Prof George Bou-Gharios BSc (Hons), PhD

Professor of Matrix Biology Musculoskeletal Biology I

    Publications

    2019

    Venous identity requires BMP signalling through ALK3. (Journal article)

    Neal, A., Nornes, S., Payne, S., Wallace, M. D., Fritzsche, M., Louphrasitthiphol, P., . . . De Val, S. (2019). Venous identity requires BMP signalling through ALK3.. Nature communications, 10(1), 453. doi:10.1038/s41467-019-08315-w

    DOI: 10.1038/s41467-019-08315-w

    2018

    Chondrocyte specific deletion of CCN2 does not exacerbate osteoarthritis in models of post-traumatic osteoarthritis in mice (Conference Paper)

    Keenan, C., Jaffa, M., Milner, P., Kanakis, I., Carter, A., Abraham, D., . . . Poulet, B. (2018). Chondrocyte specific deletion of CCN2 does not exacerbate osteoarthritis in models of post-traumatic osteoarthritis in mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A14). Retrieved from http://gateway.webofknowledge.com/

    Investigating the Role of CCN2 in a Bleomycin Model of Idiopathic Pulmonary Fibrosis (Thesis / Dissertation)

    Horwell, A. L. (2018). Investigating the Role of CCN2 in a Bleomycin Model of Idiopathic Pulmonary Fibrosis. (University of Liverpool).

    Murine cruciate ligament pathology and mechanics during osteoarthritis development (Conference Paper)

    Ramos, L., Bou-Gharios, G., Pitsillides, A. A., Comerford, E., & Poulet, B. (2018). Murine cruciate ligament pathology and mechanics during osteoarthritis development. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A63-A64). Retrieved from http://gateway.webofknowledge.com/

    Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis. (Journal article)

    Kanakis, I., Liu, K., Poulet, B., Javaheri, B., van 't Hof, R. J., Pitsillides, A. A., & Bou-Gharios, G. (2019). Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis.. Arthritis & rheumatology (Hoboken, N.J.), 71(4), 571-582. doi:10.1002/art.40765

    DOI: 10.1002/art.40765

    Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis. (Journal article)

    Bou-Gharios, G. (n.d.). Targeted inhibition of aggrecanases prevents articular cartilage degradation and augments bone mass in the STR/Ort spontaneous model of osteoarthritis.. Arthritis and Rheumatology.

    The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within? (Journal article)

    Javaheri, B., Caetano-Silva, S. P., Kanakis, I., Bou-Gharios, G., & Pitsillides, A. A. (2018). The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?. Frontiers in Bioengineering and Biotechnology. doi:10.3389/fbioe.2018.00028

    DOI: 10.3389/fbioe.2018.00028

    The effect of [-1A]TIMP3 overexpression on bone mass in the naturally developing OA STR/Ort mice (Conference Paper)

    Kanakis, I., van't Hof, R., Liu, K., Pitsillides, A., & Bou-Gharios, G. (2018). The effect of [-1A]TIMP3 overexpression on bone mass in the naturally developing OA STR/Ort mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A17-A18). Retrieved from http://gateway.webofknowledge.com/

    Ubiquitous removal of ccn2 in a bleomycin induced pulmonary fibrosis model is detrimental to survival (Conference Paper)

    Horwell, A. L., Liu, K., Spencer, L., Moots, R., Van 'T Hof, R., & Bou-Gharios, G. (2018). Ubiquitous removal of ccn2 in a bleomycin induced pulmonary fibrosis model is detrimental to survival. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A40-A41). Retrieved from http://gateway.webofknowledge.com/

    2017

    Aggrecan Gene Expression in Chondrocytes is Controlled by Multiple DNA Regulatory Elements. (Conference Paper)

    Li, I. M. H., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2017). Aggrecan Gene Expression in Chondrocytes is Controlled by Multiple DNA Regulatory Elements.. In JOURNAL OF BONE AND MINERAL RESEARCH Vol. 32 (pp. S314). Retrieved from http://gateway.webofknowledge.com/

    Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice. (Journal article)

    Miller, B., Spevak, L., Lukashova, L., Javaheri, B., Pitsillides, A. A., Boskey, A., . . . Carriero, A. (2017). Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice. CALCIFIED TISSUE INTERNATIONAL, 100(6), 631-640. doi:10.1007/s00223-017-0248-5

    DOI: 10.1007/s00223-017-0248-5

    Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer. (Journal article)

    Li, I. M. H., Horwell, A. L., Chu, G., de Crombrugghe, B., & Bou-Gharios, G. (2017). Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.. Methods in molecular biology (Clifton, N.J.), 1627, 139-161. doi:10.1007/978-1-4939-7113-8_10

    DOI: 10.1007/978-1-4939-7113-8_10

    Multiple enhancer regions govern the transcription of CCN2 during embryonic development (Journal article)

    Frost, S. L., Liu, K., Li, I. M. H., Poulet, B., Comerford, E., De Val, S., & Bou-Gharios, G. (2018). Multiple enhancer regions govern the transcription of CCN2 during embryonic development. JOURNAL OF CELL COMMUNICATION AND SIGNALING, 12(1), 231-243. doi:10.1007/s12079-017-0440-4

    DOI: 10.1007/s12079-017-0440-4

    Murine cruciate ligament degeneration and marker expression during osteoarthritis (Conference Paper)

    Ramos, L. D., Bou-Gharios, G., Pitsillides, A. A., Comerford, E., & Poulet, B. (2017). Murine cruciate ligament degeneration and marker expression during osteoarthritis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 98 (pp. A8-A9). Retrieved from http://gateway.webofknowledge.com/

    SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development (Journal article)

    Chiang, I. K. -N., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., . . . Francois, M. (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. DEVELOPMENT, 144(14), 2629-2639. doi:10.1242/dev.146241

    DOI: 10.1242/dev.146241

    2016

    A CLUSTER OF REGULATORY ELEMENTS THAT DRIVES THE AGGRECAN GENE EXPRESSION IN CHONDROCYTES (Conference Paper)

    Li, I. M., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2016). A CLUSTER OF REGULATORY ELEMENTS THAT DRIVES THE AGGRECAN GENE EXPRESSION IN CHONDROCYTES. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S136-S137). doi:10.1016/j.joca.2016.01.268

