Photo of Dr Kazuhiro Yamamoto

Dr Kazuhiro Yamamoto PhD FHEA

Lecturer Musculoskeletal & Ageing Science

Research

Research Overview

Endocytosis in Health and Disease
I have discovered that normal healthy cartilage produces several tissue-degrading metalloproteinases, but that many are rapidly internalised and degraded by chondrocytes through the endocytic receptor LRP1. This clearing system applies to numerous biologically active molecules, suggesting that the OFF switch (endocytosis) is as important as the ON switch (synthesis) to keep the constant levels of molecules in the steady state tissue. Furthermore, disruption of this balance results in unbalanced tissue homeostasis, which may become the causes various pathological conditions. My current study proposing this new paradigm on endocytosis and tissue homeostasis expands beyond cartilage to include lung, cardiovascular and dental health and diseases.

Research Grants

Proteomic Profiling of Equine Teeth to Identify Age and Disease Related Differences

THE HORSE TRUST (UK)

November 2022 - April 2024

Abdulrahman Gremida / 201496381 (bench fees)

LIBYAN EMBASSY IN LONDON

April 2020 - March 2024

Bench fees for Miss Fawziah Mohammed A Asiri 201459736

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

October 2020 - September 2024

Sara Ibrahim AlSalhi 201369309 bench fees

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

March 2020 - February 2024

Bench fees for Bilge Sari 201527933

TURKISH EMBASSY (LONDON)

February 2021 - January 2025

Shedding of the endocytic receptor LRP1 in cartilage: A novel link to the development of osteoarthritis.

ARTHRITIS RESEARCH UK

June 2017 - June 2022