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PRODID:-//University of Liverpool//University Events//EN
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UID:20260509T174231-110290-UniversityOfLiverpool
DTSTAMP:20260509T174231
DTSTART:20251113T130000
DTEND:20251113T140000
LOCATION:Physiology seminar room, Nuffield Wing, 
SUMMARY:Professor Matthias Soller - 'Keeping RNA regulation in shape for health'
DESCRIPTION:Matthias Soller received his PhD in 1997 at the University of Zurich, Switzerland. He then moved to Brandeis University, Boston, USA to study RNA binding proteins and their function in alternative splicing regulation in axon guidance, synaptic plasticity and neuronal degeneration using Drosophila as a model system with Kalpana White.In 2006, Matthias Soller started his own research group in the School of Biosciences at the University of Birmingham, UK. He is currently Professor of RNA Biology in the Division of Molecular and Cellular Function at The University of Manchester.His work is concerned about post-transcriptional control of gene-expression in the brain, adaptive immunity and cancer as well as in the regulation of behaviour. The Soller laboratory has been pioneering in studying complex alternative splicing of Down Syndrome Cell Adhesion Molecule and mRNA methylation in a genetic model organism. Fundamental contributions to the discovery of biological functions of mRNA internal m6A methylation in the regulating gene expression include an essential role in sex determination and dosage compensation. More recently, the Soller laboratory has generated the first animal knock-out for methylation of mRNA cap-adjacent nucleotides and discovered an essential role in local translation at synapses relevant to reward learning.
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