Medicinal and Bio-nano Chemistry

Key Publications

O'Neill journal cover‌                      

O'Neil cover                                           Carnell cover

Carnell AJ, Luo Y, Berry NG (2012) Chiral bicyclic [2.2.2] octadiene ligands for Rh-catalysed catalytic asymmetric conjugate additions to acyclic enones: A quantitative structure-property relationship. Chemical Communications vol 48 issue 27 pp 3279 – 3281 http://dx.doi.org/10.1039/C2CC17120A

Ho Kyth, Aissa C (2012) Regioselective Cycloaddition of 3-Azetidinones and 3-Oxetanones with Alkynes through Nickel-Catalysed Carbon-Carbon Bond Activation. Chemistry - A European Journal vol 18  pp 3486-3489. DOI: 10.1002/chem.201200167

Bhamra I, Compagnone-Post P, O'Neil IA,  Iwanejko LA,  Bates AD and Cosstick R (2012) Base-pairing preferences, physicochemical properties and mutational behavior of the DNA lesion 8-nitroguanine. Nucleic Acids Research vol 40 (21):11126-11138. DOI: 10.1093/nar/gks799

Stachulski Andrew V, Pidathala Chandrakala, Row Eleanor C, Sharma Raman, Berry Neil G, Iqbal Mazhar, Bentley Joanne, Allman Sarah A, Edwards Geoffrey, Helm Alison, Hellier Jennifer, Korba Brent E, Semple J Edward and Rossignol Jean-Francois (2011) Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication. Journal of Medicinal Chemistry vol 54 issue 12 pp 4119-4132 http://pubs.acs.org/doi/abs/10.1021/jm200153p

Krpetic Z, Saleemi S, Prior IA, Sée V, Qureshi R and Brust M (2011) Negotiation of intracellular membrane barriers by TAT-modified gold nanoparticles. ACS Nano vol 5 issue 6 pp 5195-5201. DOI: 10.1021/nn201369k

Chadwick, J, Amewu, RK, Marti, F, Bousejra-El Garah, F, Sharma, R, Berry, NG, Stocks, PA, Burrell-Saward, H, Wittlin, S, Rottmann, M, Brun, R, Taramelli, D, Parapini, S, Ward, SA, O'Neill, PM (2011) Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action. ChemMedChem vol 6 pp 1357-136 http://dx.doi.org/10.1002/cmdc.201100196

Holden DL, Goulding HV, Bacsa J, Berry NG, Greeves N, Stephenson RA, Harrington RW, Clegg W, Fogg AM (2011) Unusual hybrid materials prepared by the oxidation of a ketone.  Crystal Growth and Design  vol 11 issue 7 pp 3013-3019. DOI: 10.1021/cg200286t

A. G. Sergeev, J. F. Hartwig (2011) Selective, Nickel-Catalyzed Hydrogenolysis of Aryl Ethers. Science vol 332  pp 439-443. DOI: 10.1126/science.1200437

Sasnauskas G, Zakrys L, Zaremba M, Cosstick R, Gaynor J, Halford S and Siksnys V (2010) A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3'-5' and 5'-3' strands by rotating a single active site. Nucleic Acids Research vol 38 issue 7 pp 2399-2410. DOI: 10.1093/nar/gkp1194

Crepin D, Dawick J, Aissa C (2010) Combined Rhodium-Catalyzed Carbon-Hydrogen Activation and Beta-Carbon Elimination to access Eight-Membered Rings. Angewandte Chemie International Edition vol 49 pp 620-623 http://dx.doi.org/10.1002/chin.201021065

Luo Y, Carnell AJ (2010) Chemoenzymatic Synthesis and Application of Bicyclo[2.2.2]octadiene Ligands: Increased Efficiency in Rhodium-Catalysed Asymmetric Conjugate Additions by Electronic Tuning. Angewandte Chemie International Edition vol 49  pp 2750-2754. DOI: 10.1002/anie.200907033