    DOI: 10.1016/j.joca.2016.01.268

    Aggrecan gene expression in chondrocytes is controlled by multiple regulatory elements (Conference Paper)

    Li, I. M., Liu, K., Neal, A., Clegg, P. D., De Val, S., & Bou-Gharios, G. (2016). Aggrecan gene expression in chondrocytes is controlled by multiple regulatory elements. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A8-A9). Retrieved from http://gateway.webofknowledge.com/

    An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression (Journal article)

    Becker, P. W., Sacilotto, N., Nornes, S., Neal, A., Thomas, M. O., Liu, K., . . . De Val, S. (2016). An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(6), 1209-+. doi:10.1161/ATVBAHA.116.307517

    DOI: 10.1161/ATVBAHA.116.307517

    CONNECTIVE TISSUE GROWTH FACTOR DEFICIENCY IN ADULT ARTICULAR CARTILAGE PROMOTES CARTILAGE DEGENERATION AT EARLY TIMEPOINTSIN MOUSE POSTTRAUMATIC OSTEOARTHRITIS (Conference Paper)

    Poulet, B., Milner, P., Kanakis, I., Carter, A., Abraham, D., Leask, A., . . . Bou-Gharios, G. (2016). CONNECTIVE TISSUE GROWTH FACTOR DEFICIENCY IN ADULT ARTICULAR CARTILAGE PROMOTES CARTILAGE DEGENERATION AT EARLY TIMEPOINTSIN MOUSE POSTTRAUMATIC OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S392). doi:10.1016/j.joca.2016.01.705

    DOI: 10.1016/j.joca.2016.01.705

    Chondrocyte-specific TIMP3 overexpression disrupts endochondral growth and compromises bone structure and integrity: functional impact of the chondrocyte-to-osteoblast lineage (Conference Paper)

    Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., . . . Carrierro, A. (2016). Chondrocyte-specific TIMP3 overexpression disrupts endochondral growth and compromises bone structure and integrity: functional impact of the chondrocyte-to-osteoblast lineage. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A7). Retrieved from http://gateway.webofknowledge.com/

    Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections. (Journal article)

    Ikeda, T., Fragiadaki, M., Shi-Wen, X., Ponticos, M., Khan, K., Denton, C., . . . Abraham, D. (2016). Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections.. Data in brief, 8, 1377-1380. doi:10.1016/j.dib.2016.08.014

    DOI: 10.1016/j.dib.2016.08.014

    Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo (Journal article)

    Javaheri, B., Hopkinson, M., Poulet, B., Pollard, A. S., Shefelbine, S. J., Chang, Y. -M., . . . Pitsillides, A. A. (2016). Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo. PLOS ONE, 11(8). doi:10.1371/journal.pone.0159657

    DOI: 10.1371/journal.pone.0159657

    Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition (Journal article)

    Kitahara, H., Hirai, M., Kato, K., Bou-Gharios, G., Nakamura, H., & Kawashiri, S. (2016). Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition. ONCOLOGY REPORTS, 36(6), 3139-3144. doi:10.3892/or.2016.5189

    DOI: 10.3892/or.2016.5189

    Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome (Journal article)

    Moschidou, D., Corcelli, M., Hau, K. -L., Ekwalla, V. J., Behmoaras, J. V., De Coppi, P., . . . Guillot, P. V. (2016). Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome. STEM CELLS AND DEVELOPMENT, 25(5), 395-404. doi:10.1089/scd.2015.0305

    DOI: 10.1089/scd.2015.0305

    Investigating the role of the RNA binding protein HuR during chondrogenesis (Conference Paper)

    Johnson, K. A., McDermott, B. T., Milner, P. I., Bou-Gharios, G., & Tew, S. R. (2016). Investigating the role of the RNA binding protein HuR during chondrogenesis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A23). Retrieved from http://gateway.webofknowledge.com/

    MEF2 transcription factors are key regulators of sprouting angiogenesis (Journal article)

    Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., . . . De Val, S. (2016). MEF2 transcription factors are key regulators of sprouting angiogenesis. GENES & DEVELOPMENT, 30(20), 2297-2309. doi:10.1101/gad.290619.116

    DOI: 10.1101/gad.290619.116

    Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity (Journal article)

    Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., . . . Bou-Gharios, G. (2016). Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity. PLoS One, 11(12). doi:10.1371/journal.pone.0167971

    DOI: 10.1371/journal.pone.0167971

    RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes (Journal article)

    McDermott, B. T., Ellis, S., Bou-Gharios, G., Clegg, P. D., & Tew, S. R. (2016). RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. OSTEOARTHRITIS AND CARTILAGE, 24(7), 1263-1273. doi:10.1016/j.joca.2016.01.988

    DOI: 10.1016/j.joca.2016.01.988

    THE ROLE OF MICRORNAS IN OSTEOARTHRITIS AND AGEING RELATED FUNCTIONAL DECLINE IN JOINT TISSUE HOMEOSTASIS. (Conference Paper)

    House, L., Bou-Gharios, G., Peffers, M., Milner, P., Clegg, P. D., Young, D. A., & Whysall, K. A. (2016). THE ROLE OF MICRORNAS IN OSTEOARTHRITIS AND AGEING RELATED FUNCTIONAL DECLINE IN JOINT TISSUE HOMEOSTASIS.. In OSTEOARTHRITIS AND CARTILAGE Vol. 24 (pp. S63-S64). doi:10.1016/j.joca.2016.01.141

    DOI: 10.1016/j.joca.2016.01.141

    Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts. (Journal article)

    Ikeda, T., Fragiadaki, M., Shi-Wen, X., Ponticos, M., Khan, K., Denton, C., . . . Abraham, D. (2016). Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts.. Biochemistry and biophysics reports, 7, 246-252. doi:10.1016/j.bbrep.2016.06.022

    DOI: 10.1016/j.bbrep.2016.06.022

    2015

    Failed Degradation of JunB Contributes to Overproduction of Type I Collagen and Development of Dermal Fibrosis in Patients With Systemic Sclerosis (Journal article)

    Ponticos, M., Papaioannou, I., Xu, S., Holmes, A. M., Khan, K., Denton, C. P., . . . Abraham, D. J. (2015). Failed Degradation of JunB Contributes to Overproduction of Type I Collagen and Development of Dermal Fibrosis in Patients With Systemic Sclerosis. ARTHRITIS & RHEUMATOLOGY, 67(1), 243-253. doi:10.1002/art.38897

