Dr Shirley Leung
Research Associate School of Physical Sciences
- Work email S.C.Leung@liverpool.ac.uk
Publications
2019
Antimalarial activity of primaquine operates via a two-step biochemical relay (Journal article)
Camarda, G., Jirawatcharadech, P., Priestley, R. S., Saif, A., March, S., Wong, M. H. L., . . . Biagini, G. A. (2019). Antimalarial activity of primaquine operates via a two-step biochemical relay. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-11239-0
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis (Journal article)
Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., . . . O'Neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(4), 1414-1419. doi:10.1073/pnas.1816585116
2018
Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties (Journal article)
David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371
2017
Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis. (Journal article)
Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A. V., . . . Nixon, G. L. (2017). Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.. Journal of medicinal chemistry, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718
2015
2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties (Journal article)
Charoensutthivarakul, S., Hong, W. D., Leung, S. C., Gibbons, P. D., Bedingfield, P. T. P., Nixon, G. L., . . . O'Neill, P. M. (2015). 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties. MEDCHEMCOMM, 6(7), 1252-1259. doi:10.1039/c5md00062a
2012
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria (Journal article)
Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., . . . Ward, S. A. (2012). Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(21), 8298-8303. doi:10.1073/pnas.1205651109
Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods (Journal article)
Sharma, R., Lawrenson, A. S., Fisher, N. E., Warman, A. J., Shone, A. E., Hill, A., . . . Berry, N. G. (2012). Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods. JOURNAL OF MEDICINAL CHEMISTRY, 55(7), 3144-3154. doi:10.1021/jm3001482
Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)
Pidathala, C., Amewu, R., Pacorel, B., Nixon, G. L., Gibbons, P., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1831-1843. doi:10.1021/jm201179h
Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)
Leung, S. C., Gibbons, P., Amewu, R., Nixon, G. L., Pidathala, C., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1844-1857. doi:10.1021/jm201184h
The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc(1) protein complex (Journal article)
Cowley, R., Leung, S., Fisher, N., Al-Helal, M., Berry, N. G., Lawrenson, A. S., . . . O'Neill, P. M. (2012). The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc(1) protein complex. MEDCHEMCOMM, 3(1), 39-44. doi:10.1039/c1md00183c
2010
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. (Journal article)
Pacorel, B., Leung, S. C., Stachulski, A. V., Davies, J., Vivas, L., Lander, H., . . . O'Neill, P. M. (2010). Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.. Journal of medicinal chemistry, 53(2), 633-640. doi:10.1021/jm901216v