Prof James Gallagher B.Sc., M.Sc., Ph.D.

Professor Musculoskeletal Biology I

    Publications

    2019

    A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria. (Journal article)

    Norman, B. P., Davison, A. S., Ross, G. A., Milan, A. M., Hughes, A. T., Sutherland, H., . . . Ranganath, L. R. (2019). A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.. Clinical chemistry. doi:10.1373/clinchem.2018.295345

    DOI: 10.1373/clinchem.2018.295345

    2018

    Alkaptonuria Severity Score Index Revisited: Analysing the AKUSSI and Its Subcomponent Features. (Journal article)

    Langford, B., Besford, M., Hall, A., Eddowes, L., Timmis, O., Gallagher, J. A., & Ranganath, L. (2018). Alkaptonuria Severity Score Index Revisited: Analysing the AKUSSI and Its Subcomponent Features.. JIMD reports, 41, 53-62. doi:10.1007/8904_2018_98

    DOI: 10.1007/8904_2018_98

    Assessment of Disease Progression in the Rare Disease Alkaptonuria by Quantitative Image Analysis (Thesis / Dissertation)

    Taylor, L. F. (2018, April 4). Assessment of Disease Progression in the Rare Disease Alkaptonuria by Quantitative Image Analysis.

    COMBINED LC-QTOF-MS URINE METABOLOMICS AND 18F-NAF PET IMAGING INDICATES NOVEL COMPOUNDS ASSOCIATED WITH SPINE OSTEOARTHROPATHY IN THE RARE DISEASE ALKAPTONURIA (Conference Paper)

    Norman, B. P., Taylor, L. F., Davison, A. S., Milan, A. M., Ross, G. A., Roberts, N. B., . . . Gallagher, J. A. (2018). COMBINED LC-QTOF-MS URINE METABOLOMICS AND 18F-NAF PET IMAGING INDICATES NOVEL COMPOUNDS ASSOCIATED WITH SPINE OSTEOARTHROPATHY IN THE RARE DISEASE ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S170). Retrieved from http://gateway.webofknowledge.com/

    Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone (Journal article)

    Davison, A. S., Harrold, J. A., Hughes, G., Norman, B. P., Devine, J., Usher, J., . . . Ranganath, L. R. (2018). Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone. MOLECULAR GENETICS AND METABOLISM, 125(1-2), 135-143. doi:10.1016/j.ymgme.2018.07.008

    DOI: 10.1016/j.ymgme.2018.07.008

    DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (Conference Paper)

    Norman, B. P., Ying, C. W., Sutherland, H., Wilson, P. J., Roberts, N. B., Duer, M. J., . . . Gallagher, J. A. (2018). DISRUPTION OF COLLAGEN TRIPLE HELIX HYDROGEN BONDING IN OCHRONOTIC HUMAN CARTILAGE IN ALKAPTONURIA OBSERVED BY DYNAMIC NUCLEAR POLARISATION-ENHANCED SOLID-STATE NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S99). Retrieved from http://gateway.webofknowledge.com/

    Data on items of AKUSSI in Alkaptonuria collected over three years from the United Kingdom National Alkaptonuria Centre and the impact of nitisinone. (Journal article)

    Griffin, R., Psarelli, E. E., Cox, T. F., Khedr, M., Milan, A. M., Davison, A. S., . . . Ranganath, L. R. (2018). Data on items of AKUSSI in Alkaptonuria collected over three years from the United Kingdom National Alkaptonuria Centre and the impact of nitisinone.. Data in brief, 20, 1620-1628. doi:10.1016/j.dib.2018.09.021

    DOI: 10.1016/j.dib.2018.09.021

    GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA (Conference Paper)

    Hughes, J. H., Liu, K., Sutherland, H., Wilson, P. J., Hughes, A. T., Milan, A. M., . . . Bou-Gharios, G. (2018). GENERATION AND PHENOTYPING OF A TARGETED MOUSE MODEL OF ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S89-S90). Retrieved from http://gateway.webofknowledge.com/

    Inflammatory and oxidative stress biomarkers in alkaptonuria: data from the DevelopAKUre project (Journal article)

    Braconi, D., Giustarini, D., Marzocchi, B., Peruzzi, L., Margollicci, M., Rossi, R., . . . Santucci, A. (2018). Inflammatory and oxidative stress biomarkers in alkaptonuria: data from the DevelopAKUre project. OSTEOARTHRITIS AND CARTILAGE, 26(8), 1078-1086. doi:10.1016/j.joca.2018.05.017

    DOI: 10.1016/j.joca.2018.05.017

    LASER ABLATION MACHINED SECTIONS PERMIT CORRELATIVE STUDIES OF HDMPS BY X-RAY MICROTOMOGRAPHY, OPTICAL AND SCANNING ELECTRON MICROSCOPY (Conference Paper)

    Boyde, A., Mills, D., Ranganath, L. A., & Gallagher, J. A. (2018). LASER ABLATION MACHINED SECTIONS PERMIT CORRELATIVE STUDIES OF HDMPS BY X-RAY MICROTOMOGRAPHY, OPTICAL AND SCANNING ELECTRON MICROSCOPY. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S74-S75). Retrieved from http://gateway.webofknowledge.com/

    LONGITUDINAL SURVEY FOR HIGH DENSITY MINERALISED PROTRUSIONS IDENTIFIED BY 3D DESS MRI IN PATIENTS OF THE OSTEOARTHRITIS INITIATIVE (Conference Paper)

    Thomas, N. P., Jeffery, N., Ranganath, L. R., Boyde, A., & Gallagher, J. A. (2018). LONGITUDINAL SURVEY FOR HIGH DENSITY MINERALISED PROTRUSIONS IDENTIFIED BY 3D DESS MRI IN PATIENTS OF THE OSTEOARTHRITIS INITIATIVE. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S467). Retrieved from http://gateway.webofknowledge.com/

    Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre (Journal article)

    Ranganath, L. R., Khedr, M., Milan, A. M., Davison, A. S., Hughes, A. T., Usher, J. L., . . . Gallagher, J. A. (2018). Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre. MOLECULAR GENETICS AND METABOLISM, 125(1-2), 127-134. doi:10.1016/j.ymgme.2018.07.011

    DOI: 10.1016/j.ymgme.2018.07.011

    RAMAN SPECTROSCOPY CAN NON-INVASIVELY DISTINGUISH BETWEEN OCHRONOTIC AND NON-OCHRONOTIC CARTILAGE (Conference Paper)

    Taylor, A. M., Jenks, D., Kammath, V. D., Norman, B., Dillon, J. P., Gallagher, J. A., . . . Kerns, J. G. (2018). RAMAN SPECTROSCOPY CAN NON-INVASIVELY DISTINGUISH BETWEEN OCHRONOTIC AND NON-OCHRONOTIC CARTILAGE. In OSTEOARTHRITIS AND CARTILAGE Vol. 26 (pp. S105). Retrieved from http://gateway.webofknowledge.com/

    Serum Amino Acid Profiling in Patients with Alkaptonuria Before and After Treatment with Nitisinone. (Journal article)

    Davison, A. S., Norman, B. P., Smith, E. A., Devine, J., Usher, J., Hughes, A. T., . . . Ranganath, L. R. (2018). Serum Amino Acid Profiling in Patients with Alkaptonuria Before and After Treatment with Nitisinone.. JIMD Reports, 41, 109-117. doi:10.1007/8904_2018_109

    DOI: 10.1007/8904_2018_109

    The Rare Disease, Alkaptonuria, Reveals New Mechanisms of Joint Destruction, Subchondral Cracking and HDMP Formation, that may be Prevalent in Osteoarthritis (Conference Paper)

    Gallagher, J. A., Thomas, N. P., Jeffery, N., Ranganath, L. R., & Boyde, A. (2018). The Rare Disease, Alkaptonuria, Reveals New Mechanisms of Joint Destruction, Subchondral Cracking and HDMP Formation, that may be Prevalent in Osteoarthritis. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 33 (pp. 245). Retrieved from http://gateway.webofknowledge.com/

    2017

    AN INVESTIGATION OF HIGH DENSITY MINERALISED PROTRUSIONS IN HUMAN CADAVERIC KNEES BY MRI AND MICROTOMOGRAPHY (Conference Paper)

    Thomas, N. P., Jeffery, N., van't Hof, R., Adams, V. L., Saers, J., Ranganath, L. R., . . . Gallagher, J. A. (2017). AN INVESTIGATION OF HIGH DENSITY MINERALISED PROTRUSIONS IN HUMAN CADAVERIC KNEES BY MRI AND MICROTOMOGRAPHY. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S253-S254). doi:10.1016/j.joca.2017.02.427