    DOI: 10.1002/art.38897

    SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS (Conference Paper)

    Poulet, B., Bou-Gharios, G., & Pitsillides, A. A. (2015). SYSTEMATIZING MURINE MENISCAL AND LIGAMENT MODIFICATIONS DURING OSTEOARTHRITIS. In OSTEOARTHRITIS AND CARTILAGE Vol. 23 (pp. A283). doi:10.1016/j.joca.2015.02.516

    DOI: 10.1016/j.joca.2015.02.516

    Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis (Journal article)

    Gardiner, M. D., Vincent, T. L., Driscoll, C., Burleigh, A., Bou-Gharios, G., Saklatvala, J., . . . Chanalaris, A. (2015). Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis. OSTEOARTHRITIS AND CARTILAGE, 23(4), 616-628. doi:10.1016/j.joca.2014.12.014

    DOI: 10.1016/j.joca.2014.12.014

    2014

    Biphasic recruitment of microchimeric fetal mesenchymal cells in fibrosis following acute kidney injury (Journal article)

    Roy, E., Seppanen, E., Ellis, R., Lee, E. S., Khosroterani, K., Fisk, N. M., & Bou-Gharios, G. (2014). Biphasic recruitment of microchimeric fetal mesenchymal cells in fibrosis following acute kidney injury. KIDNEY INTERNATIONAL, 85(3), 600-610. doi:10.1038/ki.2013.459

    DOI: 10.1038/ki.2013.459

    Generation of a Mouse Line Harboring a Bi-Transgene Expressing Luciferase and Tamoxifen-Activatable CreER(T2) Recombinase in Cartilage (Journal article)

    Lo Cascio, L., Liu, K., Nakamura, H., Chu, G., Lim, N. H., Chanalaris, A., . . . Bou-Gharios, G. (2014). Generation of a Mouse Line Harboring a Bi-Transgene Expressing Luciferase and Tamoxifen-Activatable CreER(T2) Recombinase in Cartilage. GENESIS, 52(2), 110-119. doi:10.1002/dvg.22734

    DOI: 10.1002/dvg.22734

    In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen-Induced Arthritis (Journal article)

    Lim, N. H., Meinjohanns, E., Bou-Gharios, G., Gompels, L. L., Nuti, E., Rossello, A., . . . Nagase, H. (2014). In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen-Induced Arthritis. ARTHRITIS & RHEUMATOLOGY, 66(3), 589-598. doi:10.1002/art.38295

    DOI: 10.1002/art.38295

    In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis (Journal article)

    Lim, N. H., Meinjohanns, E., Meldal, M., Bou-Gharios, G., & Nagase, H. (2014). In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis. OSTEOARTHRITIS AND CARTILAGE, 22(6), 862-868. doi:10.1016/j.joca.2014.04.006

    DOI: 10.1016/j.joca.2014.04.006

    Transforming Growth Factor-beta-Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis (Journal article)

    Sakai, K., Jawaid, S., Sasaki, T., Bou-Gharios, G., & Sakai, T. (2014). Transforming Growth Factor-beta-Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis. AMERICAN JOURNAL OF PATHOLOGY, 184(10), 2611-2617. doi:10.1016/j.ajpath.2014.06.009

    DOI: 10.1016/j.ajpath.2014.06.009

    2013

    Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development (Journal article)

    Sacilotto, N., Monteiro, R., Fritzsche, M., Becker, P. W., Sanchez-del-Campo, L., Liu, K., . . . De Val, S. (2013). Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development. Proceedings of the National Academy of Sciences, 110(29), 11893-11898. doi:10.1073/pnas.1300805110

    DOI: 10.1073/pnas.1300805110

    Distant Mesenchymal Progenitors Contribute to Skin Wound Healing and Produce Collagen: Evidence from a Murine Fetal Microchimerism Model (Journal article)

    Seppanen, E., Roy, E., Ellis, R., Bou-Gharios, G., Fisk, N. M., & Khosrotehrani, K. (2013). Distant Mesenchymal Progenitors Contribute to Skin Wound Healing and Produce Collagen: Evidence from a Murine Fetal Microchimerism Model. PLoS ONE, 8(5), e62662. doi:10.1371/journal.pone.0062662

    DOI: 10.1371/journal.pone.0062662

    Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease (Journal article)

    Lindahl, G. E., Stock, C. J., Shi-Wen, X., Leoni, P., Sestini, P., Howat, S. L., . . . Renzoni, E. A. (2013). Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease. Respiratory Research, 14(1), 80. doi:10.1186/1465-9921-14-80

    DOI: 10.1186/1465-9921-14-80

    Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing (Journal article)

    Rodero, M. P., Legrand, J. M. D., Bou-Gharios, G., & Khosrotehrani, K. (2013). Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing. Experimental Dermatology, 22(2), 143-145. doi:10.1111/exd.12068

    DOI: 10.1111/exd.12068

    2012

    Fetal Microchimeric Cells in a Fetus-Treats-Its-Mother Paradigm Do Not Contribute to Dystrophin Production in Serially Parous mdx Females (Journal article)

    Seppanen, E. J., Hodgson, S. S., Khosrotehrani, K., Bou-Gharios, G., & Fisk, N. M. (2012). Fetal Microchimeric Cells in a Fetus-Treats-Its-Mother Paradigm Do Not Contribute to Dystrophin Production in Serially Parous mdx Females. Stem Cells and Development, 21(15), 2809-2816. doi:10.1089/scd.2012.0047

    DOI: 10.1089/scd.2012.0047

    Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy (Journal article)

    Fragiadaki, M., Hill, N., Hewitt, R., Bou-Gharios, G., Cook, T., Tam, F. W., . . . Mason, R. M. (2012). Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy. Diabetes, 61(9), 2280-2288. doi:10.2337/db11-1138

    DOI: 10.2337/db11-1138

    Ontological Differences in First Compared to Third Trimester Human Fetal Placental Chorionic Stem Cells (Journal article)

