Dr Andrew Jackson BSc MSc DPhil

Senior Lecturer in Parasite Biology Infection Biology & Microbiomes

    Publications

    Selected Publications

    1. The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. (Journal article - 2014)
    2. A Cell-surface Phylome for African Trypanosomes (Journal article - 2013)
    3. Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species (Journal article - 2012)
    4. The Evolution of Amastin Surface Glycoproteins in Trypanosomatid Parasites (Journal article - 2010)
    5. A comprehensive evaluation of rodent malaria parasite genomes and gene expression (Journal article - 2014)

    2021

    Bodo saltans (Kinetoplastida) is dependent on a novel Paracaedibacter-like endosymbiont that possesses multiple putative toxin-antitoxin systems (Journal article)

    Midha, S., Rigden, D. J., Siozios, S., Hurst, G. D. D., & Jackson, A. P. (2021). Bodo saltans (Kinetoplastida) is dependent on a novel Paracaedibacter-like endosymbiont that possesses multiple putative toxin-antitoxin systems. ISME JOURNAL. doi:10.1038/s41396-020-00879-6

    DOI: 10.1038/s41396-020-00879-6

    2020

    Variant antigen diversity in Trypanosoma vivax is not driven by recombination. (Journal article)

    Silva Pereira, S., de Almeida Castilho Neto, K. J. G., Duffy, C. W., Richards, P., Noyes, H., Ogugo, M., . . . Jackson, A. P. (2020). Variant antigen diversity in Trypanosoma vivax is not driven by recombination.. Nature communications, 11(1). doi:10.1038/s41467-020-14575-8

    DOI: 10.1038/s41467-020-14575-8

    2019

    VAPPER: High-throughput variant antigen profiling in African trypanosomes of livestock (Journal article)

    Pereira, S. S., Heap, J., Jones, A. R., & Jackson, A. P. (2019). VAPPER: High-throughput variant antigen profiling in African trypanosomes of livestock. GIGASCIENCE, 8(9). doi:10.1093/gigascience/giz091

    DOI: 10.1093/gigascience/giz091

    Clinical expression and antigenic profiles of a Plasmodium vivax vaccine candidate: merozoite surface protein 7 (PvMSP-7) (Journal article)

    Cheng, C. W., Jongwutiwes,, S., Putaporntip, C., & Jackson, A. P. (2019). Clinical expression and antigenic profiles of a Plasmodium vivax vaccine candidate: Merozoite Surface Protein 7 (PvMSP-7). Malaria Journal, 18, 20 pages. doi:10.1186/s12936-019-2826-7

    DOI: 10.1186/s12936-019-2826-7

    Transcriptome, proteome and draft genome of Euglena gracilis. (Journal article)

    Ebenezer, T. E., Zoltner, M., Burrell, A., Nenarokova, A., Novák Vanclová, A. M. G., Prasad, B., . . . Field, M. C. (2019). Transcriptome, proteome and draft genome of Euglena gracilis.. BMC biology, 17(1), 11. doi:10.1186/s12915-019-0626-8

    DOI: 10.1186/s12915-019-0626-8

    2018

    The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense (Journal article)

    Abbas, A. H., Pereira, S. S., D'Archivio, S., Wickstead, B., Morrison, L. J., Hall, N., . . . Jackson, A. P. (2018). The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense. Genome Biology and Evolution, 10(9), 2458-2473. doi:10.1093/gbe/evy186

    DOI: 10.1093/gbe/evy186

    Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs (Journal article)

    Pereira, S. S., Casas-Sanchez, A., Haines, L. R., Absolomon, K., Ogugo, M., Sanders, M., . . . Jackson, A. P. (n.d.). Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs. GENOME RESEARCH, 28(9), 1383-1394. doi:10.1101/gr.234146.118

    DOI: 10.1101/gr.234146.118

    UDP-glycosyltransferase genes in trypanosomatid genomes have diversified independently to meet the distinct developmental needs of parasite adaptations (Journal article)

    Pereira, S. S., & Jackson, A. P. (2018). UDP-glycosyltransferase genes in trypanosomatid genomes have diversified independently to meet the distinct developmental needs of parasite adaptations. BMC EVOLUTIONARY BIOLOGY, 18. doi:10.1186/s12862-018-1149-6