    DOI: 10.1016/j.joca.2017.02.427

    ANATOMICAL DISTRIBUTION OF 18F PET SIGNAL IN PATIENTS WITH OSTEOARTHROPATHY OF ALKAPTONURIA (Conference Paper)

    Taylor, L. F., Baker, M., Vinjamuri, S., Jeffery, N., Ranganath, L. R., & Gallagher, J. A. (2017). ANATOMICAL DISTRIBUTION OF 18F PET SIGNAL IN PATIENTS WITH OSTEOARTHROPATHY OF ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 25 (pp. S401). doi:10.1016/j.joca.2017.02.689

    DOI: 10.1016/j.joca.2017.02.689

    Assessment of the Effect of Once Daily Nitisinone Therapy on 24-h Urinary Metadrenalines and 5-Hydroxyindole Acetic Acid Excretion in Patients with Alkaptonuria After 4 Weeks of Treatment. (Journal article)

    Davison, A. S., Norman, B., Milan, A. M., Hughes, A. T., Khedr, M., Rovensky, J., . . . Ranganath, L. R. (2018). Assessment of the Effect of Once Daily Nitisinone Therapy on 24-h Urinary Metadrenalines and 5-Hydroxyindole Acetic Acid Excretion in Patients with Alkaptonuria After 4 Weeks of Treatment.. JIMD reports, 41, 1-10. doi:10.1007/8904_2017_72

    DOI: 10.1007/8904_2017_72

    Asymptomatic Corneal Keratopathy Secondary to Hypertyrosinaemia Following Low Dose Nitisinone and a Literature Review of Tyrosine Keratopathy in Alkaptonuria. (Journal article)

    Khedr, M., Judd, S., Briggs, M. C., Hughes, A. T., Milan, A. M., Stewart, R. M. K., . . . Ranganath, L. R. (2018). Asymptomatic Corneal Keratopathy Secondary to Hypertyrosinaemia Following Low Dose Nitisinone and a Literature Review of Tyrosine Keratopathy in Alkaptonuria.. JIMD reports, 40, 31-37. doi:10.1007/8904_2017_62

    DOI: 10.1007/8904_2017_62

    Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing (Journal article)

    Taylor, A. M., Hsueh, M. -F., Ranganath, L. R., Gallagher, J. A., Dillon, J. P., Huebner, J. L., . . . Kraus, V. B. (2017). Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing. RHEUMATOLOGY, 56(1), 156-164. doi:10.1093/rheumatology/kew355

    DOI: 10.1093/rheumatology/kew355

    Investigation of molecular regulators in osteoblast differentiation (Thesis / Dissertation)

    Osman, M. (2017, September 25). Investigation of molecular regulators in osteoblast differentiation.

    The effect of nitisinone on homogentisic acid and tyrosine: a two-year survey of patients attending the National Alkaptonuria Centre, Liverpool (Journal article)

    Milan, A. M., Hughes, A. T., Davison, A. S., Devine, J., Usher, J., Curtis, S., . . . Ranganath, L. R. (2017). The effect of nitisinone on homogentisic acid and tyrosine: a two-year survey of patients attending the National Alkaptonuria Centre, Liverpool. ANNALS OF CLINICAL BIOCHEMISTRY, 54(3), 323-330. doi:10.1177/0004563217691065

    DOI: 10.1177/0004563217691065

    2016

    Acute fatal metabolic complications in alkaptonuria (Journal article)

    Davison, A. S., Milan, A. M., Gallagher, J. A., & Ranganath, L. R. (2016). Acute fatal metabolic complications in alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 39(2), 203-210. doi:10.1007/s10545-015-9902-0

    DOI: 10.1007/s10545-015-9902-0

    Alkaptonuria: An example of a "fundamental disease"-A rare disease with important lessons for more common disorders (Journal article)

    Gallagher, J. A., Dillon, J. P., Sireau, N., Timmis, O., & Ranganath, L. R. (2016). Alkaptonuria: An example of a "fundamental disease"-A rare disease with important lessons for more common disorders. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 52, 53-57. doi:10.1016/j.semcdb.2016.02.020

    DOI: 10.1016/j.semcdb.2016.02.020

    Defining the Properties of an Array of -NH2-Modified Substrates for the Induction of a Mature Osteoblast/Osteocyte Phenotype from a Primary Human Osteoblast Population Using Controlled Nanotopography and Surface Chemistry (Journal article)

    Fawcett, S. A., Curran, J. M., Chen, R., Rhodes, N. P., Murphy, M. F., Wilson, P., . . . Hunt, J. A. (2017). Defining the Properties of an Array of -NH2-Modified Substrates for the Induction of a Mature Osteoblast/Osteocyte Phenotype from a Primary Human Osteoblast Population Using Controlled Nanotopography and Surface Chemistry. CALCIFIED TISSUE INTERNATIONAL, 100(1), 95-106. doi:10.1007/s00223-016-0202-y

    DOI: 10.1007/s00223-016-0202-y

    Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury (Journal article)

    Varley, I., Greeves, J. P., Sale, C., Friedman, E., Moran, D. S., Yanovich, R., . . . Gallagher, J. A. (2016). Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury. PURINERGIC SIGNALLING, 12(1), 103-113. doi:10.1007/s11302-016-9495-6

    DOI: 10.1007/s11302-016-9495-6

    IDENTIFICATION OF HIGH DENSITY MINERALISED PROTRUSIONS IN HUMAN KNEES EX-VIVO AND IN-SITU BY CLINICAL SCANNING TECHNIQUES (Journal article)

    Thomas, N. P., Jeffery, N., Dillon, B., Adams, V. L., Ranganath, L. R., Boyde, A., & Gallagher, J. A. (2016). IDENTIFICATION OF HIGH DENSITY MINERALISED PROTRUSIONS IN HUMAN KNEES EX-VIVO AND IN-SITU BY CLINICAL SCANNING TECHNIQUES. OSTEOARTHRITIS AND CARTILAGE, 24, S290-S291. doi:10.1016/j.joca.2016.01.533

    DOI: 10.1016/j.joca.2016.01.533

    Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy (Journal article)

    Nemethova, M., Radvanszky, J., Kadasi, L., Ascher, D. B., Pires, D. E. V., Blundell, T. L., . . . Zatkova, A. (2016). Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy. EUROPEAN JOURNAL OF HUMAN GENETICS, 24(1), 66-72. doi:10.1038/ejhg.2015.60

    DOI: 10.1038/ejhg.2015.60

    c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines (Journal article)

    Pacheco-Pantoja, E. L., Dillon, J. P., Wilson, P. J. M., Fraser, W. D., & Gallagher, J. A. (2016). c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines. Purinergic Signalling, 12(4), 647-651. doi:10.1007/s11302-016-9526-3

    DOI: 10.1007/s11302-016-9526-3

    2015

    ANALYSIS OF CARTILAGE BIOMARKERS OF AGING AND TURNOVER IN THE OSTEOARTHROPATHY OF ALKAPTONURIA (Conference Paper)

    Taylor, A. M., Hsueh, M. -F., Ranganath, L. R., Gallagher, J. A., Catterall, J. B., & Kraus, V. B. (2015). ANALYSIS OF CARTILAGE BIOMARKERS OF AGING AND TURNOVER IN THE OSTEOARTHROPATHY OF ALKAPTONURIA. In OSTEOARTHRITIS AND CARTILAGE Vol. 23 (pp. A135). doi:10.1016/j.joca.2015.02.867

    DOI: 10.1016/j.joca.2015.02.867

    Diagnostic tools and strategies for assessing disease progression in Alkaptonuria (Journal article)

    Ranganath, L., Psarelli, E., Cox, T., & Gallagher, J. (2015). Diagnostic tools and strategies for assessing disease progression in Alkaptonuria. Expert Opinion in Orphan Drugs, 3(6), 705-717. doi:10.1517/21678707.2015

    DOI: 10.1517/21678707.2015

    Diagnostic tools and strategies for assessing disease progression in Alkaptonuria (Journal article)

    Ranganath, L. R., Psarelli, E. E., Cox, T. F., & Gallagher, J. A. (2015). Diagnostic tools and strategies for assessing disease progression in Alkaptonuria. EXPERT OPINION ON ORPHAN DRUGS, 3(6), 705-717. doi:10.1517/21678707.2015.1042859