    Jones, G. N., Moschidou, D., Puga-Iglesias, T. -I., Kuleszewicz, K., Vanleene, M., Shefelbine, S. J., . . . Guillot, P. V. (2012). Ontological Differences in First Compared to Third Trimester Human Fetal Placental Chorionic Stem Cells. PLoS ONE, 7(9), e43395. doi:10.1371/journal.pone.0043395

    DOI: 10.1371/journal.pone.0043395

    TGF-b signaling in cartilage homeostasis and osteoarthritis (Journal article)

    Finnson, K. W., Chi, Y., Bou-Gharios, G., Leask, A., & Philip, A. (2012). TGF-b signaling in cartilage homeostasis and osteoarthritis. Front Biosci (Schol Ed), 4, 251-268. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22202058

    2011

    Differential Contribution of Dermal Resident and Bone Marrow–Derived Cells to Collagen Production during Wound Healing and Fibrogenesis in Mice (Journal article)

    Higashiyama, R., Nakao, S., Shibusawa, Y., Ishikawa, O., Moro, T., Mikami, K., . . . Inagaki, Y. (2011). Differential Contribution of Dermal Resident and Bone Marrow–Derived Cells to Collagen Production during Wound Healing and Fibrogenesis in Mice. Journal of Investigative Dermatology, 131(2), 529-536. doi:10.1038/jid.2010.314

    DOI: 10.1038/jid.2010.314

    High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1 (Journal article)

    Fragiadaki, M., Ikeda, T., Witherden, A., Mason, R. M., Abraham, D., & Bou-Gharios, G. (2011). High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. Molecular Biology of the Cell, 22(11), 1836-1844. doi:10.1091/mbc.e10-08-0669

    DOI: 10.1091/mbc.e10-08-0669

    Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo (Journal article)

    Fragiadaki, M., Witherden, A. S., Kaneko, T., Sonnylal, S., Pusey, C. D., Bou-Gharios, G., & Mason, R. M. (2011). Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo. Matrix Biology, 30(7-8), 396-403. doi:10.1016/j.matbio.2011.07.004

    DOI: 10.1016/j.matbio.2011.07.004

    Microchimeric Fetal Cells Are Recruited to Maternal Kidney following Injury and Activate Collagen Type I Transcription (Journal article)

    Bou-Gharios, G., Amin, F., Hill, P., Nakamura, H., Maxwell, P., & Fisk, N. M. (2011). Microchimeric Fetal Cells Are Recruited to Maternal Kidney following Injury and Activate Collagen Type I Transcription. Cells Tissues Organs, 193(6), 379-392. doi:10.1159/000321172

    DOI: 10.1159/000321172

    Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties (Journal article)

    Vanleene, M., Saldanha, Z., Cloyd, K. L., Jell, G., Bou-Gharios, G., Bassett, J. H. D., . . . Shefelbine, S. J. (2011). Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties. Blood, 117(3), 1053-1060. doi:10.1182/blood-2010-05-287565

    DOI: 10.1182/blood-2010-05-287565

    2010

    Fetal stem cell microchimerism: natural-born healers or killers? (Journal article)

    Lee, E. S. M., Bou-Gharios, G., Seppanen, E., Khosrotehrani, K., & Fisk, N. M. (2010). Fetal stem cell microchimerism: natural-born healers or killers?. Molecular Human Reproduction, 16(11), 869-878. doi:10.1093/molehr/gaq067

    DOI: 10.1093/molehr/gaq067

    Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis (Journal article)

    Sonnylal, S., Shi-Wen, X., Leoni, P., Naff, K., Van Pelt, C. S., Nakamura, H., . . . de Crombrugghe, B. (2010). Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis & Rheumatism, 62(5), 1523-1532. doi:10.1002/art.27382

    DOI: 10.1002/art.27382

    2009

    JunB mediates enhancer/promoter activity of COL1A2 following TGF-β induction (Journal article)

    Ponticos, M., Harvey, C., Ikeda, T., Abraham, D., & Bou-Gharios, G. (2009). JunB mediates enhancer/promoter activity of COL1A2 following TGF-β induction. Nucleic Acids Research, 37(16), 5378-5389. doi:10.1093/nar/gkp544

    DOI: 10.1093/nar/gkp544

    Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice (Journal article)

    Higashiyama, R., Moro, T., Nakao, S., Mikami, K., Fukumitsu, H., Ueda, Y., . . . Inagaki, Y. (2009). Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice. Gastroenterology, 137(4), 1459-1466.e1. doi:10.1053/j.gastro.2009.07.006

    DOI: 10.1053/j.gastro.2009.07.006

    Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen (Journal article)

    Ponticos, M., Holmes, A. M., Shi-Wen, X., Leoni, P., Khan, K., Rajkumar, V. S., . . . Lindahl, G. E. (2009). Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis & Rheumatism, 60(7), 2142-2155. doi:10.1002/art.24620

    DOI: 10.1002/art.24620

    2008

    Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction (Journal article)

    van Amerongen, M., Bou-Gharios, G., Popa, E., van Ark, J., Petersen, A., van Dam, G., . . . Harmsen, M. (2008). Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction. The Journal of Pathology, 214(3), 377-386. doi:10.1002/path.2281

    DOI: 10.1002/path.2281

    Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice (Journal article)

    Guillot, P. V., Abass, O., Bassett, J. H. D., Shefelbine, S. J., Bou-Gharios, G., Chan, J., . . . Fisk, N. M. (2007). Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice. Blood, 111(3), 1717-1725. doi:10.1182/blood-2007-08-105809

    DOI: 10.1182/blood-2007-08-105809

    Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type Iα2-deficient mouse (Journal article)

    Guillot, P., Cook, H., Pusey, C., Fisk, N., Harten, S., Moss, J., . . . Bou-Gharios, G. (2008). Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type Iα2-deficient mouse. The Journal of Pathology, 214(5), 627-636. doi:10.1002/path.2325

    DOI: 10.1002/path.2325

    Type I Collagen: Structure, Synthesis and Regulation (Chapter)

    Bou-Gharios, G., & de Crombrugghe, B. (2008). Type I Collagen: Structure, Synthesis and Regulation. In J. Bilezikian, L. Raisz, & J. Martin (Eds.), PRINCIPLES OF BONE BIOLOGY (pp. 285-318). london, New York: Elsevier Inc.

