Photo of Dr Marc Little

Dr Marc Little

Research Co-ordinator (Cooper Group) Chemistry

    Publications

    Selected Publications

    1. Trapping virtual pores by crystal retro-engineering (Journal article - 2015)
    2. Controlling the Crystallization of Porous Organic Cages: Molecular Analogs of Isoreticular Frameworks Using Shape-Specific Directing Solvents (Journal article - 2014)
    3. Separation of rare gases and chiral molecules by selective binding in porous organic cages (Journal article - 2014)
    4. Porous Organic Cages for Sulfur Hexafluoride Separation (Journal article - 2016)
    5. Acid- and Base-Stable Porous Organic Cages: Shape Persistence and pH Stability via Post-synthetic "Tying" of a Flexible Amine Cage (Journal article - 2014)

    2020

    Nano-assemblies of a soluble conjugated organic polymer and an inorganic semiconductor for sacrificial photocatalytic hydrogen production from water. (Journal article)

    Yang, H., Amari, H., Liu, L., Zhao, C., Gao, H., He, A., . . . Cooper, A. I. (2020). Nano-assemblies of a soluble conjugated organic polymer and an inorganic semiconductor for sacrificial photocatalytic hydrogen production from water.. Nanoscale. doi:10.1039/d0nr05801g

    DOI: 10.1039/d0nr05801g

    Corrigendum: Inducing Social Self-Sorting in Organic Cages To Tune The Shape of The Internal Cavity. (Journal article)

    Abet, V., Szczypinski, F. T., Little, M. A., Santolini, V., Jones, C. D., Evans, R., . . . Slater, A. G. (2020). Corrigendum: Inducing Social Self-Sorting in Organic Cages To Tune The Shape of The Internal Cavity.. Angewandte Chemie (International ed. in English), 59(46), 20272. doi:10.1002/anie.202012719

    DOI: 10.1002/anie.202012719

    Crosslinked Polyimide and Reduced Graphene Oxide Composites as Long Cycle Life Positive Electrode for Lithium-Ion Cells (Journal article)

    Gao, H., Tian, B., Yang, H., Neale, A. R., Little, M. A., Sprick, R. S., . . . Cooper, A. I. (2020). Crosslinked Polyimide and Reduced Graphene Oxide Composites as Long Cycle Life Positive Electrode for Lithium-Ion Cells. CHEMSUSCHEM, 13(20), 5571-5579. doi:10.1002/cssc.202001389

    DOI: 10.1002/cssc.202001389

    The Chemistry of Porous Organic Molecular Materials (Journal article)

    Little, M. A., & Cooper, A. I. (2020). The Chemistry of Porous Organic Molecular Materials. ADVANCED FUNCTIONAL MATERIALS, 30(41). doi:10.1002/adfm.201909842

    DOI: 10.1002/adfm.201909842

    3D Cage COFs: A Dynamic Three-Dimensional Covalent Organic Framework with High-Connectivity Organic Cage Nodes. (Journal article)

    Zhu, Q., Wang, X., Clowes, R., Cui, P., Chen, L., Little, M. A., & Cooper, A. I. (2020). 3D Cage COFs: A Dynamic Three-Dimensional Covalent Organic Framework with High-Connectivity Organic Cage Nodes.. Journal of the American Chemical Society. doi:10.1021/jacs.0c07732

    DOI: 10.1021/jacs.0c07732

    Structure–activity relationships in well-defined conjugated oligomer photocatalysts for hydrogen production from water (Journal article)

    Aitchison, C. M., Sachs, M., Little, M. A., Wilbraham, L., Brownbill, N. J., Kane, C. M., . . . Cooper, A. I. (2020). Structure–activity relationships in well-defined conjugated oligomer photocatalysts for hydrogen production from water. Chemical Science. doi:10.1039/d0sc02675a

    DOI: 10.1039/d0sc02675a

    An Expandable Hydrogen-Bonded Organic Framework Characterized by Three-Dimensional Electron Diffraction. (Journal article)

    Cui, P., Svensson Grape, E., Spackman, P. R., Wu, Y., Clowes, R., Day, G. M., . . . Cooper, A. I. (2020). An Expandable Hydrogen-Bonded Organic Framework Characterized by Three-Dimensional Electron Diffraction.. Journal of the American Chemical Society, 142(29), 12743-12750. doi:10.1021/jacs.0c04885

    DOI: 10.1021/jacs.0c04885

    Photocatalytic Proton Reduction by a Computationally Identified, Molecular Hydrogen-Bonded Framework (Journal article)