    DOI: 10.1517/21678707.2015.1042859

    HIGH DENSITY MINERALISED PROTRUSIONS FROM THE TIDEMARK INTO HYALINE CARTILAGE IN HUMAN JOINTS (Journal article)

    Gallagher, J. A., Thomas, N., Donnelly, J. L., Jeffery, N., Mills, D., Davis, G. R., & Boyde, A. (2015). HIGH DENSITY MINERALISED PROTRUSIONS FROM THE TIDEMARK INTO HYALINE CARTILAGE IN HUMAN JOINTS. OSTEOARTHRITIS AND CARTILAGE, 23, A318-A319. doi:10.1016/j.joca.2015.02.574

    DOI: 10.1016/j.joca.2015.02.574

    Investigating the Robustness and Diagnostic Potential of Extracellular Matrix Remodelling Biomarkers in Alkaptonuria. (Journal article)

    Genovese, F., Siebuhr, A. S., Musa, K., Gallagher, J. A., Milan, A. M., Karsdal, M. A., . . . Ranganath, L. R. (2015). Investigating the Robustness and Diagnostic Potential of Extracellular Matrix Remodelling Biomarkers in Alkaptonuria.. JIMD reports, 24, 29-37. doi:10.1007/8904_2015_430

    DOI: 10.1007/8904_2015_430

    Lessons from rare diseases of cartilage and bone (Journal article)

    Gallagher, J. A., Ranganath, L. R., & Boyde, A. (2015). Lessons from rare diseases of cartilage and bone. CURRENT OPINION IN PHARMACOLOGY, 22, 107-114. doi:10.1016/j.coph.2015.04.002

    DOI: 10.1016/j.coph.2015.04.002

    Musculoskeletal: Are there common targets to prevent age-related changes in muscle, cartilage and bone? (Journal article)

    Gallagher, J. A., & Russell, R. G. G. (2015). Musculoskeletal: Are there common targets to prevent age-related changes in muscle, cartilage and bone?. CURRENT OPINION IN PHARMACOLOGY, 22, V-VIII. doi:10.1016/j.coph.2015.05.007

    DOI: 10.1016/j.coph.2015.05.007

    Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice. (Journal article)

    Keenan, C. M., Preston, A. J., Sutherland, H., Wilson, P. J., Psarelli, E. E., Cox, T. F., . . . Gallagher, J. A. (2015). Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice.. JIMD reports, 24, 45-50. doi:10.1007/8904_2015_437

    DOI: 10.1007/8904_2015_437

    Progress in Alkaptonuria - are we near to an effective therapy? (Journal article)

    Ranganath, L. R., Timmis, O. G., & Gallagher, J. A. (2015). Progress in Alkaptonuria - are we near to an effective therapy?. JOURNAL OF INHERITED METABOLIC DISEASE, 38(5), 787-789. doi:10.1007/s10545-015-9888-7

    DOI: 10.1007/s10545-015-9888-7

    Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry (Journal article)

    Hughes, A. T., Milan, A. M., Davison, A. S., Christensen, P., Ross, G., Gallagher, J. A., . . . Ranganath, L. R. (2015). Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry. ANNALS OF CLINICAL BIOCHEMISTRY, 52(5), 597-605. doi:10.1177/0004563215571969

    DOI: 10.1177/0004563215571969

    What does the arthropathy of alkaptonuria teach us about disease mechanisms in osteoarthritis and ageing of joints? Lessons from a rare disease (Journal article)

    Gallagher, J. A., Ranganath, L. R., & Boyde, A. (2016). What does the arthropathy of alkaptonuria teach us about disease mechanisms in osteoarthritis and ageing of joints? Lessons from a rare disease. RHEUMATOLOGY, 55(7), 1151-1152. doi:10.1093/rheumatology/kev401

    DOI: 10.1093/rheumatology/kev401

    2014

    DEVELOPMENT OF OSTEOARTHRITIS IN ALKAPTONURIC MICE (Conference Paper)

    Keenan, C. M., Sutherland, H., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). DEVELOPMENT OF OSTEOARTHRITIS IN ALKAPTONURIC MICE. In RHEUMATOLOGY Vol. 53 (pp. 131). Retrieved from http://gateway.webofknowledge.com/

    Differential effects of adiponectin in osteoblast-like cells (Journal article)

    Pacheco-Pantoja, E. L., Fraser, W. D., Wilson, P. J. M., & Gallagher, J. A. (2014). Differential effects of adiponectin in osteoblast-like cells. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 34(5), 351-360. doi:10.3109/10799893.2014.898658

    DOI: 10.3109/10799893.2014.898658

    IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE (Conference Paper)

    Keenan, C. M., Beckett, A., Sutherland, H., Prior, I., Ranganath, L. R., Jarvis, J. C., & Gallagher, J. A. (2014). IDENTIFICATION OF CONCENTRIC LAMELLAE IN THE ARTICULAR CALCIFIED CARTILAGE OF OSTEOARTHRITIC MICE. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S363-S364). doi:10.1016/j.joca.2014.02.673

    DOI: 10.1016/j.joca.2014.02.673

    Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle (Journal article)

    Vickerton, P., Jarvis, J. C., Gallagher, J. A., Akhtar, R., Sutherland, H., & Jeffery, N. (2014). Morphological and histological adaptation of muscle and bone to loading induced by repetitive activation of muscle. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 281(1788). doi:10.1098/rspb.2014.0786

    DOI: 10.1098/rspb.2014.0786

    On fragmenting, densely mineralised acellular protrusions into articular cartilage and their possible role in osteoarthritis (Journal article)

    Boyde, A., Davis, G. R., Mills, D., Zikmund, T., Cox, T. M., Adams, V. L., . . . Gallagher, J. A. (2014). On fragmenting, densely mineralised acellular protrusions into articular cartilage and their possible role in osteoarthritis. JOURNAL OF ANATOMY, 225(4), 436-446. doi:10.1111/joa.12226

    DOI: 10.1111/joa.12226

    Purinergic signalling in cartilage (cancelled) (Journal article)

    Gallagher, J. A., Dillon, J. P., Vindigni, G., Keenan, C. M., Piselli, D., & Wilson, P. J. (2014). Purinergic signalling in cartilage (cancelled). PURINERGIC SIGNALLING, 10(4), 704. Retrieved from http://gateway.webofknowledge.com/

    RARE SYNDROMES: WHAT THEY TEACH US ABOUT OSTEOARTHRITIS DISEASE MECHANISMS (Conference Paper)

    Gallagher, J. A. (2014). RARE SYNDROMES: WHAT THEY TEACH US ABOUT OSTEOARTHRITIS DISEASE MECHANISMS. In OSTEOARTHRITIS AND CARTILAGE Vol. 22 (pp. S1). doi:10.1016/j.joca.2014.02.015

    DOI: 10.1016/j.joca.2014.02.015

    Reversible keratopathy due to hypertyrosinaemia following intermittent low-dose nitisinone in alkaptonuria: a case report. (Journal article)

    Stewart, R. M. K., Briggs, M. C., Jarvis, J. C., Gallagher, J. A., & Ranganath, L. (2014). Reversible keratopathy due to hypertyrosinaemia following intermittent low-dose nitisinone in alkaptonuria: a case report.. JIMD reports, 17, 1-6. doi:10.1007/8904_2014_307

    DOI: 10.1007/8904_2014_307

    Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment (Journal article)

    Ranganath, L. R., Milan, A. M., Hughes, A. T., Dutton, J. J., Fitzgerald, R., Briggs, M. C., . . . Rovensky, J. (2016). Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment. ANNALS OF THE RHEUMATIC DISEASES, 75(2), 362-367. doi:10.1136/annrheumdis-2014-206033

    DOI: 10.1136/annrheumdis-2014-206033

    THE CASE IS CRACKED: IDENTIFICATION OF A NEW SUSPECT IN THE INITIATION OF OSTEOARTHRITIS (Conference Paper)

    Boyde, A., Davis, G. R., Jeffery, N., Jarvis, J. C., Ranganath, L. R., & Gallagher, J. A. (2014). THE CASE IS CRACKED: IDENTIFICATION OF A NEW SUSPECT IN THE INITIATION OF OSTEOARTHRITIS. In RHEUMATOLOGY Vol. 53 (pp. 46). Retrieved from http://gateway.webofknowledge.com/

    Urine homogentisic acid and tyrosine: Simultaneous analysis by liquid chromatography tandem mass spectrometry (Journal article)