    2007

    Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts (Journal article)

    Shi-Wen, X., Renzoni, E. A., Kennedy, L., Howat, S., Chen, Y., Pearson, J. D., . . . Leask, A. (2007). Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. Matrix Biology, 26(8), 625-632. doi:10.1016/j.matbio.2007.06.003

    DOI: 10.1016/j.matbio.2007.06.003

    Endothelin is a downstream mediator of profibrotic responses to transforming growth factor β in human lung fibroblasts (Journal article)

    Shi-wen, X., Kennedy, L., Renzoni, E. A., Bou-Gharios, G., du Bois, R. M., Black, C. M., . . . Leask, A. (2007). Endothelin is a downstream mediator of profibrotic responses to transforming growth factor β in human lung fibroblasts. Arthritis & Rheumatism, 56(12), 4189-4194. doi:10.1002/art.23134

    DOI: 10.1002/art.23134

    Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction (Journal article)

    Alexakis, C., Partridge, T., & Bou-Gharios, G. (2007). Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction. American Journal of Physiology-Cell Physiology, 293(2), C661-C669. doi:10.1152/ajpcell.00061.2007

    DOI: 10.1152/ajpcell.00061.2007

    2006

    Bone Marrow-Derived Cells Do Not Contribute Significantly to Collagen I Synthesis in a Murine Model of Renal Fibrosis (Journal article)

    Roufosse, C. (2006). Bone Marrow-Derived Cells Do Not Contribute Significantly to Collagen I Synthesis in a Murine Model of Renal Fibrosis. Journal of the American Society of Nephrology, 17(3), 775-782. doi:10.1681/ASN.2005080795

    DOI: 10.1681/ASN.2005080795

    CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts (Journal article)

    Shi-wen, X., Stanton, L. A., Kennedy, L., Pala, D., Chen, Y., Howat, S. L., . . . Leask, A. (2006). CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts. Journal of Biological Chemistry, 281(16), 10715-10726. doi:10.1074/jbc.M511343200

    DOI: 10.1074/jbc.M511343200

    Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: Insight into the functional role of mutant fibrillin-1 (Journal article)

    Menon, R. P., Menon, M. R., Shi-Wen, X., Renzoni, E., Bou-Gharios, G., Black, C. M., & Abraham, D. J. (2006). Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: Insight into the functional role of mutant fibrillin-1. Experimental Cell Research, 312(9), 1463-1474. doi:10.1016/j.yexcr.2006.01.011

    DOI: 10.1016/j.yexcr.2006.01.011

    Organ-Specific Collagen Expression: Implications for Renal Disease (Journal article)

    Alexakis, C., Maxwell, P., & Bou-Gharios, G. (2006). Organ-Specific Collagen Expression: Implications for Renal Disease. Nephron Experimental Nephrology, 102(3-4), e71-e75. doi:10.1159/000089684

    DOI: 10.1159/000089684

    Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing (Journal article)

    Rajkumar, V. S., Shiwen, X., Bostrom, M., Leoni, P., Muddle, J., Ivarsson, M., . . . Abraham, D. J. (2006). Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing. Am J Pathol, 169(6), 2254-2265. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17148686

    The Bone Marrow Functionally Contributes to Liver Fibrosis (Journal article)

    Russo, F. P., Alison, M. R., Bigger, B. W., Amofah, E., Florou, A., Amin, F., . . . Forbes, S. J. (2006). The Bone Marrow Functionally Contributes to Liver Fibrosis. Gastroenterology, 130(6), 1807-1821. doi:10.1053/j.gastro.2006.01.036

    DOI: 10.1053/j.gastro.2006.01.036

    Transcriptional regulation of the human α2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases (Journal article)

    Ramirez, F., Tanaka, S., & Bou-Gharios, G. (2006). Transcriptional regulation of the human α2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases. Matrix Biology, 25(6), 365-372. doi:10.1016/j.matbio.2006.05.002

    DOI: 10.1016/j.matbio.2006.05.002

    2005

    Activation of Key Profibrotic Mechanisms in Transgenic Fibroblasts Expressing Kinase-deficient Type II Transforming Growth Factor-β Receptor (TβRIIΔk) (Journal article)

    Denton, C. P., Lindahl, G. E., Khan, K., Shiwen, X., Ong, V. H., Gaspar, N. J., . . . Black, C. M. (2005). Activation of Key Profibrotic Mechanisms in Transgenic Fibroblasts Expressing Kinase-deficient Type II Transforming Growth Factor-β Receptor (TβRIIΔk). Journal of Biological Chemistry, 280(16), 16053-16065. doi:10.1074/jbc.M413134200

    DOI: 10.1074/jbc.M413134200

    Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice (Journal article)

    Inagaki, Y., Kushida, M., Higashi, K., Itoh, J., Higashiyama, R., Hong, Y. Y., . . . Ikeda, K. (2005). Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice. Gastroenterology, 129(1), 259-268. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16012952

    Effects of T-Lymphocyte Depletion on Muscle Fibrosis in the mdx Mouse (Journal article)

    Morrison, J., Palmer, D. B., Cobbold, S., Partridge, T., & Bou-Gharios, G. (2005). Effects of T-Lymphocyte Depletion on Muscle Fibrosis in the mdx Mouse. The American Journal of Pathology, 166(6), 1701-1710. doi:10.1016/S0002-9440(10)62480-7

    DOI: 10.1016/S0002-9440(10)62480-7

    Identification of a Repressor in the First Intron of the Human α2(I) Collagen Gene ( COL1A2 ) (Journal article)

    Antoniv, T. T., Tanaka, S., Sudan, B., De Val, S., Liu, K., Wang, L., . . . Ramirez, F. (2005). Identification of a Repressor in the First Intron of the Human α2(I) Collagen Gene ( COL1A2 ). Journal of Biological Chemistry, 280(42), 35417-35423. doi:10.1074/jbc.M502681200

    DOI: 10.1074/jbc.M502681200

    Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease (Journal article)

    Chen, Y., Shi-Wen, X., van Beek, J., Kennedy, L., McLeod, M., Renzoni, E. A., . . . Leask, A. (2005). Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. Am J Pathol, 167(6), 1699-1711. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16314481

    Nude mutation influences limb skeletal muscle development (Journal article)