    DOI: 10.1186/s12862-018-1149-6

    2017

    Emerging challenges in understanding trypanosome antigenic variation (Journal article)

    McCulloch, R., Cobbold, C. A., Figueiredo, L., Jackson, A., Morrison, L. J., Mugnier, M. R., . . . Matthews, K. (2017). Emerging challenges in understanding trypanosome antigenic variation. Emerging Topics in Life Sciences, 1(6), 585-592. doi:10.1042/etls20170104

    DOI: 10.1042/etls20170104

    2016

    Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole. (Journal article)

    Fougere, A., Jackson, A. P., Bechtsi, D. P., Braks, J. A. M., Annoura, T., Fonager, J., . . . Franke-Fayard, B. (2016). Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole. PLOS PATHOGENS, 12(11). doi:10.1371/journal.ppat.1005917

    DOI: 10.1371/journal.ppat.1005917

    Gene family phylogeny and the evolution of parasite cell surfaces (Journal article)

    Jackson, A. P. (2016). Gene family phylogeny and the evolution of parasite cell surfaces. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 209(1-2), 64-75. doi:10.1016/j.molbiopara.2016.03.007

    DOI: 10.1016/j.molbiopara.2016.03.007

    Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania (Journal article)

    Flegontov, P., Butenko, A., Firsov, S., Kraeva, N., Elias, M., Field, M. C., . . . Lukes, J. (2016). Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. SCIENTIFIC REPORTS, 6. doi:10.1038/srep23704

    DOI: 10.1038/srep23704

    Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism (Journal article)

    Jackson, A. P., Otto, T. D., Aslett, M., Armstrong, S. D., Bringaud, F., Schlacht, A., . . . Berriman, M. (2016). Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism. Current Biology, 26(2), 161-172. doi:10.1016/j.cub.2015.11.055

    DOI: 10.1016/j.cub.2015.11.055

    2015

    Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax (Journal article)

    Jackson, A., Goyard, S., Xia, D., Foth, B. J., Sanders, M., Wastling, J., . . . Berriman, M. (2015). Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax. PLoS Neglected Tropical Diseases, 9(8). doi:10.1371/journal.pntd.0003975

    DOI: 10.1371/journal.pntd.0003975

    Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty (Journal article)

    Carnes, J., Anupama, A., Balmer, O., Jackson, A., Lewis, M., Brown, R., . . . Schnaufer, A. (2015). Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty. PLOS NEGLECTED TROPICAL DISEASES, 9(1). doi:10.1371/journal.pntd.0003404

    DOI: 10.1371/journal.pntd.0003404

    Genome evolution in trypanosomatid parasites (Journal article)

    Jackson, A. P. (2015). Genome evolution in trypanosomatid parasites. PARASITOLOGY, 142, S40-S56. doi:10.1017/S0031182014000894

    DOI: 10.1017/S0031182014000894

    Preface: the evolution of parasite genomes and the origins of parasitism (Journal article)

    Jackson, A. P. (2015). Preface: the evolution of parasite genomes and the origins of parasitism. PARASITOLOGY, 142, S1-S5. doi:10.1017/S0031182014001516

    DOI: 10.1017/S0031182014001516

    2014

    A comprehensive evaluation of rodent malaria parasite genomes and gene expression (Journal article)

    Otto, T. D., Boehme, U., Jackson, A. P., Hunt, M., Franke-Fayard, B., Hoeijmakers, W. A. M., . . . Janse, C. J. (2014). A comprehensive evaluation of rodent malaria parasite genomes and gene expression. BMC BIOLOGY, 12. doi:10.1186/s12915-014-0086-0

    DOI: 10.1186/s12915-014-0086-0

    The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction (Journal article)

    Jackson, A. P., Otto, T. D., Darby, A., Ramaprasad, A., Xia, D., Echaide, I. E., . . . Pain, A. (2014). The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. Nucleic Acids Research, 42(11), 7113-7131. doi:10.1093/nar/gku322

    DOI: 10.1093/nar/gku322

    The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction. (Journal article)

    Jackson, A. P., Otto, T. D., Darby, A., Ramaprasad, A., Xia, D., Echaide, I. E., . . . Pain, A. (2014). The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.. Nucleic Acids Research, 42(11), 7113-7131.