    Aitchison, C., Kane, C., McMahon, D. P., Spackman, P., Wang, X., Wilbraham, L., . . . Cooper, A. (2020). Photocatalytic Proton Reduction by a Computationally Identified, Molecular Hydrogen-Bonded Framework. Journal of Materials Chemistry A, 2020(15), 7158-7170. doi:10.1039/d0ta00219d

    DOI: 10.1039/d0ta00219d

    Organic Cage Dumbbells (Journal article)

    Greenaway, R. L., Santolini, V., Szczypinski, F. T., Bennison, M. J., Little, M. A., Marsh, A., . . . Cooper, A. I. (2020). Organic Cage Dumbbells. CHEMISTRY-A EUROPEAN JOURNAL, 26(17), 3718-3722. doi:10.1002/chem.201905623

    DOI: 10.1002/chem.201905623

    2019

    From Concept to Crystals via Prediction: Multi-Component Organic Cage Pots by Social Self-Sorting (Journal article)

    Greenaway, R. L., Santolini, V., Pulido, A., Little, M. A., Alston, B., Briggs, M., . . . Jelfs, K. E. (2019). From Concept to Crystals via Prediction: Multi-Component Organic Cage Pots by Social Self-Sorting. Angewandte Chemie (German version), 131(45), 16421-16427. doi:10.1002/ange.201909237

    DOI: 10.1002/ange.201909237

    Barely porous organic cages for hydrogen isotope separation (Journal article)

    Liu, M., Zhang, L., Little, M. A., Kapil, V., Ceriotti, M., Yang, S., . . . Cooper, A. (2019). Barely porous organic cages for hydrogen isotope separation. Science, 366(6465), 613-620. doi:10.1126/science.aax7427

    DOI: 10.1126/science.aax7427

    From Concept to Crystals via Prediction: Multi-Component Organic Cage Pots by Social Self-Sorting (Journal article)

    Greenaway, R. L., Santolini, V., Pulido, A., Little, M. A., Alston, B. M., Briggs, M. E., . . . Jelfs, K. E. (2019). From Concept to Crystals via Prediction: Multi-Component Organic Cage Pots by Social Self-Sorting. Angewandte Chemie International Edition, 58(45), 16275-16281. doi:10.1002/anie.201909237

    DOI: 10.1002/anie.201909237

    Mining predicted crystal structure landscapes with high throughput crystallisation: old molecules, new insights (Journal article)

    Cui, P., McMahon, D. P., Spackman, P. R., Alston, B. M., Little, M. A., Day, G. M., & Cooper, A. I. (2019). Mining predicted crystal structure landscapes with high throughput crystallisation: old molecules, new insights. CHEMICAL SCIENCE, 10(43), 9988-9997. doi:10.1039/c9sc02832c

    DOI: 10.1039/c9sc02832c

    Synthesis of a Large, Shape-Flexible, Solvatomorphic Porous Organic Cage (Journal article)

    Teng, B., Little, M. A., Hasell, T., Chong, S. Y., Jelfs, K. E., Clowes, R., . . . Cooper, A. I. (2019). Synthesis of a Large, Shape-Flexible, Solvatomorphic Porous Organic Cage. CRYSTAL GROWTH & DESIGN, 19(7), 3647-3651. doi:10.1021/acs.cgd.8b01761

    DOI: 10.1021/acs.cgd.8b01761

    2018

    Sulfone-containing covalent organic frameworks for photocatalytic hydrogen evolution from water (Journal article)

    Wang, X., Chen, L., Chong, S. Y., Little, M. A., Wu, Y., Zhu, W. -H., . . . Cooper, A. I. (2018). Sulfone-containing covalent organic frameworks for photocatalytic hydrogen evolution from water. Nature Chemistry, 10(12), 1180-1189. doi:10.1038/s41557-018-0141-5

    DOI: 10.1038/s41557-018-0141-5

    Computational modelling of solvent effects in a prolific solvatomorphic porous organic cage (Journal article)

    McMahon, D. P., Stephenson, A., Chong, S. Y., Little, M. A., Jones, J. T. A., Cooper, A. I., & Day, G. M. (2018). Computational modelling of solvent effects in a prolific solvatomorphic porous organic cage. FARADAY DISCUSSIONS, 211, 383-399. doi:10.1039/c8fd00031j

    DOI: 10.1039/c8fd00031j

    High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis (Journal article)