    Hughes, A. T., Milan, A. M., Christensen, P., Ross, G., Davison, A. S., Gallagher, J. A., . . . Ranganath, L. R. (2014). Urine homogentisic acid and tyrosine: Simultaneous analysis by liquid chromatography tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 963, 106-112. doi:10.1016/j.jchromb.2014.06.002

    DOI: 10.1016/j.jchromb.2014.06.002

    Urine homogentisic acid and tyrosine: simultaneous analysis by liquid chromatography tandem mass spectrometry. (Journal article)

    Hughes, A. T., Milan, A. M., Christensen, P., Ross, G., Davison, A. S., Gallagher, J. A., . . . Ranganath, L. R. (2014). Urine homogentisic acid and tyrosine: simultaneous analysis by liquid chromatography tandem mass spectrometry.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 106-112. doi:10.1016/j.jchromb.2014.06.002

    DOI: 10.1016/j.jchromb.2014.06.002

    2013

    Distribution of purinergic P2X receptors in the equine digit, cervical spinal cord and dorsal root ganglia (Journal article)

    Zamboulis, D. E., Senior, J. M., Clegg, P. D., Gallagher, J. A., Carter, S. D., & Milner, P. I. (2013). Distribution of purinergic P2X receptors in the equine digit, cervical spinal cord and dorsal root ganglia. PURINERGIC SIGNALLING, 9(3), 383-393. doi:10.1007/s11302-013-9356-5

    DOI: 10.1007/s11302-013-9356-5

    Distribution of purinergic P2X receptors in the equine digit, cervical spinal cord and dorsal root ganglia (Journal article)

    Zamboulis, D. E., Senior, J. M., Clegg, P. D., Gallagher, J. A., Carter, S. D., & Milner, P. I. (2013). Distribution of purinergic P2X receptors in the equine digit, cervical spinal cord and dorsal root ganglia. Purinergic Signalling, 9(3), 383-393. doi:10.1007/s11302-013-9356-5

    DOI: 10.1007/s11302-013-9356-5

    Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone (Journal article)

    Preston, A. J., Keenan, C. M., Sutherland, H., Wilson, P. J., Wlodarski, B., Taylor, A. M., . . . Jarvis, J. C. (2014). Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone. ANNALS OF THE RHEUMATIC DISEASES, 73(1), 284-289. doi:10.1136/annrheumdis-2012-202878

    DOI: 10.1136/annrheumdis-2012-202878

    Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone (Journal article)

    Preston, A. J., Keenan, C. M., Sutherland, H., Wilson, P. J., Wlodarski, B., Taylor, A. M., . . . Jarvis, J. C. (2014). Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone. Annals of the Rheumatic Diseases, 73(1), 284-289. doi:10.1136/annrheumdis-2012-202878

    DOI: 10.1136/annrheumdis-2012-202878

    2012

    Identification of trabecular excrescences, novel microanatomical structures, present in bone in osteoarthropathies (Journal article)

    Taylor, A. M., Boyde, A., Davidson, J. S., Jarvis, J. C., Ranganath, L. R., & Gallagher, J. A. (2012). Identification of trabecular excrescences, novel microanatomical structures, present in bone in osteoarthropathies. European Cells and Materials, 23, 300-309.

    Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition (Journal article)

    Taylor, A., Preston, A., Paulk, N., Sutherland, H., Keenan, C., Wilson, P., . . . Jarvis, J. (2012). Ochronosis in a murine model of alkaptonuria is synonymous to that in the human condition. Osteoarthritis and Cartilage, 20(8), 880-886. doi:10.1016/j.joca.2012.04.013

    DOI: 10.1016/j.joca.2012.04.013

    Primary human osteoblast cultures. (Chapter)

    Dillon, J. P., Waring-Green, V. J., Taylor, A. M., Wilson, P. J., Birch, M., Gartland, A., & Gallagher, J. A. (2012). Primary human osteoblast cultures.. In M. H. Helfrich, S. H. Ralston, & J. M. Walker (Eds.), Bone Research Protocols (Vol. 816, pp. 3-18). New York: Humana Press.

    Purinergic signalling in osteoblasts (Journal article)

    Gartland, A., Orriss, I. R., Rumney, R. M., Bond, A. P., Arnett, T., & Gallagher, J. A. (2012). Purinergic signalling in osteoblasts. Frontiers in bioscience.

    2011

    A National Survey of General Practitioners in the United Kingdom to establish a Registry for the Ultra-rare disease, Alkaptonuria: challenges, possible solutions and persistent barriers. (Journal article)

    Ranganath, L., Taylor, A. M., Shenkin, A., Fraser, W. D., Jarvis, J., Gallagher, J. A., & Sireau, N. (2011). A National Survey of General Practitioners in the United Kingdom to establish a Registry for the Ultra-rare disease, Alkaptonuria: challenges, possible solutions and persistent barriers.. J Inherited Metabolic Disease, In Press.

    Evaluation of antioxiodant drugs for the treatment of ochronotic alkaptonuria in an in vitro human cell model (Journal article)

    Tinti, L., Spreafico, A., Braconi, D., Millucci, L., Bernardini, G., Chellini, F., . . . Santucci, A. (2010). Evaluation of antioxiodant drugs for the treatment of ochronotic alkaptonuria in an in vitro human cell model. Journal of Cellular Physiology, 225(1), 84-91. doi:10.1002/jcp.22199

    DOI: 10.1002/jcp.22199

    The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria (Journal article)

    Taylor, A. M., Boyde, A., Wilson, P. J. M., Jarvis, J. C., Davidson, J. S., Hunt, J. A., . . . Gallagher, J. A. (2011). The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria. ARTHRITIS AND RHEUMATISM, 63(12), 3887-3896. doi:10.1002/art.30606

    DOI: 10.1002/art.30606

    The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria. (Journal article)

    Taylor, A., Boyde, A., Wilson, P., Jarvis, J., Davidson, J., Hunt, J., . . . Gallagher, J. (2011). The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria.. Arthritis and rheumatism, 63(12), 3887-3896.

    2010

    Development of an in vitro model to investigate joint ochronosis in alkaptonuria (Journal article)

    Tinti, L., Taylor, A. M., Santucci, A., Wlodarski, B., Wilson, P. J., Jarvis, J. C., . . . Gallagher, J. A. (2011). Development of an in vitro model to investigate joint ochronosis in alkaptonuria. Rheumatology, 50(2), 271-277. doi:10.1093/rheumatology/keq246

    DOI: 10.1093/rheumatology/keq246

    Proteomic and redox-proteomic evaluation of homogentisic acid and ascorbic acid effects on human articular chondrocytes (Journal article)

    Braconi, D., Laschi, M., Taylor, A. M., Bernardini, G., Spreafico, A., Tinti, L., . . . Santucci, A. (2010). Proteomic and redox-proteomic evaluation of homogentisic acid and ascorbic acid effects on human articular chondrocytes. J Cell Biochem, 111(4), 922-932.

    The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro (Journal article)

    Agrawal, A., Buckley, K. A., Bowers, K., Furber, M., Gallagher, J. A., & Gartland, A. (2010). The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro. Purinergic Signalling, 6(3), 307-315.

    Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment (Journal article)

    Taylor, A. M., Wlodarski, B., Prior, I. A., Wilson, P. J. M., Jarvis, J. C., Ranganath, L. R., & Gallagher, J. A. (2010). Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment. RHEUMATOLOGY, 49(7), 1412-1414. doi:10.1093/rheumatology/keq027

    DOI: 10.1093/rheumatology/keq027

    2008

    Alkaptonuria – a review of surgical and autopsy pathology (Journal article)

    Helliwell, T. R., Gallagher, J. A., & Ranganath, L. (2008). Alkaptonuria – a review of surgical and autopsy pathology. Histopathology, 0(0), 080310185205909-???. doi:10.1111/j.1365-2559.2008.03000.x

    DOI: 10.1111/j.1365-2559.2008.03000.x

    Potentiation of ATP- and Bradykinin-Induced [Ca2+]c Responses by PTHrP Peptides in the HaCaT Cell Line (Journal article)

    Burrell, H. E., Simpson, A. W., Mehat, S., McCreavy, D. T., Durham, B., Fraser, W. D., . . . Gallagher, J. A. (2008). Potentiation of ATP- and Bradykinin-Induced [Ca2+]c Responses by PTHrP Peptides in the HaCaT Cell Line. Journal of Investigative Dermatology, 128(5), 1107-1115. doi:10.1038/sj.jid.5701159

    DOI: 10.1038/sj.jid.5701159

    2007

    Caveolin-1 and caveolin-3 regulate Ca 2+ homeostasis of single smooth muscle cells from rat cerebral resistance arteries (Journal article)

    Kamishima, T., Burdyga, T., Gallagher, J. A., & Quayle, J. M. (2007). Caveolin-1 and caveolin-3 regulate Ca 2+ homeostasis of single smooth muscle cells from rat cerebral resistance arteries. American Journal of Physiology-Heart and Circulatory Physiology, 293(1), H204-H214. doi:10.1152/ajpheart.00669.2006

    DOI: 10.1152/ajpheart.00669.2006

    Multicenter Blinded Analysis of RT-PCR Detection Methods for Paramyxoviruses in Relation to Paget's Disease of Bone (Journal article)

    Ralston, S. H., Afzal, M. A., Helfrich, M. H., Fraser, W. D., Gallagher, J. A., Mee, A., & Rima, B. (2007). Multicenter Blinded Analysis of RT-PCR Detection Methods for Paramyxoviruses in Relation to Paget's Disease of Bone. Journal of Bone and Mineral Research, 22(4), 569-577. doi:10.1359/jbmr.070103

    DOI: 10.1359/jbmr.070103

    PPAR agonists modulate human osteoclast formation and activity in vitro (Journal article)

    Chan, B., Gartland, A., Wilson, P., Buckley, K., Dillon, J., Fraser, W., & Gallagher, J. (2007). PPAR agonists modulate human osteoclast formation and activity in vitro. Bone, 40(1), 149-159. doi:10.1016/j.bone.2006.07.029

    DOI: 10.1016/j.bone.2006.07.029

    The Circadian Rhythm of Osteoprotegerin and its Association with Parathyroid Hormone Secretion (Journal article)

    Joseph, F., Chan, B. Y., Durham, B. H., Ahmad, A. M., Vinjamuri, S., Gallagher, J. A., . . . Fraser, W. D. (2007). The Circadian Rhythm of Osteoprotegerin and its Association with Parathyroid Hormone Secretion. J Clin Endocrinol Metab, 92(8), 3230-3238. doi:10.1021/jc.2006-1832

    DOI: 10.1021/jc.2006-1832

    2005

    Differential effect of PPAR agonists on generation of Human osteoclasts in vitro (Journal article)

    Chan, B. Y., Buckley, K. A., Gartland, A., Fraser, W. D., & Gallagher, J. A. (2005). Differential effect of PPAR agonists on generation of Human osteoclasts in vitro. Clinical Chemistry and Applied Molecular Biology, 355, S13-S14.

    Human Cell Culture Protocols: Isolation and Culture of Human Osteoblasts. (Chapter)

    Gartland, A., Buckley, K. A., Dillon, J. B., Curran, J. M., Hunt, J. A., & Gallagher, J. A. (2005). Human Cell Culture Protocols: Isolation and Culture of Human Osteoblasts.. In J. Picotre (Ed.), Methods in Molecular Medicine. 2nd edition (Vol. 107, pp. 29-54). Totowa, New Jersey: Humana Press.

    Human Keratinocytes Release ATP and Utilize Three Mechanisms for Nucleotide Interconversion at the Cell Surface (Journal article)

    Burrell, H. E., Wlodarski, B., Foster, B. J., Buckley, K. A., Sharpe, G. R., Quayle, J. M., . . . Gallagher, J. A. (2005). Human Keratinocytes Release ATP and Utilize Three Mechanisms for Nucleotide Interconversion at the Cell Surface. Journal of Biological Chemistry, 280(33), 29667-29676. doi:10.1074/jbc.M505381200

    DOI: 10.1074/jbc.M505381200

    Human Osteoclast Culture from Peripheral Blood Monocytes (Chapter)

    Buckley, K. A., Chan, B. Y., Fraser, W. D., & Gallagher, J. A. (2005). Human Osteoclast Culture from Peripheral Blood Monocytes. In J. Picot (Ed.), Human Cell Culture Protocols (Vol. 107, pp. 55-68). New Jersey: Humana Press.

    Human osteoclast culture from peripheral blood monocytes: phenotypic characterization and quantitation of resorption (Journal article)

    Buckley, K. A., Chan, B. Y., Fraser, W. D., & Gallagher, J. A. (2005). Human osteoclast culture from peripheral blood monocytes: phenotypic characterization and quantitation of resorption. Methods Mol Med, 107, 55-68. Retrieved from http://www.ncbi.nlm.nih.gov/

    Isolation and culture of human osteoblasts. (Journal article)

    Gartland, A., Buckley, K. A., Dillon, J. P., Curran, J. M., Hunt, J. A., & Gallagher, J. A. (2005). Isolation and culture of human osteoblasts.. Methods in molecular medicine, 107, 29-54.

    The circadian rhythm of osteoprotegerin and its association with Parathyroid Hormone Secretion in Non-Osteoporotic Elderly postmenopausal women (Journal article)

    Joseph, F., Chan, B. Y., White, H. D., Ahmad, A. M., Durham, B. H., Joshi, A., . . . Fraser, W. D. (2005). The circadian rhythm of osteoprotegerin and its association with Parathyroid Hormone Secretion in Non-Osteoporotic Elderly postmenopausal women. Bone, 36, S259.

    The effects of extracellular nucleotides on EGF-Induced C-FOS Gene Expression (Journal article)

    Gartland, A., Fraser, W. D., & Gallagher, J. A. (2005). The effects of extracellular nucleotides on EGF-Induced C-FOS Gene Expression. Bone, 36(2), S257.

    The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture (Journal article)

    Curran, J. M., Gallagher, J. A., & Hunt, J. A. (2005). The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture. BIOMATERIALS, 26(26), 5313-5320. doi:10.1016/.jbiomaterials.2005.01.065

    DOI: 10.1016/.jbiomaterials.2005.01.065

    2004

    ATP P2 receptors and regulation of bone effector cells (Journal article)

    Gallagher, J. A. (2004). ATP P2 receptors and regulation of bone effector cells. J Musculoskelet Neuronal Interact, 4(2), 125-127. Retrieved from http://www.ncbi.nlm.nih.gov/

    Knock-in of nuclear localised ?-galactosidase reveals that the tyrosine phosphatasePtprv is specifically expressed in cells of the bone collar (Journal article)

    Dacquin, R., Mee, P., Kawaguchi, J., Olmsted-Davis, E., Gallagher, J., Nichols, J., . . . Smith, A. (2004). Knock-in of nuclear localised ?-galactosidase reveals that the tyrosine phosphatasePtprv is specifically expressed in cells of the bone collar. Developmental Dynamics, 229(4), 826-834. doi:10.1002/dvdy.20003

    DOI: 10.1002/dvdy.20003

    2003

    'Human keratinocytes express multiple P2Y-receptors: Evidence for functional P2Y1, P2Y2, and P2Y4 receptors' (Journal article)

    Burrell, H. E., Bowler, W. B., Gallagher, J. A., & Sharpe, G. R. (2003). 'Human keratinocytes express multiple P2Y-receptors: Evidence for functional P2Y1, P2Y2, and P2Y4 receptors'. Journal of Investigative Dermatology, 120(3), 440-447.

    'Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice (Journal article)

    Gartland, A., Buckley, K. A., Hipskind, R. A., Perry, M. J., Tobias, J. H., Buell, G., . . . Gallagher, J. A. (2003). 'Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice. Critical Reviews in Eukaryotic Gene Expression, 13(2-4), 243-253.

    'P2 receptors in bone - Modulation of osteoclast formation and activity via P2X7 activation (Journal article)

    Gartland, A., Buckley, K. A., Hipskind, R. A., Bowler, W. B., & Gallagher, J. A. (2003). 'P2 receptors in bone - Modulation of osteoclast formation and activity via P2X7 activation. Critical Reviews in Eukaryotic Gene Expression, 13(2-4), 237-242.

    Blockade of the Pore-Forming P2X 7 Receptor Inhibits Formation of Multinucleated Human Osteoclasts In Vitro (Journal article)

    Gartland, A., Buckley, K. A., Bowler, W. B., & Gallagher, J. A. (2003). Blockade of the Pore-Forming P2X 7 Receptor Inhibits Formation of Multinucleated Human Osteoclasts In Vitro. Calcified Tissue International, 73(4), 361-369. doi:10.1007/s00223-002-2098-y

    DOI: 10.1007/s00223-002-2098-y

    DNA Vaccine (Patent)

    Gallagher, J. A., Mccreavy, D. T., & Fraser, W. D. (2003). DNA Vaccine.