    2013

    The Evolution of Antigenic Variation in African Trypanosomes (Chapter)

    Jackson, A. P., & Barry, J. D. (n.d.). The Evolution of Antigenic Variation in African Trypanosomes. In Evolution of Virulence in Eukaryotic Microbes (pp. 324-336). John Wiley & Sons, Inc.. doi:10.1002/9781118308165.ch17

    DOI: 10.1002/9781118308165.ch17

    A Cell-surface Phylome for African Trypanosomes (Journal article)

    Jackson, A. P., Allison, H. C., Barry, J. D., Field, M. C., Hertz-Fowler, C., & Berriman, M. (2013). A Cell-surface Phylome for African Trypanosomes. PLOS NEGLECTED TROPICAL DISEASES, 7(3). doi:10.1371/journal.pntd.0002121

    DOI: 10.1371/journal.pntd.0002121

    2012

    Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS). (Journal article)

    Lawton, J., Brugat, T., Yan, Y. X., Reid, A. J., Böhme, U., Otto, T. D., . . . Langhorne, J. (2012). Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).. BMC genomics, 13, 125. doi:10.1186/1471-2164-13-125

    DOI: 10.1186/1471-2164-13-125

    Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species (Journal article)

    Jackson, A. P., Berry, A., Aslett, M., Allison, H. C., Burton, P., Vavrova-Anderson, J., . . . Berriman, M. (2012). Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(9), 3416-3421. doi:10.1073/pnas.1117313109

    DOI: 10.1073/pnas.1117313109

    GeneDB-an annotation database for pathogens (Journal article)

    Logan-Klumpler, F. J., De Silva, N., Boehme, U., Rogers, M. B., Velarde, G., McQuillan, J. A., . . . Berriman, M. (2012). GeneDB-an annotation database for pathogens. NUCLEIC ACIDS RESEARCH, 40(D1), D98-D108. doi:10.1093/nar/gkr1032

    DOI: 10.1093/nar/gkr1032

    2010

    Leishmania-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition (Journal article)

    Depledge, D. P., MacLean, L. M., Hodgkinson, M. R., Smith, B. A., Jackson, A. P., Ma, S., . . . Smith, D. F. (2010). Leishmania-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition. PLOS NEGLECTED TROPICAL DISEASES, 4(9). doi:10.1371/journal.pntd.0000829

    DOI: 10.1371/journal.pntd.0000829

    The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis (Journal article)

    Jackson, A. P., Sanders, M., Berry, A., McQuillan, J., Aslett, M. A., Quail, M. A., . . . Hertz-Fowler, C. (2010). The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis. PLOS NEGLECTED TROPICAL DISEASES, 4(4). doi:10.1371/journal.pntd.0000658

    DOI: 10.1371/journal.pntd.0000658

    The Evolution of Amastin Surface Glycoproteins in Trypanosomatid Parasites (Journal article)

    Jackson, A. P. (2010). The Evolution of Amastin Surface Glycoproteins in Trypanosomatid Parasites. MOLECULAR BIOLOGY AND EVOLUTION, 27(1), 33-45. doi:10.1093/molbev/msp214

    DOI: 10.1093/molbev/msp214

    The genome sequence of Trypanosoma brucei gambiense: the causative agent of chronic sleeping sickness (Journal article)

    Jackson, A. P., Sanders, M., Berry, A., McQuillan, J., Aslett, M. A., Quail, M. A., . . . Hertz-Fowler, C. (2010). The genome sequence of Trypanosoma brucei gambiense: the causative agent of chronic sleeping sickness. PLoS Neglected Tropical Diseases, 4, e658. Retrieved from http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0000658

    2009

    Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement (Journal article)

    Jackson, A. P., Thomas, G. H., Parkhill, J., & Thomson, N. R. (2009). Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement. BMC GENOMICS, 10. doi:10.1186/1471-2164-10-584

    DOI: 10.1186/1471-2164-10-584

    Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans (Journal article)

    Jackson, A. P., Gamble, J. A., Yeomans, T., Moran, G. P., Saunders, D., Harris, D., . . . Berriman, M. (2009). Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans. GENOME RESEARCH, 19(12), 2231-2244. doi:10.1101/gr.097501.109