    Greenaway, R. L., Santolini, V., Bennison, M. J., Alston, B. A., Pugh, C. J., Little, M. A., . . . Cooper, A. I. (2018). High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis. Nature Communications, 9. doi:10.1038/s41467-018-05271-9

    DOI: 10.1038/s41467-018-05271-9

    Near-Ideal Xylene Selectivity in Adaptive Molecular Pillar[n]arene Crystals (Journal article)

    Jie, K., Liu, M., Zhou, Y., Little, M., Pulido, A., Chong, S., . . . Cooper, A. (2018). Near-Ideal Xylene Selectivity in Adaptive Molecular Pillar[n]arene Crystals. Journal of the American Chemical Society, 140(22), 6921-6930. doi:10.1021/jacs.8b02621

    DOI: 10.1021/jacs.8b02621

    Cage Doubling: Solvent-Mediated Re-equilibration of a [3+6] Prismatic Organic Cage to a Large [6+12] Truncated Tetrahedron (Journal article)

    Pugh, C. J., Santolini, V., Greenaway, R. L., Little, M. A., Briggs, M. E., Jelfs, K. E., & Cooper, A. I. (2018). Cage Doubling: Solvent-Mediated Re-equilibration of a [3+6] Prismatic Organic Cage to a Large [6+12] Truncated Tetrahedron. CRYSTAL GROWTH & DESIGN, 18(5), 2759-2764. doi:10.1021/acs.cgd.7b01422

    DOI: 10.1021/acs.cgd.7b01422

    A solution-processable dissymmetric porous organic cage (Journal article)

    Slater, A. G., Little, M. A., Briggs, M. E., Jelfs, K. E., & Cooper, A. I. (2018). A solution-processable dissymmetric porous organic cage. MOLECULAR SYSTEMS DESIGN & ENGINEERING, 3(1), 223-227. doi:10.1039/c7me00090a

    DOI: 10.1039/c7me00090a

    2017

    Design and Synthesis of 3D Porous Diamondoid Frameworks by Cocrystallization (Conference Paper)

    Tothadi, S., Little, M. A., Hasell, T., Briggs, M. E., Chong, S. Y., & Cooper, A. I. (2017). Design and Synthesis of 3D Porous Diamondoid Frameworks by Cocrystallization. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 73 (pp. C470). doi:10.1107/S2053273317091033

    DOI: 10.1107/S2053273317091033

    Modular assembly of porous organic cage crystals: isoreticular quasiracemates and ternary co-crystal (Journal article)

    Tothadi, S., Little, M. A., Hasell, T., Briggs, M. E., Chong, S. Y., Liu, M., & Cooper, A. I. (2017). Modular assembly of porous organic cage crystals: isoreticular quasiracemates and ternary co-crystal. CRYSTENGCOMM, 19(33), 4933-4941. doi:10.1039/c7ce00783c

    DOI: 10.1039/c7ce00783c

    Computationally-Guided Synthetic Control over Pore Size in Isostructural Porous Organic Cages (Journal article)

    Slater, A. G., Reiss, P. S., Pulido, A., Little, M. A., Holden, D. L., Chen, L., . . . Cooper, A. I. (2017). Computationally-Guided Synthetic Control over Pore Size in Isostructural Porous Organic Cages. ACS CENTRAL SCIENCE, 3(7), 734-742. doi:10.1021/acscentsci.7b00145

    DOI: 10.1021/acscentsci.7b00145

    Chirality as a tool for function in porous organic cages (Journal article)

    Hasell, T., Little, M. A., Chong, S. Y., Schmidtmann, M., Briggs, M. E., Santolini, V., . . . Cooper, A. I. (2017). Chirality as a tool for function in porous organic cages. NANOSCALE, 9(20), 6783-6790. doi:10.1039/c7nr01301a

    DOI: 10.1039/c7nr01301a

    Computer-guided porous materials design: from rationalization to prediction (Conference Paper)

    Pulido, A., Slater, A. G., Chen, L., Little, M. A., Chong, S. Y., Holden, D., . . . Day, G. M. (2017). Computer-guided porous materials design: from rationalization to prediction. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 73 (pp. A289). doi:10.1107/S010876731709715X

    DOI: 10.1107/S010876731709715X

    Functional materials discovery using energy–structure–function maps (Journal article)

    Pulido, A., Chen, L., Kaczorowski, T., Holden, D., Little, M. A., Chong, S. Y., . . . Day, G. M. (2017). Functional materials discovery using energy–structure–function maps. Nature, 543(7647), 657-664. doi:10.1038/nature21419

