I am a (tenure-track) fellow based at the Institute for Aging and Chronic Disease (IACD) in the Apex building. My research focuses on tissue engineering of cartilage and bone, particularly how we apply advanced technologies to treat age-related diseases such as arthritis and osteoporosis.
Appropriate combinations of stem cells, biomaterials and bioreactors allow researchers to finely control the artificial microenviroment in vitro. My aims are to use this approach to generate lab-grown tissues to repair and restore damaged joints and return patients to health without the need for joint replacement.
My core interests are in i) how mechanotransduction (the cell response to exercise) interacts with growth factors and extracellular matrix signalling to regulate tissue development and repair, ii) recapitulating biological processes underlying neonatal tissue development to treat age-related degeneration.
I am also particularly interested in the development of bioreactors that can provide dynamic environments to cells in vitro, and using real time monitoring and sampling techniques to analyse the cell response.