jackson, A. P. (2010). The Evolution of Amastin Surface Glycoproteins in Trypanosomatid Parasites. MOLECULAR BIOLOGY AND EVOLUTION, 27(1), 33-45. doi:10.1093/molbev/msp214

    DOI: 10.1093/molbev/msp214

    The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis (Journal article)

    Jackson, A. P., Sanders, M., Berry, A., McQuillan, J., Aslett, M. A., Quail, M. A., . . . Hertz-Fowler, C. (2010). The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis. PLOS NEGLECTED TROPICAL DISEASES, 4(4). doi:10.1371/journal.pntd.0000658

    DOI: 10.1371/journal.pntd.0000658

    The genome sequence of Trypanosoma brucei gambiense: the causative agent of chronic sleeping sickness (Journal article)

    Jackson, A. P., Sanders, M., Berry, A., McQuillan, J., Aslett, M. A., Quail, M. A., . . . Hertz-Fowler, C. (2010). The genome sequence of Trypanosoma brucei gambiense: the causative agent of chronic sleeping sickness. PLoS Neglected Tropical Diseases, 4, e658. Retrieved from http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0000658

    2009

    Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans (Journal article)

    Jackson, A. P., Gamble, J. A., Yeomans, T., Moran, G. P., Saunders, D., Harris, D., . . . Berriman, M. (2009). Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans. GENOME RESEARCH, 19(12), 2231-2244. doi:10.1101/gr.097501.109

    DOI: 10.1101/gr.097501.109

    Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement (Journal article)

    Jackson, A. P., Thomas, G. H., Parkhill, J., & Thomson, N. R. (2009). Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement. BMC GENOMICS, 10. doi:10.1186/1471-2164-10-584

    DOI: 10.1186/1471-2164-10-584

    2008

    Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa) (Journal article)

    Jackson, A. P., Quail, M. A., & Berriman, M. (2008). Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa). BMC GENOMICS, 9. doi:10.1186/1471-2164-9-594

    DOI: 10.1186/1471-2164-9-594

    Multi-locus phylogenetic analysis of neotropical figs does not support co-speciation with the pollinators: The importance of systematic scale in fig/wasp cophylogenetic studies (Journal article)

    Jackson, A. P., Machado, C. A., Robbins, N., & Herre, E. A. (2008). Multi-locus phylogenetic analysis of neotropical figs does not support co-speciation with the pollinators: The importance of systematic scale in fig/wasp cophylogenetic studies. Symbiosis, 45(1-3), 57-72.

    Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems? (Journal article)

    Allen, J. W. A., Jackson, A. P., Rigden, D. J., Willis, A. C., Ferguson, S. J., & Ginger, M. L. (2008). Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems?. FEBS JOURNAL, 275(10), 2385-2402. doi:10.1111/j.1742-4658.2008.06380.x

    DOI: 10.1111/j.1742-4658.2008.06380.x

    Telomeric expression sites are highly conserved in Trypanosoma brucei. (Journal article)

    Hertz-Fowler, C., Figueiredo, L. M., Quail, M. A., Becker, M., Jackson, A., Bason, N., . . . Berriman, M. (2008). Telomeric expression sites are highly conserved in Trypanosoma brucei.. PloS one, 3(10), e3527. doi:10.1371/journal.pone.0003527

    DOI: 10.1371/journal.pone.0003527

    The genome of the simian and human malaria parasite Plasmodium knowlesi (Journal article)

    Pain, A., Bohme, U., Berry, A. E., Mungall, K., Finn, R. D., Jackson, A. P., . . . Berriman, M. (2008). The genome of the simian and human malaria parasite Plasmodium knowlesi. NATURE, 455(7214), 799-7U7. doi:10.1038/nature07306

    DOI: 10.1038/nature07306

    2007

    Evolutionary consequences of a large duplication event in Trypanosoma brucei: Chromosomes 4 and 8 are partial duplicons (Journal article)

    Jackson, A. P. (2007). Evolutionary consequences of a large duplication event in Trypanosoma brucei: Chromosomes 4 and 8 are partial duplicons. BMC GENOMICS, 8. doi:10.1186/1471-2164-8-432

    DOI: 10.1186/1471-2164-8-432

    Origins of amino acid transporter loci in trypanosomatid parasites (Journal article)

    Jackson, A. P. (2007). Origins of amino acid transporter loci in trypanosomatid parasites. BMC EVOLUTIONARY BIOLOGY, 7. doi:10.1186/1471-2148-7-26

    DOI: 10.1186/1471-2148-7-26

    Origins of amino acid transporter loci in trypanosomatid parasites. (Journal article)

    Jackson, A. P. (2007). Origins of amino acid transporter loci in trypanosomatid parasites.. BMC evolutionary biology, 7, 26. doi:10.1186/1471-2148-7-26

    DOI: 10.1186/1471-2148-7-26

    2006

    Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp (Journal article)

    Jackson, A. P., Vaughan, S., & Gull, K. (2006). Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp. BMC GENOMICS, 7. doi:10.1186/1471-2164-7-137

    DOI: 10.1186/1471-2164-7-137

    Evolution of Tubulin Gene Arrays in Trypanosomatid parasites: genomic restructuring in Leishmania (Journal article)

    Jackson, A. P., Vaughan, S., & Gull, K. (2006). Evolution of Tubulin Gene Arrays in Trypanosomatid parasites: genomic restructuring in Leishmania. BMC GENOMICS, 7. doi:10.1186/1471-2164-7-261

    DOI: 10.1186/1471-2164-7-261

    2005

    The effect of paralogous lineages on the application of reconciliation analysis by cophylogeny mapping. (Journal article)

    Jackson, A. (2005). The effect of paralogous lineages on the application of reconciliation analysis by cophylogeny mapping.. Systematic biology, 54(1), 127-145. doi:10.1080/10635150590905911

    DOI: 10.1080/10635150590905911

    Untitled Document