Juvenile Idiopathic Arthritis (JIA)

JIA is a condition characterised by inflammation of one or more joints for which there is no known cause.

There are several types of arthritis that fall under the term JIA, with all presenting under the age of 16 years. It is a chronic disease and around half of children will continue to suffer from arthritis as adults. There are approximately 12,000 children (1 in 1000) in the UK under 16 years of age that have JIA, with 1 in 10,000 children diagnosed each year.

There are a number of treatments for JIA including anti-inflammatory drugs, disease-modifying drugs, and biologics. Not all children respond to these drugs in the same way and some may develop side effects. Therefore, it is crucial to continue looking for new treatments.

One study that the EATC4Children has led nationally is the HTA-funded study of ‘Steroid Induction Regime in JIA (SIR-JIA); HTA14/167/0 (CI: E. Baildam). This is a feasibility study to determine whether it is possible to conduct a future randomised controlled trial to assess steroid treatment regimens in JIA. The study has closed for recruitment and is now close to completion.

Early phase JIA clinical trials that the EATC4Children are involved in include:

Experimental medicine/pre-clinical studies currently running:

  • Investigation of T cells in patients with psoriasis and/or psoriatic arthritis. Results from this study will provide new insights into the pathophysiology of psoriasis and psoriatic arthritis, and biomarkers for disease progression (CI: C. Hedrich)


List (provided by the NIHR) of research studies taking place across the UK for children and young people with JIA.

Back to: Experimental Arthritis Treatment Centre for Children