Prof George Bou-Gharios BSc (Hons), PhD

Professor of Matrix Biology Musculoskeletal Biology I

    Research

    Research Interest 1

    For most of the connective tissue diseases, there is currently no effective proven therapy. Development of efficient technologies for the identification and genetic manipulation of the central cell type(s) that are involved in matrix deposition and degradation is a definite step in development of targeted therapeutic modalities in such diseases.
    My group focuses on two aspects: 1. Fibrotic diseases where excess deposition of matrix lead to loss of function and 2. Osteoarthritis, where there is increased degradation of matrix leading to failure of cartilage function.

    Research Group Membership
    Research Grants

    UK-Israel Lectureship Scheme

    BRITISH COUNCIL (UK)

    January 2018 - May 2018

    Effects of APPA on ochronosis

    AKL RESEARCH & DEVELOPMENT LTD (UK)

    November 2016 - January 2018

    The regulation of collagen (I) homotrimer synthesis and its role in musculoskeletal dysfunction

    MEDICAL RESEARCH COUNCIL (MRC)

    December 2017 - November 2020

    The role of Syndecan 3 in bone metabolism

    MEDICAL RESEARCH COUNCIL (MRC)

    January 2018 - January 2021

    Shedding of the endocytic receptor LRP1 in cartilage: A novel link to the development of osteoarthritis.

    ARTHRITIS RESEARCH UK

    June 2017 - June 2022

    Unravelling the molecular mechanism of CCN2 in glaucoma

    FIGHT FOR SIGHT (UK)

    October 2016 - September 2019

    INVESTIGATING THE ROLE OF THE RNA BINDING PROTEIN HuR IN MUSCULOSKELETAL DEVELOPMENT AND DISEASE

    MEDICAL RESEARCH COUNCIL (MRC)

    July 2016 - December 2019

    Defining the mechanisms by which CTGF protects joints from injury -induced osteoarthritis

    ARTHRITIS RESEARCH UK

    October 2015 - December 2018

    Elucidating the pathways regulating venous identity

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2014 - June 2017

    Validating ADAMTS-4/5 as targets for therapy in a naturally occuring mouse model of osteoarthritis

    ARTHRITIS RESEARCH UK

    September 2013 - April 2017

    The role of Cux1 in scarring and fibrosis in scleroderma

    RAYNAUD'S & SCLERODERMA ASSOCIATION (UK)

    September 2013 - December 2014

    Transcriptional regulation of the Notch and Vegf signalling pathways during angiogenesis and arterio-venous differentiation

    MEDICAL RESEARCH COUNCIL (MRC)

    September 2013 - September 2015

    Understanding the regulation of the gene critical for the stuctural and functional activity of Cartilage.

    THE TERESA ROSENBAUM GOLDEN CHARITABLE TRUST (THE ROSETREES TRUST) (UK)

    December 2013 - November 2016

    Engineering ligamentous/ tendon tissue for rotator cuff repair.

    MEDICAL RESEARCH COUNCIL (MRC)

    November 2014 - March 2018