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PRODID:-//University of Liverpool//University Events//EN
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UID:20261011T120029-110291-UniversityOfLiverpool
DTSTAMP:20261011T120029
DTSTART:20251009T130000
DTEND:20251009T140000
LOCATION:Physiology seminar room, Nuffield Wing, 
SUMMARY:Professor Michael Clague - 'Ubiquitin: receptor sorting and selective autophagy'
DESCRIPTION:Michael Clague obtained a PhD in biological chemistry from University of Essex. For postdoctoral work he moved to NIH, Bethesda, USA to study the biophysics of membrane fusion. An EMBO long term fellowship allowed him to move to EMBL, Heidelberg, to study cell biology (membrane trafficking) for the first time. He was then appointed to a faculty position at Liverpool , where he is currently Professor of Molecular and Cellular Physiology.Early work at Liverpool focused on the role of phosphoinositide metabolism along the endocytic pathway. He was drawn into the ubiquitin field through studies of the MET receptor trafficking itinerary and has since developed a specific interest in the family of deubiquitylases. Working together with Sylvie Urbé, he investigates these enzymes in pathways germane to cancer and neurodegeneration. Contributions span foundational biology to development and characterisation of tool compound inhibitors. Work on USP30 has helped establish it as an actionable target for Parkinson’s Disease and led to a broader interest in mitophagy and pexophagy pathways.All welcome.
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