    MORRISON, J., PARTRIDGE, T., & BOUGHARIOS, G. (2005). Nude mutation influences limb skeletal muscle development. Matrix Biology, 23(8), 535-542. doi:10.1016/j.matbio.2004.10.003

    DOI: 10.1016/j.matbio.2004.10.003

    Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles (Journal article)

    Lu, Q. L., Rabinowitz, A., Chen, Y. C., Yokota, T., Yin, H., Alter, J., . . . Partridge, T. (2005). Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles. Proceedings of the National Academy of Sciences, 102(1), 198-203. doi:10.1073/pnas.0406700102

    DOI: 10.1073/pnas.0406700102

    2004

    Col1a2 enhancer regulates collagen activity during development and in adult tissue repair (Journal article)

    Ponticos, M., Abraham, D., Alexakis, C., Lu, Q. -L., Black, C., Partridge, T., & Bou-Gharios, G. (2004). Col1a2 enhancer regulates collagen activity during development and in adult tissue repair. Matrix Biology, 22(8), 619-628. doi:10.1016/j.matbio.2003.12.002

    DOI: 10.1016/j.matbio.2003.12.002

    Cooperativity between Far Upstream Enhancer and Proximal Promoter Elements of the Human α2(I) Collagen ( COL1A2 ) Gene Instructs Tissue Specificity in Transgenic Mice (Journal article)

    Tanaka, S., Antoniv, T. T., Liu, K., Wang, L., Wells, D. J., Ramirez, F., & Bou-Gharios, G. (2004). Cooperativity between Far Upstream Enhancer and Proximal Promoter Elements of the Human α2(I) Collagen ( COL1A2 ) Gene Instructs Tissue Specificity in Transgenic Mice. Journal of Biological Chemistry, 279(53), 56024-56031. doi:10.1074/jbc.M411406200

    DOI: 10.1074/jbc.M411406200

    Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK (Journal article)

    Shi-wen, X., Howat, S. L., Renzoni, E. A., Holmes, A., Pearson, J. D., Dashwood, M. R., . . . Abraham, D. J. (2004). Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK. Journal of Biological Chemistry, 279(22), 23098-23103. doi:10.1074/jbc.M311430200

    DOI: 10.1074/jbc.M311430200

    Endothelin-1 Promotes Myofibroblast Induction through the ETA Receptor via a rac/Phosphoinositide 3-Kinase/Akt-dependent Pathway and Is Essential for the Enhanced Contractile Phenotype of Fibrotic Fibroblasts (Journal article)

    Shi-Wen, X., Chen, Y., Denton, C. P., Eastwood, M., Renzoni, E. A., Bou-Gharios, G., . . . Abraham, D. J. (2004). Endothelin-1 Promotes Myofibroblast Induction through the ETA Receptor via a rac/Phosphoinositide 3-Kinase/Akt-dependent Pathway and Is Essential for the Enhanced Contractile Phenotype of Fibrotic Fibroblasts. Molecular Biology of the Cell, 15(6), 2707-2719. doi:10.1091/mbc.e03-12-0902

    DOI: 10.1091/mbc.e03-12-0902

    Extra-cellular matrix in vascular networks (Journal article)

    Bou-Gharios, G., Ponticos, M., Rajkumar, V., & Abraham, D. (2004). Extra-cellular matrix in vascular networks. Cell Proliferation, 37(3), 207-220. doi:10.1111/j.1365-2184.2004.00306.x

    DOI: 10.1111/j.1365-2184.2004.00306.x

    Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts (Journal article)

    Renzoni, E. A., Abraham, D. J., Howat, S., Shi-Wen, X., Sestini, P., Bou-Gharios, G., . . . du Bois, R. M. (2004). Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts. Respiratory Research, 5(1). doi:10.1186/1465-9921-5-24

    DOI: 10.1186/1465-9921-5-24

    Regulation of Collagen Type I in Vascular Smooth Muscle Cells by Competition between Nkx2.5 and  EF1/ZEB1 (Journal article)

    Ponticos, M., Partridge, T., Black, C. M., Abraham, D. J., & Bou-Gharios, G. (2004). Regulation of Collagen Type I in Vascular Smooth Muscle Cells by Competition between Nkx2.5 and  EF1/ZEB1. Molecular and Cellular Biology, 24(14), 6151-6161. doi:10.1128/MCB.24.14.6151-6161.2004

    DOI: 10.1128/MCB.24.14.6151-6161.2004

    Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium (Journal article)

    Murtuza, B., Suzuki, K., Bou-Gharios, G., Beauchamp, J. R., Smolenski, R. T., Partridge, T. A., & Yacoub, M. H. (2004). Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium. Proceedings of the National Academy of Sciences, 101(12), 4216-4221. doi:10.1073/pnas.0306205101

    DOI: 10.1073/pnas.0306205101

    2003

    Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse (Journal article)

    Lu, Q. L., Mann, C. J., Lou, F., Bou-Gharios, G., Morris, G. E., Xue, S. -A., . . . Wilton, S. D. (2003). Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse. Nature Medicine, 9(8), 1009-1014. doi:10.1038/nm897

    DOI: 10.1038/nm897

    Non-viral gene delivery in skeletal muscle: a protein factory (Journal article)

    Lu, Q. L., Bou-Gharios, G., & Partridge, T. A. (2003). Non-viral gene delivery in skeletal muscle: a protein factory. Gene Therapy, 10(2), 131-142. doi:10.1038/sj.gt.3301874

    DOI: 10.1038/sj.gt.3301874

    2002

    Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model (Journal article)

    Vernet, D., Ferrini, M. G., Valente, E. G., Magee, T. R., Bou-Gharios, G., Rajfer, J., & Gonzalez-Cadavid, N. F. (2002). Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. Nitric Oxide, 7(4), 262-276. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12446175

    Identification of the Key Regions within the Mouse Pro -α 2 ( I ) Collagen Gene Far-upstream Enhancer (Journal article)

    De Val, S., Ponticos, M., Antoniv, T. T., Wells, D. J., Abraham, D., Partridge, T., & Bou-Gharios, G. (2002). Identification of the Key Regions within the Mouse Pro -α 2 ( I ) Collagen Gene Far-upstream Enhancer. Journal of Biological Chemistry, 277(11), 9286-9292. doi:10.1074/jbc.M111040200

