2024
A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts (Preprint)
DOI: 10.1101/2024.04.10.588847
Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community. (Journal article)
Dalby, M. J., Pekovic-Vaughan, V., Shanley, D. P., Swift, J., White, L. J., & Canty-Laird, E. G. (2024). Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.. BioEssays : news and reviews in molecular, cellular and developmental biology, e2300223. doi:10.1002/bies.202300223DOI: 10.1002/bies.202300223
2023
Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue. (Journal article)
Zakic, T., Pekovic-Vaughan, V., Cvoro, A., Korac, A., Jankovic, A., & Korac, B. (2023). Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue.. FEBS letters. doi:10.1002/1873-3468.14794DOI: 10.1002/1873-3468.14794
ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING (Conference Paper)
Pekovic-Vaughan, V., Sutton, E., Carter, A., Fawcett, S., Moore, H., Sarumi, D., & Bou-Gharios, G. (2023). ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 4). doi:10.1016/j.freeradbiomed.2023.03.042DOI: 10.1016/j.freeradbiomed.2023.03.042
THE DISCREPANCY BETWEEN MORPHOLOGICAL AND FUNCTIONAL ACTIVATION OF BROWN ADIPOSE TISSUE IN THE ABSENCE OF FUNCTIONAL NRF2 (Conference Paper)
Zakic, T., Soskic, M. B., Stojanovic, S., Jankovic, A., Korac, A., Pekovic-Vaughan, V., & Korac, B. (2023). THE DISCREPANCY BETWEEN MORPHOLOGICAL AND FUNCTIONAL ACTIVATION OF BROWN ADIPOSE TISSUE IN THE ABSENCE OF FUNCTIONAL NRF2. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 25). doi:10.1016/j.freeradbiomed.2023.03.109DOI: 10.1016/j.freeradbiomed.2023.03.109
Giannos, P., Prokopidis, K., Candow, D. G., Forbes, S. C., Celoch, K., Isanejad, M., . . . Scott, D. (2023). Shorter sleep duration is associated with greater visceral fat mass in US adults: Findings from NHANES, 2011-2014.. Sleep medicine, 105, 78-84. doi:10.1016/j.sleep.2023.03.013DOI: 10.1016/j.sleep.2023.03.013
2022
Redox-metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation (Journal article)
Zakic, T., Stojanovic, S., Jankovic, A., Korac, A., Pekovic-Vaughan, V., & Korac, B. (2022). Redox-metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation. BIOFACTORS. doi:10.1002/biof.1931DOI: 10.1002/biof.1931
STRUCTURAL AND REDOX-METABOLIC REMODELLING OF BROWN ADIPOSE TISSUE IN MICE LACKING NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 UNDER BASAL CONDITIONS AND COLD ACCLIMATION (Conference Paper)
Zakic, T., Ninkovic, A., Stojanovic, S., Soskic, M. B., Kalezic, A., Jankovic, A., . . . Korac, B. (2022). STRUCTURAL AND REDOX-METABOLIC REMODELLING OF BROWN ADIPOSE TISSUE IN MICE LACKING NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 UNDER BASAL CONDITIONS AND COLD ACCLIMATION. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 189 (pp. 5-6). Retrieved from https://www.webofscience.com/
2021
A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock (Conference Paper)
Sutton, E., Carter, A., Fawcett, S., Sarumi, D., Copple, I., & Pekovic-Vaughan, V. (2021). A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.103DOI: 10.1016/j.freeradbiomed.2021.08.103
NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions (Conference Paper)
Sutton, E., Early, J., Hughes, A., Gall, L., Carter, A., Copple, I., . . . Pekovic-Vaughan, V. (2021). NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.042DOI: 10.1016/j.freeradbiomed.2021.08.042
Korac, B., Kalezic, A., Pekovic-Vaughan, V., Korac, A., & Jankovic, A. (2021). Redox changes in obesity, metabolic syndrome, and diabetes. REDOX BIOLOGY, 42. doi:10.1016/j.redox.2021.101887DOI: 10.1016/j.redox.2021.101887
2019
Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner (Conference Paper)
Sutton, E., Carter, A., Early, J., Fawcett, S., Sarumi, D., Bechtold, D., & Pekovic-Vaughan, V. (2019). Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 139 (pp. S52). Retrieved from https://www.webofscience.com/
The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis (Conference Paper)
Sarumi, D., Carter, A., Fawcett, S. A., Sutton, E., Van derhorst, G. T. J., Kearns, V., . . . Pekovic-Vaughan, V. (2019). The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A45). Retrieved from https://www.webofscience.com/
2018
Rogers, E. H., Hunt, J. A., & Pekovic-Vaughan, V. (2018). Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration?. BIOGERONTOLOGY, 19(6), 497-517. doi:10.1007/s10522-018-9772-6DOI: 10.1007/s10522-018-9772-6
Rogers, E. H., Pekovic-Vaughan, V., & Hunt, J. A. (2018). Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials. BIOMEDICINE-TAIWAN, 8(3), 3-12. doi:10.1051/bmdcn/2018080314DOI: 10.1051/bmdcn/2018080314
Rodriguez, B. M., Khouzami, L., Decostre, V., Varnous, S., Pekovic-Vaughan, V., Hutchison, C. J., . . . Muchir, A. (2018). N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene. Human Molecular Genetics, 27(19), 3353-3360. doi:10.1093/hmg/ddy243DOI: 10.1093/hmg/ddy243
A novel role for fibrillin 1 in the regulation of clock gene transcription and circadian rhythmicity through the TGF b pathway (Conference Paper)
Fawcett, S. A., & Pekovic-Vaughan, V. (2018). A novel role for fibrillin 1 in the regulation of clock gene transcription and circadian rhythmicity through the TGF b pathway. In Matrix biology Europe. Manchester.
Cellular mechano-environment regulates the mammary circadian clock (Conference Paper)
Yang, N., Williams, J., Pekovic-Vaughan, V., Wang, P., Olabi, S., McConnell, J., . . . Meng, Q. J. (2018). Cellular mechano-environment regulates the mammary circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A67). Retrieved from https://www.webofscience.com/
2017
Rogers, E. H., Fawcett, S. A., Pekovic-Vaughan, V., & Hunt, J. A. (2017). Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue. STEM CELLS INTERNATIONAL, 2017, 13 pages. doi:10.1155/2017/2057168DOI: 10.1155/2017/2057168
NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function (Conference Paper)
Horton, N. S., Copple, I. M., Vasilaki, A., Jackson, M. J., McArdle, A., & Pekovic-Vaughan, V. (2017). NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 108 (pp. S48). doi:10.1016/j.freeradbiomed.2017.04.174DOI: 10.1016/j.freeradbiomed.2017.04.174
Yang, N., Williams, J., Pekovic-Vaughan, V., Wang, P., Olabi, S., McConnell, J., . . . Meng, Q. -J. (2017). Cellular mechano-environment regulates the mammary circadian clock. Nature Communications, 8. doi:10.1038/ncomms14287DOI: 10.1038/ncomms14287
Ageing-induced osteoarthritis in nrf2 knockout mice (Conference Paper)
Lyon, M., Pekovic-Vaughan, V., & Poulet, B. (2017). Ageing-induced osteoarthritis in nrf2 knockout mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 98 (pp. A4). Retrieved from https://www.webofscience.com/
2016
Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression (Journal article)
Goljanek-Whysall, K., Iwanejko, L. A., Vasilaki, A., Pekovic-Vaughan, V., & McDonagh, B. (2016). Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression. MAMMALIAN GENOME, 27(7-8), 341-357. doi:10.1007/s00335-016-9643-xDOI: 10.1007/s00335-016-9643-x
Pharmacological manipulation of Nrf2/Keap1-mediated antioxidant defence pathway regulates the circadian clock (Conference Paper)
