Understanding pathogens

Understanding how pathogens cause disease

We are studying the interactions between pathogens and their hosts and looking at key molecular, cellular and immunological processes involved in disease. Highlights of our current work include:

 

Antimicrobial Resistance (AMR)

We are working on projects using genomics and molecular techniques to study the evolution, population behaviour and pathogenicity of bacterial pathogens associated with high levels of antibiotic resistance, and aiming to develop better therapies against them.

Dean Everett and team MalawiS‌evere respiratory infections

We are working with high risk groups in Malawi to understand the impact of influenza on more vulnerable parts of society. Read more...

 

HIV Blood sampleHIV co-infections

We are researching the interaciton between ‌HIV and other infections such as Hepatitis B, tuberculosis, malaria and hepatitis C. Read more...

 

Photograph of children and cattle standing in a river.River Blindness in Africa

We have found that the parasitic worm which causes River Blindness carries bacteria that help it trick the body's immune system into thinking it is fighting a different infection. Read more...

 

Scientific image of influenza virusThe host response to influenza infection

We are investigating how proteins secreted by cells in our airways can help defend against the flu virus. Read more...

 


Latest news

 

Major new MRC funding for pneumococcal research

A five year Medical Research Council (MRC) Programme grant totalling more than £1.5 million has been awarded to determine the bacterial, host and environmental factors that lead to pneumococcal disease. Read more...

 

Phage therapy shown to kill drug-resis/media/livacuk/infectionandglobalhealth/sliderbannerimages/Antibiotics,banner.jpgtant superbug

Scientists from the Institute of Infection and Global Health have shown that phage therapy could offer a safe and effective alternative to antibiotics in the treatment of Cystic Fibrosis lung infections. Read more...

 

Simple changes to antibiotic treatment of MRSA may help beat the bacteria

A study co-lead by Professor Aras Kadioglu have identified how MRSA may be more effectively treated by modern-day antibiotics, if old-fashioned penicillin is also used. Read More...

 

Genomic data reveals emergence in Africa of drug resistant strain of typhoid

In partnership with the Liverpool School of Tropical Medicine and the Wellcome Trust Sanger Institute we have revealed the emergence of a novel strain of Typhoid fever in Malawi, Africa. Read more...

 

Pre-clinical development of a new generation of pneumococcal vaccines.

Prof Aras Kadioglu, Dr Marie Yang and Dr Dean Everett were awarded £246,783 from Meningitis Now for the project “The preclinical development and evaluation of a mucosal protein-based adjuvanted vaccine against pneumococcal meningitis and sepsis”. Read More...

 

Scientists discover bacterial cause behind fatal heart complications

We have shown that the cause of Streptococcus pneumoniae associated cardiac injury is a toxin called pneumolysin, which is released by the bacteria during infection. Read more...

 

Hot Desert storms increase risk of bacterial meningitis in Africa

A study led by Professor Aras Kadioglu found that exposure to airborne dust and high temperatures are significant risk factors for bacterial meningitis. Read more...

 

Scientists investigate extent of severe respiratory infection in Malawi

We have been awarded more than £3 million to define the nature and extent of influenza-associated Severe Acute Respiratory Infection (SARI) amongst adults and children in Malawi. Read more...