    DOI: 10.1038/nature21419

    Styrene Purification by Guest-Induced Restructuring of Pillar[6]arene (Journal article)

    Jie, K., Liu, M., Zhou, Y., Llittle, M. A., Bonakala, S., Chong, S. Y., . . . Cooper, A. I. (2017). Styrene Purification by Guest-Induced Restructuring of Pillar[6]arene. Journal of the American Chemical Society, 139(8), 2908-2911. doi:10.1021/jacs.6b13300

    DOI: 10.1021/jacs.6b13300

    Reticular synthesis of porous molecular 1D nanotubes and 3D networks (Journal article)

    Slater, A. G., Little, M. A., Pulido, A., Chong, S. Y., Holden, D., Chen, L., . . . Cooper, A. I. (2017). Reticular synthesis of porous molecular 1D nanotubes and 3D networks. Nature Chemistry, 9, 17-25. doi:10.1038/nchem.2663

    DOI: 10.1038/nchem.2663

    2016

    Periphery-Functionalized Porous Organic Cages (Journal article)

    Reiss, P. S., Little, M. A., Santolini, V., Chong, S. Y., Hasell, T., Jelfs, K. E., . . . Cooper, A. I. (2016). Periphery-Functionalized Porous Organic Cages. CHEMISTRY-A EUROPEAN JOURNAL, 22(46), 16547-16553. doi:10.1002/chem.201603593

    DOI: 10.1002/chem.201603593

    Three-dimensional Protonic Conductivity in Porous Organic Cage Solids (Journal article)

    Liu, M., Chen, L., Lewis, S., Chong, S. Y., Little, M. A., Hasell, T., . . . Cooper, A. I. (2016). Three-dimensional Protonic Conductivity in Porous Organic Cage Solids. Nature Communications, 7. doi:10.1038/ncomms12750

    DOI: 10.1038/ncomms12750

    A Unified Treatment of the Relationship Between Ligand Substituents and Spin State in a Family of Iron(II) Complexes (Journal article)

    Cook, L. J. K., Kulmaczewski, R., Mohammed, R., Dudley, S., Barrett, S. A., Little, M. A., . . . Halcrow, M. A. (2016). A Unified Treatment of the Relationship Between Ligand Substituents and Spin State in a Family of Iron(II) Complexes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 55(13), 4327-4331. doi:10.1002/anie.201600165

    DOI: 10.1002/anie.201600165

    Porous Organic Cages for Sulfur Hexafluoride Separation (Journal article)

    Hasell, T., Miklitz, M., Stephenson, A., Little, M. A., Chong, S. Y., Clowes, R., . . . Cooper, A. I. (2016). Porous Organic Cages for Sulfur Hexafluoride Separation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138(5), 1653-1659. doi:10.1021/jacs.5b11797

    DOI: 10.1021/jacs.5b11797

    2015

    Dynamic flow synthesis of porous organic cages (Journal article)

    Briggs, M. E., Slater, A. G., Lunt, N., Jiang, S., Little, M. A., Greenaway, R. L., . . . Cooper, A. I. (2015). Dynamic flow synthesis of porous organic cages. CHEMICAL COMMUNICATIONS, 51(98), 17390-17393. doi:10.1039/c5cc07447a

    DOI: 10.1039/c5cc07447a

    The effect of solvent choice on the gelation and final hydrogel properties of Fmoc-diphenylalanine (Journal article)

    Raeburn, J., Mendoza-Cuenca, C., Cattoz, B. N., Little, M. A., Terry, A. E., Cardoso, A. Z., . . . Adams, D. J. (2015). The effect of solvent choice on the gelation and final hydrogel properties of Fmoc-diphenylalanine. SOFT MATTER, 11(5), 927-935. doi:10.1039/c4sm02256d

    DOI: 10.1039/c4sm02256d

    Hydrogels formed from Fmoc amino acids (Journal article)

    Draper, E. R., Morris, K. L., Little, M. A., Raeburn, J., Colquhoun, C., Cross, E. R., . . . Adams, D. J. (2015). Hydrogels formed from Fmoc amino acids. CRYSTENGCOMM, 17(42), 8047-8057. doi:10.1039/c5ce00801h

    DOI: 10.1039/c5ce00801h

    Trapping virtual pores by crystal retro-engineering (Journal article)

    Little, M., Briggs, M., Jones, J., Schmidtmann, M., Hasell, T., Chong, S., . . . Cooper, A. (2015). Trapping virtual pores by crystal retro-engineering. Nature Chemistry, 7(02), 153-159. doi:10.1038/nchem.2156