    DOI: 10.1101/gr.097501.109

    2008

    Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa) (Journal article)

    Jackson, A. P., Quail, M. A., & Berriman, M. (2008). Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa). BMC GENOMICS, 9. doi:10.1186/1471-2164-9-594

    DOI: 10.1186/1471-2164-9-594

    Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei (Journal article)

    Hertz-Fowler, C., Figueiredo, L. M., Quail, M. A., Becker, M., Jackson, A., Bason, N., . . . Berriman, M. (2008). Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei. PLOS ONE, 3(10). doi:10.1371/journal.pone.0003527

    DOI: 10.1371/journal.pone.0003527

    The genome of the simian and human malaria parasite Plasmodium knowlesi (Journal article)

    Pain, A., Bohme, U., Berry, A. E., Mungall, K., Finn, R. D., Jackson, A. P., . . . Berriman, M. (2008). The genome of the simian and human malaria parasite Plasmodium knowlesi. NATURE, 455(7214), 799-7U7. doi:10.1038/nature07306

    DOI: 10.1038/nature07306

    Multi-locus phylogenetic analysis of neotropical figs does not support co-speciation with the pollinators: The importance of systematic scale in fig/wasp cophylogenetic studies (Journal article)

    Jackson, A. P., Machado, C. A., Robbins, N., & Herre, E. A. (2008). Multi-locus phylogenetic analysis of neotropical figs does not support co-speciation with the pollinators: The importance of systematic scale in fig/wasp cophylogenetic studies. Symbiosis, 45(1-3), 57-72.

    Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems? (Journal article)

    Allen, J. W. A., Jackson, A. P., Rigden, D. J., Willis, A. C., Ferguson, S. J., & Ginger, M. L. (2008). Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems?. FEBS JOURNAL, 275(10), 2385-2402. doi:10.1111/j.1742-4658.2008.06380.x

    DOI: 10.1111/j.1742-4658.2008.06380.x

    2007

    Evolutionary consequences of a large duplication event in Trypanosoma brucei: Chromosomes 4 and 8 are partial duplicons (Journal article)

    Jackson, A. P. (2007). Evolutionary consequences of a large duplication event in Trypanosoma brucei: Chromosomes 4 and 8 are partial duplicons. BMC GENOMICS, 8. doi:10.1186/1471-2164-8-432

    DOI: 10.1186/1471-2164-8-432

    Tandem gene arrays in Trypanosoma brucei: Comparative phylogenomic analysis of duplicate sequence variation (Journal article)

    Jackson, A. P. (2007). Tandem gene arrays in Trypanosoma brucei: Comparative phylogenomic analysis of duplicate sequence variation. BMC EVOLUTIONARY BIOLOGY, 7. doi:10.1186/1471-2148-7-54

    DOI: 10.1186/1471-2148-7-54

    Origins of amino acid transporter loci in trypanosomatid parasites. (Journal article)

    Jackson, A. P. (2007). Origins of amino acid transporter loci in trypanosomatid parasites.. BMC evolutionary biology, 7, 26. doi:10.1186/1471-2148-7-26

    DOI: 10.1186/1471-2148-7-26

    2006

    Evolution of Tubulin Gene Arrays in Trypanosomatid parasites: genomic restructuring in Leishmania (Journal article)

    Jackson, A. P., Vaughan, S., & Gull, K. (2006). Evolution of Tubulin Gene Arrays in Trypanosomatid parasites: genomic restructuring in Leishmania. BMC GENOMICS, 7. doi:10.1186/1471-2164-7-261

    DOI: 10.1186/1471-2164-7-261

    Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp (Journal article)

    Jackson, A. P., Vaughan, S., & Gull, K. (2006). Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp. BMC GENOMICS, 7. doi:10.1186/1471-2164-7-137

    DOI: 10.1186/1471-2164-7-137

    2005

    The effect of paralogous lineages on the application of reconciliation analysis by cophylogeny mapping. (Journal article)

    Jackson, A. (2005). The effect of paralogous lineages on the application of reconciliation analysis by cophylogeny mapping.. Systematic biology, 54(1), 127-145. doi:10.1080/10635150590905911

    DOI: 10.1080/10635150590905911