    DOI: 10.1074/jbc.M111040200

    2001

    Activation of a fibroblast-specific enhancer of the Pro?2(I) collagen gene in tight-skin mice (Journal article)

    Denton, C. P., Zheng, B., Shiwen, X., Zhang, Z., Bou-Gharios, G., Eberspaecher, H., . . . De Crombrugghe, B. (2001). Activation of a fibroblast-specific enhancer of the Pro?2(I) collagen gene in tight-skin mice. Arthritis & Rheumatism, 44(3), 712-722. doi:3.0.CO;2-1">10.1002/1529-0131(200103)44:3<712::AID-ANR121>3.0.CO;2-1

    DOI: 10.1002/1529-0131(200103)44:3<712::AID-ANR121>3.0.CO;2-1

    Characterization of an Evolutionarily Conserved Far-upstream Enhancer in the Human α2(I) Collagen (COL1A2) Gene (Journal article)

    Antoniv, T. T., De Val, S., Wells, D., Denton, C. P., Rabe, C., de Crombrugghe, B., . . . Bou-Gharios, G. (2001). Characterization of an Evolutionarily Conserved Far-upstream Enhancer in the Human α2(I) Collagen (COL1A2) Gene. Journal of Biological Chemistry, 276(24), 21754-21764. doi:10.1074/jbc.M101397200

    DOI: 10.1074/jbc.M101397200

    Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1 (Journal article)

    Shi-wen, X., Denton, C. P., Holmes, A. M., Black, C. M., Abraham, D. J., Dashwood, M. R., . . . Pearson, J. D. (2001). Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1. Journal of Investigative Dermatology, 116(3), 417-425. doi:10.1046/j.1523-1747.2001.01256.x

    DOI: 10.1046/j.1523-1747.2001.01256.x

    2000

    T-cell-dependent fibrosis in the mdx dystrophic mouse (Journal article)

    Morrison, J., Lu, Q. L., Pastoret, C., Partridge, T., & Bou-Gharios, G. (2000). T-cell-dependent fibrosis in the mdx dystrophic mouse. Lab Invest, 80(6), 881-891. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10879739

    1999

    Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast (Journal article)

    Bou-Gharios, G., Wells, D. J., Lu, Q. L., Morgan, J. E., & Partridge, T. (1999). Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast. Gene Therapy, 6(6), 1021-1029. doi:10.1038/sj.gt.3300933

    DOI: 10.1038/sj.gt.3300933

    Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery (Journal article)

    Gross, J. G., Bou-Gharios, G., & Morgan, J. E. (1999). Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery. Cell Tissue Res, 298(2), 371-375. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10571126

    1998

    Activation of Proα2(I) Collagen Promoter during Hepatic Fibrogenesis in Transgenic Mice (Journal article)

    Inagaki, Y., Truter, S., Bou-Gharios, G., Garrett, L. A., de Crombrugghe, B., Nemoto, T., & Greenwel, P. (1998). Activation of Proα2(I) Collagen Promoter during Hepatic Fibrogenesis in Transgenic Mice. Biochemical and Biophysical Research Communications, 250(3), 606-611. doi:10.1006/bbrc.1998.9345

    DOI: 10.1006/bbrc.1998.9345

    1997

    Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis (Journal article)

    Shi-Wen, X., Denton, C. P., McWhirter, A., Bou-Gharios, G., Abraham, D. J., du Bois, R. M., & Black, C. M. (1997). Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis. Arthritis Rheum, 40(7), 1237-1244. doi:10.1002/1529-0131(199707)40:7<1237::AID-ART7>3.0.CO;2-Y

    DOI: 10.1002/1529-0131(199707)40:7<1237::AID-ART7>3.0.CO;2-Y

    1996

    A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice (Journal article)

    Bou-Gharios, G., Garrett, L. A., Rossert, J., Niederreither, K., Eberspaecher, H., Smith, C., . . . Crombrugghe, B. (1996). A potent far-upstream enhancer in the mouse pro alpha 2(I) collagen gene regulates expression of reporter genes in transgenic mice. J Cell Biol, 134(5), 1333-1344. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8794872

    1995

    Expression of ectopeptidases in scleroderma (Journal article)

    Bou-Gharios, G., Osman, J., Atherton, A., Monoghan, P., Vancheeswaran, R., Black, C., & Olsen, I. (1995). Expression of ectopeptidases in scleroderma. Ann Rheum Dis, 54(2), 111-116. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7702397

    Scleroderma-derived human fibroblasts retain abnormal phenotypic and functional characteristics following retroviral transduction with the SV40 tsT antigen (Journal article)

    Xu, S., Vancheeswaran, R., Bou-Gharios, G., O'Hare, M. J., Olsen, I., Abraham, D., & Black, C. (1995). Scleroderma-derived human fibroblasts retain abnormal phenotypic and functional characteristics following retroviral transduction with the SV40 tsT antigen. Exp Cell Res, 220(2), 407-414. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7556450

    1994

    Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis (Journal article)

    Bou-Gharios, G., Osman, J., Black, C., & Olsen, I. (1994). Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis. Clin Chim Acta, 231(1), 69-78. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7704950

    Regulation of CD2-Mediated Heterotypic Interactions of Murine T Lymphocytes (Journal article)

    Abraham, D., Bou-Gharios, G., Tulip, G., Sumner, H., & Olsen, I. (1994). Regulation of CD2-Mediated Heterotypic Interactions of Murine T Lymphocytes. Cellular Immunology, 156(2), 342-356. doi:10.1006/cimm.1994.1180

    DOI: 10.1006/cimm.1994.1180

    1993

    Correction of a lysosomal deficiency by contact-mediated enzyme transfer after bone marrow transplantation (Journal article)

    Bou-Gharios, G., Adams, G., Pace, P., Warden, P., & Olsen, I. (1993). Correction of a lysosomal deficiency by contact-mediated enzyme transfer after bone marrow transplantation. Transplantation, 56(4), 991-996. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8212223

    Lysosomal Enzyme Transfer from Different Types of Lymphoid Cell (Journal article)

    Olsen, I., Bou-Gharios, G., Abraham, D., & Chain, B. (1993). Lysosomal Enzyme Transfer from Different Types of Lymphoid Cell. Experimental Cell Research, 209(1), 133-139. doi:10.1006/excr.1993.1293

