Chemistry at the University of Liverpool

Medicinal and Bio-nano Chemistry

Key Publications

O'Neill journal cover‌                      

O'Neil cover                                           Carnell cover

Medicinal Chemistry, Nanomedicines and  Chemical Biology

M. J. Capper, Gareth. S.A. Wright et al., The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation, Nature Communications, 2018, 9, 1693 DOI: 10.1038/s41467-018-04114-x

Bakshi, R. P., Tatham, L. M., Savage, A. C., Tripathi, A. K., Mlambo, G., Ippolito, M. M. et al;.. Long-acting injectable atovaquone nanomedicines for malaria prophylaxis. Nature Communications, 2018, 9. DOI: 10.1038/s41467-017-02603-z

O'Neill, P. M.; Amewu, R. K. et al., A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature Communications, 2017, 8, 15159 DOI: 10.1038/ncomms15159

Giardiello, M., Liptrott, N. J., McDonald, T. O., Moss, D., Siccardi, M., Martin, P., et al. (2016). Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies. Nature Communications, 2016, 7. doi:10.1038/ncomms13184

Ismail, H.M.; Barton, V.E.; Panchana, M.; Charoensutthivarakul, S. et al., A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile, Angewandte Chemie-International Edition 2016, 55, 6401-6405

Ismail, H. M.; Barton, V.; Phanchana, M.; Charoensutthivarakul, S.; Wong, M. H. L. et al.,  Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. Proc. Natl. Acad. Sci. U. S. A.,2016, 113, 2080-2085 DOI: 10.1073/pnas.1600459113

Capper, M. J., O'Neill, P. M., Fisher, N., Strange, R. W., Moss, D., Ward, S. A., et al. (2015). Antimalarial 4(1H)-pyridones bind to the Q(i) site of cytochrome bc(1). Proc. Natl. Acad. Sci. U. S. A.,2015, 112(3), 755-760. DOI: 10.1073/pnas.1416611112

Hatton, F. L., Tatham, L. M., Tidbury, L. R., Chambon, P., He, T., Owen, A., & Rannard, S. P. (2015). Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium. Chemical Science, 2015, 6(1), 326-334. DOI: 10.1039/c4sc02889a

Hatton, F. L., Chambon, P., McDonald, T. O., Owen, A., & Rannard, S. P. (2014). Hyperbranched polydendrons: a new controlled macromolecular architecture with self-assembly in water and organic solvents. Chemical Science, 5(5), 2014, 1844-1853. DOI: 10.1039/c4sc00360h 

Olorunniji, F. J., McPherson, A. L., Pavlou, H. J., McIlwraith, M. J., Brazier, J. A., Cosstick, R. et al.  Nicked-site substrates for a serine recombinase reveal enzyme-DNA communications and an essential tethering role of covalent enzyme-DNA linkages Nucleic Acids Res, 2015, 43(12), 6134-6143. doi:10.1093/nar/gkv521

Alexander, K. J., McConville, M., Williams, K. R., Luzyanin, K. V., O'Neil, I. A., & Cosstick, R. Chemistry of the 8-Nitroguanine DNA Lesion: Reactivity, Labelling and Repair. Chemistry- A European Journal, 2018, 24(12), 3013-3020. DOI: 10.1002/chem.201705541

Synthesis Methodology, Green Chemistry and Mechanochemistry

Barday, M.; Janot, C.; Halcovitch, N. R.; Muir, J.; Aïssa, C. Cross-Coupling of a-Carbonyl Sulfoxonium Ylides with C–H Bonds. Angew. Chem. Int. Ed. 2017, 56, 13117–13121. DOI: 10.1002/anie.201706804

Aïssa, C.; Ho, K. Y. T.; Tetlow, D. J.; Pin-No, M. Diastereoselective Carbocyclization of 1,6-Heptadienes Triggered by Rhodium-Catalyzed Activation of an Olefinic C-H Bond. Angew. Chem. Int. Ed. 2014, 53, 4209–4212.

Jakoobi, M.; Halcovitch, N.; Whitehead, G. F. S.; Sergeev, A. G. Selective Arene Cleavage by Direct Insertion of Iridium into the Aromatic Ring. Angew. Chem. Int Ed., 2017, 56, 3266-3269; doi: 10.1002/anie.201611409

Sergeev, A. G.; Hartwig, J. F. Selective, Nickel-Catalyzed Hydrogenolysis of Aryl Ethers.  Science 2011, 332, 439-443. DOI: 10.1126/science.1200437

Akbulatov, S.; Tian, Y.; Huang, Z.; Kucharski, T. J.; Yang, Q.; Boulatov, R. Experimentally realized mechanochemistry distinct from force-accelerated dissociation of loaded bonds. Science, 2017, 357, 299-303 DOI: 10.1126/science.aan1026

Zhang, H.; Li, X.; Lin, Y.; Gao, F.; Tang, Z.; Su, P.; Zhang, W.; Xu, Y.; Weng, W.; Boulatov, R. Multimodal mechanophores based on cinnamate dimers. Nature Commun., 2017, 8, 1147; DOI: 10.1038/s41467-017-01412-8

McKenna, S. M., Mines, P., Law, P., Kovacs-Schreiner, K., Birmingham, W. R., et al.  The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC). Green Chemistry, 2017, 19(19), 4660-4665. DOI: 10.1039/c7gc01696d

McKenna, S. M., Leimkuehler, S., Herter, S., Turner, N. J., & Carnell, A. J.  Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem. Green Chemistry, 2015, 17(6), 3271-3275. DOI: 10.1039/c5gc00707k