    DOI: 10.1038/nchem.2156

    2014

    Separation of rare gases and chiral molecules by selective binding in porous organic cages (Journal article)

    Chen, L., Reiss, P., Chong, S., Holden, D., Jelfs, K., Hasell, T., . . . Cooper, A. (2014). Separation of rare gases and chiral molecules by selective binding in porous organic cages. Nature Materials, 13(10), 954-960. doi:10.1038/nmat4035

    DOI: 10.1038/nmat4035

    Guest control of structure in porous organic cages (Journal article)

    Little, M. A., Chong, S. Y., Schmidtmann, M., Hasell, T., & Cooper, A. I. (2014). Guest control of structure in porous organic cages. CHEMICAL COMMUNICATIONS, 50(67), 9465-9468. doi:10.1039/c4cc04158e

    DOI: 10.1039/c4cc04158e

    Complex thermal expansion properties in a molecular honeycomb lattice (Journal article)

    Loughrey, J. J., Comyn, T. P., Apperley, D. C., Little, M. A., & Halcrow, M. A. (2014). Complex thermal expansion properties in a molecular honeycomb lattice. Chemical Communications, 50(57), 7601. doi:10.1039/c4cc02198c

    DOI: 10.1039/c4cc02198c

    Acid- and Base-Stable Porous Organic Cages: Shape Persistence and pH Stability via Post-synthetic "Tying" of a Flexible Amine Cage (Journal article)

    Liu, M., Little, M. A., Jelfs, K. E., Jones, J. T. A., Schmidtmann, M., Chong, S. Y., . . . Cooper, A. I. (2014). Acid- and Base-Stable Porous Organic Cages: Shape Persistence and pH Stability via Post-synthetic "Tying" of a Flexible Amine Cage. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(21), 7583-7586. doi:10.1021/ja503223j

    DOI: 10.1021/ja503223j

    Iron(II) complexes of 2,6-di(1H-pyrazol-3-yl)-pyridine derivatives with hydrogen bonding and sterically bulky substituents. (Journal article)

    Roberts, T. D., Little, M. A., Kershaw Cook, L. J., & Halcrow, M. A. (2014). Iron(II) complexes of 2,6-di(1H-pyrazol-3-yl)-pyridine derivatives with hydrogen bonding and sterically bulky substituents.. Dalton transactions (Cambridge, England : 2003), 43(20), 7577-7588. doi:10.1039/c4dt00355a

    DOI: 10.1039/c4dt00355a

    Hexasulfanyl analogues of cyclotriveratrylene (Journal article)

    Little, M. A., Loughrey, J. J., Santoro, A., Halcrow, M. A., & Hardie, M. J. (2014). Hexasulfanyl analogues of cyclotriveratrylene. Tetrahedron Letters, 55(15), 2530-2533. doi:10.1016/j.tetlet.2014.03.025

    DOI: 10.1016/j.tetlet.2014.03.025

    Controlling the Crystallization of Porous Organic Cages: Molecular Analogs of Isoreticular Frameworks Using Shape-Specific Directing Solvents (Journal article)

    Hasell, T., Culshaw, J. L., Chong, S., Schmidtmann, M., Little, M., Jelfs, K. E., . . . Cooper, A. (2014). Controlling the Crystallization of Porous Organic Cages: Molecular Analogs of Isoreticular Frameworks Using Shape-Specific Directing Solvents. Journal of the American Chemical Society, 136(4), 1438-1448. doi:10.1021/ja409594s

    DOI: 10.1021/ja409594s

    Design and Synthesis of 3D Porous Diamondoid Frameworks by Cocrystallization (Conference Paper)

    Tothadi, S., Little, M. A., Hasell, T., Briggs, M. E., Chong, S. Y., & Cooper, A. I. (2014). Design and Synthesis of 3D Porous Diamondoid Frameworks by Cocrystallization. In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES Vol. 70 (pp. C470). Retrieved from http://gateway.webofknowledge.com/

    Predicted crystal energy landscapes of porous organic cages (Journal article)

    Pyzer-Knapp, E. O., Thompson, H. P. G., Schiffmann, F., Jelfs, K. E., Chong, S. Y., Little, M. A., . . . Day, G. M. (2014). Predicted crystal energy landscapes of porous organic cages. CHEMICAL SCIENCE, 5(6), 2235-2245. doi:10.1039/c4sc00095a

    DOI: 10.1039/c4sc00095a