    Effect of Anticoagulants and Storage Temperature on the Stability of Receptor Activator for Nuclear Factor- B Ligand and Osteoprotegerin in Plasma and Serum (Journal article)

    Chan, B. Y. (2003). Effect of Anticoagulants and Storage Temperature on the Stability of Receptor Activator for Nuclear Factor- B Ligand and Osteoprotegerin in Plasma and Serum. Clinical Chemistry, 49(12), 2083-2085. doi:10.1373/clinchem.2003.023747

    DOI: 10.1373/clinchem.2003.023747

    Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors (Journal article)

    Burrell, H. E., Bowler, W. B., Gallagher, J. A., & Sharpe, G. R. (2003). Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. J Invest Dermatol, 120(3), 440-447. Retrieved from http://www.ncbi.nlm.nih.gov/

    Human osteoblast culture (Journal article)

    Gallagher, J. A. (2003). Human osteoblast culture. Methods Mol Med, 80, 3-18. Retrieved from http://www.ncbi.nlm.nih.gov/

    Immuno Polymerase Chain Reaction Method (Patent)

    Fraser, W. D., Mccreavy, D. T., & Gallagher, J. A. (2003). Immuno Polymerase Chain Reaction Method.

    P2 Receptors in Bone - Modulation of Osteoclast Formation and Activity via P2X7 Activation. (Journal article)

    Gartland, A., Buckley, K. A., Hipskind, R. A., Bowler, W. B., & Gallagher, J. A. (2003). P2 Receptors in Bone - Modulation of Osteoclast Formation and Activity via P2X7 Activation.. Critical Reviews in Eukaryotic Gene Expression, 13(2-4), 237-242.

    P2X7 receptor-deficient mice maintain the ability to form multinucleated osteoclasts in vivo and in vitro. (Journal article)

    Gartland, A., Buckley, K. A., Hipskind, R. A., Perry, M. J., Tobias, J. H., Buell, G., . . . Gallagher, J. A. (2003). P2X7 receptor-deficient mice maintain the ability to form multinucleated osteoclasts in vivo and in vitro.. Crit Reviews in Eukaryotic Gene Expression, 13(2-4), 243-253.

    Quantitative Evaluation of the Biocompatible and Osteogenic Properties of a Range of Biphasic Calcium Phosphate (BCP) Granules Using Primary Cultures of Human Osteoblasts and Monocytes (Journal article)

    Rice, J. M., Hunt, J. A., & Gallagher, J. A. (2003). Quantitative Evaluation of the Biocompatible and Osteogenic Properties of a Range of Biphasic Calcium Phosphate (BCP) Granules Using Primary Cultures of Human Osteoblasts and Monocytes. Calcified Tissue International, 72(6), 726-736. doi:10.1007/s00223-002-2045-y

    DOI: 10.1007/s00223-002-2045-y

    Quantitative assessment of the response of primary derived human osteoblasts and macrophages to a range of nanotopography surfaces in a single culture model in vitro (Journal article)

    Rice, J. M., Hunt, J. A., Gallagher, J. A., Hanarp, P., Sutherland, D. S., & Gold, J. (2003). Quantitative assessment of the response of primary derived human osteoblasts and macrophages to a range of nanotopography surfaces in a single culture model in vitro. BIOMATERIALS, 24(26), 4799-4818. doi:10.1016/S0142-9612(03)00381-8

    DOI: 10.1016/S0142-9612(03)00381-8

    Release and interconversion of P2 receptor agonists by human osteoblast-like cells (Journal article)

    BUCKLEY, K. A., GOLDING, S. L., RICE, J. M., DILLON, J. P., & GALLAGHER, J. A. (2003). Release and interconversion of P2 receptor agonists by human osteoblast-like cells. The FASEB Journal, 17(11), 1401-1410. doi:10.1096/fj.02-0940com

    DOI: 10.1096/fj.02-0940com

    2002

    Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand (Journal article)

    Buckley, K. A., Hipskind, R. A., Gartland, A., Bowler, W. B., & Gallagher, J. A. (2002). Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand. Bone, 31(5), 582-590. Retrieved from http://www.ncbi.nlm.nih.gov/

    Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-κB ligand (Journal article)

    Buckley, K., Hipskind, R., Gartland, A., Bowler, W., & Gallagher, J. (2002). Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-κB ligand. Bone, 31(5), 582-590. doi:10.1016/S8756-3282(02)00877-3

    DOI: 10.1016/S8756-3282(02)00877-3

    Expression and function of P2 receptors in bone (Journal article)

    Gallagher, J. A., & Buckley, K. A. (2002). Expression and function of P2 receptors in bone. J Musculoskelet Neuronal Interact, 2(5), 432-439. Retrieved from http://www.ncbi.nlm.nih.gov/

    2001

    Expression of a P2X7 Receptor by a Subpopulation of Human Osteoblasts (Journal article)

    Gartland, A., Hipskind, R. A., Gallagher, J. A., & Bowler, W. B. (2001). Expression of a P2X7 Receptor by a Subpopulation of Human Osteoblasts. Journal of Bone and Mineral Research, 16(5), 846-856. doi:10.1359/jbmr.2001.16.5.846

    DOI: 10.1359/jbmr.2001.16.5.846

    Expression of a P2X7 receptor by a subpopulation of human osteoblasts (Journal article)

    Gartland, A., Hipskind, R. A., Gallagher, J. A., & Bowler, W. B. (2001). Expression of a P2X7 receptor by a subpopulation of human osteoblasts. J Bone Miner Res, 16(5), 846-856. Retrieved from http://www.ncbi.nlm.nih.gov/

    Extracellular Nucleotide Signalling: A Mechanism for Integrating Local and Systemic Responses in the Activation of Bone Remodelling (Journal article)

    Bowler, W. B., Buckley, K. A., Gartland, A., Hipskind, R. A., Bilbe, G., & Gallagher, J. A. (2001). Extracellular Nucleotide Signalling: A Mechanism for Integrating Local and Systemic Responses in the Activation of Bone Remodelling. Bone, 28(5), 507-512.

    Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling (Journal article)

    Bowler, W., Buckley, K., Gartland, A., Hipskind, R., Bilbe, G., & Gallagher, J. (2001). Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling. Bone, 28(5), 507-512. doi:10.1016/S8756-3282(01)00430-6

    DOI: 10.1016/S8756-3282(01)00430-6

    Parathyroid Hormone Potentiates Nucleotide-induced [Ca 2+ ] Release in Rat Osteoblasts Independently of G q Activation or Cyclic Monophosphate Accumulation (Journal article)

    Buckley, K. A., Wagstaff, S. C., McKay, G., Gaw, A., Hipskind, R. A., Bilbe, G., . . . Bowler, W. B. (2001). Parathyroid Hormone Potentiates Nucleotide-induced [Ca 2+ ] Release in Rat Osteoblasts Independently of G q Activation or Cyclic Monophosphate Accumulation. Journal of Biological Chemistry, 276(12), 9565-9571. doi:10.1074/jbc.M005672200

    DOI: 10.1074/jbc.M005672200

    2000

    A CD36-binding peptide from thrombospondin-1 can stimulate resorption by osteoclasts in vitro (Journal article)

    Carron, J. A., Wagstaff, S. C., Gallagher, J. A., & Bowler, W. B. (2000). A CD36-binding peptide from thrombospondin-1 can stimulate resorption by osteoclasts in vitro. Biochemical and Biophysical Research Communications, 270(3), 1124-1127.

    A compound for use in medicine (Patent)

    Gallagher, J. A. (2000). A compound for use in medicine.

