Photo of Dr Shirley Leung

Dr Shirley Leung

Research Associate School of Physical Sciences

Publications

2019

Antimalarial activity of primaquine operates via a two-step biochemical relay (Journal article)

Camarda, G., Jirawatcharadech, P., Priestley, R. S., Saif, A., March, S., Wong, M. H. L., . . . Biagini, G. A. (2019). Antimalarial activity of primaquine operates via a two-step biochemical relay. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-11239-0

DOI: 10.1038/s41467-019-11239-0

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis (Journal article)

Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., . . . O'Neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(4), 1414-1419. doi:10.1073/pnas.1816585116

DOI: 10.1073/pnas.1816585116

2018

Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties (Journal article)

David Hong, W., Leung, S. C., Amporndanai, K., Davies, J., Priestley, R. S., Nixon, G. L., . . . O'Neill, P. M. (2018). Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties. ACS Medicinal Chemistry Letters, 9(12), 1205-1210. doi:10.1021/acsmedchemlett.8b00371

DOI: 10.1021/acsmedchemlett.8b00371

2017

Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis. (Journal article)

Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A. V., . . . Nixon, G. L. (2017). Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.. Journal of medicinal chemistry, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718

DOI: 10.1021/acs.jmedchem.6b01718

2015

2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties (Journal article)

Charoensutthivarakul, S., Hong, W. D., Leung, S. C., Gibbons, P. D., Bedingfield, P. T. P., Nixon, G. L., . . . O'Neill, P. M. (2015). 2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties. MEDCHEMCOMM, 6(7), 1252-1259. doi:10.1039/c5md00062a

DOI: 10.1039/c5md00062a

2012

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria (Journal article)

Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., . . . Ward, S. A. (2012). Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(21), 8298-8303. doi:10.1073/pnas.1205651109

DOI: 10.1073/pnas.1205651109

Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods (Journal article)

Sharma, R., Lawrenson, A. S., Fisher, N. E., Warman, A. J., Shone, A. E., Hill, A., . . . Berry, N. G. (2012). Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods. JOURNAL OF MEDICINAL CHEMISTRY, 55(7), 3144-3154. doi:10.1021/jm3001482

DOI: 10.1021/jm3001482

Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)

Pidathala, C., Amewu, R., Pacorel, B., Nixon, G. L., Gibbons, P., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Bisaryl Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1831-1843. doi:10.1021/jm201179h

DOI: 10.1021/jm201179h

Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2) (Journal article)

Leung, S. C., Gibbons, P., Amewu, R., Nixon, G. L., Pidathala, C., Hong, W. D., . . . O'Neill, P. M. (2012). Identification, Design and Biological Evaluation of Heterocyclic Quinolones Targeting Plasmodium falciparum Type II NADH:Quinone Oxidoreductase (PfNDH2). JOURNAL OF MEDICINAL CHEMISTRY, 55(5), 1844-1857. doi:10.1021/jm201184h

DOI: 10.1021/jm201184h

The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc(1) protein complex (Journal article)

Cowley, R., Leung, S., Fisher, N., Al-Helal, M., Berry, N. G., Lawrenson, A. S., . . . O'Neill, P. M. (2012). The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc(1) protein complex. MEDCHEMCOMM, 3(1), 39-44. doi:10.1039/c1md00183c

DOI: 10.1039/c1md00183c

2010

Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. (Journal article)

Pacorel, B., Leung, S. C., Stachulski, A. V., Davies, J., Vivas, L., Lander, H., . . . O'Neill, P. M. (2010). Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.. Journal of medicinal chemistry, 53(2), 633-640. doi:10.1021/jm901216v

DOI: 10.1021/jm901216v