Professor George Bou-Gharios BSc (Hons), PhD

Professor of Matrix Biology Musculoskeletal & Ageing Science

Research

Research Overview

https://spark.adobe.com/page/FVoDi7bsWDe4c/

Research Interest 1

For most of the connective tissue diseases, there is currently no effective proven therapy. Development of efficient technologies for the identification and genetic manipulation of the central cell type(s) that are involved in matrix deposition and degradation is a definite step in development of targeted therapeutic modalities in such diseases.
My group focuses on two aspects: 1. Fibrotic diseases where excess deposition of matrix lead to loss of function and 2. Osteoarthritis, where there is increased degradation of matrix leading to failure of cartilage function.

Research Group Membership

Research Grants

Genetic approaches for repair & correction of disease associated therapy in Alkaptonuria

THE ALKAPTONURIA SOCIETY (UK)

December 2022 - November 2026

Innovative Approaches to Regulation of Homogentisic Acid and Tyrosine in Alkaptonuria

THE ALKAPTONURIA SOCIETY (UK)

December 2020 - November 2022

The role of circadian rhythms in Collagen VI related Myopathies

MUSCULAR DYSTROPHY UK - MDUK (UK)

July 2022 - November 2024

Abdulrahman Gremida / 201496381 (bench fees)

LIBYAN EMBASSY IN LONDON🚩

April 2020 - March 2024

Bench fee Majed Alghamdi / 201484626

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

February 2021 - January 2025

Bench fees for Miss Fawziah Mohammed A Asiri 201459736

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

October 2020 - September 2024

Metabolomic consequences of silencing the HGD gene

ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)

November 2019 - November 2023

MOHAMED HASSAN A ALHASHMI - Bench Fees

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

July 2018 - September 2022

Sara Ibrahim AlSalhi 201369309 bench fees

ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)

March 2020 - February 2024

Development and pre-clinical evaluation of innovative, multi-disciplinary approaches to target the accumulation of specific amino acids for the treatment of inherited rare diseases with unmet need

BRITISH ACADEMY (UK)

February 2022 - March 2022

Circadian disruption and fibrosis progression in Systemic Sclerosis: towards chrono-based prognostic biomarkers and therapeutic stratification

THE TERESA ROSENBAUM GOLDEN CHARITABLE TRUST (THE ROSETREES TRUST) (UK)

December 2022 - September 2026

UK-Israel Lectureship Scheme

BRITISH COUNCIL (UK)

January 2018 - May 2018

Effects of APPA on ochronosis

AKL RESEARCH & DEVELOPMENT LTD (UK)

November 2016 - January 2018

The role of Syndecan 3 in bone metabolism

MEDICAL RESEARCH COUNCIL

January 2018 - September 2021

Shedding of the endocytic receptor LRP1 in cartilage: A novel link to the development of osteoarthritis.

ARTHRITIS RESEARCH UK

June 2017 - June 2022

Unravelling the molecular mechanism of CCN2 in glaucoma

FIGHT FOR SIGHT (UK)

October 2016 - September 2019

INVESTIGATING THE ROLE OF THE RNA BINDING PROTEIN HuR IN MUSCULOSKELETAL DEVELOPMENT AND DISEASE

MEDICAL RESEARCH COUNCIL

July 2016 - December 2019

Defining the mechanisms by which CTGF protects joints from injury -induced osteoarthritis

ARTHRITIS RESEARCH UK

October 2015 - December 2018

Elucidating the pathways regulating venous identity

BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL

July 2014 - June 2017

Validating ADAMTS-4/5 as targets for therapy in a naturally occuring mouse model of osteoarthritis

ARTHRITIS RESEARCH UK

September 2013 - April 2017

The role of Cux1 in scarring and fibrosis in scleroderma

RAYNAUD'S & SCLERODERMA ASSOCIATION (UK)

September 2013 - December 2014

Transcriptional regulation of the Notch and Vegf signalling pathways during angiogenesis and arterio-venous differentiation

MEDICAL RESEARCH COUNCIL

September 2013 - September 2015

Understanding the regulation of the gene critical for the stuctural and functional activity of Cartilage.

THE TERESA ROSENBAUM GOLDEN CHARITABLE TRUST (THE ROSETREES TRUST) (UK)

December 2013 - November 2016

Engineering ligamentous/ tendon tissue for rotator cuff repair.

MEDICAL RESEARCH COUNCIL

November 2014 - March 2018