    Absence of measles virus and canine distemper virus transcripts in long-term bone marrow cultures from patients with Paget’s disease of bone (Journal article)

    Ooi, C., Walsh, C., Gallagher, J., & Fraser, W. (2000). Absence of measles virus and canine distemper virus transcripts in long-term bone marrow cultures from patients with Paget’s disease of bone. Bone, 27(3), 417-421. doi:10.1016/S8756-3282(00)00343-4

    DOI: 10.1016/S8756-3282(00)00343-4

    Cultured human retinal pigment epithelial cells differentially express thrombospondin-1,-2,-3, and-4 (Journal article)

    Carron, J. A., Hiscott, P., Hagan, S., Sheridan, C. M., Magee, R., & Gallagher, J. A. (2000). Cultured human retinal pigment epithelial cells differentially express thrombospondin-1,-2,-3, and-4. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 32(11-12), 1137-1142. doi:10.1016/S1357-2725(00)00065-0

    DOI: 10.1016/S1357-2725(00)00065-0

    Cytokine expression by cultured osteoblasts from patients with osteoporotic fractures (Journal article)

    Walsh., Birch, M. A., Fraser, W. D., Ginty, A. F., & Gallagher, J. A. (2000). Cytokine expression by cultured osteoblasts from patients with osteoporotic fractures. International Journal of Experimental Pathology, 81(2), 159-163. doi:10.1046/j.1365-2613.2000.00147.x

    DOI: 10.1046/j.1365-2613.2000.00147.x

    Extracellular ATP activates multiple signalling pathways and potentiates growth factor-induced c-fos gene expression in MCF-7 breast cancer cells (Journal article)

    Wagstaff, S. C., Bowler, W. B., Gallagher, J. A., & Hipskind, R. A. (2000). Extracellular ATP activates multiple signalling pathways and potentiates growth factor-induced c-fos gene expression in MCF-7 breast cancer cells. Carcinogenesis, 21(12), 2175-2181.

    Parathyroid hormone-related protein in the aetiology of fibrous dysplasia of bone in the McCune Albright syndrome (Journal article)

    Fraser, W. D., Walsh, C. A., Birch, M. A., Durham, B., Dillon, J. P., McCreavy, D., & Gallagher, J. A. (2000). Parathyroid hormone-related protein in the aetiology of fibrous dysplasia of bone in the McCune Albright syndrome. Clinical Endocrinology, 53(5), 621-628. doi:10.1046/j.1365-2265.2000.01112.x

    DOI: 10.1046/j.1365-2265.2000.01112.x

    1999

    Expression of members of the thrombospondin family by human skeletal tissues and cultured cells (Journal article)

    Carron, J. A., Bowler, W. B., Wagstaff, S. C., & Gallagher, J. A. (1999). Expression of members of the thrombospondin family by human skeletal tissues and cultured cells. Biochemical and Biophysical Research Communications, 263(2), 389-391.

    Regulation of epidermal homeostasis through P2Y 2 receptors (Journal article)

    Dixon, C. J., Bowler, W. B., Littlewood-Evans, A., Dillon, J. P., Bilbe, G., Sharpe, G. R., & Gallagher, J. A. (1999). Regulation of epidermal homeostasis through P2Y 2 receptors. British Journal of Pharmacology, 127(7), 1680-1686. doi:10.1038/sj.bjp.0702653

    DOI: 10.1038/sj.bjp.0702653

    Signaling in Human Osteoblasts by Extracellular Nucleotides (Journal article)

    Bowler, W. B., Dixon, C. J., Halleux, C., Maier, R., Bilbe, G., Fraser, W. D., . . . Hipskind, R. A. (1999). Signaling in Human Osteoblasts by Extracellular Nucleotides. Journal of Biological Chemistry, 274(20), 14315-14324. doi:10.1074/jbc.274.20.14315

    DOI: 10.1074/jbc.274.20.14315

    1998

    G-protein coupled receptors in bone (Journal article)

    Bowler, W. B., Gallagher, J. A., & Bilbe, G. (1998). G-protein coupled receptors in bone. Front Biosci, 3, d769-d780. Retrieved from http://www.ncbi.nlm.nih.gov/

    Human keratinocytes express transcripts for three isoforms of parathyroid hormone-related protein (PTHrP), but not for the parathyroid hormone/PTHrP receptor: effects of 1,25(OH)2 vitamin D3 (Journal article)

    Sharpe., Dillon., Durham., Gallagher., & Fraser. (1998). Human keratinocytes express transcripts for three isoforms of parathyroid hormone-related protein (PTHrP), but not for the parathyroid hormone/PTHrP receptor: effects of 1,25(OH)2 vitamin D3. British Journal of Dermatology, 138(6), 944-951. doi:10.1046/j.1365-2133.1998.02259.x

    DOI: 10.1046/j.1365-2133.1998.02259.x

    Novel methods (Patent)

    Gallagher, J. A. (1998). Novel methods.

    P2 receptor agonists, antagonists and modulators of endogenous ATP release (Patent)

    Gallagher, J. A. (1998). P2 receptor agonists, antagonists and modulators of endogenous ATP release.

    P2Y2 receptors are expressed by human osteoclasts of giant cell tumor but do not mediate ATP-induced bone resorption (Journal article)

    Bowler, W., Littlewood-Evans, A., Bilbe, G., Gallagher, J., & Dixon, C. (1998). P2Y2 receptors are expressed by human osteoclasts of giant cell tumor but do not mediate ATP-induced bone resorption. Bone, 22(3), 195-200. doi:10.1016/S8756-3282(97)00280-9

    DOI: 10.1016/S8756-3282(97)00280-9

    Steroid bisphosphonates (Patent)

    Gallagher, J. A. (1998). Steroid bisphosphonates.

    1997

    Effects of PTH on PTHrP gene expression in human osteoblasts: up-regulation with the kinetics of an immediate early gene (Journal article)

    Walsh, C. A., Bowler, W. B., Bilbe, G., Fraser, W. D., & Gallagher, J. A. (1997). Effects of PTH on PTHrP gene expression in human osteoblasts: up-regulation with the kinetics of an immediate early gene. Biochem Biophys Res Commun, 239(1), 155-159. Retrieved from http://www.ncbi.nlm.nih.gov/

    Effects of extracellular nucleotides on single cells and populations of human osteoblasts: contribution of cell heterogeneity to relative potencies (Journal article)

    Jane Dixon, C., Bowler, W. B., Walsh, C. A., & Gallagher, J. A. (1997). Effects of extracellular nucleotides on single cells and populations of human osteoblasts: contribution of cell heterogeneity to relative potencies. British Journal of Pharmacology, 120(5), 777-780. doi:10.1038/sj.bjp.0700961

    DOI: 10.1038/sj.bjp.0700961

    Extracellular nucleotides stimulate proliferation in MCF-7 breast cancer cells via P2-purinoceptors (Journal article)

    Dixon, C., Bowler, W., Fleetwood, P., Ginty, A., Gallagher, J., & Carron, J. (1997). Extracellular nucleotides stimulate proliferation in MCF-7 breast cancer cells via P2-purinoceptors. British Journal of Cancer, 75(1), 34-39. doi:10.1038/bjc.1997.6

    DOI: 10.1038/bjc.1997.6

    PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours (Journal article)

    Carron, J., Fraser, W., & Gallagher, J. (1997). PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours. British Journal of Cancer, 76(8), 1095-1098. doi:10.1038/bjc.1997.513

    DOI: 10.1038/bjc.1997.513

    1996

    RT-PCR detection of cytokine transcripts in a series of cultured human meningiomas (Journal article)

    Boyle-Walsh, E., Birch, M., Gallagher, J. A., Speirs, V., White, M. C., Shenkin, A., & Fraser, W. D. (1996). RT-PCR detection of cytokine transcripts in a series of cultured human meningiomas. J Pathol, 178(4), 442-446. Retrieved from http://www.ncbi.nlm.nih.gov/

    1995

    Expression and secretion of parathyroid hormone-related protein by human bone-derived cells in vitro: Effects of glucocorticoids (Journal article)

    Walsh, C., Birch, M., Fraser, W., Lawton, R., Dorgan, J., Walsh, S., . . . Gallagher, J. (1995). Expression and secretion of parathyroid hormone-related protein by human bone-derived cells in vitro: Effects of glucocorticoids. Journal of Bone and Mineral Research, 10(1), 17-25. doi:10.1002/jbmr.5650100106

    DOI: 10.1002/jbmr.5650100106

    Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone, and osteoblasts (Journal article)

    Bowler, W., Birch, M., Gallagher, J., & Bilbe, G. (1995). Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone, and osteoblasts. Journal of Bone and Mineral Research, 10(7), 1137-1145. doi:10.1002/jbmr.5650100720

    DOI: 10.1002/jbmr.5650100720

    Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines (Journal article)

    Birch, M., Carron, J., Scott, M., Fraser, W., & Gallagher, J. (1995). Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines. British Journal of Cancer, 72(1), 90-95. doi:10.1038/bjc.1995.282

    DOI: 10.1038/bjc.1995.282

    Thrombospondin promotes resorption by osteoclasts in vitro (Journal article)

    Carron, J. A., Walsh, C. A., Fraser, W. D., & Gallagher, J. A. (1995). Thrombospondin promotes resorption by osteoclasts in vitro. Biochem Biophys Res Commun, 213(3), 1017-1025. Retrieved from http://www.ncbi.nlm.nih.gov/

    1994

    Absence of paramyxovirus RNA in cultures of Pagetic bone cells and in Pagetic bone (Journal article)

    Birch, M. A., Taylor, W., Fraser, W. D., Ralston, S. H., Hart, C. A., & Gallacher, J. A. (1994). Absence of paramyxovirus RNA in cultures of Pagetic bone cells and in Pagetic bone. Journal of Bone and Mineral Research, 9, 11-16.