Horton, N., Copple, I., Park, K., Jackson, M., McArdle, A., & Pekovic-Vaughan, V. (2016). Pharmacological manipulation of Nrf2/Keap1-mediated antioxidant defence pathway regulates the circadian clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 96 (pp. S38-S39). doi:10.1016/j.freeradbiomed.2016.04.077DOI: 10.1016/j.freeradbiomed.2016.04.077
An ageing matrix weakens the breast circadian clock (Conference Paper)
Williams, J. L., Yang, N., Pekovic-Vaughan, V., Wang, P., McConnell, J., Olabi, S., . . . Meng, Q. J. (2016). An ageing matrix weakens the breast circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A2-A3). Retrieved from https://www.webofscience.com/
Nuclear lamins as mediators of mechano-transduction pathways regulating the temporal activation of circadian clock genes in skeletal muscle cells in response to mechanical cues (Conference Paper)
Roskell, C., Goldberg, M., Shanley, D., Clegg, P., & Pekovic-Vaughan, V. (2016). Nuclear lamins as mediators of mechano-transduction pathways regulating the temporal activation of circadian clock genes in skeletal muscle cells in response to mechanical cues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A19-A20). Retrieved from https://www.webofscience.com/
Tissue mechanics control the robustness of the circadian clock (Conference Paper)
Yang, N., Williams, J., Pekovic-Vaughan, V., Gossan, N., Hughes, A., Cheung, J., . . . Meng, Q. J. (2016). Tissue mechanics control the robustness of the circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A3). Retrieved from https://www.webofscience.com/
2014
Pekovic-Vaughan, V., Gibbs, J., Yoshitane, H., Yang, N., Pathiranage, D., Guo, B., . . . Meng, Q. -J. (2014). The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes and Development, 28(6), 548-560. doi:10.1101/gad.237081.113DOI: 10.1101/gad.237081.113
2011
Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation (Journal article)
Pekovic, V., Gibbs-Seymour, I., Markiewicz, E., Alzoghaibi, F., Benham, A. M., Edwards, R., . . . Hutchison, C. J. (2011). Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation. AGING CELL, 10(6), 1067-1079. doi:10.1111/j.1474-9726.2011.00750.xDOI: 10.1111/j.1474-9726.2011.00750.x
A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal (Journal article)
Korfali, N., Srsen, V., Waterfall, M., Batrakou, D. G., Pekovic, V., Hutchison, C. J., & Schirmer, E. C. (2011). A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal. PLOS ONE, 6(4). doi:10.1371/journal.pone.0018762DOI: 10.1371/journal.pone.0018762
2009
A-type lamins, disease and ageing: a stress-induced relationship? (Chapter)
Pekovic, V., & Hutchison, C. J. (2009). A-type lamins, disease and ageing: a stress-induced relationship?. In Unknown Book (Vol. 62, pp. 139-170).
2008
The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation (Journal article)
Ojeh, N., Pekovic, V., Jahoda, C., & Maatta, A. (2008). The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. JOURNAL OF CELL SCIENCE, 121(16), 2705-2717. doi:10.1242/jcs.025643DOI: 10.1242/jcs.025643
Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches (Journal article)
Pekovic, V., & Hutchison, C. J. (2008). Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches. JOURNAL OF ANATOMY, 213(1), 5-25. doi:10.1111/j.1469-7580.2008.00928.xDOI: 10.1111/j.1469-7580.2008.00928.x
2007
Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts (Journal article)
Pekovic, V., Harborth, J., Broers, J. L. V., Ramaekers, F. C. S., van Engelen, B., Lammens, M., . . . Markiewicz, E. (2007). Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts. JOURNAL OF CELL BIOLOGY, 176(2), 163-172. doi:10.1083/jcb.200606139DOI: 10.1083/jcb.200606139