Aspinall HC, Greeves NG and Lo Fan Hin S (2010) A new Yb3+- catalyzed pinacol and imine coupling reaction. Tetrahedron Letters vol 51 issue 12 pp 1558-1561. DOI: 10.1016/j.tetlet.2010.01.057

O'Neill, P. M. Amewu, R. K. Nixon, G. L. ElGarah, F. B. Mungthin, M. Chadwick, J. Shone, A. E. Vivas, L. Lander, H. Barton, V. Muangnoicharoen, S. Bray, P. G. Davies, J. Park, B. K. Wittlin, S. Brun, R. Preschel, M. Zhang, K. S. Ward, S. A. (2010) Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins. Angewandte Chemie-International Edition vol 49  pp 5693-5697. DOI: 10.1002/anie.201001026

Yang Qing-Zheng, Huang Zhen, Kucharski Timothy J, Khvostichenko Daria, Chen Joseph and Boulatov Roman (2009) A molecular force probe. Nat. Nanotechnol. vol 4  pp 302-306. DOI: 10.1038/nnano.2009.55

Kucharski Timothy J, Huang Zhen, Yang Qing-Zheng, Tian Yancong, Rubin Nicholas C, Concepcion Carlos D and Boulatov Roman (2009) Kinetics of Thiol/Disulfide Exchange Correlate Weakly with the Restoring Force in the Disulfide Moiety. Angew. Chem., Int. Ed. vol 48  pp 7040-7043, S7040/1-S7040/43. DOI: 10.1002/anie.200901511

Whynes R, Gonzales Barriuso M, Cosstick R and Volk M (2009) Nitrobenzyl Phototrigger for Fast Protein Folding Processes. Biophysical Journal vol 96 Supplement 1 pp 324a http://dx.doi.org/10.1016/j.bpj.2008.12.1629

O'Neill PM, Park BK, Shone AE, Maggs JL, Roberts P, Stocks PA, Biagini GA, Bray PG, Gibbons P, Berry N, Winstanley PA, Mukhtar A, Bonar-Law R, Hindley S, Bambal RB, Davis CB, Bates M, Hart TK, Gresham SL, Lawrence RM, Brigandi RA, Gomez-Delas-Heras FM, Gargallo DV and Ward SA. (2009) Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century. Journal of Medicinal Chemistry vol 52 issue 5 pp 1408-1415 http://dx.doi.org/10.1021/jm8012618

I. A. O'Neil and I. Bhamra (2009) The Synthesis of functionalised Peptides using alpha-Lithio Quinuclidine N-Oxide (Li-QNO). Tetrahedron Letters vol 50 pp 3635-363 http://dx.doi.org/10.1016/j.tetlet.2009.03.105

J.V.M. Weaver, S.P. Rannard and A.I. Cooper (2009) Polymer-mediated hierarchical and reversible emulsion droplet assembly. Angewandte Chemie Vol 48, 12, pp 2131–2134. DOI: 10.1002/anie.200805448

Nativo P, Prior IA and Brust M (2008) Uptake and intracellular fate of surface-modified gold nanoparticles. ACS Nano vol 2 issue 8 pp 1639-1644. DOI: 10.1021/nn800330a

Zhang, H, Wang, D, Butler, R, Campbell, NL, Long, J, Tan, B, Duncalf, DJ, Foster, AJ, Hopkinson, A, Taylor, D, Angus, D, Cooper, AI, Rannard, SP (2008) Formation and enhanced biocidal activity of water-dispersable organic nanoparticles. Nature Nanotechnology vol 3  pp 506-511. DOI: 10.1038/nnano.2008.188

A. G. Sergeev, A. Spannenberg, M. Beller (2008) Palladium-Catalyzed Formylation of Aryl Bromides: Elucidation of the Catalytic Cycle of an Industrially Applied Coupling Reaction. J. Am. Chem. Soc. vol 130  pp 15549-15563. DOI: 10.1021/ja804997z