    Primary cultures of human bone-derived cells produce parathyroid hormone-related protein: a study of 40 patients of varying age and pathology (Journal article)

    Walsh, C., Birch, M., Fraser, W., Robinson, J., Lawton, R., Dorgan, J., . . . Gallagher, J. (1994). Primary cultures of human bone-derived cells produce parathyroid hormone-related protein: a study of 40 patients of varying age and pathology. Bone and Mineral, 27(1), 43-50. doi:10.1016/S0169-6009(08)80185-7

    DOI: 10.1016/S0169-6009(08)80185-7

    1993

    Hypercalcaemia due to parathyroid hormone-related protein: long-term circulating levels may not reflect tumour activity (Journal article)

    Savage, M. W., Fraser, W. D., Bodmer, C. W., Ginty, A. F., Gallagher, J. A., Robinson, J., & Williams, G. (1993). Hypercalcaemia due to parathyroid hormone-related protein: long-term circulating levels may not reflect tumour activity. Clin Endocrinol (Oxf), 39(6), 695-8 discussion 699. Retrieved from http://www.ncbi.nlm.nih.gov/

    PCR detection of cytokines in normal human and pagetic osteoblast-like cells (Journal article)

    Birch, M., Ginty, A., Walsh, C., Fraser, W., Gallagher, J., & Bilbe, G. (1993). PCR detection of cytokines in normal human and pagetic osteoblast-like cells. Journal of Bone and Mineral Research, 8(10), 1155-1162. doi:10.1002/jbmr.5650081002

    DOI: 10.1002/jbmr.5650081002

    1991

    Application of reflected light microscopy to identify and quantitate resorption by isolated osteoclasts (Journal article)

    Walsh, C., Beresford, J., Birch, M., Boothroyd, B., & Gallagher, J. (1991). Application of reflected light microscopy to identify and quantitate resorption by isolated osteoclasts. Journal of Bone and Mineral Research, 6(7), 661-671. doi:10.1002/jbmr.5650060703

    DOI: 10.1002/jbmr.5650060703

    1990

    Maintenance of cell viability in stored bone (Journal article)

    Treble, N. J., Dorgan, J. C., & Gallagher, J. A. (1990). Maintenance of cell viability in stored bone. Spine, 15(8), 830-832. Retrieved from http://www.ncbi.nlm.nih.gov/

    The effects of extracellular pH on bone resorption by avian osteoclasts in vitro (Journal article)

    Walsh, C., Dawson, W., Birch, M., & Gallagher, J. (1990). The effects of extracellular pH on bone resorption by avian osteoclasts in vitro. Journal of Bone and Mineral Research, 5(12), 1243-1247. doi:10.1002/jbmr.5650051209

    DOI: 10.1002/jbmr.5650051209

    1985

    The Effects of Mononuclear Cell Factor(MCF) and Interleukin-1 (IL-1) on Synthesis of Matrix by Skeletal and Articular Cells In Vitro (Journal article)

    Gallagher, J., Beresford, J., Dillon, J., Richardson, H., Wood, D., & Russell, R. (1985). The Effects of Mononuclear Cell Factor(MCF) and Interleukin-1 (IL-1) on Synthesis of Matrix by Skeletal and Articular Cells In Vitro. Rheumatology, XXIV(suppl 1), 158-161. doi:10.1093/rheumatology/XXIV.suppl_1.158

    DOI: 10.1093/rheumatology/XXIV.suppl_1.158

    The effects of mononuclear cell factor (MCF) and interleukin 1 on synthesis of matrix by skeletal and articular cells in vitro (Journal article)

    Dillon, J. P., Russell, R. G. G., Gallagher, J. A., Beresford, J. N., Richardson, H. J., & Wood, D. D. (1985). The effects of mononuclear cell factor (MCF) and interleukin 1 on synthesis of matrix by skeletal and articular cells in vitro. British journal of rheumatology.

    Vitamin D metabolites regulate osteocalcin synthesis and proliferation of human bone cells in vitro (Journal article)

    Skjodt, H., Gallagher, J. A., Beresford, J. N., Couch, M., Poser, J. W., & Russell, R. G. G. (1985). Vitamin D metabolites regulate osteocalcin synthesis and proliferation of human bone cells in vitro. Journal of Endocrinology, 105(3), 391-396. doi:10.1677/joe.0.1050391

    DOI: 10.1677/joe.0.1050391

    1984

    Differential response of bone cells isolated by sequential digestion to dichloromethylenebisphonate in culture (Journal article)

    Guenther, H. L., Gallagher, J. A., & Fleisch, H. (1984). Differential response of bone cells isolated by sequential digestion to dichloromethylenebisphonate in culture. Calcified Tissue International, 36(1), 568-575. doi:10.1007/BF02405368

    DOI: 10.1007/BF02405368

    Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids (Journal article)

    Beresford, J., Gallagher, J., Poser, J., & Russell, R. (1984). Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids. Metabolic Bone Disease and Related Research, 5(5), 229-234. doi:10.1016/0221-8747(84)90064-X

    DOI: 10.1016/0221-8747(84)90064-X

    Studies of the growth of human bone-derived cells in culture using aqueous two-phase partition (Journal article)

    Sharpe, P. T., MacDonald, B. R., Gallagher, J. A., Treffry, T. E., & Russell, R. G. G. (1984). Studies of the growth of human bone-derived cells in culture using aqueous two-phase partition. Bioscience Reports, 4(5), 415-419. doi:10.1007/BF01122506

    DOI: 10.1007/BF01122506

    The effects of monocyte-conditioned medium and interleukin 1 on the synthesis of collagenous and non-collagenous proteins by mouse bone and human bone cells in vitro (Journal article)

    Beresford, J., Gallagher, J., Gowen, M., Couch, M., Poser, J., Wood, D., & Russell, R. (1984). The effects of monocyte-conditioned medium and interleukin 1 on the synthesis of collagenous and non-collagenous proteins by mouse bone and human bone cells in vitro. Biochimica et Biophysica Acta (BBA) - General Subjects, 801(1), 58-65. doi:10.1016/0304-4165(84)90212-5

    DOI: 10.1016/0304-4165(84)90212-5

    1983

    Hormonal regulation of osteocalcin production by human bone cells in vitro (Journal article)

    Gallagher, J., Beresford, J., Sharrard, M., Poser, J., & Russell, R. (1983). Hormonal regulation of osteocalcin production by human bone cells in vitro. Metabolic Bone Disease and Related Research, 5(1), 49. doi:10.1016/0221-8747(83)90059-0

    DOI: 10.1016/0221-8747(83)90059-0

    1982

    Rapid intracellular degradation of newly synthesized collagen by bone cells Effect of dichloromethylenebisphosphonate (Journal article)

    Gallagher, J. A., Guenther, H. L., & Fleisch, H. A. (1982). Rapid intracellular degradation of newly synthesized collagen by bone cells Effect of dichloromethylenebisphosphonate. Biochimica et Biophysica Acta (BBA) - General Subjects, 719(2), 349-355. doi:10.1016/0304-4165(82)90109-X

    DOI: 10.1016/0304-4165(82)90109-X

    1980

    Histological observations on the failure of rachitic rat bones to respond to 1,25/OH)2D3 (Journal article)

    Gallagher, J. A., & Lawson, D. E. M. (1980). Histological observations on the failure of rachitic rat bones to respond to 1,25/OH)2D3. Calcified Tissue International, 31(1), 215-223. doi:10.1007/BF02407184

    DOI: 10.1007/BF02407184

    Undated

    Purinergic signalling in osteoblasts (Thesis / Dissertation)

    Bond, A. (n.d.). Purinergic signalling in osteoblasts. (PhD Thesis, University of Liverpool).
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