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GeneMill Synthetic Biology services

The CGR is now offering open access to synthetic biology services through the new allied research facility, GeneMill.

Synthetic biology is an emerging field that has been described as the construction of artificial biological devices, pathways or networks or the re-engineering of existing ones.

RoboLector

The Liverpool GeneMill has been funded by the BBSRC with an initial investment of £3M to establish a facility for the rapid high throughput construction and testing of synthetic DNA constructs. Liverpool GeneMill removes complexity for the end user, providing end-to-end design, construction and phenotypic validation of libraries of gene constructs for academic and industrial applications.

Services now include:

  • Construct design
  • DNA synthesis (sequence verified); from plasmid libraries to artificial chromosomes
  • Genome editing tools e.g. CRISPR/Cas9 and TALENs
  • Protein design and expression systems (including bacteria, yeast, plant, mammalian and cell-free systems)
  • Protein expression and function prototyping
  • Scalable fermentation analysis
  • Metabolomic / proteomic analyses.

Applications of synthetic biology include:

  • Structure / function analysis
  • Directed evolution
  • De novo design
  • Synthetic pathway creation and biosensors
  • Biological re-engineering.

These services can be applied to a variety of research topics such as:

  • Agri-chem
  • Bio-engineering
  • Biofuels
  • Plant sciences
  • Life sciences
  • Pharmaceuticals
  • Designer chemicals
  • Flavours and fragrances.

In addition to synthetic biology services, the GeneMill offers consultancy and training.