    DOI: 10.1006/excr.1993.1293

    Lysosomal storage diseases: mechanisms of enzyme replacement therapy (Journal article)

    Bou-Gharios, G., Abraham, D., & Olsen, I. (1993). Lysosomal storage diseases: mechanisms of enzyme replacement therapy. Histochem J, 25(9), 593-605. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/8226100

    1992

    Expression and function of heterotypic adhesion molecules during differentiation of human skeletal muscle in culture (Journal article)

    Beauchamp, J. R., Abraham, D. J., Bou-Gharios, G., Partridge, T. A., & Olsen, I. (1992). Expression and function of heterotypic adhesion molecules during differentiation of human skeletal muscle in culture. Am J Pathol, 140(2), 387-401. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1739132

    Long-term effects of bone marrow transplantation on lysosomal enzyme replacement in beta-glucuronidase-deficient mice (Journal article)

    Bou-Gharios, G., Adams, G., Pace, P., & Olsen, I. (1992). Long-term effects of bone marrow transplantation on lysosomal enzyme replacement in beta-glucuronidase-deficient mice. J Inherit Metab Dis, 15(6), 899-910. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1293387

    1991

    Contact-dependent transfer of a lysosomal enzyme from lymphocytes to fibroblasts (Journal article)

    Bou-Gharios, G., Moss, J., Partridge, T., Abraham, D., & Olsen, I. (1991). Contact-dependent transfer of a lysosomal enzyme from lymphocytes to fibroblasts. J Cell Sci, 100 (, 443-449. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1808198

    Function and regulation of the murine lymphocyte CD2 receptor (Journal article)

    Abraham, D. J., Bou-Gharios, G., Beauchamp, J. R., Plater-Zyberk, C., Maini, R. N., & Olsen, I. (1991). Function and regulation of the murine lymphocyte CD2 receptor. J Leukoc Biol, 49(4), 329-341. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1672140

    Localization of lysosomal antigens in activated T-lymphocytes (Journal article)

    Bou-Gharios, G., Moss, J., & Olsen, I. (1991). Localization of lysosomal antigens in activated T-lymphocytes. Histochem J, 23(10), 474-482. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1743996

    Simultaneous measurement of cell surface and intracellular antigens by multiple flow cytometry (Journal article)

    Sumner, H., Abraham, D., Bou-Gharios, G., Plater-Zyberk, C., & Olsen, I. (1991). Simultaneous measurement of cell surface and intracellular antigens by multiple flow cytometry. J Immunol Methods, 136(2), 259-267. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1671872

    1990

    Interactions between lymphocytes and dermal fibroblasts: an in vitro model of cutaneous lymphocyte trafficking (Journal article)

    Abraham, D., Bokth, S., Bou-Gharios, G., Beauchamp, J., & Olsen, I. (1990). Interactions between lymphocytes and dermal fibroblasts: an in vitro model of cutaneous lymphocyte trafficking. Exp Cell Res, 190(1), 118-126. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1696898

    The activation of resting lymphocytes is accompanied by the biogenesis of lysosomal organelles (Journal article)

    Olsen, I., Bou-Gharios, G., & Abraham, D. (1990). The activation of resting lymphocytes is accompanied by the biogenesis of lysosomal organelles. European Journal of Immunology, 20(10), 2161-2170. doi:10.1002/eji.1830201003

    DOI: 10.1002/eji.1830201003

    1989

    Adhesion of lymphoid cells to fibroblasts in tissue culture (Journal article)

    Abraham, D., Bou-Gharios, G., Muir, H., & Olsen, I. (1989). Adhesion of lymphoid cells to fibroblasts in tissue culture. Cell Immunol, 122(1), 33-47. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2752430

    Endopeptidase activities associated with the plasma membrane compartment of an antigen-presenting B cell (Journal article)

    Chain, B. M., Bou-Gharios, G., & Olsen, I. (1989). Endopeptidase activities associated with the plasma membrane compartment of an antigen-presenting B cell. Clin Exp Immunol, 75(1), 87-92. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2539276

    1988

    A simple technique for in situ embedding of monolayer cultures in Lowicryl K4M (Journal article)

    Bou-Gharios, G., Adams, G., Moss, J., Shore, I., & Olsen, I. (1988). A simple technique for in situ embedding of monolayer cultures in Lowicryl K4M. J Microsc, 150(Pt 2), 161-163. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3411605

    Cell contact induces the synthesis of a lysosomal enzyme precursor in lymphocytes and its direct transfer to fibroblasts (Journal article)

    Olsen, I., Abraham, D., Shelton, I., Bou-Gharios, G., Muir, H., & Winchester, B. (1988). Cell contact induces the synthesis of a lysosomal enzyme precursor in lymphocytes and its direct transfer to fibroblasts. Biochim Biophys Acta, 968(3), 312-322. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3278745

    Forms and intracellular distribution of alpha-D-mannosidases in murine liver and spleen (Journal article)

    Abraham, D., Bou-Gharios, G., Olsen, I., Shelton, I., Smith, R., & Winchester, B. (1988). Forms and intracellular distribution of alpha-D-mannosidases in murine liver and spleen. Int J Biochem, 20(4), 439-447. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3366302

    Ultrastructural localization of a lysosomal enzyme in resin-embedded lymphocytes (Journal article)

    Bou-Gharios, G., Moss, J., Olsen, I., & Partridge, T. (1988). Ultrastructural localization of a lysosomal enzyme in resin-embedded lymphocytes. Histochemistry, 89(1), 69-74. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3284854

    Ultrastructural studies of a lysosomal enzyme during lymphocyte activation (Journal article)

    Bou-Gharios, G., Moss, J., Abraham, D., Partridge, T., & Olsen, I. (1988). Ultrastructural studies of a lysosomal enzyme during lymphocyte activation. Br J Exp Pathol, 69(5), 661-670. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3264180

    1986

    Effects of mitogenic stimulation on lymphocyte alpha-D-mannosidases (Journal article)

    Abraham, D., Bou-Gharios, G., Muir, H., Olsen, I., Smith, R., & Winchester, B. (1986). Effects of mitogenic stimulation on lymphocyte alpha-D-mannosidases. Eur J Cell Biol, 40(2), 167-175. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3709545
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