Most of the group's current research programme is centred on the use of Influenza A virus, respiratory syncytial virus (RSV) and murine γ-herpesvirus-68 (MHV-68) to study pathogenesis, immunology and virus-host interactions in the respiratory tract. In addition, there are projects working on the pathogenesis of ovine herpesvirus 2 (OvHV-2) in malignant catarrhal fever of domestic cattle and the role of equine herpesvirus 5 in equine multinodular pulmonary fibrosis.
MAJOR CURRENT PROJECT - Investigating the host response to Influenza infection
The respiratory epithelium secretes multiple proteins that function in innate defence. With funding from the BBSRC, and in collaboration with Dr Colin Bingle (Sheffield) and Professor Ralph Tripp (University of Georgia Athens), the group is currently investigating the role of the BFPIFA1 protein in defence mechanisms against influenza A infection. The team is using genetic models in combination with state-of-the-art genomic and proteomic analysis to carry out the work which lead to a better understanding of fundamental aspects of the host response to infection.
Further information on projects, groups members and additional online resources can be found here.