Bacterial Pathogenicity

About our Research

Research themes covered by the Bacterial Pathogenicity Group include:

  • Understanding pneumococcal diversity and population structure and its impact on the evolution of drug resistance using whole genome sequencing. Respiratory viral pathogen diversity, spread and evolution (Dr. Dean Everett).
  • Microbiology of black (haem) - pigmenting anaerobes (BPAs) and the pathogenic mechanisms through which they initiate and maintain periodontal (gum) disease in diabetes. Haem as a virulence up-regulatory factor in BPAs, the role of their secreted proteases in the haem acquisition process and in dysregulation of host defences (Dr. John Smalley).
  • Use of genomics and molecular techniques to study Gram-negative bacterial pathogens, specifically their evolution, population behaviour and pathogenicity. Particularly, Pseudomonas aeruginosa, Escherichia coli and Campylobacter (Professor Craig Winstanley).
  • Bacterial pathogenesis & host pathogen interactions (species including Streptococcus pneumoniae, S. pyogenes, S. suis, Pseudomonas aeruginosa). Host immune responses. Vaccines and Therapeutics (Professor Aras Kadioglu).